메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages 217-224

Treatment of advanced pancreatic neuroendocrine tumors: Potential role of everolimus

Author keywords

Biomarker; Everolimus; mTOR inhibitor; Pancreatic neuroendocrine tumor; panNETs; RAD001

Indexed keywords

BEVACIZUMAB; EVEROLIMUS; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; OCTREOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; RAF PROTEIN; RAS PROTEIN;

EID: 84861391667     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S16289     Document Type: Review
Times cited : (6)

References (39)
  • 1
    • 36348967668 scopus 로고    scopus 로고
    • Population-based study of islet cell carcinoma
    • Yao JC, Eisner MP, Leary C, et al. Population-based study of islet cell carcinoma. Ann Surg Oncol. 2007;14(12):3492-3500.
    • (2007) Ann Surg Oncol , vol.14 , Issue.12 , pp. 3492-3500
    • Yao, J.C.1    Eisner, M.P.2    Leary, C.3
  • 2
    • 46449110634 scopus 로고    scopus 로고
    • One hundred years after "carcinoid": Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
    • Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26(18): 3063-3072.
    • (2008) J Clin Oncol , vol.26 , Issue.18 , pp. 3063-3072
    • Yao, J.C.1    Hassan, M.2    Phan, A.3
  • 3
    • 70350442637 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group
    • Rinke A, Muller HH, Schade-Brittinger C, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol. 2009;27(28):4656-4663.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4656-4663
    • Rinke, A.1    Muller, H.H.2    Schade-Brittinger, C.3
  • 4
    • 0026530547 scopus 로고
    • Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma
    • Moertel CG, Lefkopoulo M, Lipsitz S, Hahn RG, Klaassen D. Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med. 1992; 326(8):519-523.
    • (1992) N Engl J Med , vol.326 , Issue.8 , pp. 519-523
    • Moertel, C.G.1    Lefkopoulo, M.2    Lipsitz, S.3    Hahn, R.G.4    Klaassen, D.5
  • 5
    • 14644413806 scopus 로고    scopus 로고
    • Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas
    • Kouvaraki MA, Ajani JA, Hoff P, et al. Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol. 2004; 22(23):4762-4771.
    • (2004) J Clin Oncol , vol.22 , Issue.23 , pp. 4762-4771
    • Kouvaraki, M.A.1    Ajani, J.A.2    Hoff, P.3
  • 6
    • 34249818466 scopus 로고    scopus 로고
    • Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors
    • Ekeblad S, Sundin A, Janson ET, et al. Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res. 2007;13(10):2986-2991.
    • (2007) Clin Cancer Res , vol.13 , Issue.10 , pp. 2986-2991
    • Ekeblad, S.1    Sundin, A.2    Janson, E.T.3
  • 7
    • 33644846851 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
    • Kulke MH, Stuart K, Enzinger PC, et al. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol. 2006;24(3):401-406.
    • (2006) J Clin Oncol , vol.24 , Issue.3 , pp. 401-406
    • Kulke, M.H.1    Stuart, K.2    Enzinger, P.C.3
  • 8
    • 58849093671 scopus 로고    scopus 로고
    • O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors
    • Kulke MH, Hornick JL, Frauenhoffer C, et al. O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Clin Cancer Res. 2009; 15(1):338-345.
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 338-345
    • Kulke, M.H.1    Hornick, J.L.2    Frauenhoffer, C.3
  • 9
    • 78650993549 scopus 로고    scopus 로고
    • First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas
    • Strosberg JR, Fine RL, Choi J, et al. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 2010;117(2):268-275.
    • (2010) Cancer , vol.117 , Issue.2 , pp. 268-275
    • Strosberg, J.R.1    Fine, R.L.2    Choi, J.3
  • 11
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao Y, Shi C, Edil BH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331(6021):1199-1203.
    • (2011) Science , vol.331 , Issue.6021 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 12
    • 74949122343 scopus 로고    scopus 로고
    • Pancreatic endocrine tumors: Expression profiling evidences a role for AKT-mTOR pathway
    • Missiaglia E, Dalai I, Barbi S, et al. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol. 2010;28(2):245-255.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 245-255
    • Missiaglia, E.1    Dalai, I.2    Barbi, S.3
  • 13
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011;364(6):514-523.
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 14
    • 0036899644 scopus 로고    scopus 로고
    • Elucidating TOR signaling and rapamycin action: Lessons from Saccharomyces cerevisiae
    • Crespo JL, Hall MN. Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 2002; 66(4):579-591.
    • (2002) Microbiol Mol Biol Rev , vol.66 , Issue.4 , pp. 579-591
    • Crespo, J.L.1    Hall, M.N.2
  • 15
    • 17144373720 scopus 로고    scopus 로고
    • Inhibitors of the mammalian target of rapamycin
    • Dancey JE. Inhibitors of the mammalian target of rapamycin. Expert Opin Investig Drugs. 2005;14(3):313-328.
    • (2005) Expert Opin Investig Drugs , vol.14 , Issue.3 , pp. 313-328
    • Dancey, J.E.1
  • 16
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4(5):335-348.
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 17
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • Beuvink I, Boulay A, Fumagalli S, et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell. 2005;120(6):747-759.
    • (2005) Cell , vol.120 , Issue.6 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3
  • 18
    • 4444311880 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha as a cancer drug target
    • Powis G, Kirkpatrick L. Hypoxia inducible factor-1alpha as a cancer drug target. Mol Cancer Ther. 2004;3(5):647-654.
    • (2004) Mol Cancer Ther , vol.3 , Issue.5 , pp. 647-654
    • Powis, G.1    Kirkpatrick, L.2
  • 19
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist. 2004;9 Suppl 5:10-17.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 10-17
    • Vaupel, P.1
  • 20
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res. 1989; 49(17):4682-4689.
    • (1989) Cancer Res , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 22
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 2002;14(5):381-395.
    • (2002) Cell Signal , vol.14 , Issue.5 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 24
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004;22(14):2954-2963.
    • (2004) J Clin Oncol , vol.22 , Issue.14 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 25
    • 53949094574 scopus 로고    scopus 로고
    • Inherited pancreatic endocrine tumor syndromes: Advances in molecular pathogenesis, diagnosis, management, and controversies
    • Jensen RT, Berna MJ, Bingham DB, Norton JA. Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. Cancer. 2008;113(7 Suppl): 1807-1843.
    • (2008) Cancer , vol.113 , Issue.7 SUPPL , pp. 1807-1843
    • Jensen, R.T.1    Berna, M.J.2    Bingham, D.B.3    Norton, J.A.4
  • 26
    • 65549145022 scopus 로고    scopus 로고
    • Are neuroendocrine tumours a feature of tuberous sclerosis? A systematic review
    • Dworakowska D, Grossman AB. Are neuroendocrine tumours a feature of tuberous sclerosis? A systematic review. Endocr Relat Cancer. 2009; 16(1):45-58.
    • (2009) Endocr Relat Cancer , vol.16 , Issue.1 , pp. 45-58
    • Dworakowska, D.1    Grossman, A.B.2
  • 27
    • 33947271014 scopus 로고    scopus 로고
    • Neuroendocrine tumors. Molecular targeted therapy for carcinoid and islet-cell carcinoma
    • Yao JC. Neuroendocrine tumors. Molecular targeted therapy for carcinoid and islet-cell carcinoma. Best Pract Res Clin Endocrinol Metab. 2007;21(1):163-172.
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , Issue.1 , pp. 163-172
    • Yao, J.C.1
  • 28
    • 0034662634 scopus 로고    scopus 로고
    • Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells
    • von Wichert G, Jehle PM, Hoeflich A, et al. Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res. 2000;60(16): 4573-4581.
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4573-4581
    • von Wichert, G.1    Jehle, P.M.2    Hoeflich, A.3
  • 29
    • 32944477371 scopus 로고    scopus 로고
    • Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression
    • Theodoropoulou M, Zhang J, Laupheimer S, et al. Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression. Cancer Res. 2006;66(3):1576-1582.
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1576-1582
    • Theodoropoulou, M.1    Zhang, J.2    Laupheimer, S.3
  • 30
    • 41349119602 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
    • Moreno A, Akcakanat A, Munsell MF, Soni A, Yao JC, Meric-Bernstam F. Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors. Endocr Relat Cancer. 2008; 15(1):257-266.
    • (2008) Endocr Relat Cancer , vol.15 , Issue.1 , pp. 257-266
    • Moreno, A.1    Akcakanat, A.2    Munsell, M.F.3    Soni, A.4    Yao, J.C.5    Meric-Bernstam, F.6
  • 31
    • 34047255081 scopus 로고    scopus 로고
    • The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells
    • Zitzmann K, De Toni EN, Brand S, et al. The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. Neuroendocrinology. 2007; 85(1):54-60.
    • (2007) Neuroendocrinology , vol.85 , Issue.1 , pp. 54-60
    • Zitzmann, K.1    de Toni, E.N.2    Brand, S.3
  • 32
    • 52049125970 scopus 로고    scopus 로고
    • Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low-to intermediate-grade neuroendocrine tumors: Results of a phase II study
    • Yao JC, Phan AT, Chang DZ, et al. Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low-to intermediate-grade neuroendocrine tumors: results of a phase II study. J Clin Oncol. 2008; 26(26):4311-4318.
    • (2008) J Clin Oncol , vol.26 , Issue.26 , pp. 4311-4318
    • Yao, J.C.1    Phan, A.T.2    Chang, D.Z.3
  • 33
    • 73949088959 scopus 로고    scopus 로고
    • Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II trial
    • Yao JC, Lombard-Bohas C, Baudin E, et al. Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial. J Clin Oncol. 2010;28(1):69-76.
    • (2010) J Clin Oncol , vol.28 , Issue.1 , pp. 69-76
    • Yao, J.C.1    Lombard-Bohas, C.2    Baudin, E.3
  • 34
    • 77954789459 scopus 로고    scopus 로고
    • Randomized run-in study of bevacizumab (B) and everolimus (E) in low-to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker. ASCO 2010
    • (suppl; abstr 4002)
    • Yao JP, Fogleman AT, Ng D, et al. Randomized run-in study of bevacizumab (B) and everolimus (E) in low-to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker. ASCO 2010. J Clin Oncol. 2010;28:15s(suppl; abstr 4002).
    • (2010) J Clin Oncol , vol.28
    • Yao, J.P.1    Fogleman, A.T.2    Ng, D.3
  • 35
    • 77953609118 scopus 로고    scopus 로고
    • Compensatory activation of Akt in response to mTOR and Raf inhibitors-a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
    • Zitzmann K, Ruden J, Brand S, et al. Compensatory activation of Akt in response to mTOR and Raf inhibitors-a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease. Cancer Lett. 2010; 295(1):100-109.
    • (2010) Cancer Lett , vol.295 , Issue.1 , pp. 100-109
    • Zitzmann, K.1    Ruden, J.2    Brand, S.3
  • 36
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun S, Rosenberg LM, Wang X, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 2005;65(16):7052-7058.
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7052-7058
    • Sun, S.1    Rosenberg, L.M.2    Wang, X.3
  • 37
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006; 66(3):1500-1508.
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 38
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanismFeedback activation of Akt by rapamycin
    • Wan X, Harkavy B, Shen N, Grohar P, Helman LJ. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanismFeedback activation of Akt by rapamycin. Oncogene. 2007; 26(13):1932-1940.
    • (2007) Oncogene , vol.26 , Issue.13 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 39
    • 80052557069 scopus 로고    scopus 로고
    • Exploiting cancer cell vulnerabilities to develop a combination therapy for RAS-driven tumors
    • De Raedt T, Walton Z, Yecies JL, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for RAS-driven tumors. Cancer Cell. 2011;20(3):400-413.
    • (2011) Cancer Cell , vol.20 , Issue.3 , pp. 400-413
    • de Raedt, T.1    Walton, Z.2    Yecies, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.