Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections

Annals of the Rheumatic Diseases

Volumn 68, Issue 6, 2009, Pages 1017-1021

  Dieguez Gonzalez, R ^a   Calaza, M ^a   Shi, D ^b,c   Meulenbelt, I ^d   Loughlin, J ^e   Tsezou, A ^f   Dai, J ^b   Malizos, K N ^f,g   Slagboom, E P ^d   Kloppenburg, M ^d   Chapman, K ^h   Jiang, Q ^b,c   Kremer, D ^d   Gomez Reino, J J ^a,i   Nakajima, N ^j   Ikegawa, S ^j   Gonzalez, A ^a  

^a Instituto de Salud Carlos III   (Spain)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f UNIVERSITY OF THESSALY   (Greece)

^g Institute for Biomedical Research and Technology   (Greece)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^j RIKEN   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

ADULT; ARTICLE; ASIAN; CONTROLLED STUDY; ENDOTHELIAL DIFFERENTIATION GENE 2; EUROPEAN AMERICAN; GENE; GENE FREQUENCY; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HEREDITY; HUMAN; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; OSTEOARTHRITIS, KNEE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LYSOPHOSPHATIDIC ACID;

EID: 67449128720     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.093641     Document Type: Article

References (26)

1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646-656 (Pubitemid 37254686)
2. Mototani H, Iida A, Nakajima M, Furuichi T, Miyamoto Y, Tsunoda T, et al. A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Hum Mol Genet 2008;17:1790-1797 (Pubitemid 351791505)
3. Loughlin J, Chapman K. Molecular Genetics of Osteoarthritis. In: Moskovitz R, Altman R, et al, eds. Osteoarthritis, 4th edn. Philadelphia, Pennsylvania, USA: Lippincott Williams & Wilkins, 2007: 127-136
4. Drews J. Drug discovery: a historical perspective. Science 2000;287:1960-1964 (Pubitemid 30158662)
5. Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S. Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett 2002;520:97-101. (Pubitemid 34607281)
6. Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH. G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 2004;92:949-966 (Pubitemid 44264244)
7. Umezu-Goto M, Tanyi J, Lahad J, Liu S, Yu S, Lapushin R, et al. Lysophosphatidic acid production and action: validated targets in cancer? J Cell Biochem 2004;92:1115-1140
8. Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001;44:1237-1247 (Pubitemid 32537520)
9. Graler MH, Goetzl EJ. Lysophospholipids and their G protein-coupled receptors in inflammation and immunity. Biochim Biophys Acta 2002;1582:168-174
10. Lin CI, Chen CN, Lin PW, Chang KJ, Hsieh FJ, Lee H, et al. Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3. Biochem Biophys Res Commun 2007;363:1001-1008 (Pubitemid 47552970)
11. Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Ann Rheum Dis 2007;66:1052-1055 (Pubitemid 47122318)
12. Mustafa Z, Dowling B, Chapman K, Sinsheimer JS, Carr A, Loughlin J, et al. Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. Arthritis Rheum 2005;52:3502-3506
13. Fytili P, Giannatou E, Papanikolaou V, Stripeli F, Karachalios T, Malizos K, et al. Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. Clin Genet 2005;68:268-277 (Pubitemid 41179555)
14. Riyazi N, Meulenbelt I, Kroon HM, Ronday KH, Hellio le GrM, Rosendaal FR, et al. Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study. Ann Rheum Dis 2005;64:438-443
15. Jiang Q, Shi D, Nakajima M, Dai J, Wei J, Malizos KN, et al. Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility. J Hum Genet 2008;53:42-47
16. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560 (Pubitemid 37088507)
17. Dupont WD, Plummer WD Jr. Power and sample size calculations. A review and computer program. Control Clin Trials 1990;11:116-128
18. Lathrop GM. Estimating genotype relative risks. Tissue Antigens 1983;22:160-166
19. Ikegawa S. New gene associations in osteoarthritis: what do they provide, and where are we going? Curr Opin Rheumatol 2007;19:429-434
20. Todd JA. Statistical false positive or true disease pathway? Nat Genet 2006;38:731-733
21. Loughlin J, Chapman K. Big is beautiful. Osteoarthritis Cartilage 2008;16:277-278 (Pubitemid 351309190)
22. Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, et al. Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum Mol Genet 2007;16:1676-1681 (Pubitemid 47241827)
23. Hunter DJ, Demissie S, Cupples LA, Aliabadi P, Felson DT. A genome scan for joint-specific hand osteoarthritis susceptibility: The Framingham Study. Arthritis Rheum 2004;50:2489-2496 (Pubitemid 39062709)
24. Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 2007;56:137-146 (Pubitemid 46106186)
25. Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R, et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 59 UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet 2008;17:1497-1504 (Pubitemid 351627345)
26. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003;33:177-182 (Pubitemid 36177070)