Epidemiology of extended-spectrum beta-lactamases in Brazil: Clinical impact and implications for agribusiness;Epidemiologia das betalactamases de espectro estendido no Brasil: Impacto clínico e implicações para o agronegócio

Jornal Brasileiro de Patologia e Medicina Laboratorial

Volumn 48, Issue 2, 2012, Pages 91-99

  De Silva, Ketrin Cristina ^a   Lincopan, Nilton ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Agribusiness; Bacterial resistance; Enterobacteriaceae; ESBL; Nosocomial infection

Indexed keywords

EID: 84861561575     PISSN: 16762444     EISSN: 16784774     Source Type: Journal    
DOI: 10.1590/s1676-24442012000200004     Document Type: Article

References (90)

1. ANDRADE, L. N. et al. Determinants of β-lactam resistance in meningitis-causing Enterobacteriaceae in Brazil. Can J Microbiol, v. 56, n. 5, p. 399-407, 2010.
2. ANTONIO, C. S. et al. High prevalence of carbapenemresistant Acinetobacter baumannii carrying the blaOXA-143 gene in Brazilian hospitals. Antimicrob Agents Chemother, v. 55, n. 3, p. 1322-3, 2011.
3. ABEF. Associação Brasileira dos Exportadores de Frango. São Paulo. Disponível em: http://www.abef.com.br/noticias-portal/ exibenoticia.php?notcodigo=2389>. Acesso em: 20 jun. 2010.
4. BAUERFEIND, A. J. M. et al. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection, v. 20, p. 158-63, 1992.
5. BAUERNFEIND, A. J. M. et al. A new plasmidic cefotaximase in a clinical isolate of Escherichia coli. Infection, v. 18, p. 294-8, 1990.
6. BAUERNFEIND, A. J. M. Sequences of β-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases. Antimicrob Agents Chemother, v. 40, n. 2, p. 509-13, 1996.
7. BEIRÃO, E. M. et al. Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil. Braz J Infect Dis, v. 15, n. 1, p. 69-73, 2011.
8. BERNARD, H. et al. A novel plasmid-mediated extendedspectrum β-lactamase not derived from TEM-or SHV-type enzymes. J Antimicrob Chemother, v. 29, p. 590-2, 1992.
9. BONNET, R. et al. A novel class A extended-spectrum β-lactamase (BES-1) in Serratia marcescens isolated in Brazil. Antimicrob Agents Chemother, v. 44, n. 11, p. 3061-8, 2000.
10. BONNET, R. et al. A novel CTX-M β-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil. Antimicrob Agents Chemother, v. 44, n. 7, p. 1936-42, 2000. (Pubitemid 30422952)
11. BONNET, R. et al. Novel cefotaximase (CTX-M-16) with increased catalytic effciency due to substitution Asp-240 Gly. Antimicrob Agents Chemother, v. 45, n. 8, p. 2269-75, 2001. (Pubitemid 32664466)
12. BUSH, K. et al. A functional classifcation scheme for β-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother, v. 39, n. 6, p. 1211-33, 1995.
13. BUSH, K.; JACOBY, G. β-lactamases classification and amino acid sequences for TEM, SHV and OXA extended-spectrum and inhibitor resistant enzymes. Disponível em: . Acesso em: 3 abr. 2011.
14. BUSH, K.; JACOBY, G. A. Update functional classifcation of beta-lactamases. Antimicrob Agents Chemother, v. 54, n. 3, p. 969-76, 2010.
15. CARTER, M. W. et al. Detection of extended-spectrum β-lactamases in Klebsiellae with the oxoid combination disk method. J Clin Microbiol, v. 38, n. 11, p. 4228-32, 2000. (Pubitemid 32233232)
16. CASSETARI, V. C. et al. Risk factors for colonisation of newborn infantis during an outbreak of extendedspectrum β-lactamase producing Klebsiella pneumoniae in an intermediate-risk neonatal unit. J Hosp Infec, v. 71, n. 4, p. 340-7, 2009.
17. CASTANHEIRA, M. et al. Emergence of the extendedspectrum beta-lactamase GES-1 in a Pseudomonas aeruginosa strain from Brazil: report from the SENTRY antimicrobial surveillance program. Antimicrob Agents Chemother, v. 48, n. 6, p. 2344-5, 2004. (Pubitemid 38691649)
18. CERGOLE-NOVELLA, M. C. et al. First description of blaCTX-M-14 and blaCTX-M-15-producing Escherichia coli isolates in Brazil. Microb Drug Resist, v. 16, n. 3, p. 177-84, 2010.
19. CLERMONT, O. et al. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl Environ Microbiol, v. 66, n. 10, p. 4555-8, 2000.
20. CLIMACO, E. C. et al. CTX-M-producing Klebsiella spp. in a Brazilian hospital: what has changed in 6 years? Diagn Microbiol Infect Dis, v. 68, n. 2, p. 186-9, 2010.
21. Clinical and Laboratory Standards Institute (CLSI 2009). Normas de desempenho para testes de sensibilidade a agentes antimicrobianos por diluição para crescimento de bactérias aeróbias.15o suplemento informativo. CLSI documento M100-S19. v. 29, n. 3, 2009.
22. COELHO, A. et al. Spread of Escherichia coli O25b:H4-B2-ST131 producing CTX-M-15 and SHV-12 with high virulence gene content in Barcelona (Spain). J Antimicrob Chemother, v. 66, n. 3, p. 517-26, 2011.
23. COQUE, T. M. et al. Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15. Emerg Infect Dis, v. 14, n. 2, p. 195-200, 2008. (Pubitemid 351213667)
24. CORKILL, J. E. et al. SHV-27, a novel cefotaximehydrolysing β-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital. J Antimicrob Chemother, v. 47, p. 463-5, 2001. (Pubitemid 32303415)
25. CORTEZ, A. L. L. et al. Resistência antimicrobiana de cepas de Salmonella spp. isoladas de abatedouros de aves. Arq Inst Biol, v. 73, n. 2, p. 157-63, 2006.
26. DATTA, N.; KONTOMICHALOU, P. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature, v. 208, n. 5007, p. 239-41, 1965.
27. DHANJI, H. et al. Isolation of fuoroquinolone-resistant O25b:H4-ST131 Escherichia coli with CTX-M-14 extended-spectrum beta-lactamase from UK river water. J Antimicrob Chemother, v. 66, n. 3, p. 512-6, 2010.
28. DROPA, M. Caracterização genotípica de cepas da família Enterobacteriaceae produtoras de β-lactamases de espectro estendido, isoladas de pacientes de um hospital da rede pública da cidade de São Paulo. 2006. Dissertação (Mestrado) - Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, 2006.
29. DROPA, M. Emergence of Klebsiella pneumoniae carrying the novel extended-spectrum beta-lactamase gene variants blaSHV-40, blaTEM-116 and the class 1 integron-associated blaGES-7, Brazil. Clinical Microbiology and Infection, v. 16, n. 6, p. 630-2, 2010.
30. FALAGAS, M. E.; KARAGEORGOPOULOS, D. E. Extendedspectrum beta-lactamases-producing organisms. J Hosp Infect, v. 73, p. 345-54, 2009.
31. FERNANDES, S. A. et al. CTX-M-2-producing Salmonella typhymurium isolated from pediatric patients and poultry in Brazil. Microb Drug Resist, v. 15, n. 4, p. 317-21, 2009.
32. FERREIRA, A. E. et al. Presence of OXA-23-producing isolates of Acinetobacter baumannii in wastewater from hospitals in southern Brazil. Microb Drug Resist, v. 17, n. 2, p. 221-7, 2011.
33. FONTES, L. C. et al. Isolation of Pseudomonas aeruginosa co-producing metallo-β-lactamase SPM-1 and 16S rRNA methylase RmtD-1 in an urban river. Antimicrob Agents Chemother, v. 55, n. 6, p. 3063-4, 2011.
34. FUENTEFRIA, D. B. et al. Antibiotic-resistant Pseudomonas aeruginosa from hospital wastewater and superfcial water: are they genetically related? J Environ Manage, v. 92, n. 1, p. 250-5, 2010.
35. GARCIA, D. O. et al. Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. Antimicrob Agents Chemother, v. 52, n. 5, p. 1790-3, 2008.
36. GEOGRAFIA PARA TODOS. Geografa para o Ensino Médio. Disponível em: . Acesso em: 29 mar. 2011.
37. GROSSO, F. et al. OXA-23-producing Acinetobacter baumannii: a new hotspot of diversity in Rio de Janeiro? J Antimicrob Chemother, v. 66, n. 1, p. 62-5, 2011.
38. GUENTHER, S. et al. CTX-M-15 extended-spectrum beta-lactamases-producing Escherichia coli from wild birds in Germany. Envir Microbiol Reports, v. 2. n. 5, p. 641-5, 2010.
39. GUTMANN, L. et al. SHV-5, a novel SHV-type β-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams. Antimicrob Agents Chemother, v. 33, n. 6, p. 951-6, 1989. (Pubitemid 19146590)
40. HARADA, S. et al. Extended-spectrum β-lactamases: implications for the clinical laboratory and therapy. Korean J Lab Med, v. 28, v. 6, p. 401-12, 2008.
41. HUMENIUK, C. et al. β-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types. Antimicrob Agents Chemother, v. 46, n. 9, p. 3045-9, 2002.
42. JACOBY, G. A. AmpC β-lactamases. Clin Microbiol Rev, v. 22, n. 1, p. 161-82, 2009.
43. KIFFER, C. et al. Antimicrobial susceptibility of Gramnegative bacteria in Brazilian hospitals: the MYSTIC Program Brazil 2003. Braz J Infect Dis, v. 9, n. 3, p. 216-24, 2005. (Pubitemid 41657674)
44. KNOTHE, H. et al. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection, v. 11, n. 6, p. 315-7, 1983. (Pubitemid 14213754)
45. LINCOPAN, N et al. Enterobacteria producing extendedspectrum beta-lactamases and IMP-1 metallo-betalactamases isolated from Brazilian hospitals. J Med Microbiol, v. 55, n. 11, p. 1611-3, 2006. (Pubitemid 44713884)
46. LIVERMORE, D. M. Beta-lactamases in laboratory and clinical resistance. Clin Microbiol Rev, v. 8, n. 4, p. 557-84, 1995.
47. LOPES, A. C. bla (CTX-M-2) and bla (CTX-M-28) extendedspectrum beta-lactamase genes and class 1 integrons in clinical isolates of Klebsiella pneumoniae from Brazil. Mem Inst Oswaldo Cruz, v. 105, n. 2, p. 163-7, 2010.
48. MARRA, A. R. et al. Health and economic outcomes of the detection of Klebsiella pneumoniae-produced extended-spectrum β-lactamase (ESBL) in a hospital with high prevalence of this infection. Int J Infect Dis, v. 10, n. 1, p. 56-60, 2006. (Pubitemid 43003592)
49. MARRA, A. R. et al. Nosocomial bloodstream infections caused by Klebsiella pneumoniae: impact of extendedspectrum beta-lactamase (ESBL) production on clinical outcome in a hospital with high ESBL prevalence. BMC Infect Dis, v. 6, p. 24, 2006.
50. MARTINS, A. F. et al. Dissemination of Pseudomonas aeruginosa producing SPM-1-like and IMP-1-like metallo-beta-lactamases in hospitals from southern Brazil. Infection, v. 35, n. 6, p. 457-60, 2007. (Pubitemid 50005158)
51. MATSUMOTO, Y. et al. Novel plasmid-mediated betalactamase from Escherichia coli that inactivates oxymino-cephalosporinas. Antimicrob Agents and Chemoterapy, v. 32, n. 8, p. 1243-2146, 1988.
52. MINARINI, L. A. R. et al. Clonal transmission of ESBL-producing Klebsiella spp. at a university hospital in Brazil. Curr Microbiol, v. 56, n. 6, p. 587-91, 2008.
53. MINARINI, L. A. R. et al. Multilocus sequence typing of uropathogenic ESBL-producing Escherichia coli isolated in a Brazilian community. Curr Microbiol, v. 55, p. 524-9, 2007. (Pubitemid 47632287)
54. MINARINI, L. A. R. et al. Predominance of CTX-M-type extended-spectrum β-lactamase genes among enterobacterial isolates from outpatients in Brazil. Diagn Microbiol Infect Dis, v. 65, n. 2, p. 202-6, 2009.
55. MINARINI, L. A. R. et al. Prevalence of communityoccurring extended spectrum β-lactamase-producing Enterobacteriaceae in Brazil. Curr Microbiol, v. 54, n. 5, p. 335-41, 2007. (Pubitemid 46733866)
56. MINISTÉRIO DA SAÚDE. Análise epidemiológica dos surtos de doenças transmissíveis por alimentos no Brasil. Disponível em: . Acesso em: 28 fev. 2009.
57. MOTTA, R. N. et al. Plasmid-mediated extended-spectrum beta-lactamase-producing strains of Enterobacteriaceae isolated from diabetes foot infections in a Brazilian diabetic center. Braz J Infect Dis, v. 7, n. 2, p. 129-34, 2003.
58. MURLEY, M. R. et al. Characterization of a Salmonella enteric serovar Agona strain harbouring a class 1 integron containing novel OXA-type β-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac (6')-130]. J Antimicrob Chemother, v. 54, n. 2, p. 354-9, 2004.
59. NOGUEIRA, K. S. et al. Ocurrence of extended-spectrum beta-lactamases in Enterobacteriaceae isolated from hospitalized patients in Curitiba, southern Brazil. Braz J Infect Dis, v. 10, n. 6, p. 390-5, 2006.
60. OKEEFE, A. et al. First Detection of CTX-M and SHV extendedspectrum β-lactamases in Escherichia coli urinary tract isolates from dogs and cats in the United States. Antimicrob Agents Chemother, v. 54, n. 8, p. 3489-92, 2010.
61. OLIVEIRA, C. F. et al. Prevalência das famílias TEM, SHV, CTX-M de β-lactamases de espectro estendido em Escherichia coli e Klebsiella spp. no Hospital Universitário de Santa Maria, estado do Rio Grande do Sul. Rev Soc Bras Med Trop, v. 42, n. 5, p. 556-60, 2009.
62. PEIRANO, G. et al. Carbapenem-hydrolysing betalactamase KPC-2 in Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil. J Antimicrob Chemother, v. 63, n. 2, p. 265-8, 2009.
63. PEIRANO, G. et al. Molecular characteristics of extendedspectrum beta-lactamase-producing Escherichia coli from Rio de Janeiro, Brazil. Clin Microbiol Infect, v. 17, n. 7, p. 1039-43, 2011.
64. PELLEGRINO, F. L. et al. blaGES carrying Pseudomonas aeruginosa from a public hospital in Rio de Janeiro, Brazil. Braz J Infect Dis, v. 10, n. 4, p. 251-3, 2006. (Pubitemid 46443748)
65. PFEIFER, Y. et al. Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens. Int J Med Microbiol, v. 300, n. 6, p. 371-379, 2010.
66. PHILLIPS, I. et al. Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J Antimicrob Chemother, v. 53, n. 1, p. 28-52, 2004. (Pubitemid 38072182)
67. PICÃO, R. C. et al. Detection of GES-5-producing Klebsiella pneumoniae in Brazil. J Antimicrob Chemother, v. 65, n. 4, p. 796-807, 2010.
68. PICÃO, R. C. et al. Further identifcation of CTX-M-2 extended-spectrum β-lactamase in Pseudomonas aeruginosa. Antimicrob Agents Chemother, v. 53, n. 5, p. 2225-6, 2009.
69. PITOUT, J. D. Infections with extended-spectrum betalactamase-producing Enterobacteriaceae: changing epidemiology and drug treatment choices. Drugs, v. 70, n. 3, p. 313-33, 2010.
70. POIREL, L. et al. Chromosome-encoded Ambler class A β-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum β-lactamases. Antimicrob Agents Chemother, v. 46, n. 12, p. 4038-40, 2002. (Pubitemid 35403293)
71. PRADO, T. et al. Detection of extended-spectrum β-lactamase- producing Klebsiella pneumonia in effuents and sludge of a hospital sewage treatment plant. Lett Appl Microbiol, v. 46, n. 1, p. 136-41, 2007.
72. QUEENAN, A. M.; BUSH, K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev, v. 20, n. 3, 440-58, 2007.
73. QUINTEIROS, M. et al. Extended-spectrum betalactamases in Enterobacteriaceae in Buenos Aires, Argentina, public hospitals. Antimicrob Agents Chemother, v. 47, n. 9, p. 2864-7, 2003.
74. RADICE, M. et al. Early dissemination of CTX-M-derived enzymes in South America. Antimicrob Agents Chemother, v. 46, n. 2, p. 602-4, 2002. (Pubitemid 34087228)
75. RAWAT, D.; NAIR, D. Extended-spectrum β-lactamases in Gram negative bacteria. J Glob Infect Dis, v. 2, n. 3, p. 263-74, 2010.
76. SADER, H. S. et al. Pathogen frequency and resistance patterns in Brazilian hospitals: summary of results from three years of the SENTRY Antimicrobial Surveillance Program. Braz J Infect Dis, v. 5, n. 4, p. 200-14, 2003.
77. SANTOS, C. D. M. Staphylococccus sp. e enterobactérias isoladas de mastite recorrente em oito rebanhos da região de Uberlândia-MG: perfl de suscetibilidade aos antimicrobianos. 2006. Dissertação (Mestrado) - Faculdade de Medicina Veterinária, Universidade Federal de Uberlância, Uberlândia.
78. SANTOS, D. F. et al. Extended-spectrum β-lactamase producing Klebsiella pneumoniae isolated in two hospitals in Goiânia-Brazil: detection, prevalence, antimicrobial susceptibility and molecular typing. Braz J Microbiol, v. 39, n. 4, p. 608-12, 2008.
79. SILVA, K. C. et al. Dissemination of CTX-M-2-type extendedspectrum β-lactamase-producing Salmonella spp. in poultry farms in Brazil. In: 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, 50, Boston, EUA. Anais: divulgação digital, C2 687, Boston: ICAAC, 2010.
80. SILVA, N. et al. Risk factors for infection by extendedspectrum beta-lactamase producing Klebsiella pneumoniae in a tertiary hospital in Salvador, Brazil. Braz J Infect Dis, v. 10. n. 3, p. 191-3, 2006. (Pubitemid 44463145)
81. SU-YING, S. et al. High diversity of extended-spectrum beta-lactamase-producing bacteria in an urban river sediment habitat. App Envir Microbiol, v. 76, n. 17, p. 5972-6, 2010.
82. SUPERTI, S. V. et al. Risk factors for and mortality of extended-spectrum-β-lactamase-producing Klebsiella pneumoniae and Escherichia coli nosocomial bloodstream infections. Rev Inst Med Trop S. Paulo, v. 51, n. 4, p. 211-6, 2009.
83. TOLLENTINO, F. M. et al. High prevalence of blaCTX-M extended spectrum beta-lactamase genes in Klebsiella pneumoniae isolates from a tertiary care hospital: frst report of blaSHV-12, blaSHV-31, blaSHV-38 and blaCTX-M-15 in Brazil. Microb Drug Resist, v. 17, n. 1, p. 7-16, 2011.
84. THRELFALL, E. J. et al. The emergence and spread of antibiotic resistance in food-borne bacteria. Int J Food Microbiol, v. 62, v. 1-2, p. 1-5, 2000.
85. TUON, F. F. et al. Epidemiology of extended spectrum β-lactamase producing Enterobacter bacteremia in a Brazilian hospital. Rev Soc Bras Med Trop, v. 43, n. 4, p. 452-4, 2010.
86. VASQUES, M. R. G. β-lactamase producing enterobacteria isolated from surveillance swabs of patients in a cardiac intensive care unit in Rio de Janeiro, Brazil. Braz Infect Dis, v. 15, n. 1, p. 28-33, 2011.
87. VERAS, D, L. et al. Prevalence of the blaSHV gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil. Curr Microbiol, v. 62, n. 5, p. 1610-6, 2011.
88. VILLEGAS, M. et al. Increasing prevalence of extendedspectrum- betalactamase among Gram-negative bacilli in Latin America: 2008 update from the Study for Monitoring Antimicrobial Resistance Trends (SMART). Braz J Infect Dis, v. 15, n. 1, p. 34-9, 2011.
89. WARREN, R. E. et al. Chicken meat as a potencial source of quinolone-resistant Escherichia coli producing extended-spectrum β-lactamases in the UK. J Antimicrobial Chemother, v. 61, n. 3, p. 504-8, 2008. (Pubitemid 351321121)
90. WELDHAGEN, G. F. Integrons and β-lactamases-a novel perspective on resistance. Int J Antimicrob Agents, v. 23, n. 6, p. 556-62, 2004. (Pubitemid 38759670)