Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malaria

Journal of Infectious Diseases

Volumn 189, Issue 7, 2004, Pages 1245-1256

  Sexton, Adrienne C ^a,b   Good, Robert T ^a   Hansen, Diana S ^a   D'Ombrain, Marthe C ^a   Buckingham, Lynn ^a   Simpson, Ken ^a   Schofield, Louis ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ANKYRIN; BLOOD CLOTTING FACTOR; CHEMOKINE; COLLAGEN; COMPLEMENTARY DNA; CYTOKINE; CYTOKINE RECEPTOR; ENOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEXOKINASE; INTERFERON; LACTATE DEHYDROGENASE; MEMBRANE PROTEIN; PHOSPHOGLYCERATE KINASE; PROTEASOME; PYRUVATE DEHYDROGENASE; PYRUVATE KINASE; RNA; TRANSCRIPTION FACTOR; TRIOSEPHOSPHATE ISOMERASE;

ANEMIA; ANIMAL MODEL; ARTICLE; BRAIN; DNA MICROARRAY; ERYTHROPOIESIS; GENETIC TRANSCRIPTION; GLYCOLYSIS; HISTOPATHOLOGY; LUNG; MALARIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SPLEEN; UNINDEXED SEQUENCE;

EID: 1842503151     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/382596     Document Type: Article

References (35)

1. Rest JR. Cerebral malaria in inbred mice. I. A new model and its pathology. Trans R Soc Trop Med Hyg 1982; 76:410-5.
2. Lou J, Lucas R, Grau GE. Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clin Microbiol Rev 2001; 14:810-20.
3. de Souza JB, Riley EM. Cerebral malaria: contribution of studies in animal models to our understanding of immunopathogenesis. Microbes Infect 2002; 4:291-300.
4. Hearn J, Rayment N, Landon DN, Katz DR, de Souza JB. Immunopathology of cerebral malaria: morphological evidence of parasite sequestration in murine brain microvasculature. Infect Immun 2000; 68: 5364-76.
5. Porta J, Carota A, Pizzolato GP, et al. Immunopathological changes in human cerebral malaria. Clin Neuropathol 1993; 12:142-6.
6. Patnaik JK, Das BS, Mishra SK, Mohanty S, Satpathy SK, Mohanty D. Vascular dogging, mononuclear cell margination, and enhanced vascular permeability in the pathogenesis of human cerebral malaria. Am J Trop Med Hyg 1994; 51:642-7.
7. Oo MM, Aikawa M, Than T, et al. Human cerebral malaria: a pathological study. J Neuropathol Exp Neurol 1987; 46:223-31.
8. Grau GE, Fajardo LF, Piguet PF, Allet B, Lambert PH, Vassalli P Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 1987; 237:1210-2.
9. Grau GE, Heremans H, Piguet PF, et al. Monoclonal antibody against interferon can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc Natl Acad Sci USA 1989; 86:5572-4.
10. Grau GE, Pointaire P, Piguet PF, et al. Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria. Eur J Immunol 1991; 21:2265-7.
11. Jennings VM, Actor JK, Lal AA, Hunter RL. Cytokine profile suggesting that murine cerebral malaria is an encephalitis. Infect Immun 1997; 65:4883-7.
12. Weghofer M, Karlic H, Haslberger A. Quantitative analysis of immune-mediated stimulation of tumour necrosis factor - α in macrophages measured at the level of mRNA and protein synthesis. Ann Hematol 2001; 80:733-6.
13. Hein I, Schellenberg U, Bein G, Hackstein H. Quantification of murine IFN-γ mRNA and protein expression: impact of real-time kinetic RT-PCR using SYBR green I dye. Scand J Immunol 2001; 54:285-91.
14. Engwerda CR, Mynott TL, Sawhney S, De Souza IB, Bickle QD, Kaye PM. Locally up-regulated lymphotoxin α, not systemic tumor necrosis factor α, is the principle mediator of murine cerebral malaria. J Exp Med 2002; 195:1371-7.
15. + T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice. Infect Immun 2001; 69:7341-8.
16. Schofield L, Hewitt MC Evans K, Siomos MA, Seeberger PH. Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature 2002; 418:785-9.
17. Day NP, Phu NH, Mai NT, et al. The pathophysiologic and prognostic significance of acidosis in severe adult malaria. Grit Care Med 2000; 28:1833-40.
18. Marsh K, English M, Crawley J. The pathogenesis of severe malaria in African children. Ann Trop Med Parasitol 1996; 90:395-402.
19. Menendez C, Fleming AF, Alonso PL. Malaria-related anaemia. Parasitol Today 2000; 16:469-76.
20. Boehm U, Guethlein L, Klamp T, et al. Two families of GTPases dominate the complex cellular response to IFN-γ. J Immunol 1998; 161:6715-23.
21. Collazo CM, Yap GS, Sempowski GD, et al. Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma;-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med 2001; 194:181-8.
22. Monso-Hinard C, Lou JN, Behr C, Juillard P, Grau GE. Expression of major histocompatibility complex antigens on mouse brain microvascular endothetial cells in relation to susceptibility to cerebral malaria. Immunology 1997; 92:53-9.
23. Smith JB, Herschman HR. The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains. Arch Biochem Biophys 1996; 330:290-300.
24. Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP. Interferon-γ and tumor necrosis factor-α suppress both early and late stages of haematopoiesis and induce programmed cell death. J Cell Physiol 1995; 165:538-46.
25. Zoumbos NC, Gascon P, Djeu JY, Young NS. Interferon is a mediator of haematopoietic suppression in aplastic anaemia in vitro and possibly in vivo. Proc Natl Acad Sci USA 1985; 82:188-92.
26. Grau GE, Taylor TE, Molyneux ME, Wirima JJ, Vassalli P. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 1989; 320:1586-91.
27. Chinnaiyan AM, Huber-Lang M, Kumar-Sinha C, et al. Molecular signatures of sepsis. Am J Pathol 2001; 159:1199-209.
28. Hansen D, Siomos MA, Buckingham L, Scalzo AA, Schofield L. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 2003; 18:391-402,
29. Xu HJ, Yan H, Zeng M, et al. The mechanism and significance of deletion of parasite-specific T cells in malaria infection. J Exp Med 2002; 195:881-5.
30. + anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 2002; 99:2468-76.
31. Manger ID, Relman DA. How the host "sees" pathogens: global gene expression responses to infection. Curr Opin Immunol 2000; 12:215-8.
32. de Avalos SV, Blader IJ, Fisher M, Boothroyd JC Burleigh BA. Immediate/ early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription. J Biol Chem 2002; 277:639-44.
33. Blader IJ, Manger ID, Boothroyd JC Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. J Biol Chem 2001; 276:24223-31.
34. Mouse Genome Sequencing Consortium. Initial sequencing and comparative analysis of the mouse genome. Nature 2002; 420:520-62.
35. Villeval JL, Lew A, Metcalf D. Changes in hemopoietic and regulator levels in mice during fatal or nonfatal malarial infections. I. Erythropoietic populations. Exp Parasitol 1990; 71:364-74.