Effects of vibration training on bone metabolism: Results from a short-term bed rest study

European Journal of Applied Physiology

Volumn 112, Issue 5, 2012, Pages 1741-1750

  Baecker, Natalie ^a,b   Frings Meuthen, Petra ^a   Heer, Martina ^a,b   Mester, Jochen ^c   Liphardt, Anna Maria ^a,c  

^a GERMAN AEROSPACE CENTER DLR   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Bone formation; Bone resorption; Bone turnover markers; Mechanical loading; Vibration training

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CALCIUM;

ADULT; ARTICLE; BED REST; BLOOD; BONE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; HUMAN; MALE; METABOLISM; OSTEOLYSIS; URINE; VIBRATION;

ADULT; ALKALINE PHOSPHATASE; BED REST; BIOLOGICAL MARKERS; BONE AND BONES; BONE RESORPTION; CALCIUM; CROSS-OVER STUDIES; HUMANS; MALE; VIBRATION;

EID: 84861526722     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-2137-3     Document Type: Article

References (75)

1. Agerbaek MO, Eriksen EF, Kragstrup J, Mosekilde L, Melsen F(1991) A reconstruction of the remodelling cycle in normal human cortical iliac bone. Bone Miner 12: 101-112
2. Alexandre C, Vico L, Pilonchery G, Chapuy MC, Delmas PD, Chappard D (1988) Effects of weightlessness on phosphocalcium metabolism and its hormonal regulation in man during the 51 G Franco-American space flight. Pathol Biol (Paris) 36: 144-148 (Pubitemid 18069515)
3. Antonutto G, Capelli C, Girardis M, Zamparo P, di Prampero PE (1999) Effects of microgravity on maximal power of lower limbsduring very short efforts in humans. J Appl Physiol 86: 85-92 (Pubitemid 29046944)
4. Armbrecht G, Belavy DL, Gast U, Bongrazio M, Touby F, Beller G, Roth HJ, Perschel FH, Rittweger J, Felsenberg D (2009) Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism. Osteoporos Int 21: 597-607
5. Baecker N, Tomic A, Mika C, Gotzmann A, Platen P, Gerzer R, Heer M (2003) Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial. J Appl Physiol 95: 977-982 (Pubitemid 37033990)
6. Baecker N, Frings-Meuthen P, Smith SM, Heer M (2010) Short-term high dietary calcium intake during bed rest has no effect on markers of bone turnover in healthy men. Nutrition 26: 522-527
7. Belavy DL, Hides JA, Wilson SJ, Stanton W, Dimeo FC, Rittweger J, Felsenberg D, Richardson CA (2008) Resistive simulated weightbearing exercise with whole body vibration reduces lumbar spine deconditioning in bed-rest. Spine (Phila Pa 1976) 33: E121-E131 (Pubitemid 351644468)
8. Belavy DL, Armbrecht G, Gast U, Richardson CA, Hides JA, Felsenberg D (2010) Countermeasures against lumbar spine deconditioning in prolonged bed rest: resistive exercise with and without whole body vibration. J Appl Physiol 109: 1801-1811
9. Belavy DL, Beller G, Armbrecht G, Perschel FH, Fitzner R, Bock O, Borst H, Degner C, Gast U, Felsenberg D (2011) Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed rest. Osteoporos Int 22: 1581-1591
10. Caillot-Augusseau A, Lafage-Proust MH, Soler C, Dubois F, Alexandre C (1998) Bone formation and resorption biological markers in cosmonauts during and after a 180 day spaceflight (Euromir 95). Clin Chem 44: 578-585 (Pubitemid 28141355)
11. Caillot-Augusseau A, Vico L, Heer M, Voroviev D, Souberbielle JC, Zitterman A, Alexandre C, Lafage-Proust MH (2000) Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts. Clin Chem 46: 1136-1143 (Pubitemid 30643316)
12. Cardinale M, Rittweger J (2006) Vibration exercise makes your muscles and bones stronger: fact or fiction? J Br Menopause Soc 12: 12-18 (Pubitemid 43349417)
13. Cardinale M, Wakeling J (2005) Whole body vibration exercise: are vibrations good for you? Br J Sports Med 39: 585-589 (Pubitemid 41265300)
14. Cardinale M, Leiper J, Farajian P, Heer M (2007) Whole-body vibration can reduce calciuria induced by high protein intakes and may counteract bone resorption: a preliminary study. J Sports Sci 25: 111-119 (Pubitemid 44824385)
15. Chesnut CH III, Bell NH, Clark GS, Drinkwater BL, English SC, Johnson CC Jr, Notelovitz M, Rosen C, Cain DF, Flessland KA et al (1997) Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med 102: 29-37 (Pubitemid 27089984)
16. Cochrane DJ (2011) Vibration exercise: the potential benefits. Int JSports Med 32: 75-99
17. Delmas PD (2000) Markers of bone turnover for monitoring treatment of osteoporosis with antiresorptive drugs. Osteoporos Int 11(Suppl 6): S66-S76 (Pubitemid 32039514)
18. DGE (2000) Referenzwerte für die Nährstoffzufuhr Frankfurt am Main
19. Eisman JA (2001) Good, good, good. good vibrations: the best option for better bones? Lancet 358: 1924-1925 (Pubitemid 34072869)
20. Fitts RH, Riley DR, Widrick JJ (2000) Physiology of a microgravity environment invited review: microgravity and skeletal muscle. J Appl Physiol 89: 823-839 (Pubitemid 30637134)
21. Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD (1994) Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 79: 1693-1700
22. Gilsanz V, Gibbens DT, Roe TF, Carlson M, Senac MO, Boechat MI, Huang HK, Schulz EE, Libanati CR, Cann CC (1988) Vertebral bone density in children: effect of puberty. Radiology 166: 847-850 (Pubitemid 18058955)
23. Hannon R, Eastell R (2000) Preanalytical variability of biochemical markers of bone turnover. Osteoporos Int 11(Suppl 6): S30-S44 (Pubitemid 32039511)
24. Hert J, Liskova M, Landa J (1971) Reaction of bone to mechanical stimuli. 1. Continuous and intermittent loading of tibia in rabbit. Folia Morphol (Praha) 19: 290-300
25. Issurin VB (2005) Vibrations and their applications in sport. Areview. J Sports Med Phys Fit 45: 324-336 (Pubitemid 41746097)
26. Jordan J (2005) Good vibrations and strong bones? Am J Physiol Regul Integr Comp Physiol 288: R555-R556 (Pubitemid 40250561)
27. Jordan MJ, Norris SR, Smith DJ, HerzogW (2005) Vibration training: an overview of the area, training consequences, and future considerations. J Strength Cond Res 19: 459-466 (Pubitemid 40807102)
28. Judex S, Lei X, Han D, Rubin C (2007) Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude. J Biomech 40: 1333-1339 (Pubitemid 46483448)
29. Kakurin LI, Lobachik VI, Mikhailov VM, Senkevich YA (1976) Antiorthostatic hypokinesia as a method of weightlessness simulation. Aviat Space Environ Med 47: 1083-1086
30. Kluthe B (2001) PRODI-Ernährungs- und Diätberatungsprogramm. [4.5 LE]. Stuttgart, Wissenschaftliche Verlagsgesellschaft mbH
31. Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A (2004) Cortical and trabecular bone mineral loss from the spine and hip in longduration spaceflight. J Bone Miner Res 19: 1006-1012 (Pubitemid 41103458)
32. LeBlanc A, Schneider VS, Evans HJ, Engelbretson DA, Krebs JM (1990) Bone mineral loss and recovery after 17 weeks of bed rest. J Bone Miner Res 5: 843-850 (Pubitemid 20294768)
33. LeBlanc A, Schneider V, Spector E, Evans H, Rowe R, Lane H, Demers L, Lipton A (1995) Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest. Bone 16: 301S-304S
34. LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A, Voronin L (2000) Bone mineral and lean tissue loss after long duration space flight. J Musculoskelet Neuronal Interact 1: 157-160
35. Leblanc AD, Driscol TB, Shackelford LC, Evans HJ, Rianon NJ, Smith SM, Feeback DL, Lai D (2002) Alendronate as an effective countermeasure to disuse induced bone loss. J Musculoskelet Neuronal Interact 2: 335-343
36. Leblanc AD, Spector ER, Evans HJ, Sibonga JD (2007) Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact 7: 33-47 (Pubitemid 46730302)
37. Liphardt AM, Mundermann A, Koo S, Backer N, Andriacchi TP, Zange J, Mester J, Heer M (2009) Vibration training intervention to maintain cartilage thickness and serum concentrations ofcartilage oligometric matrix protein (COMP) during immobilization. Osteoarthritis Cartilage 17: 1598-1603
38. Luo J, McNamara B, Moran K (2005) The use of vibration training to enhance muscle strength and power. Sports Med 35: 23-41 (Pubitemid 40170623)
39. Marcus R, Holloway L, Wells B, Greendale G, James MK, Wasilauskas C, Kelaghan J (1999) The relationship of biochemical markers of bone turnover to bone density changes in postmenopausal women: results from the postmenopausal estrogen/ progestin interventions (PEPI) trial. J Bone Miner Res 14: 1583-1595 (Pubitemid 29416686)
40. Mikhael M, Orr R, Fiatarone Singh MA (2010) The effect of whole body vibration exposure on muscle or bone morphology and function in older adults: a systematic review of the literature. Maturitas 66: 150-157
41. Nordlund MM, Thorstensson A (2007) Strength training effects of whole-body vibration? Scand J Med Sci Sports 17: 12-17
42. Norimatsu H, Mori S, Kawanishi J, Kaji Y, Li J (1997) Immobilization as the pathogenesis of osteoporosis: experimental and clinical studies. Osteoporos Int 7(Suppl 3): S57-S62
43. Oganov VS, Grigor'ev AI, Voronin LI, Rakhmanov AS, Bakulin AV, Schneider VS, Leblanc AD (1992) Bone mineral density in cosmonauts after flights lasting 4.5-6 months on the Mir orbital station. Aviakosm Ekolog Med 26: 20-24 (Pubitemid 23258379)
44. Rauch F (2009) Vibration therapy. Dev Med Child Neurol 51(Suppl 4): 166-168
45. Rauch F, Sievanen H, Boonen S, Cardinale M, Degens H, Felsenberg D, Roth J, Schoenau E, Verschueren S, Rittweger J (2010) Reporting whole-body vibration intervention studies: recommendations of the International Society of Musculoskeletal and Neuronal Interactions. J Musculoskelet Neuronal Interact 10: 193-198
46. Rehn B, Lidstrom J, Skoglund J, Lindstrom B (2007) Effects on leg muscular performance from whole-body vibration exercise: asystematic review. Scand J Med Sci Sports 17: 2-11
47. Rittweger J (2010) Vibration as an exercise modality: how it may work, and what its potential might be. Eur J Appl Physiol 108: 877-904
48. Rittweger J, Frost HM, Schiessl H, Ohshima H, Alkner B, Tesch P, Felsenberg D (2005) Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Bone 36: 1019-1029 (Pubitemid 40798003)
49. Rittweger J, Beller G, Armbrecht G, Mulder E, Buehring B, Gast U, Dimeo F, Schubert H, De HA, Stegeman DF et al (2010) Prevention of bone loss during 56 days of strict bed rest by sidealternating resistive vibration exercise. Bone 46: 137-147
50. Rogers A, Hannon RA, Eastell R (2000) Biochemical markers as predictors of rates of bone loss after menopause. J Bone Miner Res 15: 1398-1404 (Pubitemid 30413874)
51. Rubin C, Turner AS, Bain S, Mallinckrodt C, McLeod K (2001) Anabolism. Low mechanical signals strengthen long bones. Nature 412: 603-604 (Pubitemid 32772264)
52. Rubin C, Turner AS, Mallinckrodt C, Jerome C, McLeod K, Bain S(2002a) Mechanical strain, induced noninvasively in the highfrequency domain, is anabolic to cancellous bone, but not cortical bone. Bone 30: 445-452 (Pubitemid 34204118)
53. Rubin C, Turner AS, Muller R, Mittra E, McLeod K, Lin W, Qin YX (2002b) Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res 17: 349-357 (Pubitemid 34087668)
54. Rubin C, Pope M, Fritton JC, Magnusson M, Hansson T, McLeod K(2003) Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli toskeletal regions at greatest risk of fracture because of osteoporosis. Spine 28: 2621-2627 (Pubitemid 37490471)
55. Schneider V, Oganov V, LeBlanc A, Rakmonov A, Taggart L, Bakulin A, Huntoon C, Grigoriev A, Varonin L (1995) Bone and body mass changes during space flight. Acta Astronaut 36: 463-466
56. Shackelford LC, Leblanc AD, Driscoll TB, Evans HJ, Rianon NJ, Smith SM, Spector E, Feeback DL, Lai D (2004) Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 97: 119-129 (Pubitemid 38802510)
57. Smith SM, Nillen JL, LeBlanc A, Lipton A, Demers LM, Lane HW, Leach CS (1998) Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 83: 3584-3591 (Pubitemid 28500894)
58. Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Shih CY, Nillen JL, Davis-Street JE et al (1999) Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes. Am J Physiol 277: R1-R10 (Pubitemid 29356771)
59. Smith SM, Dillon EL, DeKerlegand DE, Davis-Street JE (2004) Variability of collagen crosslinks: impact of sample collection period. Calcif Tissue Int 74: 336-341 (Pubitemid 38480857)
60. Smith SM, Zwart SR, Heer M, Lee SM, Baecker N, Meuche S, Macias BR, Shackelford LC, Schneider S, Hargens AR (2008) WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60 day simulated microgravity. Bone 42: 572-581
61. Snow-Harter C, Marcus R (1991) Exercise, bone mineral density, and osteoporosis. Exerc Sport Sci Rev 19: 351-388
62. Takata S, Yasui N (2001) Disuse osteoporosis. J Med Invest 48: 147-156
63. Torvinen S, Kannus P, Sievanen H, Jarvinen TA, Pasanen M, Kontulainen S, Nenonen A, Jarvinen TL, Paakkala T, Jarvinen Met al (2003) Effect of 8 month vertical whole body vibration on bone, muscle performance, and body balance: a randomized controlled study. J Bone Miner Res 18: 876-884 (Pubitemid 37294971)
64. Turner CH, Pavalko FM (1998) Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation. J Orthop Sci 3: 346-355 (Pubitemid 28551411)
65. Turner CH, Robling AG (2003) Designing exercise regimens to increase bone strength. Exerc Sport Sci Rev 31: 45-50 (Pubitemid 36158011)
66. Turner CH, Robling AG (2005) Exercises for improving bone strength. Br J Sports Med 39: 188-189 (Pubitemid 40478200)
67. Turner CH, Forwood MR, Otter MW (1994) Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J8: 875-878 (Pubitemid 24268880)
68. Vico L, Collet P, Guignandon A, Lafage-Proust MH, Thomas T, Rehaillia M, Alexandre C (2000) Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355: 1607-1611 see comments (Pubitemid 30240506)
69. Vose GP (1974) Review of roentgenographic bone demineralization studies of the Gemini space flights. Am J Roentgenol Radium Ther Nucl Med 121: 1-4
70. Ward K, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z (2004) Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res 19: 360-369 (Pubitemid 38787390)
71. Watanabe Y, Ohshima H, Mizuno K, Sekiguchi C, Fukunaga M, Kohri K, Rittweger J, Felsenberg D, Matsumoto T, Nakamura T(2004) Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90 day bed rest. J Bone Miner Res 19: 1771-1778 (Pubitemid 41103427)
72. Whedon GD (1984) Disuse osteoporosis: physiological aspects. Calcif Tissue Int 36(Suppl 1): S146-S150 (Pubitemid 14043329)
73. World Health Organization (1985) WHO: energy and protein requirements. World Health Organization, Geneva Xie L, Jacobson JM, Choi ES, Busa B, Donahue LR, Miller LM, Rubin CT, Judex S (2006) Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton. Bone 39: 1059-1066 (Pubitemid 44550100)
74. You L, Cowin SC, Schaffler MB, Weinbaum S (2001) A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. J Biomech 34: 1375-1386 (Pubitemid 32970752)
75. Zange J, Mester J, Heer M, Kluge G, Liphardt AM (2009) 20 Hz whole body vibration training fails to counteract the decrease in leg muscle volume caused by 14 days of 6 degrees head down tilt bed rest. Eur J Appl Physiol 105: 271-277