High prevalence of blaCTX-M extended spectrum beta-lactamase genes in Klebsiella pneumoniae isolates from a tertiary care hospital: First report of blaSHV-12, blaSHV-31, blaSHV-38, and blaCTX-M-15 in Brazil

Microbial Drug Resistance

Volumn 17, Issue 1, 2011, Pages 7-16

  Tollentino, Fernanda M ^a,b   Polotto, Milena ^a,b   Nogueira, Mauricio L ^a   Lincopan, Nilton ^c   Neves, Patrícia ^c   Mamizuka, Elsa M ^c   Remeli, Gisele A ^a   De Almeida, Margarete T G ^a   Rúbio, Fernando G ^a   Nogueira, Mara C L ^a  

^a FACULDADE DE MEDICINA DE SÃO JOSÉ DO RIO PRETO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AZTREONAM; BETA LACTAMASE CTX M; BETA LACTAMASE CTX M 15; BETA LACTAMASE CTX M 2; BETA LACTAMASE CTX M 59; BETA LACTAMASE SHV; BETA LACTAMASE SHV 12; BETA LACTAMASE SHV 2; BETA LACTAMASE SHV 2A; BETA LACTAMASE SHV 31; BETA LACTAMASE SHV 38; BETA LACTAMASE SHV 5; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CLAVULANIC ACID; EXTENDED SPECTRUM BETA LACTAMASE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BRAZIL; CLUSTER ANALYSIS; CONTROLLED STUDY; ESCHERICHIA COLI; GENE SEQUENCE; GENOTYPE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; TERTIARY HEALTH CARE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BRAZIL; DRUG RESISTANCE, BACTERIAL; GENOTYPE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; POLYMERASE CHAIN REACTION; PREVALENCE;

ENTEROBACTERIACEAE; KLEBSIELLA PNEUMONIAE;

EID: 79952403520     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.2010.0055     Document Type: Article

References (68)

1. Abbassi, M. S., C. Torres, W. Achour, L. Vinué, Y. Y. Sáenz, D. D. Costa, O. Bouchami, and A. B. Hassen. 2008. Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia. Int. J. Antimicrob. Agents 32:308-314.
2. Babin., G. S. and D. M. Livermore. 2000. Are SHV betalactamases universal in Klebsiella pneumoniae? Antimicrob. Agents Chemother. 44:2230. (Pubitemid 30484462)
3. Bauernfeind, A., J. M. Casellas, M. Goldberg, M. Holley, R. Jungwirth, P. Mangold, T. Röhnisch, S. Schweighart, and R. Wilhelm. 1992. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection 20:158-163.
4. Billot-Klein, D., L. Gutmann, and E. Collatz. 1990. Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid. Antimicrob. Agents Chemother. 34:2439-2441.
5. Bonnet, R. 2004. Growing group of extended-spectrum betalactamases: the CTX-M enzymes. Antimicrob. Agents Chemother. 48:1-14. (Pubitemid 38040170)
6. Borges, D. A. L. G., V. Dalla Vechia, and G. Corção. 2003. Characterization and genetic diversity via REP-PCR of Escherichia coli isolates from polluted waters in southern Brazil. FEMS Microbiol. Ecol. 45:173-180. (Pubitemid 36859787)
7. Bush, K. 2010. Bench-to-bedside review: the role of betalactamases in antibiotic-resistant Gram-negative infections. Crit. Care 14:224.
8. Canton, R., A. Novais, A. Valverde, E. Machado, L. Peixe, F. Baquero, and T. M. Coque. 2008. Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin. Microbiol. Infect. 14 (Suppl 1):144-153. (Pubitemid 350269194)
9. Canton, R., and T. M. Coque. 2006. The CTX-M betalactamase pandemic. Curr. Opin. Microbiol. 9:466-475.
10. Cantón, R., T. M. Coque, and F. Baquero. 2003. Multiresistant Gram-negative bacilli: from epidemics to endemics. Curr. Opin. Infect. Dis. 16:315-325. (Pubitemid 36936670)
11. Cartelle, M., T. M. del Mar, S. Pertega, A. Beceiro, M. A. Dominguez, D. Velasco, F. Molina, R. Villanueva, and G. Bou. 2004. Risk factors for colonization and infection in a hospital outbreak caused by a strain of Klebsiella pneumoniae with reduced susceptibility to expanded-spectrum cephalosporins. J. Clin. Microbiol. 42:4242-4249. (Pubitemid 39296151)
12. Cassettari, V. C., I. R. da Silveira, M. Dropa, N. Lincopan, E. M. Mamizuka, M. H. Matté, G. R. Matté, and P. R. Menezes. 2009. Risk factors for colonization of newborn infants during an outbreak of extended-spectrum beta-lactamaseproducing Klebsiella pneumoniae in an intermediate-risk neonatal unit. J. Hosp. Infect. 71:340-347.
13. Chang, F. Y., L. K. Siu, C. P. Fung, M. H. Huang, and M. Ho. 2001. Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26. Antimicrob. Agents Chemother. 45:2407-2413. (Pubitemid 32801887)
14. Clinical and Laboratory Standards Institute (CLSI). 2009. Performance Standards for Antimicrobial Susceptibility Testing: Nineteenth Informational Supplement M100-S19. CLSI, Wayne, PA.
15. Coelho, A., J. J. González-Ló pez, E. Miró, C. Alonso-Tarrés, B. Mirelis, M. N. Larrosa, R. M. Bartolomé, A. Andreu, F. Navarro, J. R. Johnson, and G. Prats. 2010. Characterisation of the CTX-M-15-encoding gene in Klebsiella pneumoniae strains from the Barcelona metropolitan area: plasmid diversity and chromosomal integration. Int. J. Antimicrob. Agents. 36:73-78.
16. Cuzon, G., T. Naas, and P. Nordmann. 2010. KPC carbapenemases: what is at stake in clinical microbiology? Pathol. Biol. 58:39-45.
17. Daza, R., J. Gutiérrez, and G. Piédrola. 2001. Antibiotic susceptibility of bacterial strains isolated from patients with community-acquired urinary tract infections. Int. J. Antimicrob. Agents 18:211-215. (Pubitemid 32979192)
18. Deshpande, L. M., T. R. Fritsche, and R. N. Jones. 2004. Molecular epidemiology of selected multidrug-resistant bacteria: a global report from the SENTRY Antimicrobial Surveillance Program. Diagn. Microbiol. Infect. Dis. 49:231-236. (Pubitemid 39094612)
19. CTX-M among Klebsiella pneumoniae isolates collected in an intensive care unit in Brazil. J. Chemother. 20:600-603.
20. Dropa, M., L. C. Balsalobre, N. Lincopan, E. M. Mamizuka, V. C. Cassettari, G. R. Matté, and M. H. Matté. 2010. Emergence of Klebsiella pneumoniae carrying the novel extendedspectrum beta-lactamase gene variants bla (SHV-40), bla (TEM-116) and the class 1 integron-associated bla (GES-7) in Brazil. Clin. Microbiol. Infect. 16:630-632.
21. Edelstein, M., M. Pimkin, I. Palagin, I. Edelstein, and Stratchounsli, L. 2003. Prevalence and molecular epidemiology of CTX-M extended-spectrum beta-lactamaseproducing Escherichia coli and Klebsiella pneumoniae in Russian hospitals. Antimicrob. Agents Chemother. 47:3724-3732. (Pubitemid 37484979)
22. Ensor, V. M., W. Jamal, V. O. Rotimi, J. T. Evans, and P. M. Hawkey. 2008. Predominance of CTX-M-15 extended spectrum B-lactamases in diverse Escherichia coli and Klebsiella pneumoniae from hospital and community patients in Kuwait. Int. J. Antimicrob. Agents. 33:487-489.
23. Falaga., M. E. and D. E. Karageorgopoulos. 2009. Extendedspectrum beta-lactamase-producing organisms. J. Hosp. Infect. 73:345-354.
24. Garcia, D. O., Y. Doi, D. Szabo, J. M. Adams-Haduch, Y. M. I. Vaz, D. Leite, M. C. Padoveze, M. P. Freire, F. P. Silveira, and D. L. Paterson. 2008. Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. Antimicrob. Agents Chemother. 52:1790-1793. (Pubitemid 351614673)
25. Giakoupi, P., H. Maltezou, M. Polemis, O. Pappa, G. Saroglou, and A. Vatopoulos. 2009. KPC-2-producing Klebsiella pneumoniae infections in Greek hospitals are mainly due to a hyperepidemic clone. Euro Surveill. 14: pii: 19218.
26. Gootz, T. D. 2006. The forgotten Gram-negative bacilli: what genetic determinats are telling us about the spread of antibiotic resistance. Biochem. Pharmacol. 71:1073-1084.
27. Gupta, V. 2007. An update on newer beta-lactamases. Indian J. Med. Res. 126:417-427.
28. Hawkey, P. M. 2008. Molecular epidemiology of clinically significant antibiotic resistance genes. Br. J. Pharmacol. 153 (Suppl 1):406-413.
29. Hawke., P. M. and A. M. Jones. 2009. The changing epidemiology of resistance. J. Antimicrob. Chemother. 56 (Suppl 1): i3-i10.
30. Karim, A., L. Poirel, S. Nagarajan, and P. Nordmann. 2001. Plasmid-mediated extended-spectrum beta-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1. FEMS Microbiol. Lett. 201:237-241. (Pubitemid 32695460)
31. Kiffer, C., A. Hsiung, C. Oplustil, J. Sampaio, E. Sakagami, P. Turner, and C. Mendes; The MYSTIC Brazil group. 2005. Antimicrobial susceptibility of Gram-negative bacteria in Brazilian hospitals: the MYSTIC program Brazil Braz. J. Infect. Dis. 9:216-224. (Pubitemid 41657674)
32. Lewis, J. S. II, M. Herrera, B. Wickes, J. E. Patterson, and J. H. Jorgensen. 2007. First report of the emergence of CTX-M type ESBLs as the predominant ESBL isolated in a U. S. healthcare system. Antimicrob. Agents Chemother. 51:4015-4021 (Pubitemid 350057800)
33. [published erratum appears in: Antimicrob. Agents Chemother. 2008;52:810].
34. Livermore, D., R. Canton, and M. Gniadkowski. 2007. CTX-M: changing faces of ESBLs in Europe. J. Antimicrob. Chemother. 59:165-174. (Pubitemid 47072053)
35. Livermor., D. M. and P. M. Hawkey. 2005. CTX-M: changing the face of ESBLs in the UK. J. Antimicrob. Chemother. 56:451-454. (Pubitemid 41264119)
36. Lytsy, B., L. Sandegren, E. Tano, E. Torell, D. I. Andersson, and A. Melhus. 2008. The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15. APMIS 116:302-308. (Pubitemid 351499162)
37. Mena, A., V. Plasencia, L. García, O. Hidalgo, J. I. Ayestarán, S. Alberti, N. Borrell, J. L. Pérez, and A. Oliver. 2006. Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development. J. Clin. Microbiol. 44:2831-2837. (Pubitemid 44228577)
38. Messai, Y., H. Iabadene, T. Benhassine, S. Alouache, M. Tazir, V. Gautier, G. Arlet, and Bakour, R. 2008. Prevalence and characterization of extended-spectrum beta-lactamases in Klebsiella pneumoniae in Algiers hospitals (Algeria). Pathol. Biol. 56:319-325.
39. Minarini, L. A., A. C. Gales, I. C. Palazzo, and A. L. Darini. 2007. Prevalence of community-occurring extended spectrum beta-lactamase-producing Enterobacteriaceae in Brazil. Curr. Microbiol. 54:335-341. (Pubitemid 46733866)
40. Minarini, L. A., E. C. Clímaco, D. B. Guimarães, J. C. Ferreira, I. C. Palazzo, R. Martinez, and A. L. Darini. 2008. Clonal transmission of ESBL-producing Klebsiella spp. at a university hospital in Brazil. Curr. Microbiol. 56:587-591.
41. Mshana, S. E., C. Imirzalioglu, H. Hossain, T. Hain, E. Domann, T. Chakraborty. 2009. Conjugative IncFI plasmids carrying CTX-M-15 among Escherichia coli ESBL producing isolates at a University hospital in Germany. BMC Infect. Dis. 9:97
42. Naas, T., L. Poirel, and P. Nordmann. 2008. Minor extended-spectrum β-lactamases. Clin. Microbiol. Infect. 14 (Suppl 1):42-52.
43. Nordmann, P., G. Cuzzon, and T. Naas. 2009. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect. Dis. 9:228-236.
44. Palucha, A., B. Mikiewicz, W. Hryniewicz, and M. Gniadkowski. 1999. Concurrent outbreaks of extendedspectrum beta-lactamase-producing organisms of the family Enterobacteriaceae in a Warsaw hospital. J. Antimicrob. Chemother. 44:489-499. (Pubitemid 29490620)
45. Paterson, D. L. 2006. Resistance in gram-negative bacteria: Enterobacteriaceae. Am. J. Infect. Control. 34 (5 Suppl 1):20S-28S.
46. Paterso., D. L. and R. L. Bonomo. 2005. Extended-spectrum beta-lactamases: a clinical update. Clin. Microbiol. Rev. 18:657-686.
47. Pavez, M., E. M. Mamizuka, and N. Lincopan. 2009. Early dissemination of KPC-2-producing Klebsiella pneumoniae strains in Brazil. Antimicrob. Agents Chemother. 53:2702.
48. Peirano, G., L. M. Seki, V. L. Val Passos, M. C. Pinto, L. R. Guerra, and M. D. Asensi. 2009. Carbapenem-hydrolysing beta-lactamase KPC-2 in Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil. J. Antimicrob. Chemother. 63:265-826.
49. Perez, F., A. Endimiani, K. M. Hujer, and R. A. Bonomo. 2007. The continuing challenge of ESBLs. Curr. Opin. Pharmacol. 7:459-469. (Pubitemid 47560222)
50. Philippon, A., G. Arlet, and G. A. Jacoby. 2002. Plasmiddetermined Amp-C Type B-lactamases. Antimicrob. Agents Chemother. 210:87-92.
51. Pitout, J. D. 2008. Multiresistant Enterobacteriaceae: new threat of an old problem. Expert Rev. Antiinfect Ther. 5:657-669.
52. Pitout, J. D., D. L. Church, D. B. Gregson, B. L. Chow, M. McCracken, M. R. Mulvey, and K. B. Laupland. 2007. Molecular epidemiology of CTX-M-producing Escherichia coli in the Calgary Health Region: emergence of CTX-M-15-producing isolates. Antimicrob. Agents Chemother. 51:1281-1286. (Pubitemid 46586806)
53. Pitou., J. D. and K. B. Laupland. 2008. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect. Dis. 8:159-166. (Pubitemid 351249250)
54. Poirel, L., C. Héritier, I. Podglajen, W. Sougakoff, L. Gutmann, and P. Nordmann. 2003. Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem. Antimicrob. Agents Chemother. 47:755-758. (Pubitemid 36158111)
55. Poirel, L., I. le Thomas, T. Nass, A. Karim, and P. Nordmann. 2000. Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae. Antimicrob. Agents Chemother. 44:622-632. (Pubitemid 30117952)
56. Poirel, L., M. Gniadkowski, and P. Nordmann. 2002. Biochemical analysis of the ceftazidime-hydrolysing extendedspectrum beta-lactamase CTX-M-15 and of its structurally related beta-lactamase CTX-M-3. J. Antimicrob. Chemother. 50:1031-1034. (Pubitemid 36049950)
57. Poirel, L., T. Naas, and P. Nordmann. 2008. Genetic support of extended-spectrum β-lactamases. Clin. Microbiol. Infect. 14 (Suppl 1):75-81.
58. Radice, M., P. Power, J. di Conza, and G. Gutkind. 2002. Early dissemination of CTX-M-derived enzymes in South America. Antimicrob. Agents Chemother. 46:602-604. (Pubitemid 34087228)
59. Rasheed, J. K., C. Jay, B. Metchock, F. Berkowitz, L. Weigel, J. Crellin, C. Steward, B. Hill, A. A. Medeiros, and F. C. Tenover. 1997. Evolution of extend-spectrum β-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia. Antimicrob. Agents Chemother. 41:647-653. (Pubitemid 27098419)
60. Saladin, M., V. T. B. Cao, T. Lambert, J. L. Donay, J. L. Herrmann, Z. Ould-Hocine, C. Verdet, F. Delisle, A. Philippon, and G. Arlet. 2002. Diversity of CTX-M β-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals. FEMS Microbiol. Lett. 209:161-168. (Pubitemid 34465587)
61. Sanbroo., J. and D. W. Russel. 2001. Molecular Cloning: A Laboratory Manual, eigth edition. CSHL Press, New York.
62. Schwaber, M. J., S. Navon-Venezia, K. S. Kaye, R. Ben-Ami, D. Schwartz, and Y. Carmeli. 2006. Clinical and economic impact of bacteremia with extended-spectrumbeta-lactamase-producing Enterobacteriaceae. Antimicrob. Agents Chemother. 50:1257-1262.
63. Villegas, M. V., J. N. Kattan, M. G. Quinteros, and J. M. Casellas. 2008. Prevalence of extended-spectrum betalactamases in South America. Clin. Microbiol. Infect. 14 (Suppl 1):154-158 (Pubitemid 350269195)
64. [published erratum appears in Clin Microbiol Infect. 2008;14(Suppl 5):21-24].
65. Winokur, P. L., R. Canton, J. M. Casellas, and N. Legakis. 2001. Variations in the prevalence of strains expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region. Clin. Infect. Dis. 32 (Suppl 2):94-103.
66. Yang, D., Y. Guo, and Z. Zhang. 2009. Combined porin loss and extended spectrum beta-lactamase production is associated with an increasing imipenem minimal inhibitory concentration in clinical Klebsiella pneumoniae strains. Curr. Microbiol. 58:366-370.
67. Yigit, H., A. M. Queenan, J. K. Rasheed, J. W. Biddle, A. Domenech-Sanchez, S. Alberti, K. Bush, and F. C. Tenover. 2003. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem- hydrolyzing beta-lactamase KPC-2. Antimicrob. Agents Chemother. 47:3881-3889. (Pubitemid 37485004)
68. Zavascki, A. P., C. M. Zoccoli, A. B. Machado, K. R. de Oliveira, S. V. Superti, D. A. Pilger, V. V. Cantarelli, and A. L. Barth. 2010. KPC-2-producing Klebsiella pneumoniae in Brazil: a widespread threat in waiting? Int. J. Infect. Dis. 14: e539-e540.