Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans

Journal of Lipid Research

Volumn 53, Issue 6, 2012, Pages 1153-1162

  Zheng, Hui ^a,b   Zou, Haibo ^c   Liu, Xiaopeng ^a   Chu, Ji ^b   Zhou, Yali ^b   Loh, Horace H ^b   Law, Ping Yee ^b  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b UNIVERSITY OF MINNESOTA   (United States)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

Anesthesia; cAMP signaling; G protein coupling; Simvastatin

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; CHOLESTEROL; FENTANYL; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; MU OPIATE RECEPTOR; SIMVASTATIN;

ANALGESIA; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; BRAIN LEVEL; CELL LEVEL; CELL STRAIN HEK293; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL BRAIN LEVEL; CHOLESTEROL CELL LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG INHIBITION; HIPPOCAMPUS; HUMAN; HUMAN CELL; LIPID RAFT; MALE; MEDICAL RECORD REVIEW; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANALGESIA; ANALGESICS, OPIOID; ANIMALS; CHOLESTEROL; CHOLESTEROL, DIETARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FENTANYL; HEK293 CELLS; HUMANS; MALE; MEMBRANE MICRODOMAINS; MICE; MORPHOLINES; NEURONS; RATS; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 84861452611     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M024455     Document Type: Article

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