Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4028-4032

  Axten, Jeffrey M ^a   Medina, Jesús R ^a   Blackledge, Charles W ^a   Duquenne, Céline ^a   Grant, Seth W ^a   Bobko, Mark A ^a   Peng, Tony ^a   Miller, William H ^a   Pinckney, Theresa ^a   Gallagher, Timothy F ^a   Kulkarni, Swarupa ^a   Lewandowski, Thomas ^a   Van Aller, Glenn S ^a   Zonis, Rimma ^a   Ward, Paris ^a   Campobasso, Nino ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Antibacterial; Antibiotic; PDF inhibitor; Peptide deformylase

Indexed keywords

ACYLPROLINAMIDE; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIINFECTIVE AGENT; LEVOFLOXACIN; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN CELL; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NONHUMAN; RAT; RESPIRATORY TRACT INFECTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMIDES; AMIDOHYDROLASES; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; HAEMOPHILUS INFLUENZAE; HUMANS; INJECTIONS, INTRAVENOUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROLINE; RATS; RESPIRATORY TRACT INFECTIONS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861579222     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.086     Document Type: Article

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