Life-threatening complications of vitamin D intoxication due to over-the-counter supplements

Clinical Toxicology

Volumn 48, Issue 5, 2010, Pages 460-462

  Kaptein, Sara ^a   Risselada, Arne J ^b   Boerma, E Christiaan ^a   Egbers, Peter H M ^a   Nieboer, Peter ^b  

^a MEDICAL CENTER LEEUWARDEN   (Netherlands)

^b Wilhelmina Ziekenhuis   (Netherlands)

Author keywords

Dietary supplement; Hypercalcemia; Status epilepticus; Vitamin D toxicity

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CALCIUM ION; COLECALCIFEROL; ETIRACETAM; FUROSEMIDE; MIDAZOLAM; NON PRESCRIPTION DRUG; PAMIDRONIC ACID; PARATHYROID HORMONE; PHENYTOIN; PROPOFOL; VALPROIC ACID; ZOLEDRONIC ACID;

AGED; ARTICLE; ARTIFICIAL VENTILATION; CALCIUM BLOOD LEVEL; CASE REPORT; CONFUSION; DIET SUPPLEMENTATION; DISEASE SEVERITY; DRUG LABELING; DRUG MEGADOSE; DYSARTHRIA; EPILEPTIC STATE; FEMALE; HUMAN; HYPERCALCEMIA; INTENSIVE CARE; LABORATORY DIAGNOSIS; LETHARGY; REHYDRATION; VITAMIN D INTOXICATION;

AGED; CALCIUM; DIETARY SUPPLEMENTS; DRUG TOXICITY; FEMALE; HUMANS; HYPERCALCEMIA; HYPERPARATHYROIDISM, PRIMARY; NETHERLANDS; VITAMIN D;

EID: 77954237625     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2010.486382     Document Type: Article

References (17)

1. Carroll MF, Schade DS. A practical approach to hypercalcemia. Am Fam Physician 2003; 67:1959-1966.
2. e herziene druk. Hfdst 19. Houten: Bohn Stafleu van Loghum; 2005:717-718.
3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001; 345:66-67.
4. Klontz KC, Acheson DW. Dietary supplement-induced vitamin D intoxication. N Engl J Med 2007; 357:308-309.
5. Blank S, Scanlon KS, Sinks TH, Lett S, Falk H. An outbreak of hyper-vitaminosis D associated with the overfortification of milk from a home delivery dairy. Am J Public Health 1995; 85:656-659.
6. Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Ann Intern Med 1995; 122:511-513.
7. Health Council of the Netherlands. Dietary reference intakes: calcium, vitamin D, thiamin, riboflavin, niacin, pantothenic acid, and biotin. The Hague: Health Council of the Netherlands; 2000; publication no. 2000/12.
8. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999; 69:842-856.
9. Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 2008; 88(Suppl.):582S-586S.
10. Mawer EB, Schaefer K, Lumb GA, Stanbury SW. The metabolism of isotopically labelled vitamin D3 in man: the influence of the state of vitamin D nutrition. Clin Sci 1971; 40:39-53.
11. Jones G, Horst RL, Carter G, Makin HLJ. Measurement of 25-OH-D (RIA, HPLC, LC-MS/MS). J Bone Miner Res 2007; 22(Suppl.):V11-V15.
12. Chen TH, Huang CC, Chang YY, Chen YF, Chen WH, Lai SL. Vaso-constriction as the etiology of hypercalcemia-induced seizures. Epilepsia 2004; 45(5):551-554.
13. Kümpfel T, Lechner C, Auer D, Kraft E, Lydtin H, Trenkwalder C. Non-convulsive status epilepticus with marked neuropsychiatric manifestations and MRI changes after treatment of hypercalcaemia. Acta Neurol Scand 2000; 102:337-339.
14. Suzuki T, Aoki K. Hypertensive effects of calcium infusion in subjects with normotension and hypertension. J Hypertens 1998; 6:1003-1008.
15. Ihle SW, Nelson RW, Cook JR Jr. Seizures as a manifestation of primary hyperparathyroidism in a dog. J Am Vet Med Assoc 1998; 192:71-72.
16. Dinnerstein E, McDonald BC, Cleavinger HB, Thadani VM, Jobst BC. Mesial temporal sclerosis after status epilepticus due to milk alkali syndrome. Seizure 2008; 17(3):292-295.
17. Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, Yunus F, Bell R, Body J, Quebe-Fehling E, Seaman J. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 2001; 19:558-567.