Treatment of leg ischemia with biodegradable gelatin hydrogel microspheres incorporating granulocyte colony-stimulating factor

Journal of Cardiovascular Pharmacology

Volumn 57, Issue 4, 2011, Pages 416-423

  Kawamura, Itta ^a   Takemura, Genzou ^a   Tsujimoto, Akiko ^a   Watanabe, Takatomo ^a   Kanamori, Hiromitsu ^a   Esaki, Masayasu ^a   Kobayashi, Hiroyuki ^a   Takeyama, Toshiaki ^a   Kawaguchi, Tomonori ^a   Goto, Kazuko ^a   Maruyama, Rumi ^a   Fujiwara, Takako ^b   Fujiwara, Hisayoshi ^c   Tabata, Yasuhiko ^d   Minatoguchi, Shinya ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO WOMEN'S UNIVERSITY   (Japan)

^c HYOGO PREFECTURAL AMAGASAKI GENERAL MEDICAL CENTER   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Angiogenesis; granulocyte colony stimulating factor; ischemia; vascular disease

Indexed keywords

GELATIN; MICROSPHERE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY LIGATION; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DRUG EFFICACY; FLUORESCENCE ACTIVATED CELL SORTING; GRANULOCYTE; HINDLIMB; HYDROGEL; IMMUNOHISTOCHEMISTRY; LEG ISCHEMIA; LEUKOCYTE COUNT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL MOBILIZATION; TREATMENT DURATION; TREATMENT RESPONSE;

ANIMALS; DISEASE MODELS, ANIMAL; GELATIN; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HINDLIMB; HUMANS; HYDROGELS; INJECTIONS, INTRAMUSCULAR; ISCHEMIA; MALE; MICE; MICE, INBRED BALB C; MICROSPHERES; PERIPHERAL ARTERIAL DISEASE; TIME FACTORS;

EID: 79955041500     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31820c9776     Document Type: Article

References (18)

1. Second European Conensus Document on chronic critical leg ischemia. Circulation. 1991;84(Suppl IV):1-26.
2. Dormandy JA, Rutherford RB. Management ofperipheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC). J Vasc Surg. 2000;31:S1-S296.
3. Youssoufian H, Longmore G, Neumann D, et al. Structure, function, and activation of the erythropoietin receptor Blood. 1993;81:2223-2236. (Pubitemid 23127056)
4. Ribatti D, Presta M, Vacca A, et al. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood. 1999;93:2627-2636. (Pubitemid 29181195)
5. Li L, Okada H, Takemura G, et al. Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia. JAm Coll Cardiol. 2009;53:2378-2388.
6. Bussolino F, Wang JM, Defilippi P, et al. Granulocyte-and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature. 1989;337:471-473. (Pubitemid 19047464)
7. Lee M, Aoki M, Kondo T, et al. Therapeutic angiogenesis with intramuscular injection of low-dose recombinant granulocyte-colony stimulating factor Arterioscler Thromb Vasc Biol. 2005;25:2535-2541. (Pubitemid 43732275)
8. Tabata Y, Hijikata S, Ikada Y Enhanced vascularization and tissue granulation by basic fibroblast growth factor impregnated in gelatin hydrogels. J Control Release. 1994;31:189-199. (Pubitemid 24268165)
9. Fukunaka Y Iwanaga K, Morimoto K, et al. Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. J Control Release. 2002;80:333-343. (Pubitemid 34273770)
10. Tritsaris K, Myren M, Ditlev SB, et al. IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs. Proc Natl Acad Sci USA. 2007;104:15364-15369. (Pubitemid 47502923)
11. Takahashi T, Kalka C, Masuda H, et al. Ischemia-and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med. 1999;5:434-438. (Pubitemid 29180584)
12. Carmeliet P. Angiogenesis in health and disease. NatMed. 2003;9:653-660. (Pubitemid 36749213)
13. Arras M, Ito WD, Scholz D, et al. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest. 1998;101:40-50. (Pubitemid 28058901)
14. Zhang Y Adachi Y Iwasaki M, et al. G-CSF and/or M-CSF accelerate differentiation of bone marrow cells into endothelial progenitor cells in vitro. Oncol Rep. 2006;15:1523-1527.
15. Tura O, Crawford J, Barclay GR, et al. Granulocyte colony-stimulating factor (G-CSF) depresses angiogenesis in vivo and in vitro: implications for sourcing cells for vascular regeneration therapy J Thromb Haemost. 2010;8:1614-1623.
16. Layman H, Sacasa M, Murphy AE, et al. Co-delivery of FGF-2 and G-CSF from gelatin-based hydrogels as angiogenic therapy in a murine critical limb ischemic model. Acta Biomater. 2009;5:230-239.
17. Nakano M, Satoh K, Fukumoto Y et al. Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res. 2007;100:662-669. (Pubitemid 46594880)
18. Cheng XW, Kuzuya M, Nakamura K, et al. Mechanisms underlying the impairment of ischemia-induced neovascularization in matrix metal-loproteinase 2-deficient mice. CircRes. 2007;100:904-913. (Pubitemid 46555696)