Ghrelin and PYY levels in adolescents with severe obesity: EVects of weight loss induced by long-term exercise training and modified food habits

European Journal of Applied Physiology

Volumn 112, Issue 5, 2012, Pages 1797-1805

  Gueugnon, Carine ^a,b,c   Mougin, Fabienne ^a,b,c   Nguyen, Nhu Uyen ^a,b,d   Bouhaddi, Malika ^a,b,d   Nicolet Guénat, Marie ^b   Dumoulin, Gilles ^a,b,d  

^a UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^b Physiopathologie Cardiovasculaire et Prévention ^*  (France)

^c UPFR des Sports   (France)

^d UNIVERSITY HOSPITAL OF BESANÇON   (France)

Author keywords

Adolescents; Ghrelin; Obesity; Peptide YY; Physical exercise; Weight loss

Indexed keywords

GHRELIN; PEPTIDE YY;

ADOLESCENT; ARTICLE; BLOOD; DIET THERAPY; EXERCISE; FEMALE; HUMAN; KINESIOTHERAPY; LIFESTYLE; MALE; MORBID OBESITY; PHYSIOLOGY; WEIGHT REDUCTION;

ADOLESCENT; EXERCISE; EXERCISE THERAPY; FEMALE; GHRELIN; HUMANS; LIFE STYLE; MALE; OBESITY, MORBID; PEPTIDE YY; WEIGHT LOSS;

EID: 84861530059     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-2154-2     Document Type: Article

References (45)

1. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR (1985) Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89: 1070-1077 (Pubitemid 16231572)
2. Akamizu T, Shinomiya T, Irako T, Fukunaga M, Nakai Y, Kangawa K (2005) Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab 90: 6-9 (Pubitemid 40116625)
3. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E (2000) Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 23: 493-495
4. Balagopal PB, Gidding SS, Buckloh LM, Yarandi HN, Sylvester JE, George DE, Funanage VL (2010) Changes in circulating satiety hormones in obese children: a randomized controlled physical activity-based intervention study. Obesity (Silver Spring)18: 1747-1753
5. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR (2003) Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941-948 (Pubitemid 37064767)
6. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654
7. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV (1996) Decreased cerebrospinal-Xuid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348: 159-161 (Pubitemid 26238099)
8. Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ (2001) The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord 25(Suppl 5): S63-S67 (Pubitemid 34146326)
9. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719 (Pubitemid 33641587)
10. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346: 1623-1630 (Pubitemid 34755670)
11. De Ambrogi M, Volpe S, Tamanini C (2003) Ghrelin: central and peripheral eVects of a novel peptydil hormone. Med Sci Monit 9: RA217-RA224 (Pubitemid 37295242)
12. Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE (2005) Human plasma ghrelin levels increase during a one-year exercise program. J Clin Endocrinol Metab 90: 820-825 (Pubitemid 40279203)
13. Gil-Campos M, Aguilera CM, Ramirez-Tortosa MC, Canete R, Gil A (2010) Fasting and postprandial relationships among plasma leptin, ghrelin, and insulin in prepubertal obese children. Clin Nutr 29: 54-59
14. Halatchev IG, Ellacott KL, Fan W, Cone RD (2004) Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptorindependent mechanism. Endocrinology 145: 2585-2590 (Pubitemid 38686200)
15. Jones TE, Basilio JL, Brophy PM, McCammon MR, Hickner RC (2009) Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. Obesity (Silver Spring) 17: 1189-1195
16. Kelishadi R, Hashemipour M, Mohammadifard N, Alikhassy H, Adeli K (2008) Short-and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two diVerent weight loss programmes. Clin Endocrinol (Oxf) 69: 721-729
17. Kim HJ, Lee S, Kim TW, Kim HH, Jeon TY, Yoon YS, Oh SW, Kwak H, Lee JG (2008) EVects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children. Clin Endocrinol (Oxf) 68: 416-422 (Pubitemid 351257861)
18. King PJ (2005) The hypothalamus and obesity. Curr Drug Targets 6: 225-240 (Pubitemid 40394317)
19. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660 (Pubitemid 129516334)
20. Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85: 495-522 (Pubitemid 40404635)
21. Konturek PC, Konturek JW, Czesnikiewicz-Guzik M, Brzozowski T, Sito E, Konturek SJ (2005) Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol 56(Suppl 6): 5-25 (Pubitemid 43120939)
22. Krohn K, Boczan C, Otto B, Heldwein W, Landgraf R, Bauer CP, Koletzko B (2006) Regulation of ghrelin is related to estimated insulin sensitivity in obese children. Int J Obes (Lond) 30: 1482-1487 (Pubitemid 44470195)
23. Labayen I, Ortega FB, Ruiz JR, Lasa A, Simon E, Margareto J (2011) Role of baseline leptin and ghrelin levels on body weight and fat mass changes after an energy-restricted diet intervention in obese women: eVects on energy metabolism. J Clin Endocrinol Metab 96: E996-E1000
24. le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR (2006) Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147: 3-8 (Pubitemid 43004254)
25. Leidy HJ, Gardner JK, Frye BR, Snook ML, Schuchert MK, Richard EL, Williams NI (2004) Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normalweight young women. J Clin Endocrinol Metab 89: 2659-2664 (Pubitemid 38766346)
26. Martin A (2001) Apports nutritionnels conseillés pour la population française. TEC & DOC Lavoisier, Paris, p 67
27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419 (Pubitemid 15018832)
28. Murphy KG, Bloom SR (2004) Gut hormones in the control of appetite. Exp Physiol 89: 507-516 (Pubitemid 39255722)
29. Murphy KG, Bloom SR (2006) Gut hormones and the regulation of energy homeostasis. Nature 444: 854-859 (Pubitemid 46024992)
30. PaciWco L, Poggiogalle E, Costantino F, Anania C, Ferraro F, Chiarelli F, Chiesa C (2009) Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome. Eur J Endocrinol 161: 861-870
31. Pedrosa C, Oliveira BM, Albuquerque I, Simoes-Pereira C, Vaz-de-Almeida MD, Correia F (2011) Metabolic syndrome, adipokines and ghrelin in overweight and obese schoolchildren: results of a 1-year lifestyle intervention programme. Eur J Pediatr 170: 483-492
32. Reinehr T, de Sousa G, Roth CL (2008) Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight. Clin Endocrinol (Oxf) 68: 304-310
33. Reinehr T, Roth CL, Alexy U, Kersting M, Kiess W, Andler W (2005) Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents. Int J Obes (Lond) 29: 362-368 (Pubitemid 40462757)
34. Reinehr T, Roth CL, Enriori PJ, Masur K (2010) Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin sensitivity. J Pediatr Endocrinol Metab 23: 101-108
35. Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A (1991) Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr 45: 13-21
36. Roth CL, Enriori PJ, Harz K, WoelXe J, Cowley MA, Reinehr T (2005) Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss. J Clin Endocrinol Metab 90: 6386-6391 (Pubitemid 41759289)
37. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404: 661-671 (Pubitemid 30205071)
38. Takano H, Morita T, Iida H, Asada K, Kato M, Uno K, Hirose K, Matsumoto A, Takenaka K, Hirata Y, Eto F, Nagai R, Sato Y, Nakajima T (2005) Hemodynamic and hormonal responses to ashort-term low-intensity resistance exercise with the reduction of muscle blood Xow. Eur J Appl Physiol 95: 65-73 (Pubitemid 43008898)
39. Tanner JM (1981) Growth and maturation during adolescence. Nutr Rev 39: 43-55
40. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707-709 (Pubitemid 32242624)
41. Wang Y, Lobstein T (2006) Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 1: 11-25
42. Weigle DS, Cummings DE, Newby PD, Breen PA, Frayo RS, Matthys CC, Callahan HS, Purnell JQ (2003) Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet. J Clin Endocrinol Metab 88: 1577-1586 (Pubitemid 36623373)
43. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992
44. Wynne K, Stanley S, Bloom S (2004) The gut and regulation of body weight. J Clin Endocrinol Metab 89: 2576-2582 (Pubitemid 38766334)
45. Zou CC, Liang L, Wang CL, Fu JF, Zhao ZY (2009) The change in ghrelin and obestatin levels in obese children after weight reduction. Acta Paediatr 98: 159-165