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Volumn 105, Issue 7, 2008, Pages 2634-2639

High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria

Author keywords

Anemia; Plasmodium falciparum; Severe malaria; Vascular endothelial growth factor

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

EID: 40649100555     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709715105     Document Type: Article
Times cited : (94)

References (53)
  • 1
    • 0031849928 scopus 로고    scopus 로고
    • Severe falciparum malaria in children: Current understanding of pathophysiology and supportive treatment
    • Newton CR, Krishna S (1998) Severe falciparum malaria in children: Current understanding of pathophysiology and supportive treatment. Pharmacol Ther 79:1-53.
    • (1998) Pharmacol Ther , vol.79 , pp. 1-53
    • Newton, C.R.1    Krishna, S.2
  • 2
    • 13244263273 scopus 로고    scopus 로고
    • Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children
    • Carter JA, et al. (2005) Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children. J Neurol Neurosurg Psychiatry 76:476-481.
    • (2005) J Neurol Neurosurg Psychiatry , vol.76 , pp. 476-481
    • Carter, J.A.1
  • 3
    • 13244290219 scopus 로고    scopus 로고
    • Developmental impairments following severe falciparum malaria in children
    • Carter JA, et al. (2005) Developmental impairments following severe falciparum malaria in children. Trop Med Int Health 10:3-10.
    • (2005) Trop Med Int Health , vol.10 , pp. 3-10
    • Carter, J.A.1
  • 4
    • 4043081388 scopus 로고    scopus 로고
    • Increased prevalence of epilepsy associated with severe falciparum malaria in children
    • Carter JA, et al. (2004) Increased prevalence of epilepsy associated with severe falciparum malaria in children. Epilepsia 45:978-981.
    • (2004) Epilepsia , vol.45 , pp. 978-981
    • Carter, J.A.1
  • 5
    • 33745229993 scopus 로고    scopus 로고
    • Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa
    • Ngoungou EB, et al. (2006) Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa. Epilepsia 47:873-879.
    • (2006) Epilepsia , vol.47 , pp. 873-879
    • Ngoungou, E.B.1
  • 6
    • 0030923027 scopus 로고    scopus 로고
    • Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa
    • Snow RW, et al. (1997) Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349:1650-1654.
    • (1997) Lancet , vol.349 , pp. 1650-1654
    • Snow, R.W.1
  • 7
    • 27744563110 scopus 로고    scopus 로고
    • Pathogenesis, clinical features, and neurological outcome of cerebral malaria
    • Idro R, Jenkins NE, Newton CR (2005) Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol 4:827-8240.
    • (2005) Lancet Neurol , vol.4 , pp. 827-8240
    • Idro, R.1    Jenkins, N.E.2    Newton, C.R.3
  • 8
    • 0025080932 scopus 로고
    • Neurological sequelae of cerebral malaria in children
    • Brewster DR, Kwiatkowski D, White NJ (1990) Neurological sequelae of cerebral malaria in children. Lancet 336:1039-1043.
    • (1990) Lancet , vol.336 , pp. 1039-1043
    • Brewster, D.R.1    Kwiatkowski, D.2    White, N.J.3
  • 9
    • 0024340659 scopus 로고
    • Clinical features and prognostic indicators in pediatric cerebral malaria: A study of 131 comatose Malawian children
    • Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. (1989) Clinical features and prognostic indicators in pediatric cerebral malaria: A study of 131 comatose Malawian children. Q J Med 71:441-459.
    • (1989) Q J Med , vol.71 , pp. 441-459
    • Molyneux, M.E.1    Taylor, T.E.2    Wirima, J.J.3    Borgstein, A.4
  • 10
    • 33644637973 scopus 로고    scopus 로고
    • Risk factors for persisting neurological and cognitive impairments following cerebral malaria
    • Idro R, Carter JA, Fegan G, Neville BG, Newton CR (2006) Risk factors for persisting neurological and cognitive impairments following cerebral malaria. Arch Dis Child 91:142-148.
    • (2006) Arch Dis Child , vol.91 , pp. 142-148
    • Idro, R.1    Carter, J.A.2    Fegan, G.3    Neville, B.G.4    Newton, C.R.5
  • 11
    • 0000909936 scopus 로고
    • Sur l'activité hémopoié tique des différents organes au cours de la régéné ration du sang.
    • Carnot P, Deflandre C (1906) Sur l'activité hémopoié tique des différents organes au cours de la régéné ration du sang. C R Acad Sci 143:384-386.
    • (1906) C R Acad Sci , vol.143 , pp. 384-386
    • Carnot, P.1    Deflandre, C.2
  • 12
    • 0027956115 scopus 로고
    • A novel site of erythropoietin production: Oxygen-dependent production in cultured rat astrocytes
    • Masuda S, et al. (1994) A novel site of erythropoietin production: Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269:19488-19493.
    • (1994) J Biol Chem , vol.269 , pp. 19488-19493
    • Masuda, S.1
  • 13
    • 0032516086 scopus 로고    scopus 로고
    • In vivo evidence that erythropoietin protects neurons from ischemic damage
    • Sakanaka M, et al. (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95:4635-4640.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4635-4640
    • Sakanaka, M.1
  • 14
    • 0034641710 scopus 로고    scopus 로고
    • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    • Brines ML, et al. (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97:10526-10531.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10526-10531
    • Brines, M.L.1
  • 15
    • 0037117577 scopus 로고    scopus 로고
    • Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage
    • Grasso G, et al. (2002) Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage. Proc Natl Acad Sci USA 99:5627-5631.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5627-5631
    • Grasso, G.1
  • 16
    • 33645096803 scopus 로고    scopus 로고
    • Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro
    • Liu R, Suzuki A, Guo Z, Mizuno Y, Urabe T. (2006) Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro. J Neurochem 96:1101-1110.
    • (2006) J Neurochem , vol.96 , pp. 1101-1110
    • Liu, R.1    Suzuki, A.2    Guo, Z.3    Mizuno, Y.4    Urabe, T.5
  • 17
    • 0035957426 scopus 로고    scopus 로고
    • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • Siren AL, et al. (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98:4044-4049.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4044-4049
    • Siren, A.L.1
  • 18
    • 0037086295 scopus 로고    scopus 로고
    • Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression
    • Wen TC, et al. (2002) Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression. J Neurosci Res 67:795-803.
    • (2002) J Neurosci Res , vol.67 , pp. 795-803
    • Wen, T.C.1
  • 19
    • 0036705708 scopus 로고    scopus 로고
    • Erythropoietin therapy for acute stroke is both safe and beneficial
    • Ehrenreich H, et al. (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 8:495-505.
    • (2002) Mol Med , vol.8 , pp. 495-505
    • Ehrenreich, H.1
  • 20
    • 33750626412 scopus 로고    scopus 로고
    • Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
    • Casals-Pascual C, et al. (2006) Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo. Blood 108:2569-2577.
    • (2006) Blood , vol.108 , pp. 2569-2577
    • Casals-Pascual, C.1
  • 21
    • 0030887508 scopus 로고    scopus 로고
    • Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria
    • Kurtzhals JA, et al. (1997) Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria. Br J Haematol 97:169-174.
    • (1997) Br J Haematol , vol.97 , pp. 169-174
    • Kurtzhals, J.A.1
  • 22
    • 0031051670 scopus 로고    scopus 로고
    • Severe anemia in children living in a malaria ndemic area of Kenya
    • Newton CR, et al. (1997) Severe anemia in children living in a malaria ndemic area of Kenya. Trop Med Int Health 2:165-178.
    • (1997) Trop Med Int Health , vol.2 , pp. 165-178
    • Newton, C.R.1
  • 23
    • 33645369420 scopus 로고    scopus 로고
    • Recombinant human erythropoietin prevents the death of mice during cerebral malaria
    • Kaiser K, et al. (2006) Recombinant human erythropoietin prevents the death of mice during cerebral malaria. J Infect Dis 193:987-995.
    • (2006) J Infect Dis , vol.193 , pp. 987-995
    • Kaiser, K.1
  • 24
    • 0036320934 scopus 로고    scopus 로고
    • Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
    • Wenger RH (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 16:1151-1162.
    • (2002) FASEB J , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 25
    • 30744477950 scopus 로고    scopus 로고
    • From angiogenesis to neuropathology
    • Greenberg DA, Jin K (2005) From angiogenesis to neuropathology. Nature 438:954-959.
    • (2005) Nature , vol.438 , pp. 954-959
    • Greenberg, D.A.1    Jin, K.2
  • 26
    • 33748937723 scopus 로고    scopus 로고
    • Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat
    • Wang Y, et al. (2006) Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. Brain Res 1115:186-193.
    • (2006) Brain Res , vol.1115 , pp. 186-193
    • Wang, Y.1
  • 27
    • 3242808153 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) in seizures: A double-edged sword
    • Croll SD, Goodman JH, Scharfman HE (2004) Vascular endothelial growth factor (VEGF) in seizures: A double-edged sword. Adv Exp Med Biol 548:57-68.
    • (2004) Adv Exp Med Biol , vol.548 , pp. 57-68
    • Croll, S.D.1    Goodman, J.H.2    Scharfman, H.E.3
  • 28
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang ZG, et al. (2000) VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106:829-838.
    • (2000) J Clin Invest , vol.106 , pp. 829-838
    • Zhang, Z.G.1
  • 29
    • 29044446692 scopus 로고    scopus 로고
    • Effects of VEGF and nitric oxide synthase inhibition on blood-brain barrier disruption in the ischemic and nonischemic cerebral cortex
    • Chi OZ, Hunter C, Liu X, Weiss HR (2005) Effects of VEGF and nitric oxide synthase inhibition on blood-brain barrier disruption in the ischemic and nonischemic cerebral cortex. Neurol Res 27:864-868.
    • (2005) Neurol Res , vol.27 , pp. 864-868
    • Chi, O.Z.1    Hunter, C.2    Liu, X.3    Weiss, H.R.4
  • 30
    • 1342291175 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients
    • Intiso D, et al. (2004) Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients. Neurol Sci 24:390-396.
    • (2004) Neurol Sci , vol.24 , pp. 390-396
    • Intiso, D.1
  • 31
    • 0030976856 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha:Amediator of focal ischemic brain injury
    • Barone FC, et al. (1997) Tumor necrosis factor-alpha:Amediator of focal ischemic brain injury. Stroke 28:1233-1244.
    • (1997) Stroke , vol.28 , pp. 1233-1244
    • Barone, F.C.1
  • 32
    • 0024327071 scopus 로고
    • Tumor necrosis factor and disease severity in children with falciparum malaria
    • Grau GE, et al. (1989) Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 320:1586-1591.
    • (1989) N Engl J Med , vol.320 , pp. 1586-1591
    • Grau, G.E.1
  • 33
    • 0025015479 scopus 로고
    • TNF concentration in fatal cerebral, nonfatal cerebral, and uncomplicated Plasmodium falciparum malaria
    • Kwiatkowski D, et al. (1990) TNF concentration in fatal cerebral, nonfatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 336:1201-1204.
    • (1990) Lancet , vol.336 , pp. 1201-1204
    • Kwiatkowski, D.1
  • 34
    • 4644318784 scopus 로고    scopus 로고
    • Erythropoietin and the hypoxic brain
    • Marti HH (2004) Erythropoietin and the hypoxic brain. J Exp Biol 207:3233-3242.
    • (2004) J Exp Biol , vol.207 , pp. 3233-3242
    • Marti, H.H.1
  • 35
    • 20044373442 scopus 로고    scopus 로고
    • Emerging biological roles for erythropoietin in the nervous system
    • Brines M, Cerami A. (2005) Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6:484-494.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 484-494
    • Brines, M.1    Cerami, A.2
  • 36
    • 0141784841 scopus 로고    scopus 로고
    • Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    • Villa P, et al. (2003) Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 198:971-975.
    • (2003) J Exp Med , vol.198 , pp. 971-975
    • Villa, P.1
  • 37
    • 33746263669 scopus 로고    scopus 로고
    • Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice
    • Wiese L, Kurtzhals JA, Penkowa M. (2006) Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice. Exp Neurol 200:216-226.
    • (2006) Exp Neurol , vol.200 , pp. 216-226
    • Wiese, L.1    Kurtzhals, J.A.2    Penkowa, M.3
  • 38
    • 20944439418 scopus 로고    scopus 로고
    • High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention
    • Namiuchi S, et al. (2005) High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention. J Am Coll Cardiol 45:1406-1412.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1406-1412
    • Namiuchi, S.1
  • 39
    • 34547218007 scopus 로고    scopus 로고
    • Age-related changes in adaptation to severe anemia in childhood in developing countries
    • O'Donnell A, et al. (2007) Age-related changes in adaptation to severe anemia in childhood in developing countries. Proc Natl Acad Sci USA 104:9440-9444.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9440-9444
    • O'Donnell, A.1
  • 40
    • 0031038417 scopus 로고    scopus 로고
    • Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species
    • Fandrey J, et al. (1997) Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species. Kidney Int 51:492-496.
    • (1997) Kidney Int , vol.51 , pp. 492-496
    • Fandrey, J.1
  • 41
    • 29244485561 scopus 로고    scopus 로고
    • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system
    • Siddiq A, et al. (2005) Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system. J Biol Chem 280:41732-41743.
    • (2005) J Biol Chem , vol.280 , pp. 41732-41743
    • Siddiq, A.1
  • 42
    • 18744438254 scopus 로고    scopus 로고
    • Iron chelating agents for treating malaria
    • 10.1002/14651858.CD001474
    • Smith HJ, Meremikwu M (2003) Iron chelating agents for treating malaria. Cochrane Database Syst Rev, 10.1002/14651858.CD001474.
    • (2003) Cochrane Database Syst Rev
    • Smith, H.J.1    Meremikwu, M.2
  • 43
    • 0026459549 scopus 로고
    • Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria
    • Gordeuk V, et al. (1992) Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. N Engl J Med 327:1473-1477.
    • (1992) N Engl J Med , vol.327 , pp. 1473-1477
    • Gordeuk, V.1
  • 45
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy AP, Levy NS, Goldberg MA (1996) Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271:2746-2753.
    • (1996) J Biol Chem , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 46
    • 0026071814 scopus 로고
    • Intracranial pressure in African children with cerebral malaria
    • Newton CR, et al. (1991) Intracranial pressure in African children with cerebral malaria. Lancet 337:573-576.
    • (1991) Lancet , vol.337 , pp. 573-576
    • Newton, C.R.1
  • 47
    • 0029953517 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells: Possible roles of SP-1
    • Ryuto M, et al. (1996) Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells: Possible roles of SP-1. J Biol Chem 271:28220-28228.
    • (1996) J Biol Chem , vol.271 , pp. 28220-28228
    • Ryuto, M.1
  • 48
    • 0035064310 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    • Nagai A, et al. (2001) Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 60:386-392.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 386-392
    • Nagai, A.1
  • 49
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, et al. (2004) Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305:239-242.
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1
  • 50
    • 0035796004 scopus 로고    scopus 로고
    • Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa
    • Berkley JA, et al. (2001) Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa. Lancet 357:1753-1757.
    • (2001) Lancet , vol.357 , pp. 1753-1757
    • Berkley, J.A.1
  • 51
    • 1942504773 scopus 로고    scopus 로고
    • Management of severe falciparum malaria
    • Njuguna P, Newton C (2004) Management of severe falciparum malaria. J Postgrad Med 50:45-50.
    • (2004) J Postgrad Med , vol.50 , pp. 45-50
    • Njuguna, P.1    Newton, C.2
  • 52
    • 0038300947 scopus 로고    scopus 로고
    • WHO Expert Committee on Malaria , WHO, Geneva
    • WHO Expert Committee on Malaria (2000) Twentieth Report (WHO, Geneva).
    • (2000) Twentieth Report
  • 53
    • 24644496011 scopus 로고    scopus 로고
    • Manifestations, quality of emergency care, and outcome of severe malaria in mulago hospital
    • Idro R, Aloyo J (2004) Manifestations, quality of emergency care, and outcome of severe malaria in mulago hospital. Uganda Afr Health Sci 4:50-57.
    • (2004) Uganda Afr Health Sci , vol.4 , pp. 50-57
    • Idro, R.1    Aloyo, J.2


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