Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients

Journal of Clinical Immunology

Volumn 32, Issue 3, 2012, Pages 565-573

  Gernez, Yael ^a   Tirouvanziam, Rabindra ^a,b   Reshamwala, Neha ^a   Yu, Grace ^a   Weldon, Brittany C ^a   Galli, Stephen J ^a   Herzenberg, Leonore A ^a   Nadeau, Kari C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Eosinophils; flow cytometry; food allergy; inflammation; neutrophils

Indexed keywords

CD203C ANTIGEN; CD63 ANTIGEN; INITIATION FACTOR 4E; LYMPHOCYTE ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; PROTEIN S6; RAPAMYCIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BASOPHIL; BLOOD SAMPLING; CELL LEVEL; CELL STIMULATION; CHICKEN; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; LEUKOCYTE ACTIVATION; MALE; NEUTROPHIL; NUT; NUT ALLERGY; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RICE; SCHOOL CHILD; UPREGULATION;

ADOLESCENT; ALLERGENS; ANACARDIUM; BASOPHILS; CHILD; CHILD, PRESCHOOL; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; HUMANS; JUGLANS; MALE; NUT HYPERSENSITIVITY; PEANUT HYPERSENSITIVITY; PHOSPHORYLATION; PLANT EXTRACTS; RIBOSOMAL PROTEIN S6; SIROLIMUS; TOR SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 84861482375     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-012-9651-x     Document Type: Article

References (38)

1. Gough NR. Focus Issue: demystifying mTOR signaling. Sci Signal. 2009;2:eg5.
2. Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 2009;10:307-18.
3. Ruvinsky I, Meyuhas O. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci. 2006;31:342-8. (Pubitemid 43903237)
4. Alessi DR, Pearce LR, Garcia-Martinez JM. New insights into mTOR signaling: mTORC2 and beyond. Sci Signal. 2009;2:pe27.
5. Kim MS, Kuehn HS, Metcalfe DD, Gilfillan AM. Activation and function of the mTORC1 pathway in mast cells. J Immunol. 2008;180:4586-95.
6. Li Q, Rao RR, Araki K, Pollizzi K, Odunsi K, Powell JD, Shrikant PA. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity. 2011;34:541-53.
7. Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, Larsen CP, Ahmed R. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009;460:108-12.
8. Yang CS, Song CH, Lee JS, Jung SB, Oh JH, Park J, Kim HJ, Park JK, Paik TH, Jo EK. Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Cell Microbiol. 2006;8:1158-71. (Pubitemid 43871650)
9. Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Tirouvanziam R. Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Proc Natl Acad Sci U S A. 2009;106:5779-83.
10. Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM. Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. J Biol Chem. 2011;286:391-402.
11. Meng Q, Ying S, Corrigan CJ, Wakelin M, Assoufi B, Moqbel R, Kay AB. Effects of rapamycin, cyclosporin A, and dexamethasone on interleukin 5-induced eosinophil degranulation and prolonged survival. Allergy. 1997;52:1095-101. (Pubitemid 27496256)
12. Miura K, MacGlashan DW. Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils. Blood. 2000;96:2199-205.
13. Sha Q, Poulsen LK, Gerwien J, Dum N, Skov PS. Signaling transduction pathways involved in basophil adhesion and histamine release. Chin Med J (Engl). 2006;119:122-30. (Pubitemid 43796928)
14. Rudders SA, Banerji A, Vassallo MF, Clark S, Camargo Jr CA. Trends in pediatric emergency department visits for food-induced anaphylaxis. J Allergy Clin Immunol. 2010;126:385-8.
15. Burks AW. Peanut allergy. Lancet. 2008;371:1538-46. (Pubitemid 351626191)
16. Krutzik PO, Irish JM, Nolan GP, Perez OD. Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Cl in Immunol. 2004;110:206-21. (Pubitemid 38402001)
17. Tirouvanziam R, Diaz D, Gernez Y, Laval J, Crubezy M, Makam M, Herzenberg LA: An integrative approach for immune monitoring of human health and disease by advanced flow cytometry methods. In: Tuchin V, editor. Advanced optical flow cytometry: methods and disease diagnoses. Wiley-VCH Verlag GmbH & Co.; 2011. p. 333-362
18. Gernez Y, Tirouvanziam R, Nguyen KD, Herzenberg LA, Krensky AM, Nadeau KC. Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids. J Allergy Clin Immunol. 2007;120:1441-8. (Pubitemid 350216597)
19. Tirouvanziam R, Gernez Y, Conrad CK, Moss RB, Schrijver I, Dunn CE, Davies ZA, Herzenberg LA. Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Proc Natl Acad Sci U S A. 2008;105:4335-9. (Pubitemid 351754381)
20. Nowak-Wegrzyn A, Assa'ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123:S365-83.
21. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Nadeau KC. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol. 2010;154:318-27.
22. Reiling JH, SabatiniDM. Stress and mTORture signaling. Oncogene. 2006;25:6373-83. (Pubitemid 44582282)
23. Tung JW, Heydari K, Tirouvanziam R, Sahaf B, Parks DR, Herzenberg LA. Modern flow cytometry: a practical approach. Clin Lab Med. 2007;27:453-68. (Pubitemid 47068806)
24. Kawakami T, Galli SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol. 2002;2:773-86. (Pubitemid 37328717)
25. Botana LM, MacGlashan DW. Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils. J Leukoc Biol. 1994;55:798-804. (Pubitemid 24207412)
26. Pramod SN, Venkatesh YP, Mahesh PA. Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E. Clin Exp Immunol. 2007;148:391-401. (Pubitemid 46701031)
27. Shichijo M, Shimizu Y, Hiramatsu K, Inagaki N, Tagaki K, Nagai H. Cyclic AMP-elevating agents inhibit mite-antigen-induced IL-4 and IL-13 release from basophil-enriched leukocyte preparation. Int Arch Allergy Immunol. 1997;114:348-53. (Pubitemid 27504102)
28. Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008;28:581-9.
29. Tsai M, Chen RH, Tam SY, Blenis J, Galli SJ. Activation of MAP kinases, pp 90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. Eur J Immunol. 1993;23:3286-91. (Pubitemid 23353780)
30. Kim MS, Radinger M, Gilfillan AM. The multiple roles of phosphoinositide 3-kinase in mast cell biology. Trends Immunol. 2008;29:493-501.
31. Gibbs BF, Grabbe J. PI 3-kinase and MEK kinase inhibitors differentially affect IgE-dependent and IgE-independent basophil mediator release. Inflamm Res. 2001;50:S53-4. (Pubitemid 32452965)
32. Gibbs BF, Plath KE, Wolff HH, Grabbe J. Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. J Leukoc Biol. 2002;72:391-400.
33. MacGlashan D Jr., Undem BJ: Inducing an anergic state in mast cells and basophils without secretion. J Allergy Clin Immunol. 2008;121:1500-1506, 1506
34. Zaidi AK, Saini SS, Macglashan Jr DW. Regulation of Syk kinase and FcεRI expression in human basophils during treatment with omalizumab. J Allergy Clin Immunol. 2010;125:902-8.
35. Aerts NE, Dombrecht EJ, Bridts CH, Hagendorens MM, de Clerck LS, Stevens WJ, Ebo DG. Simultaneous flow cytometric detection of basophil activation marker CD63 and intracellular phosphorylated p38 mitogen-activated protein kinase in birch pollen allergy. Cytometry B Clin Cytom. 2008;76B:8-17.
36. Perez OD, Krutzik PO, Nolan GP. Flow cytometric analysis of kinase signaling cascades. Methods Mol Biol. 2004;263:67-94.
37. Mourani PM, Garl PJ, Wenzlau JM, Carpenter TC, Stenmark KR, Weiser-Evans MC. Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN. Circulation. 2004;109:1299-306. (Pubitemid 38372790)
38. Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci USA. 2010;107:14134-9.