Anticonvulsant activity of artificial sweeteners: A structural link between sweet-taste receptor T1R3 and brain glutamate receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4072-4074

  Talevi, Alan ^a   Enrique, Andrea V ^a   Bruno Blanch, Luis E ^a  

^a FACULTAD DE CIENCIAS EXACTAS   (Argentina)

Author keywords

Anticonvulant; Epilepsy; Knowledge based drug repurposing; Sweetener; T1R3; Virtual screening

Indexed keywords

ACESULFAME POTASSIUM; ANTICONVULSIVE AGENT; CYCLAMATE SODIUM; GLUTAMATE RECEPTOR; PROTEIN T1R3; RECEPTOR; SACCHARIN; SWEETENING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; MOUSE; NONHUMAN; SWEETNESS;

ANIMALS; ANTICONVULSANTS; BRAIN; COMPUTATIONAL BIOLOGY; CYCLAMATES; DRUG REPOSITIONING; ELECTROSHOCK; MICE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, METABOTROPIC GLUTAMATE; SACCHARIN; SEIZURES; SEQUENCE HOMOLOGY, AMINO ACID; SWEETENING AGENTS; TASTE; TASTE PERCEPTION; THIAZINES;

MUS;

EID: 84861579934     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.076     Document Type: Article

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