Hypercalcemia, hypervitaminosis A and 3-epi-25-OH-D3 levels after consumption of an "over the counter" vitamin D remedy. A case report

Food and Chemical Toxicology

Volumn 50, Issue 6, 2012, Pages 2106-2108

  Granado Lorencio, F ^a   Rubio, E ^a   Blanco Navarro, I ^a   Perez Sacristan B ^a   Rodriguez Pena R ^a   Garcia Lopez F J ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

25 Hydroxyvitamin D; Acute kidney injury; C 3 epimer of 25 hydroxyvitamin D; Hypervitaminosis A; Vitamin D toxicity

Indexed keywords

25 HYDROXYERGOCALCIFEROL; ALKALINE PHOSPHATASE; ATENOLOL; C 3 EPIMER OF 25 HYDROXYVITAMIN D3; CALCIFEDIOL; CALCIUM; CREATININE; ERGOCALCIFEROL; FUROSEMIDE; HYDROCHLOROTHIAZIDE; INFUSION FLUID; NON PRESCRIPTION DRUG; PARATHYROID HORMONE; PHOSPHATE; RETINOL; RETINOL ESTER; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CASE REPORT; CLEARANCE; DISEASE ASSOCIATION; DRUG USE; DRUG WITHDRAWAL; ECHOGRAPHY; ECUADOR; FEMALE; HUMAN; HYPERCALCEMIA; HYPERTENSION; INTENSIVE CARE; JAW PAIN; LABORATORY TEST; MEDICATION ERROR; NEPHROLITHIASIS; PROTEIN URINE LEVEL; RETINOL INTOXICATION; URINALYSIS; VITAMIN BLOOD LEVEL; VITAMIN D INTOXICATION; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

25-HYDROXYVITAMIN D 2; ACUTE KIDNEY INJURY; CALCIFEDIOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; FEMALE; HUMANS; HYPERCALCEMIA; HYPERVITAMINOSIS A; MEDICAL ERRORS; MIDDLE AGED; QUALITY CONTROL; VITAMIN A; VITAMIN D; VITAMINS;

EID: 84861439017     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.03.001     Document Type: Article

References (24)

1. Araki T., Holick M.F., Alfonso B.D., Charlap E., Romero C.M., Rizk D., Newman L.G. Intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. J. Clin. Endocrinol. Metab. 2010, 96:3603-3608.
2. Bhalla K., Ennis D.M., Ennis E.D. Hypercalcemia caused by iatrogenic hypervitaminosis A. J. Am. Diet. Assoc. 2005, 105:119-121.
3. de la Hunty A., Wallace A.M., Gibson S., Viljakainen H., Lambert-Allardt C., Ashwell M.U.K. Food.Standards.Agency.Workshop.Consensus.Report the choice of method for measuring 25-hydroxyvitamin D to estimate vitamin D status for the UK national Diet and Nutrition Survey. Brit. J. Nutr. 2010, 104:612-619.
4. DeLuca H.F., Prahl J.M., Plum L.A. 1,25-dihydroxyvitamin D is not responsible for toxicity caused by vitamin D or 25-hydroxyvitamin D. Arch. Biochem. & Biophys. 2011, 505:226-230.
5. Doireau V., Macher M.A., Brun P., Bernard O., Loirat C. Vitamin A poisoning revealed by hypercalcemia in a child with kidney failure. Arch Pediatr. 1996, 3:888-890.
6. Granado-Lorencio F., Herrero-Barbudo C., Blanco-Navarro I., Pérez-Sacristán B. Suitability of ultra-high performance liquid chromatography for the determination of fat-soluble nutritional status (vitamins A, E, D, and individual carotenoids). Anal. Bioanal. Chem. 2010, 397:1389-1393.
7. Institute of Medicine (IOM), 2011 Dietary reference intakes for calcium and vitamin D. The National Academies Press, Washington, DC.
8. Jones G. Pharmacokinetics of vitamin D toxicity. Am. J. Clin. Nutr. 2008, 88(suppl):582S-586S.
9. Joshi R. Hypercalcemia due to hypervitaminosis D: report of seven patients. J. Trop. Pediatr. 2009, 55:396-398.
10. Kaptein S., Risselada A.J., Boerma E.C., Egbers P.H., Nieboer P. Life-threatening complications of vitamin D intoxication due to over-the-counter supplements. Clin. Toxicol. (Phila) 2007, 48:460-462.
11. Kimmoun A., Leheup B., Feillet F., Dubois F., Morali A. Hypercalcemia revealing iatrogenic hypervitaminosis A in a child with autistic troubles. Arch. Pediatr. 2008, 5:29-32.
12. 3 is present in adult serum. J. Clin. Endocrinol. Metab. 2012, 97:163-168.
13. Levey A.S., Bosch J.P., Lewis J.B., Greene T., Rogers N., Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann. Intern. Med. 1999, 130:461-470.
14. Lowe H., Cusano N.E., Binkley N., Blaner W.S., Bilezikian J.P. Vitamin D toxicity due to a commonly available "over the counter" remedy from the Dominican Republic. J. Clin. Endocrinol. Metab. 2011, 96:291-295.
15. Molnár F., Sigüeiro R., Sato Y., Araujo C., Schuster I., Antony P., Peluso J., Muller C., Mouriño A., Moras D., Rochel N. 1-alpha-25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: Its synthesis, biological activity and crystal structure with its receptor. PLoS. One. 2011, 6:e18124.
16. Penniston K., Tanumihardjo S.A. The acute and chronic toxic effects of vitamin A. Am. J. Clin. Nutr. 2006, 83:191-201.
17. Scragg R. Vitamin D and public health: an overview of recent research on common diseases and mortality in adulthood. Publ. Health Nutr. 2011, 14:1515-1532.
18. Singh R.J., Taylor R.L., Reddy G.S., Grebe S.K.G. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J. Clin. Endocrinol. Metab. 2006, 91:3055-3061.
19. 3 in serum of infants and adults. Clin. Chem. Lab. Med. 2011, 49:249-256.
20. Strathmann F.G., Sadilkova K., Laha T.J., LeSourd S.E., Bornhorst J.A., Hoofnagle A.N., Jack R. 3-epi-25 hydroxyvitamin D concentrations are not correlated with age in a cohort of infants and adults. Clin. Chim. Acta. 2012, 413:203-206.
21. Tai S.S.-C., Bedner M., Phinney K.W. Development of a candidate reference measurement procedure for the determination of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum using isotope-dilution liquid chromatography/tandem mass spectrometry. Anal. Chem. 2010, 82:1942-1948.
22. Titan S.M., Callas S.H., Uip D.E., Kalil-Filho R., A Galvão P.C. Acute renal failure and hypercalcemia in an athletic young man. Clin. Nephrol. 2009, 71:445-447.
23. Van den Ouweland J., Beijers A.M., van Daal H. Fast separation of 25-hydroxyvitamin D3 from 3-epi-hydroxyvitamin D3 in human serum by liquid chromatography-tandem mass spectrometry: variable prevalence of 3-epi-25-hydroxyvitamin D3 in infants, children and adults. Clin. Chem. 2011, 57:1618-1619.
24. Yetley E.A., Pfeiffer C.M., Schleicher R.L., Phinney K.W., Lacher D.A., Christakos S., Eckfeldt J.H., Fleet J.C., Howard G., Hoofnagle A.N., Hui S.L., Lensmeyer G.L., Massaro J., Peacock M., Rosner B., Wiebe D., Bailey R.L., Coates P.M., Looker A.C., Sempos C., Johnson C.L., Picciano M.F., Vitamin D. Roundtable on the NHANES monitoring of serum 25(OH)D: assay challenges and options for resolving them., NHANES monitoring of serum 25-hydroxyvitamin D: a rountable summary. J. Nutr. 2010, 140:2030S-2045S.