Inhibitory effects of a spinasterol glycoside on lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines via down-regulating MAP kinase pathways and NF-κB activation in RAW264.7 macrophage cells

International Immunopharmacology

Volumn 13, Issue 3, 2012, Pages 264-270

  Lee, Tae Hoon ^a   Jung, Mira ^a   Bang, Myun Ho ^a   Chung, Dae Kyun ^a   Kim, Jiyoung ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Inflammation; iNOS; NF B; Nitric oxide; Proinflammatory cytokine; Spinasterol

Indexed keywords

ANTIINFLAMMATORY AGENT; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PLANT EXTRACT; SPINASTEROL GLYCOSIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENDOTOXEMIA; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SEPSIS; SURVIVAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BASE SEQUENCE; CELL LINE; CYTOKINES; DOWN-REGULATION; GLYCOSIDES; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MALE; MAP KINASE SIGNALING SYSTEM; MEDICINE, KOREAN TRADITIONAL; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; STIGMASTEROL; THEACEAE;

EID: 84861446024     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.05.005     Document Type: Article

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