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Volumn 30, Issue 1, 2005, Pages 23-28

LBM-415: Antibacterial peptide deformylase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIINFECTIVE AGENT; CEFTRIAXONE; CIPROFLOXACIN; CLARITHROMYCIN; LINEZOLID; METICILLIN; N (5 FLUORO 1 OXIDO 2 PYRIDINYL) 1 [2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANOYL]PROLINAMIDE; N (5 FLUORO 1 OXIDOPYRIDIN 2 YL) 1 [2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANOYL]PROLINAMIDE; PENICILLIN G; PEPTIDE DEFORMYLASE INHIBITOR; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

EID: 14944375645     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2005.030.01.871650     Document Type: Article
Times cited : (7)

References (38)
  • 1
    • 14944345017 scopus 로고    scopus 로고
    • (Vicuron Pharmaceuticals Inc.; Novartis AG). N-Formyl hydroxylamine cpds. as inhibitors of PDF. CA 2448526, EP 1401828, US 2003045479, WO 02102790
    • Patel, D.V., Yuan, Z., Jain, R.K., Garcia Alvarez, S., Jacobs, J. (Vicuron Pharmaceuticals Inc.; Novartis AG). N-Formyl hydroxylamine cpds. as inhibitors of PDF. CA 2448526, EP 1401828, US 2003045479, WO 02102790.
    • Patel, D.V.1    Yuan, Z.2    Jain, R.K.3    Garcia Alvarez, S.4    Jacobs, J.5
  • 2
    • 0037439518 scopus 로고    scopus 로고
    • Bacterial resistance: Origins, epidemiology, and impact
    • Livermore, D.M. Bacterial resistance: Origins, epidemiology, and impact. Clin Infect Dis 2003, 36(Suppl. 1.): S11-23.
    • (2003) Clin Infect Dis , vol.36 , Issue.SUPPL. 1
    • Livermore, D.M.1
  • 3
    • 0033936704 scopus 로고    scopus 로고
    • Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents
    • Giglione, C., Pierre, M., Meinnel, T. Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents. Mol Microbiol 2000, 36: 1197-205.
    • (2000) Mol Microbiol , vol.36 , pp. 1197-1205
    • Giglione, C.1    Pierre, M.2    Meinnel, T.3
  • 4
    • 0036771389 scopus 로고    scopus 로고
    • Novel approaches to antimicrobial therapy: Peptide deformylase
    • Waller, A.S., Clements, J.M. Novel approaches to antimicrobial therapy: Peptide deformylase. Curr Opin Drug Discov Dev 2002, 5: 785-92.
    • (2002) Curr Opin Drug Discov Dev , vol.5 , pp. 785-792
    • Waller, A.S.1    Clements, J.M.2
  • 5
    • 2342654040 scopus 로고    scopus 로고
    • Antimicrobial spectrum and activity of NVP PDF-713, a novel peptide deformylase inhibitor, tested against 1,837 recent Gram-positive clinical isolates
    • Jones, R.N., Fritsche, T.R., Sader, H.S. Antimicrobial spectrum and activity of NVP PDF-713, a novel peptide deformylase inhibitor, tested against 1,837 recent Gram-positive clinical isolates. Diagn Microbiol Infect Dis 2004, 49: 63-5.
    • (2004) Diagn Microbiol Infect Dis , vol.49 , pp. 63-65
    • Jones, R.N.1    Fritsche, T.R.2    Sader, H.S.3
  • 6
    • 2342654040 scopus 로고    scopus 로고
    • Antimicrobial spectrum and activity of NVP PDF-713 (PDF7), a novel peptide deformylase inhibitor, tested against 1,837 recent Gram-positive clinical isolates
    • Abst P914
    • Jones, R.N., Fritsche, T., Sader, H. Antimicrobial spectrum and activity of NVP PDF-713 (PDF7), a novel peptide deformylase inhibitor, tested against 1,837 recent Gram-positive clinical isolates. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P914.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Jones, R.N.1    Fritsche, T.2    Sader, H.3
  • 7
    • 14944353862 scopus 로고    scopus 로고
    • Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor (PDI)
    • (Oct 30-Nov 2, Washington DC) Abst F-1961
    • Fritsche, T.R., Rhomberg, P.R., Jones, R.N. Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor (PDI). 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1961.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Fritsche, T.R.1    Rhomberg, P.R.2    Jones, R.N.3
  • 8
    • 14944377128 scopus 로고    scopus 로고
    • In vitro profiling of the new peptide deformylase inhibitor LBM415 (VIC-104959)
    • (Oct 30-Nov 2, Washington DC) Abst F-1960
    • Lopez, S., Wu, C., Blais, J. et al. In vitro profiling of the new peptide deformylase inhibitor LBM415 (VIC-104959). 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1960.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Lopez, S.1    Wu, C.2    Blais, J.3
  • 9
    • 14944351122 scopus 로고    scopus 로고
    • LBM415, a new peptide deformylase inhibitor with potent in vitro activity against drug-resistant bacteria
    • (Oct 30-Nov 2, Washington DC) Abst F-1959
    • Ryder, N.S., Dzink-Fox, J., Kubik, B. et al. LBM415, a new peptide deformylase inhibitor with potent in vitro activity against drug-resistant bacteria. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1959.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Ryder, N.S.1    Dzink-Fox, J.2    Kubik, B.3
  • 10
    • 4644341060 scopus 로고    scopus 로고
    • Antistaphylococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents
    • Credito, K., Lin, G., Ednie, L.M., Appelbaum, P.C. Antistaphylococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents. Antimicrob Agents Chemother 2004, 48: 4033-6.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4033-4036
    • Credito, K.1    Lin, G.2    Ednie, L.M.3    Appelbaum, P.C.4
  • 11
    • 14944345460 scopus 로고    scopus 로고
    • Antistaphylococcal activity of NVP-PDF713, a new peptide deformylase inhibitor compared to other agents
    • Abst P915
    • Appelbaum, P., Ednie, L., Jacobs, M. Antistaphylococcal activity of NVP-PDF713, a new peptide deformylase inhibitor compared to other agents. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P915.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Appelbaum, P.1    Ednie, L.2    Jacobs, M.3
  • 12
    • 14944343055 scopus 로고    scopus 로고
    • Time-kill study of antistaphylococcal activity of NVP PDF-713 compared to other agents
    • Abst P919
    • Appelbaum, P., Credito, K., Lin, G., Jacobs, M. Time-kill study of antistaphylococcal activity of NVP PDF-713 compared to other agents. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P919.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Appelbaum, P.1    Credito, K.2    Lin, G.3    Jacobs, M.4
  • 13
    • 0242437814 scopus 로고    scopus 로고
    • Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center
    • Bozdogan, B., Esel, D., Whitener, C., Browne, F.A., Appelbaum, P.C. Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center. J Antimicrob Chemother 2003, 52: 864-8.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 864-868
    • Bozdogan, B.1    Esel, D.2    Whitener, C.3    Browne, F.A.4    Appelbaum, P.C.5
  • 14
    • 4444295568 scopus 로고    scopus 로고
    • Activity of oxazolidinones, DNA nanobinders and peptide deformylase (PDF) inhibitors against a vancomycin resistant Staphylococcus aureus (VRSA)
    • (Sept 14-17, Chicago) Abst F-1471
    • Bozdogan, B., Esel, D., Appelbaum, P.C. Activity of oxazolidinones, DNA nanobinders and peptide deformylase (PDF) inhibitors against a vancomycin resistant Staphylococcus aureus (VRSA). 43rd Intersci Conf Antimicrob Agents Chemother (Sept 14-17, Chicago) 2003, Abst F-1471.
    • (2003) 43rd Intersci Conf Antimicrob Agents Chemother
    • Bozdogan, B.1    Esel, D.2    Appelbaum, P.C.3
  • 15
    • 4644249672 scopus 로고    scopus 로고
    • Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents
    • Ednie, L.M., Pankuch, G., Appelbaum, P.C. Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents. Antimicrob Agents Chemother 2004, 48: 4027-32.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4027-4032
    • Ednie, L.M.1    Pankuch, G.2    Appelbaum, P.C.3
  • 16
    • 14944357417 scopus 로고    scopus 로고
    • Antipneumococcal activity of NVP-PDF713 compared to 18 other agents
    • Abst P916
    • Appelbaum, P., Ednie, L., Jacobs, M. Antipneumococcal activity of NVP-PDF713 compared to 18 other agents. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P916.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Appelbaum, P.1    Ednie, L.2    Jacobs, M.3
  • 17
    • 14944360771 scopus 로고    scopus 로고
    • Time-kill study of the antipneumococcal activity of NVP PDF-713, a new peptide deformylase inhibitor, compared to 13 other agents
    • Abst P920
    • Appelbaum, P., Pankuch, G., Jacobs, M. Time-kill study of the antipneumococcal activity of NVP PDF-713, a new peptide deformylase inhibitor, compared to 13 other agents. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P920.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Appelbaum, P.1    Pankuch, G.2    Jacobs, M.3
  • 18
    • 14944353124 scopus 로고    scopus 로고
    • Evaluation of the in vitro activity of NVP PDF-713 against clinical anaerobic isolates with emphasis on the Bacteroides fragilis group
    • Abst P917
    • Snydman, D.R., Jacobus, N.V., McDermott, L.A. Evaluation of the in vitro activity of NVP PDF-713 against clinical anaerobic isolates with emphasis on the Bacteroides fragilis group. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P917.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Snydman, D.R.1    Jacobus, N.V.2    McDermott, L.A.3
  • 19
    • 14944354940 scopus 로고    scopus 로고
    • Potential utility of a peptide deformylase inhibitor, NVP PDF-713 (PDF7) against oxazolidinone-resistant or streptogramin-resistant Gram-positive isolates
    • Abst P918
    • Jones, R., Moet, G., Sader, H., Pritsche, T. Potential utility of a peptide deformylase inhibitor, NVP PDF-713 (PDF7) against oxazolidinone- resistant or streptogramin-resistant Gram-positive isolates. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P918.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Jones, R.1    Moet, G.2    Sader, H.3    Pritsche, T.4
  • 20
    • 14944383277 scopus 로고    scopus 로고
    • Antimicrobial activity of LBM 415 (NVP PDF-713) tested against Neisseria meningitidis (NM) and N. gonorrhoeae (NG)
    • (Oct 30-Nov 2, Washington DC) Abst F-1962
    • Fritsche, T.R., Jones, R.N. Antimicrobial activity of LBM 415 (NVP PDF-713) tested against Neisseria meningitidis (NM) and N. gonorrhoeae (NG). 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1962.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Fritsche, T.R.1    Jones, R.N.2
  • 21
    • 14944358763 scopus 로고    scopus 로고
    • Comparative in vitro activities of an investigational peptide deformylase inhibitor LBM-415 and other agents against mycoplasmas and ureaplasmas of human origin
    • (Oct 30-Nov 2, Washington DC) Abst E-2050
    • Waites, K.B., Crabb, D.M., Duffy, L.B. Comparative in vitro activities of an investigational peptide deformylase inhibitor LBM-415 and other agents against mycoplasmas and ureaplasmas of human origin. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst E-2050.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Waites, K.B.1    Crabb, D.M.2    Duffy, L.B.3
  • 24
    • 14944376227 scopus 로고    scopus 로고
    • LBM415, a new oral peptide deformlyase inhibitor: Efficacy in murine infection models
    • (Oct 30-Nov 2, Washington DC) Abst F-1964
    • Neckermann, G., Yu, D., Manni, K. et al. LBM415, a new oral peptide deformlyase inhibitor: Efficacy in murine infection models. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1964.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Neckermann, G.1    Yu, D.2    Manni, K.3
  • 25
    • 14944368733 scopus 로고    scopus 로고
    • Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus
    • (Oct 30-Nov 2, Washington DC) Abst F-1541
    • Wang, W., Wu, C., White, R., Yuan, Z. Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1541.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Wang, W.1    Wu, C.2    White, R.3    Yuan, Z.4
  • 27
    • 14944366075 scopus 로고    scopus 로고
    • Role of efflux in decreasing susceptibility to the peptide deformylase inhibitor LBM415 in Haemophilus influenzae
    • (Oct 30-Nov 2, Washington DC) Abst C1-1881
    • Dean, C.R., Narayan, S., Dzink-Fox, J., Puyang, X., Ryder, N.S. Role of efflux in decreasing susceptibility to the peptide deformylase inhibitor LBM415 in Haemophilus influenzae. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst C1-1881.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Dean, C.R.1    Narayan, S.2    Dzink-Fox, J.3    Puyang, X.4    Ryder, N.S.5
  • 28
    • 14944357773 scopus 로고    scopus 로고
    • LBM415 (VIC-104959), a novel peptide deformylase inhibitor with favorable pharmacokinetic profile in rodents
    • (Oct 30-Nov 2, Washington DC) Abst F-1965
    • Chen, D., Tembe, V., Cramer, J. et al. LBM415 (VIC-104959), a novel peptide deformylase inhibitor with favorable pharmacokinetic profile in rodents. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst F-1965.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Chen, D.1    Tembe, V.2    Cramer, J.3
  • 30
    • 14944377786 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of NVP-PDF-713, a new peptide deformylase inhibitor
    • Abst P921
    • Craig, W., Andes, D. In vivo pharmacodynamics of NVP-PDF-713, a new peptide deformylase inhibitor. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P921.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Craig, W.1    Andes, D.2
  • 31
    • 14944377786 scopus 로고    scopus 로고
    • In vivo pharmacodynamic activity of NVP-PDF-713 against multiple bacterial pathogens
    • Abst P922
    • Craig, W., Andes, D. In vivo pharmacodynamic activity of NVP-PDF-713 against multiple bacterial pathogens. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P922.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Craig, W.1    Andes, D.2
  • 32
    • 14944356040 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of LBM415, a novel peptide deformylase (PDF) inhibitor
    • (Oct 3-5, Phoenix) Abst 30
    • Sun, H., MacLeod, C., Zheng, W., Dobson, C., Skerjanec, A. Single and multiple dose pharmacokinetics of LBM415, a novel peptide deformylase (PDF) inhibitor. 33rd Annu Meet Amer Coll Clin Pharmacol (Oct 3-5, Phoenix) 2004, Abst 30.
    • (2004) 33rd Annu Meet Amer Coll Clin Pharmacol
    • Sun, H.1    MacLeod, C.2    Zheng, W.3    Dobson, C.4    Skerjanec, A.5
  • 33
    • 14944346073 scopus 로고    scopus 로고
    • Preclinical characterization and pharmacokinetics of a novel peptide deformylase inhibitor, LBM415
    • November 23
    • Preclinical characterization and pharmacokinetics of a novel peptide deformylase inhibitor, LBM415. DailyDrugNews.com (Daily Essentials) November 23, 2004.
    • (2004) DailyDrugNews.com (Daily Essentials)
  • 34
    • 0842303166 scopus 로고    scopus 로고
    • Disk diffusion quality control guidelines for NVP-PDF 713: A novel peptide deformylase inhibitor
    • Anderegg, T.R., Jones, R.N., Quality Control Working Group. Disk diffusion quality control guidelines for NVP-PDF 713: A novel peptide deformylase inhibitor. Diagn Microbiol Infect Dis 2004, 48: 55-7.
    • (2004) Diagn Microbiol Infect Dis , vol.48 , pp. 55-57
    • Anderegg, T.R.1    Jones, R.N.2
  • 35
    • 14944358762 scopus 로고    scopus 로고
    • Determination of quality control guidelines for MIC dilution and disk diffusion methods when testing NVP-PDF713, a novel peptide deformylase inhibitor
    • Abst P923
    • Fritsche, T., Anderegg, T., Jones, R. Determination of quality control guidelines for MIC dilution and disk diffusion methods when testing NVP-PDF713, a novel peptide deformylase inhibitor. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P923.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Fritsche, T.1    Anderegg, T.2    Jones, R.3
  • 36
    • 0038046837 scopus 로고    scopus 로고
    • Quality control guidelines for MIC susceptibility testing of NVP PDF-713: A novel peptide deformylase inhibitor
    • Anderegg, T.R., Biedenbach, D.J., Jones, R.N., Quality Control Working Group. Quality control guidelines for MIC susceptibility testing of NVP PDF-713: A novel peptide deformylase inhibitor. Int J Antimicrob Agents 2003, 22: 84-6.
    • (2003) Int J Antimicrob Agents , vol.22 , pp. 84-86
    • Anderegg, T.R.1    Biedenbach, D.J.2    Jones, R.N.3
  • 37
    • 14944375969 scopus 로고    scopus 로고
    • Comparisons of inter-method susceptibility testing accuracy for LBM415 (NVP PDF-713) using 2,625 recent clinical isolates
    • (Oct 30-Nov 2, Washington DC) Abst D-1919
    • Fritsche, T.R., Rhomberg, P.R., Jones, R.N. Comparisons of inter-method susceptibility testing accuracy for LBM415 (NVP PDF-713) using 2,625 recent clinical isolates. 44th Intersci Conf Antimicrob Agents Chemother (Oct 30-Nov 2, Washington DC) 2004, Abst D-1919.
    • (2004) 44th Intersci Conf Antimicrob Agents Chemother
    • Fritsche, T.R.1    Rhomberg, P.R.2    Jones, R.N.3
  • 38
    • 14944339300 scopus 로고    scopus 로고
    • Determination of dry-form commercial reagent reproducibility and MIC validations for NVP-PDF713, a novel peptide deformylase inhibitor
    • Abst P924
    • Moet, G., Jones, R., Rhomberg, P., Fritsche, T. Determination of dry-form commercial reagent reproducibility and MIC validations for NVP-PDF713, a novel peptide deformylase inhibitor. Clin Microbiol Infect 2004, 10(Suppl. 3): Abst P924.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 3
    • Moet, G.1    Jones, R.2    Rhomberg, P.3    Fritsche, T.4


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