Melanoblasts on the move: Rac1 sets the pace

Small GTPases

Volumn 3, Issue 2, 2012, Pages 5-

  Li, Ang ^a   Machesky, Laura M ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

In vivo; Melanoblast; Melanoma; Pseudopod; Rac

Indexed keywords

MYOSIN II; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; CELL ACTIVITY; CELL INVASION; CELL MIGRATION; CELL MOTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; IN VIVO STUDY; INTRACELLULAR SIGNALING; MELANOBLAST; MELANOCYTE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

PSEUDOPODA;

EID: 84861464555     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Mayer TC. The migratory pathway of neural crest cells into the skin of mouse embryos. Dev Biol 1973; 34:39-46; PMID: 4595498; DOI: 10.1016/0012-1606(73)90337-0.
2. Kelsh RN, Harris ML, Colanesi S, Erickson CA. Stripes and belly-spots--a review of pigment cell morphogenesis in vertebrates. Semin Cell Dev Biol 2009; 20:90-104; PMID: 18977309; DOI: 10.1016/j.semcdb.2008.10.001.
3. Baxter LL, Hou L, Loftus SK, Pavan WJ. Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders. Pigment Cell Res 2004; 17:215-24; PMID: 15140066; DOI: 10.1111/j.1600-0749.2004.00147.x.
4. Bennett DC, Lamoreux ML. The color loci of mice--a genetic century. Pigment Cell Res 2003; 16:333-44; PMID: 12859616; DOI: 10.1034/j.1600-0749.2003.00067.x.
5. Mort RL, Hay L, Jackson IJ. Ex vivo live imaging of melanoblast migration in embryonic mouse skin. Pigment Cell Melanoma Res 2010; 23:299-301; PMID: 20067551; DOI: 10.1111/j.1755-148X.2010.00669.x.
6. Jordan SA, Jackson IJ. MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles. Dev Biol 2000; 225:424-36; PMID: 10985860; DOI: 10.1006/dbio.2000.9856.
7. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008; 9:690-701; PMID: 18719708; DOI: 10.1038/nrm2476.
8. Vidali L, Chen F, Cicchetti G, Ohta Y, Kwiatkowski DJ. Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell 2006; 17:2377-90; PMID: 16525021; DOI: 10.1091/mbc.E05-10-0955.
9. Guo F, Debidda M, Yang L, Williams DA, Zheng Y. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J Biol Chem 2006; 281:18652-9; PMID: 16698790; DOI: 10.1074/jbc.M603508200.
10. Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, et al. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression. Dev Cell 2011; 21:722-34; PMID: 21924960; DOI: 10.1016/j.devcel.2011.07.008.
11. Murphy AM, Montell DJ. Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J Cell Biol 1996; 133:617-30; PMID: 8636236; DOI: 10.1083/jcb.133.3.617.
12. Duchek P, Rørth P. Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 2001; 291:131-3; PMID: 11141565; DOI: 10.1126/science.291.5501.131.
13. Migeotte I, Omelchenko T, Hall A, Anderson KV. Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol 2010; 8:e1000442; PMID: 20689803; DOI: 10.1371/journal.pbio.1000442.
14. Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, et al. Structure and control of the actin regulatory WAVE complex. Nature 2010; 468:533-8; PMID: 21107423; DOI: 10.1038/nature09623.
15. Rakeman AS, Anderson KV. Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development 2006; 133:3075-83; PMID: 16831833; DOI: 10.1242/dev.02473.
16. Wells CM, Walmsley M, Ooi S, Tybulewicz V, Ridley AJ. Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci 2004; 117:1259-68; PMID: 14996945; DOI: 10.1242/jcs.00997.
17. Wheeler AP, Wells CM, Smith SD, Vega FM, Henderson RB, Tybulewicz VL, et al. Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci 2006; 119:2749-57; PMID: 16772332; DOI: 10.1242/jcs.03024.
18. Wang X, He L, Wu YI, Hahn KM, Montell DJ. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat Cell Biol 12, 591-597, doi:http://www.nature.com/ncb/journal/v12/n6/suppinfo/ncb2061_S1.html (2010).
19. Gaggioli C, et al. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 9, 1392-1400, doi:http://www.nature.com/ncb/journal/v9/n12/suppinfo/ncb1658_S1.html (2007).
20. Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, et al. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008; 135:510-23; PMID: 18984162; DOI: 10.1016/j.cell.2008.09.043.
21. Kunwar PS, Siekhaus DE, Lehmann R. In vivo migration: a germ cell perspective. Annu Rev Cell Dev Biol 2006; 22:237-65; PMID: 16774460; DOI: 10.1146/annurev.cellbio.22.010305.103337.
22. Kardash E, et al. A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol 12, 47-53, doi:http://www.nature.com/ncb/journal/v12/n1/suppinfo/ncb2003_S1.html (2010).
23. Theveneau E, Marchant L, Kuriyama S, Gull M, Moepps B, Parsons M, et al. Collective chemotaxis requires contact-dependent cell polarity. Dev Cell 2010; 19:39-53; PMID: 20643349; DOI: 10.1016/j.devcel.2010.06.012.
24. Luciani F, Champeval D, Herbette A, Denat L, Aylaj B, Martinozzi S, et al. Biological and mathematical modeling of melanocyte development. Development 2011; 138:3943-54; PMID: 21862558; DOI: 10.1242/dev.067447.
25. Nishikawa S, Kusakabe M, Yoshinaga K, Ogawa M, Hayashi S, Kunisada T, et al. In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development. EMBO J 1991; 10:2111-8; PMID: 1712289.
26. Sanz-Moreno V, Marshall CJ. The plasticity of cytoskeletal dynamics underlying neoplastic cell migration. Curr Opin Cell Biol 2010; 22:690-6; PMID: 20829016; DOI: 10.1016/j.ceb.2010.08.020.
27. Xia M, Land H. Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility. Nat Struct Mol Biol 14, 215-223, doi:http://www.nature.com/nsmb/journal/v14/n3/suppinfo/nsmb1208_S1.html (2007).
28. Machacek M, et al. Coordination of Rho GTPase activities during cell protrusion. Nature 461, 99-103, doi:http://www.nature.com/nature/journal/v461/n7260/suppinfo/nature08242_S1.html (2009).
29. Nalbant P, Hodgson L, Kraynov V, Toutchkine A, Hahn KM. Activation of endogenous Cdc42 visualized in living cells. Science 2004; 305:1615-9; PMID: 15361624; DOI: 10.1126/science.1100367.
30. Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 440, 1069-1072, doi:http://www.nature.com/nature/journal/v440/n7087/suppinfo/nature04665_S1.html (2006).
31. Olson M. F. GTPase Signalling: New Functions for Diaphanous-Related Formins. Curr Biol 2003; 13:R360-R362.
32. Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr Biol 2001; 11:1645-55; PMID: 11696321; DOI: 10.1016/S0960-9822(01)00506-1.
33. Urban E, Jacob S, Nemethova M, Resch GP, Small JV. Electron tomography reveals unbranched networks of actin filaments in lamellipodia. Nat Cell Biol 2010; 12:429-35; PMID: 20418872; DOI: 10.1038/ncb2044.
34. Lebensohn AM, Kirschner MW. Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell 2009; 36:512-24; PMID: 19917258; DOI: 10.1016/j.molcel.2009.10.024.