Revealing the anti-tumor effect of artificial miRNA p-27-5p on human breast carcinoma cell line T-47D

International Journal of Molecular Sciences

Volumn 13, Issue 5, 2012, Pages 6352-6369

  Tseng, Chien Wei ^a   Huang, Hsuan Cheng ^b   Shih, Arthur Chun Chieh ^c   Chang, Ya Ya ^a   Hsu, Chung Cheng ^a   Chang, Jen Yun ^a   Li, Wen Hsiung ^d,e   Juan, Hsueh Fen ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c INSTITUTE OF INFORMATION SCIENCE   (Taiwan)

^d BIODIVERSITY RESEARCH CENTER   (Taiwan)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

Breast cancer; Cell cycle; Cyclin dependent kinase 4; Exon array; MiR P 27 5p; Retinoblastoma protein

Indexed keywords

CYCLIN DEPENDENT KINASE 4; MICRORNA; MICRORNA P27 5P; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; CDK4 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENETICS; MCF 7 CELL LINE; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 4; DOWN-REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; MICRORNAS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN;

EID: 84861561275     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13056352     Document Type: Article

References (39)

1. Esquela-Kerscher, A.; Slack, F.J. Oncomirs-MicroRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6, 259-269.
2. Ventura, A.; Jacks, T. MicroRNAs and cancer: Short RNAs go a long way. Cell 2009, 136, 586-591.
3. Mattie, M.D.; Benz, C.C.; Bowers, J.; Sensinger, K.; Wong, L.; Scott, G.K.; Fedele, V.; Ginzinger, D.; Getts, R.; Haqq, C. Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol. Cancer 2006, 5, doi:10.1186/1476-4598-5-24.
4. Yanaihara, N.; Caplen, N.; Bowman, E.; Seike, M.; Kumamoto, K.; Yi, M.; Stephens, R.M.; Okamoto, A.; Yokota, J.; Tanaka, T.; et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9, 189-198.
5. Lieberman, J. Micromanaging cancer. N. Engl. J. Med. 2009, 361, 1500-1501.
6. Chang, Y.M.; Juan, H.F.; Lee, T.Y.; Chang, Y.Y.; Yeh, Y.M.; Li, W.H.; Shih, A.C. Prediction of human miRNAs using tissue-selective motifs in 3' UTRs. Proc. Natl. Acad. Sci. USA 2008, 105, 17061-17066.
7. Yue, H.; Eastman, P.S.; Wang, B.B.; Minor, J.; Doctolero, M.H.; Nuttall, R.L.; Stack, R.; Becker, J.W.; Montgomery, J.R.; Vainer, M.; et al. An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expression. Nucleic Acids Res. 2001, 29, doi:10.1093/nar/29.8.e41.
8. Ideker, T.; Thorsson, V.; Ranish, J.A.; Christmas, R.; Buhler, J.; Eng, J.K.; Bumgarner, R.; Goodlett, D.R.; Aebersold, R.; Hood, L. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 2001, 292, 929-934.
9. Hughes, T.R.; Marton, M.J.; Jones, A.R.; Roberts, C.J.; Stoughton, R.; Armour, C.D.; Bennett, H.A.; Coffey, E.; Dai, H.; He, Y.D.; et al. Functional discovery via a compendium of expression profiles. Cell 2000, 102, 109-126.
10. Abdueva, D.; Wing, M.R.; Schaub, B.; Triche, T.J. Experimental comparison and evaluation of the Affymetrix exon and U133Plus2 GeneChip arrays. PLoS One 2007, 2, doi:10.1371/journal. pone.0000913.
11. Seo, J.; Kim, M.; Kim, J. Identification of novel genes differentially expressed in PMA-induced HL-60 cells using cDNA microarrays. Mol. Cells 2000, 10, 733-739.
12. Le Naour, F.; Hohenkirk, L.; Grolleau, A.; Misek, D.E.; Lescure, P.; Geiger, J.D.; Hanash, S.; Beretta, L. Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics. J. Biol. Chem. 2001, 276, 17920-17931.
13. Dong, Y.; Sui, L.; Sugimoto, K.; Tai, Y.; Tokuda, M. Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and prognosis in laryngeal squamous cell carcinomas. Int. J. Cancer 2001, 95, 209-215.
14. Dean, J.L.; Thangavel, C.; McClendon, A.K.; Reed, C.A.; Knudsen, E.S. Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure. Oncogene 2010, 29, 4018-4032.
15. Sun, Y.; Li, Y.X.; Wu, H.J.; Wu, S.H.; Wang, Y.A.; Luo, D.Z.; Liao, D.J. Effects of an indolocarbazole-derived CDK4 inhibitor on breast cancer cells. J. Cancer 2011, 2, 36-51.
16. Lin, S.L.; Chang, D.C.; Ying, S.Y.; Leu, D.; Wu, D.T. MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways. Cancer Res. 2010, 70, 9473-9482.
17. Burkhart, D.L.; Sage, J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 2008, 8, 671-682.
18. Yoon, S.; Choi, Y.C.; Lee, S.; Jeong, Y.; Yoon, J.; Baek, K. Induction of growth arrest by miR-542-3p that targets survivin. FEBS Lett. 2010, 584, 4048-4052.
19. Lim, L.P.; Lau, N.C.; Garrett-Engele, P.; Grimson, A.; Schelter, J.M.; Castle, J.; Bartel, D.P.; Linsley, P.S.; Johnson, J.M. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005, 433, 769-773.
20. Tseng, C.W.; Lin, C.C.; Chen, C.N.; Huang, H.C.; Juan, H.F. Integrative network analysis reveals active microRNAs and their functions in gastric cancer. BMC Syst. Biol. 2011, 5, doi:10.1186/1752-0509-5-99.
21. Tseng, C.W.; Yang, J.C.; Chen, C.N.; Huang, H.C.; Chuang, K.N.; Lin, C.C.; Lai, H.S.; Lee, P.H.; Chang, K.J.; Juan, H.F. Identification of 14-3-3beta in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker. Proteomics 2011, 11, 2423-2439.
22. Mathivanan, S.; Periaswamy, B.; Gandhi, T.K.; Kandasamy, K.; Suresh, S.; Mohmood, R.; Ramachandra, Y.L.; Pandey, A. An evaluation of human protein-protein interaction data in the public domain. BMC Bioinform. 2006, 7, doi:10.1186/1471-2105-7-S5-S19.
23. Maere, S.; Heymans, K.; Kuiper, M. BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics 2005, 21, 3448-3449.
24. Shannon, P.; Markiel, A.; Ozier, O.; Baliga, N.S.; Wang, J.T.; Ramage, D.; Amin, N.; Schwikowski, B.; Ideker, T. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 2003, 13, 2498-2504.
25. Sutherland, R.L.; Musgrove, E.A. CDK inhibitors as potential breast cancer therapeutics: New evidence for enhanced efficacy in ER+ disease. Breast Cancer Res. 2009, 11, doi:10.1186/bcr2454.
26. Zelivianski, S.; Cooley, A.; Kall, R.; Jeruss, J.S. Cyclin-dependent kinase 4-mediated phosphorylation inhibits Smad3 activity in cyclin D-overexpressing breast cancer cells. Mol. Cancer Res. 2010, 8, 1375-1387.
27. Farazi, T.A.; Horlings, H.M.; ten Hoeve, J.J.; Mihailovic, A.; Halfwerk, H.; Morozov, P.; Brown, M.; Hafner, M.; Reyal, F.; van Kouwenhove, M.; et al. MicroRNA sequence and expression analysis in breast tumors by deep sequencing. Cancer Res. 2011, 71, 4443-4453.
28. Takada, S.; Berezikov, E.; Yamashita, Y.; Lagos-Quintana, M.; Kloosterman, W.P.; Enomoto, M.; Hatanaka, H.; Fujiwara, S.; Watanabe, H.; Soda, M.; et al. Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res. 2006, 34, doi:10.1093/nar/gkl653.
29. Kuhn, D.E.; Nuovo, G.J.; Martin, M.M.; Malana, G.E.; Pleister, A.P.; Jiang, J.; Schmittgen, T.D.; Terry, A.V., Jr.; Gardiner, K.; Head, E.; et al. Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem. Biophys. Res. Commun. 2008, 370, 473-477.
30. Kwon, O.H.; Park, J.L.; Kim, M.; Kim, J.H.; Lee, H.C.; Kim, H.J.; Noh, S.M.; Song, K.S.; Yoo, H.S.; Paik, S.G.; et al. Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer. Biochem. Biophys. Res. Commun. 2011, 406, 539-545.
31. Kita, Y.; Mimori, K.; Tanaka, F.; Matsumoto, T.; Haraguchi, N.; Ishikawa, K.; Matsuzaki, S.; Fukuyoshi, Y.; Inoue, H.; Natsugoe, S.; et al. Clinical significance of LAMB3 and COL7A1 mRNA in esophageal squamous cell carcinoma. Eur. J. Surg. Oncol. 2009, 35, 52-58.
32. Calaluce, R.; Bearss, D.J.; Barrera, J.; Zhao, Y.; Han, H.; Beck, S.K.; McDaniel, K.; Nagle, R.B. Laminin-5 beta3A expression in LNCaP human prostate carcinoma cells increases cell migration and tumorigenicity. Neoplasia 2004, 6, 468-479.
33. De Guire, V.; Caron, M.; Scott, N.; Menard, C.; Gaumont-Leclerc, M.F.; Chartrand, P.; Major, F.; Ferbeyre, G. Designing small multiple-target artificial RNAs. Nucleic Acids Res. 2010, 38, doi:10.1093/nar/gkq354.
34. Brown, B.D.; Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat. Rev. Genet. 2009, 10, 578-585.
35. Idogawa, M.; Sasaki, Y.; Suzuki, H.; Mita, H.; Imai, K.; Shinomura, Y.; Tokino, T. A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. Clin. Cancer Res. 2009, 15, 3725-3732.
36. Prud'homme, G.J.; Glinka, Y.; Toulina, A.; Ace, O.; Subramaniam, V.; Jothy, S. Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist. PLoS One 2010, 5, doi:10.1371/journal.pone.0013831.
37. Zhong, Z.; Yeow, W.S.; Zou, C.; Wassell, R.; Wang, C.; Pestell, R.G.; Quong, J.N.; Quong, A.A. Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res. 2010, 70, 2105-2114.
38. Ye, X.; Liu, Z.; Hemida, M.G.; Yang, D. Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA. PLoS One 2011, 6, doi:10.1371/journal.pone.0021215.
39. Dchip Software: Analysis and visualization of gene expression and SNP microarrays. Available online: http://biosun1.harvard.edu/complab/dchip (accessed on 3 January 2012).