Disulfide prodrugs of albitiazolium (T3/SAR97276): Synthesis and biological activities

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4619-4628

  Caldarelli, Sergio A ^a   Hamel, Matthieu ^a   Duckert, Jean Frédéric ^a   Ouattara, Mahama ^a   Calas, Michèle ^a   Maynadier, Marjorie ^b   Wein, Sharon ^b   Périgaud, Christian ^a   Pellet, Alain ^c   Vial, Henri J ^b   Peyrottes, Suzanne ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,2' ( 5,18 DIFORMYL 4,19 DIMETHYL 1,2 DITHIA 5,18 DIAZACYCLOICOSA 3,19 DIENE 3,20 DIYL)BIS(ETHANE 2,1 DIYL)BIS[( 2 (TERT BUTOXYCARBONYL)AMINO) 3 METHYLBUTANOIC ACID]; 2,2' ( 5,18 DIFORMYL 4,19 DIMETHYL 1,2 DITHIA 5,18 DIAZACYCLOICOSA 3,19 DIENE 3,20 DIYL)BIS(ETHANE 2,1 DIYL)BIS[( 2 AMINO 3 METHYLBUTANOIC ACID)]; 2,2' ( 5,18 DIFORMYL 4,19 DIMETHYL 1,2 DITHIA 5,18 DIAZACYCLOICOSA 3,19 DIENE 3,20 DIYL)BIS(ETHANE 2,1 DIYL)BIS[( 2,6 BIS(TERT BUTOXYCARBONYL)DIAMINO)HEXANOIC ACID]; 2,2' ( 5,18 DIFORMYL 4,19 DIMETHYL 1,2 DITHIA 5,18 DIAZACYCLOICOSA 3,19 DIENE 3,20 DIYL)BIS(ETHANE 2,1 DIYL)BIS[( 2,6 DIAMINOHEXANOIC ACID)]; 3,20 BIS( 2 HYDROXYETHYL) 4,19 DIMETHYL 1,2 DITHIA 5,18 DIAZACYCLOICOSA 3,19 DIENE 5,18 DICARBALDEHYDE; 3,20 BIS[( 2 (ACETOXY)ETHYL)] 4,19 DIMETHYL 1,2 DITHIA 5,18 DIAZACYCLOICOSA 3,19 DIENE 5,18 DICARBALDEHYDE; 4,4' (DODECAN 1,12 DIYL)BIS[ 4 (FORMYLAMINO) 3 (METHYLDISULFANYL)PENTEN 3 YL]BIS[( 2 AMINO 3 METHYLBUTANOIC ACID)]; 4,4' (DODECAN 1,12 DIYL)BIS[ 4 (FORMYLAMINO) 3 (METHYLDISULFANYL)PENTEN 3 YL]BIS[( 2,6 DAMINOHEXANOIC ACID)]; ALBITIAZOLIUM BROMIDE; AMINO ACID; ANTIMALARIAL AGENT; BENFOTIAMINE; CHLOROQUINE; DISULFIDE; FORMAMIDE DERIVATIVE; LYSINE; N,N' (DODECAN 1,12 DIEYL)BIS[ 4 (FORMYLAMINO) 3 (METHYLDISULFANYL)PENTEN 3 YL]BIS[( 2 (TERT BUTOXYCARBONYL)AMINO) 3 METHYLBUTANOIC ACID]; N,N' (DODECAN 1,12 DIYL)BIS[ 2 (BENZYLDISULFANYL) 4 HYDROXY 1 METHYL BUTEN 1 YL]DIFORMAMIDE; N,N' (DODECAN 1,12 DIYL)BIS[ 2 (ETHYLDISULFANYL) 4 HYDROXY 1 METHYLBUTEN 1 YL]DIFORMAMIDE; N,N' (DODECAN 1,12 DIYL)BIS[ 4 (FORMYLAMINO) 3 (METHYLDISULFANYL)PENTEN 3 YL]BIS[( 2,6 BIS(TERT BUTOXYCARBONYL)DIAMINO)HEXANOIC ACID]; N,N' (DODECAN 1,12 DIYL)BIS[ 4 HYDROXY 1 METHYL 2 (METHYLDISULFANYL)BUTEN 1 YL]DIFORMAMIDE; N,N' (DODECAN 1,12 DIYL)BIS[ 4 HYDROXY 1 METHYL 2 (PROPYLDISULFANYL)BUTEN 1 YL]DIFORMAMIDE; N,N' (DODECAN 1,12 DIYL)BIS[( 1 ( 2 THIETANYLIDENE)ETHYL]DIFORMAMIDE; N,N' (DODECAN 1,12 DIYL)BIS[( 2 ( 4 METHYL 1,3 THIAZOL 3 IUM 5 YL)ETHYL DIHYDROGEN PHOSPHATE]; N,N' (DODECAN 1,12 DIYL)BIS[( 3 (ETHYLDISULFANYL) 4 (FORMYLAMINO)PENTEN 3 YL]BIS[DIETHYL PHOSPHATE]; PHOSPHATE; PRODRUG; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DISULFIDE BOND; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DISULFIDES; MALARIA; MICE; PLASMODIUM FALCIPARUM; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84861513926     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3000328     Document Type: Article

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