메뉴 건너뛰기




Volumn 12, Issue 3, 2012, Pages 185-196

Array-based pharmacogenomics of molecular-targeted therapies in oncology

Author keywords

cetuximab; erlotinib; gefitinib; molecular targeted agents; trastuzumab

Indexed keywords

ANTHRACYCLINE; CAPECITABINE; CELECOXIB; CETUXIMAB; DASATINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; GEFITINIB; GEMCITABINE; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 1; IMATINIB; LAPATINIB; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; NILOTINIB; PURVALANOL A; RAPAMYCIN; RETINOIC ACID; SORAFENIB; STEM CELL FACTOR RECEPTOR; SUNITINIB; TANESPIMYCIN; TAXANE DERIVATIVE; TOZASERTIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; UO 126; VANDETANIB;

EID: 84861422473     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2011.53     Document Type: Review
Times cited : (12)

References (112)
  • 1
    • 77955635784 scopus 로고    scopus 로고
    • Clinical pharmacogenetics in oncology: The paradigm of molecular targeted therapies
    • Mountzios G, Sanoudou D, Syrigos KN. Clinical pharmacogenetics in oncology: the paradigm of molecular targeted therapies. Curr Pharm Des 2010; 16: 2184-2193.
    • (2010) Curr Pharm des , vol.16 , pp. 2184-2193
    • Mountzios, G.1    Sanoudou, D.2    Syrigos, K.N.3
  • 12
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009; 360: 790-800.
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 21
    • 51349159152 scopus 로고    scopus 로고
    • Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines
    • Solmi R, Lauriola M, Francesconi M, Martini D, Voltattorni M, Ceccarelli C et al. Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines. BMC Cancer 2008; 8: 227.
    • (2008) BMC Cancer , vol.8 , pp. 227
    • Solmi, R.1    Lauriola, M.2    Francesconi, M.3    Martini, D.4    Voltattorni, M.5    Ceccarelli, C.6
  • 22
    • 0344872791 scopus 로고    scopus 로고
    • A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839)
    • DOI 10.1038/sj.bjc.6601346
    • Hopfner M, Sutter AP, Gerst B, Zeitz M, Scherubl H. A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839). Br J Cancer 2003; 89: 1766-1775. (Pubitemid 37464152)
    • (2003) British Journal of Cancer , vol.89 , Issue.9 , pp. 1766-1775
    • Hopfner, M.1    Sutter, A.P.2    Gerst, B.3    Zeitz, M.4    Scherubl, H.5
  • 23
    • 33845950511 scopus 로고    scopus 로고
    • Gefitinib-related gene signature in bladder cancer cells identified by a cDNA microarray
    • Inoue R, Matsuyama H, Yano S, Yamamoto Y, Iizuka N, Naito K. Gefitinib-related gene signature in bladder cancer cells identified by a cDNA microarray. Anticancer Res 2006; 26(6B): 4195-4202. (Pubitemid 46031491)
    • (2006) Anticancer Research , vol.26 , Issue.6 B , pp. 4195-4202
    • Inoue, R.1    Matsuyama, H.2    Yano, S.3    Yamamoto, Y.4    Iizuka, N.5    Naito, K.6
  • 24
    • 35348826772 scopus 로고    scopus 로고
    • A phase II study of gefitinib monotherapy in advanced esophageal adenocarcinoma: Evidence of gene expression, cellular, and clinical response
    • DOI 10.1158/1078-0432.CCR-06-1970
    • Ferry DR, Anderson M, Beddard K, Tomlinson S, Atherfold P, Obszynska J et al. A phase II study of gefitinib monotherapy in advanced esophageal adenocarcinoma: evidence of gene expression, cellular, and clinical response. Clin Cancer Res 2007; 13: 5869-5875. (Pubitemid 47583913)
    • (2007) Clinical Cancer Research , vol.13 , Issue.19 , pp. 5869-5875
    • Ferry, D.R.1    Anderson, M.2    Beddard, K.3    Tomlinson, S.4    Atherfold, P.5    Obszynska, J.6    Harrison, R.7    Jankowski, J.8
  • 25
    • 34250711876 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma
    • DOI 10.1158/1535-7163.MCT-07-0138
    • Frederick BA, Helfrich BA, Coldren CD, Zheng D, Chan D, Bunn Jr PA et al. Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. Mol Cancer Ther 2007; 6: 1683-1691. (Pubitemid 46954044)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.6 , pp. 1683-1691
    • Frederick, B.A.1    Helfrich, B.A.2    Coldren, C.D.3    Zheng, D.4    Chan, D.5    Bunn Jr., P.A.6    Raben, D.7
  • 26
    • 42049116522 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    • DOI 10.1158/0008-5472.CAN-07-2460
    • Fuchs BC, Fujii T, Dorfman JD, Goodwin JM, Zhu AX, Lanuti M et al. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008; 68: 2391-2399. (Pubitemid 351521814)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2391-2399
    • Fuchs, B.C.1    Fujii, T.2    Dorfman, J.D.3    Goodwin, J.M.4    Zhu, A.X.5    Lanuti, M.6    Tanabe, K.K.7
  • 34
    • 24344444819 scopus 로고    scopus 로고
    • Gene expression patterns and profile changes pre- and post-erlotinib treatment in patients with metastatic breast cancer
    • DOI 10.1158/1078-0432.CCR-05-0270
    • Yang SX, Simon RM, Tan AR, Nguyen D, Swain SM. Gene expression patterns and profile changes pre- and post-erlotinib treatment in patients with metastatic breast cancer. Clin Cancer Res 2005; 11: 6226-6232. (Pubitemid 41262952)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6226-6232
    • Yang, S.X.1    Simon, R.M.2    Tan, A.R.3    Nguyen, D.4    Swain, S.M.5
  • 35
    • 35148816105 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer
    • DOI 10.1158/0008-5472.CAN-07-0710
    • Buchanan FG, Holla V, Katkuri S, Matta P, DuBois RN. Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. Cancer Res 2007; 67: 9380-9388. (Pubitemid 47535928)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9380-9388
    • Buchanan, F.G.1    Holla, V.2    Katkuri, S.3    Matta, P.4    DuBois, R.N.5
  • 37
    • 34248643673 scopus 로고    scopus 로고
    • Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors
    • Balko JM, Potti A, Saunders C, Stromberg A, Haura EB, Black EP. Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors. BMC Genomics 2006; 7: 289.
    • (2006) BMC Genomics , vol.7 , pp. 289
    • Balko, J.M.1    Potti, A.2    Saunders, C.3    Stromberg, A.4    Haura, E.B.5    Black, E.P.6
  • 40
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced nonsmall-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R et al. Cetuximab plus chemotherapy in patients with advanced nonsmall-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009; 373: 1525-1531.
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3    Von Pawel, J.4    Krzakowski, M.5    Ramlau, R.6
  • 41
    • 74049108229 scopus 로고    scopus 로고
    • Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer
    • Debucquoy A, Haustermans K, Daemen A, Aydin S, Libbrecht L, Gevaert O et al. Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer. J Clin Oncol 2009; 27: 2751-2757.
    • (2009) J Clin Oncol , vol.27 , pp. 2751-2757
    • Debucquoy, A.1    Haustermans, K.2    Daemen, A.3    Aydin, S.4    Libbrecht, L.5    Gevaert, O.6
  • 42
    • 40549089236 scopus 로고    scopus 로고
    • Integrating microarray and proteomics data to predict the response on cetuximab in patients with rectal cancer
    • Daemen A, Gevaert O, De Bie T, Debucquoy A, Machiels JP, De Moor B et al. Integrating microarray and proteomics data to predict the response on cetuximab in patients with rectal cancer. Pac Symp Biocomput 2008: 166-177.
    • (2008) Pac Symp Biocomput , pp. 166-177
    • Daemen, A.1    Gevaert, O.2    De Bie, T.3    Debucquoy, A.4    Machiels, J.P.5    De Moor, B.6
  • 44
    • 66749120729 scopus 로고    scopus 로고
    • A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer
    • Balko JM, Black EP. A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer. BMC Cancer 2009; 9: 145.
    • (2009) BMC Cancer , vol.9 , pp. 145
    • Balko, J.M.1    Black, E.P.2
  • 46
    • 0037434791 scopus 로고    scopus 로고
    • Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
    • DOI 10.1038/nature01392
    • Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney Jr DW et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421: 756-760. (Pubitemid 36227628)
    • (2003) Nature , vol.421 , Issue.6924 , pp. 756-760
    • Cho, H.-S.1    Mason, K.2    Ramyar, K.X.3    Stanley, A.M.4    Gabelli, S.B.5    Denney Jr., D.W.6    Leahy, D.J.7
  • 47
    • 0037226462 scopus 로고    scopus 로고
    • Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis
    • Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP, Chinnaiyan AM. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res 2003; 63: 132-139. (Pubitemid 36070431)
    • (2003) Cancer Research , vol.63 , Issue.1 , pp. 132-139
    • Kumar-Sinha, C.1    Ignatoski, K.W.2    Lippman, M.E.3    Ethier, S.P.4    Chinnaiyan, A.M.5
  • 48
    • 12544250381 scopus 로고    scopus 로고
    • Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
    • Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T et al. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 2005; 280: 2092-2104.
    • (2005) J Biol Chem , vol.280 , pp. 2092-2104
    • Le, X.F.1    Lammayot, A.2    Gold, D.3    Lu, Y.4    Mao, W.5    Chang, T.6
  • 49
    • 0036521783 scopus 로고    scopus 로고
    • Trastuzumab: Hopes and realities
    • Leyland-Jones B. Trastuzumab: hopes and realities. Lancet Oncol 2002; 3: 137-144.
    • (2002) Lancet Oncol , vol.3 , pp. 137-144
    • Leyland-Jones, B.1
  • 50
    • 0036274024 scopus 로고    scopus 로고
    • c-erbB-2 in breast cancer: Development of a clinically useful marker
    • DOI 10.1053/sonc.2002.32899
    • Hayes DF, Thor AD. c-erbB-2 in breast cancer: development of a clinically useful marker. Semin Oncol 2002; 29: 231-245. (Pubitemid 34620440)
    • (2002) Seminars in Oncology , vol.29 , Issue.3 , pp. 231-245
    • Hayes, D.F.1    Thor, A.D.2
  • 55
    • 70349966201 scopus 로고    scopus 로고
    • Gene expression profile and response to trastuzumab-docetaxelbased treatment in breast carcinoma
    • Vegran F, Boidot R, Coudert B, Fumoleau P, Arnould L, Garnier J et al. Gene expression profile and response to trastuzumab-docetaxelbased treatment in breast carcinoma. Br J Cancer 2009; 101: 1357-1364.
    • (2009) Br J Cancer , vol.101 , pp. 1357-1364
    • Vegran, F.1    Boidot, R.2    Coudert, B.3    Fumoleau, P.4    Arnould, L.5    Garnier, J.6
  • 56
    • 73149125324 scopus 로고    scopus 로고
    • Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines
    • Gu L, Lau SK, Loera S, Somlo G, Kane SE. Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines. Clin Cancer Res 2009; 15: 7196-7206.
    • (2009) Clin Cancer Res , vol.15 , pp. 7196-7206
    • Gu, L.1    Lau, S.K.2    Loera, S.3    Somlo, G.4    Kane, S.E.5
  • 57
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes N et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 2001; 1: 85-94.
    • (2001) Mol Cancer Ther , vol.1 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3    Wood, E.R.4    Alligood, K.J.5    Rhodes, N.6
  • 58
    • 41649111490 scopus 로고    scopus 로고
    • Combined lapatinib and cetuximab enhance cytotoxicity against gefitinibresistant lung cancer cells
    • Kim HP, Han SW, Kim SH, Im SA, Oh DY, Bang YJ et al. Combined lapatinib and cetuximab enhance cytotoxicity against gefitinibresistant lung cancer cells. Mol Cancer Ther 2008; 7: 607-615.
    • (2008) Mol Cancer Ther , vol.7 , pp. 607-615
    • Kim, H.P.1    Han, S.W.2    Kim, S.H.3    Im, S.A.4    Oh, D.Y.5    Bang, Y.J.6
  • 59
    • 34548071359 scopus 로고    scopus 로고
    • Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network
    • DOI 10.1158/1078-0432.CCR-07-0701
    • Ritter CA, Perez-Torres M, Rinehart C, Guix M, Dugger T, Engelman JA et al. Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. Clin Cancer Res 2007; 13: 4909-4919. (Pubitemid 47294799)
    • (2007) Clinical Cancer Research , vol.13 , Issue.16 , pp. 4909-4919
    • Ritter, C.A.1    Perez-Torres, M.2    Rinehart, C.3    Guix, M.4    Dugger, T.5    Engelman, J.A.6    Arteaga, C.L.7
  • 61
    • 33847013396 scopus 로고    scopus 로고
    • Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers
    • Xia W, Husain I, Liu L, Bacus S, Saini S, Spohn J et al. Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer Res 2007; 67: 1170-1175.
    • (2007) Cancer Res , vol.67 , pp. 1170-1175
    • Xia, W.1    Husain, I.2    Liu, L.3    Bacus, S.4    Saini, S.5    Spohn, J.6
  • 62
    • 77957771125 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: Final survival analysis of a phase III randomized trial
    • Cameron D, Casey M, Oliva C, Newstat B, Imwalle B, Geyer CE. Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial. Oncologist 2010; 15: 924-934.
    • (2010) Oncologist , vol.15 , pp. 924-934
    • Cameron, D.1    Casey, M.2    Oliva, C.3    Newstat, B.4    Imwalle, B.5    Geyer, C.E.6
  • 63
    • 34250766250 scopus 로고    scopus 로고
    • Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles
    • DOI 10.1158/1535-7163.MCT-05-0399
    • Hegde PS, Rusnak D, Bertiaux M, Alligood K, Strum J, Gagnon R et al. Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles. Mol Cancer Ther 2007; 6: 1629-1640. (Pubitemid 46954030)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.5 , pp. 1629-1640
    • Hegde, P.S.1    Rusnak, D.2    Bertiaux, M.3    Alligood, K.4    Strum, J.5    Gagnon, R.6    Gilmer, T.M.7
  • 64
    • 55949117201 scopus 로고    scopus 로고
    • The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines
    • Kim JW, Kim HP, Im SA, Kang S, Hur HS, Yoon YK et al. The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Cancer Lett 2008; 272: 296-306.
    • (2008) Cancer Lett , vol.272 , pp. 296-306
    • Kim, J.W.1    Kim, H.P.2    Im, S.A.3    Kang, S.4    Hur, H.S.5    Yoon, Y.K.6
  • 65
    • 67650128519 scopus 로고    scopus 로고
    • Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2
    • Kim HP, Yoon YK, Kim JW, Han SW, Hur HS, Park J et al. Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2. PLoS One 2009; 4: e5933.
    • (2009) PLoS One , vol.4
    • Kim, H.P.1    Yoon, Y.K.2    Kim, J.W.3    Han, S.W.4    Hur, H.S.5    Park, J.6
  • 66
    • 51549083821 scopus 로고    scopus 로고
    • Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases
    • Medina PJ, Goodin S. Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther 2008; 30: 1426-1447.
    • (2008) Clin Ther , vol.30 , pp. 1426-1447
    • Medina, P.J.1    Goodin, S.2
  • 67
    • 56949094800 scopus 로고    scopus 로고
    • Targeted therapies in breast cancer: Where are we now?
    • Di Cosimo S, Baselga J. Targeted therapies in breast cancer: where are we now? Eur J Cancer 2008; 44: 2781-2790.
    • (2008) Eur J Cancer , vol.44 , pp. 2781-2790
    • Di Cosimo, S.1    Baselga, J.2
  • 68
    • 70350738476 scopus 로고    scopus 로고
    • Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer
    • Havaleshko DM, Smith SC, Cho H, Cheon S, Owens CR, Lee JK et al. Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer. Neoplasia 2009; 11: 1185-1193.
    • (2009) Neoplasia , vol.11 , pp. 1185-1193
    • Havaleshko, D.M.1    Smith, S.C.2    Cho, H.3    Cheon, S.4    Owens, C.R.5    Lee, J.K.6
  • 70
    • 1642453732 scopus 로고    scopus 로고
    • Pharmacogenomic Analysis of Cytogenetic Response in Chronic Myeloid Leukemia Patients Treated with Imatinib
    • DOI 10.1158/1078-0432.CCR-0784-3
    • McLean LA, Gathmann I, Capdeville R, Polymeropoulos MH, Dressman M. Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib. Clin Cancer Res 2004; 10(1 Part 1): 155-165. (Pubitemid 38114174)
    • (2004) Clinical Cancer Research , vol.10 , Issue.1 I , pp. 155-165
    • McLean, L.A.1    Gathmann, I.2    Capdeville, R.3    Polymeropoulos, M.H.4    Dressman, M.5
  • 72
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • Radich JP, Dai H, Mao M, Oehler V, Schelter J, Druker B et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci USA 2006; 103: 2794-2799.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2794-2799
    • Radich, J.P.1    Dai, H.2    Mao, M.3    Oehler, V.4    Schelter, J.5    Druker, B.6
  • 73
    • 67651174451 scopus 로고    scopus 로고
    • Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors
    • Grosso S, Puissant A, Dufies M, Colosetti P, Jacquel A, Lebrigand K et al. Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors. Mol Cancer Ther 2009; 8: 1924-1933.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1924-1933
    • Grosso, S.1    Puissant, A.2    Dufies, M.3    Colosetti, P.4    Jacquel, A.5    Lebrigand, K.6
  • 74
    • 60549100690 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: A clinical overview
    • Quek R, George S. Gastrointestinal stromal tumor: a clinical overview. Hematol Oncol Clin North Am 2009; 23: 69-78, viii.
    • (2009) Hematol Oncol Clin North Am , vol.23
    • Quek, R.1    George, S.2
  • 75
    • 31544456658 scopus 로고    scopus 로고
    • Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer
    • DOI 10.1158/1078-0432.CCR-05-1652
    • Febbo PG, Thorner A, Rubin MA, Loda M, Kantoff PW, Oh WK et al. Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer. Clin Cancer Res 2006; 12: 152-158. (Pubitemid 43166189)
    • (2006) Clinical Cancer Research , vol.12 , Issue.1 , pp. 152-158
    • Febbo, P.G.1    Thorner, A.2    Rubin, M.A.3    Loda, M.4    Kantoff, P.W.5    Oh, W.K.6    Golub, T.7    George, D.8
  • 76
    • 51649123049 scopus 로고    scopus 로고
    • Slug (SNAI2) down-regulation by RNA interference facilitates apoptosis and inhibits invasive growth in neuroblastoma preclinical models
    • Vitali R, Mancini C, Cesi V, Tanno B, Mancuso M, Bossi G et al. Slug (SNAI2) down-regulation by RNA interference facilitates apoptosis and inhibits invasive growth in neuroblastoma preclinical models. Clin Cancer Res 2008; 14: 4622-4630.
    • (2008) Clin Cancer Res , vol.14 , pp. 4622-4630
    • Vitali, R.1    Mancini, C.2    Cesi, V.3    Tanno, B.4    Mancuso, M.5    Bossi, G.6
  • 77
    • 71549130141 scopus 로고    scopus 로고
    • Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data
    • Ochs MF, Rink L, Tarn C, Mburu S, Taguchi T, Eisenberg B et al. Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data. Cancer Res 2009; 69: 9125-9132.
    • (2009) Cancer Res , vol.69 , pp. 9125-9132
    • Ochs, M.F.1    Rink, L.2    Tarn, C.3    Mburu, S.4    Taguchi, T.5    Eisenberg, B.6
  • 81
    • 33947225176 scopus 로고    scopus 로고
    • Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: Rationale for patient selection
    • DOI 10.1158/0008-5472.CAN-06-3633
    • Huang F, Reeves K, Han X, Fairchild C, Platero S, Wong TW et al. Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection. Cancer Res 2007; 67: 2226-2238. (Pubitemid 46424242)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 2226-2238
    • Huang, F.1    Reeves, K.2    Han, X.3    Fairchild, C.4    Platero, S.5    Wong, T.W.6    Lee, F.7    Shaw, P.8    Clark, E.9
  • 83
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • DOI 10.1126/science.1099480
    • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399-401. (Pubitemid 38938156)
    • (2004) Science , vol.305 , Issue.5682 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 85
    • 4544235743 scopus 로고    scopus 로고
    • C-Src and cooperating partners in human cancer
    • DOI 10.1016/j.ccr.2004.09.001, PII S1535610804002429
    • Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer Cell 2004; 6: 209-214. (Pubitemid 39222033)
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 209-214
    • Ishizawar, R.1    Parsons, S.J.2
  • 86
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004; 4: 470-480. (Pubitemid 38745532)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 470-480
    • Yeatman, T.J.1
  • 87
    • 27144547509 scopus 로고    scopus 로고
    • Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-05-1731
    • Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R et al. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res 2005; 65: 9185-9189. (Pubitemid 41507982)
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9185-9189
    • Nam, S.1    Kim, D.2    Cheng, J.Q.3    Zhang, S.4    Lee, J.-H.5    Buettner, R.6    Mirosevich, J.7    Lee, F.Y.8    Jove, R.9
  • 88
    • 70449555464 scopus 로고    scopus 로고
    • Pathway targets to explore in the treatment of small cell and large cell lung cancers
    • Paripati A, Kingsley C, Weiss GJ. Pathway targets to explore in the treatment of small cell and large cell lung cancers. J Thorac Oncol 2009; 4: 1313-1321.
    • (2009) J Thorac Oncol , vol.4 , pp. 1313-1321
    • Paripati, A.1    Kingsley, C.2    Weiss, G.J.3
  • 89
    • 58949092362 scopus 로고    scopus 로고
    • Pathway targets to explore in the treatment of non-small cell lung cancer
    • Weiss GJ, Kingsley C. Pathway targets to explore in the treatment of non-small cell lung cancer. J Thorac Oncol 2008; 3: 1342-1352.
    • (2008) J Thorac Oncol , vol.3 , pp. 1342-1352
    • Weiss, G.J.1    Kingsley, C.2
  • 90
    • 46349105930 scopus 로고    scopus 로고
    • Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: Rationale for patient selection and efficacy monitoring
    • Wang XD, Reeves K, Luo FR, Xu LA, Lee F, Clark E et al. Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring. Genome Biol 2007; 8: R255.
    • (2007) Genome Biol , vol.8
    • Wang, X.D.1    Reeves, K.2    Luo, F.R.3    Xu, L.A.4    Lee, F.5    Clark, E.6
  • 91
    • 67349283061 scopus 로고    scopus 로고
    • A systems biology perspective on cholangiocellular carcinoma development: Focus on MAPK-signaling and the extracellular environment
    • Wang C, Maass T, Krupp M, Thieringer F, Strand S, Worns MA et al. A systems biology perspective on cholangiocellular carcinoma development: focus on MAPK-signaling and the extracellular environment. J Hepatol 2009; 50: 1122-1131.
    • (2009) J Hepatol , vol.50 , pp. 1122-1131
    • Wang, C.1    Maass, T.2    Krupp, M.3    Thieringer, F.4    Strand, S.5    Worns, M.A.6
  • 92
    • 66649094149 scopus 로고    scopus 로고
    • Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion
    • Cheepala SB, Yin W, Syed Z, Gill JN, McMillian A, Kleiner HE et al. Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion. Mol Cancer 2009; 8: 27.
    • (2009) Mol Cancer , vol.8 , pp. 27
    • Cheepala, S.B.1    Yin, W.2    Syed, Z.3    Gill, J.N.4    McMillian, A.5    Kleiner, H.E.6
  • 93
    • 69949129964 scopus 로고    scopus 로고
    • Ras pathway activation in hepatocellular carcinoma and antitumoral effect of combined sorafenib and rapamycin in vivo
    • Newell P, Toffanin S, Villanueva A, Chiang DY, Minguez B, Cabellos L et al. Ras pathway activation in hepatocellular carcinoma and antitumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol 2009; 51: 725-733.
    • (2009) J Hepatol , vol.51 , pp. 725-733
    • Newell, P.1    Toffanin, S.2    Villanueva, A.3    Chiang, D.Y.4    Minguez, B.5    Cabellos, L.6
  • 94
    • 67651006061 scopus 로고    scopus 로고
    • Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions
    • Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M et al. Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest 2009; 119: 1727-1740.
    • (2009) J Clin Invest , vol.119 , pp. 1727-1740
    • Sos, M.L.1    Michel, K.2    Zander, T.3    Weiss, J.4    Frommolt, P.5    Peifer, M.6
  • 95
    • 70449995469 scopus 로고    scopus 로고
    • Identifying genotype-dependent efficacy of single and combined PI3Kand MAPK-pathway inhibition in cancer
    • Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M et al. Identifying genotype-dependent efficacy of single and combined PI3Kand MAPK-pathway inhibition in cancer. Proc Natl Acad Sci USA 2009; 106: 18351-18356.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18351-18356
    • Sos, M.L.1    Fischer, S.2    Ullrich, R.3    Peifer, M.4    Heuckmann, J.M.5    Koker, M.6
  • 96
    • 70349667211 scopus 로고    scopus 로고
    • Transcriptional profiling of the dose response: A more powerful approach for characterizing drug activities
    • Ji RR, de Silva H, Jin Y, Bruccoleri RE, Cao J, He A et al. Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities. PLoS Comput Biol 2009; 5: e1000512.
    • (2009) PLoS Comput Biol , vol.5
    • Ji, R.R.1    De Silva, H.2    Jin, Y.3    Bruccoleri, R.E.4    Cao, J.5    He, A.6
  • 97
    • 33745107800 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition and nonsmall cell lung cancer
    • von Eyben FE. Epidermal growth factor receptor inhibition and nonsmall cell lung cancer. Crit Rev Clin Lab Sci 2006; 43: 291-323.
    • (2006) Crit Rev Clin Lab Sci , vol.43 , pp. 291-323
    • Von Eyben, F.E.1
  • 100
    • 78651246674 scopus 로고    scopus 로고
    • Retraction: Genomic signatures to guide the use of chemotherapeutics
    • Potti A, Dressman HK, Bild A, Riedel RF, Chan G, Sayer R et al. Retraction: genomic signatures to guide the use of chemotherapeutics. Nat Med 2011; 17: 135.
    • (2011) Nat Med , vol.17 , pp. 135
    • Potti, A.1    Dressman, H.K.2    Bild, A.3    Riedel, R.F.4    Chan, G.5    Sayer, R.6
  • 101
    • 33746875641 scopus 로고    scopus 로고
    • Retraction: A genomic strategy to refine prognosis in early-stage nonsmall-cell lung cancer
    • Potti A, Mukherjee S, Petersen R, Dressman HK, Bild A, Koontz J et al. Retraction: a genomic strategy to refine prognosis in early-stage nonsmall-cell lung cancer. N Engl J Med 2006; 355: 570-580.
    • (2006) N Engl J Med , vol.355 , pp. 570-580
    • Potti, A.1    Mukherjee, S.2    Petersen, R.3    Dressman, H.K.4    Bild, A.5    Koontz, J.6
  • 102
    • 79953174014 scopus 로고    scopus 로고
    • N Engl J Med 2011; 364(12): 1176.
    • (2011) N Engl J Med , vol.364 , Issue.12 , pp. 1176
  • 104
    • 79251528216 scopus 로고    scopus 로고
    • Retraction-validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: A substudy of the EORTC 10994/BIG 00-01 clinical trial
    • Bonnefoi H, Potti A, Delorenzi M, Mauriac L, Campone M, Tubiana-Hulin M et al. Retraction-validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial. Lancet Oncol 2011; 12: 116.
    • (2011) Lancet Oncol , vol.12 , pp. 116
    • Bonnefoi, H.1    Potti, A.2    Delorenzi, M.3    Mauriac, L.4    Campone, M.5    Tubiana-Hulin, M.6
  • 105
    • 70350718130 scopus 로고    scopus 로고
    • Methods comparison for high-resolution transcriptional analysis of archival material on Affymetrix Plus 2.0 and Exon 1.0 microarrays
    • Linton K, Hey Y, Dibben S, Miller C, Freemont A, Radford J et al. Methods comparison for high-resolution transcriptional analysis of archival material on Affymetrix Plus 2.0 and Exon 1.0 microarrays. Biotechniques 2009; 47: 587-596.
    • (2009) Biotechniques , vol.47 , pp. 587-596
    • Linton, K.1    Hey, Y.2    Dibben, S.3    Miller, C.4    Freemont, A.5    Radford, J.6
  • 106
    • 70349823244 scopus 로고    scopus 로고
    • Identification of methods for use of formalin-fixed, paraffin-embedded tissue samples in RNA expression profiling
    • Roberts L, Bowers J, Sensinger K, Lisowski A, Getts R, Anderson MG. Identification of methods for use of formalin-fixed, paraffin-embedded tissue samples in RNA expression profiling. Genomics 2009; 94: 341-348.
    • (2009) Genomics , vol.94 , pp. 341-348
    • Roberts, L.1    Bowers, J.2    Sensinger, K.3    Lisowski, A.4    Getts, R.5    Anderson, M.G.6
  • 107
    • 70449727917 scopus 로고    scopus 로고
    • A high-sensitivity, medium-density, and target amplification-free planar waveguide microarray system for gene expression analysis of formalin-fixed and paraffin-embedded tissue
    • Schwers S, Reifenberger E, Gehrmann M, Izmailov A, Bohmann K. A high-sensitivity, medium-density, and target amplification-free planar waveguide microarray system for gene expression analysis of formalin-fixed and paraffin-embedded tissue. Clin Chem 2009; 55: 1995-2003.
    • (2009) Clin Chem , vol.55 , pp. 1995-2003
    • Schwers, S.1    Reifenberger, E.2    Gehrmann, M.3    Izmailov, A.4    Bohmann, K.5
  • 108
    • 79952331417 scopus 로고    scopus 로고
    • Gene expression analysis using long-term preserved formalin-fixed and paraffinembedded tissue of non-small cell lung cancer
    • Jacobson TA, Lundahl J, Mellstedt H, Moshfegh A. Gene expression analysis using long-term preserved formalin-fixed and paraffinembedded tissue of non-small cell lung cancer. Int J Oncol 2011; 38: 1075-1081.
    • (2011) Int J Oncol , vol.38 , pp. 1075-1081
    • Jacobson, T.A.1    Lundahl, J.2    Mellstedt, H.3    Moshfegh, A.4
  • 109
    • 79956307545 scopus 로고    scopus 로고
    • Gene expression profiling from formalin-fixed, paraffin-embedded tissue for tumor diagnosis
    • Grenert JP, Smith A, Ruan W, Pillai R, Wu AH. Gene expression profiling from formalin-fixed, paraffin-embedded tissue for tumor diagnosis. Clin Chim Acta 2011; 412: 1462-1464.
    • (2011) Clin Chim Acta , vol.412 , pp. 1462-1464
    • Grenert, J.P.1    Smith, A.2    Ruan, W.3    Pillai, R.4    Wu, A.H.5
  • 110
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • Simon RM, Paik S, Hayes DF. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 2009; 101: 1446-1452.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 111
    • 46249130709 scopus 로고    scopus 로고
    • The beginning of the end for microarrays?
    • DOI 10.1038/nmeth0708-585, PII NMETH0708-585
    • Shendure J. The beginning of the end for microarrays? Nat Methods 2008; 5: 585-587. (Pubitemid 351911858)
    • (2008) Nature Methods , vol.5 , Issue.7 , pp. 585-587
    • Shendure, J.1
  • 112
    • 77955649695 scopus 로고    scopus 로고
    • Pharmacogenomics: Achievements, challenges and prospects, for patients, pharmaceutical industries and healthcare systems
    • Sanoudou D. Pharmacogenomics: achievements, challenges and prospects, for patients, pharmaceutical industries and healthcare systems. Curr Pharm Des 2010; 16: 2182-2183.
    • (2010) Curr Pharm des , vol.16 , pp. 2182-2183
    • Sanoudou, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.