Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4-C12 compounds

Reproductive Toxicology

Volumn 33, Issue 4, 2012, Pages 546-551

  Wolf, Cynthia J ^a   Schmid, Judith E ^a   Lau, Christopher ^a   Abbott, Barbara D ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

COS 1; Human; Mouse; Perfluoroalkyl acids; PPAR ; PPAR alpha; Relative potency; Reporter gene assay

Indexed keywords

ORGANOFLUORINE DERIVATIVE; PERFLEXANE; PERFLUORO COMPOUND; PERFLUOROALKYL ACID; PERFLUORODECANOIC ACID; PERFLUORODODECANOIC ACID; PERFLUOROHEPTANOIC ACID; PERFLUOROHEXANE SULFONIC ACID; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; PERFLUOROPENTANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN COS1; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; MOUSE; NONHUMAN; TOXICITY TESTING;

ANIMALS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FLUOROCARBONS; HUMANS; LINEAR MODELS; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PLASMIDS; PPAR ALPHA; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

RODENTIA;

EID: 84861530252     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.09.009     Document Type: Article

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