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Volumn 59, Issue 116, 2012, Pages 1208-1212

Selective depletion of hepatic kupffer cells significantly alleviated hepatosteatosis and intrahepatic inflammation induced by high fat diet

Author keywords

Gadolinium chloride; Insulin resistance; Kupffer cell; Steatosis

Indexed keywords

ADIPOCYTOKINE; CHOLESTEROL; FAT; GADOLINIUM CHLORIDE; GLUCOSE; INSULIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; SODIUM CHLORIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84861386072     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11903     Document Type: Article
Times cited : (17)

References (30)
  • 2
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK: Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72:219-246.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 3
    • 0037184995 scopus 로고    scopus 로고
    • Pattern recognition receptors: Doubling up for the innate immune response
    • Gordon S: Pattern recognition receptors: doubling up for the innate immune response. Cell 2002; 111:927-930
    • (2002) Cell , vol.111 , pp. 927-930
    • Gordon, S.1
  • 4
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, et al.: Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007; 56:16-23.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3
  • 5
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR: Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117:175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 6
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio G, Das M, Mora A, et al.: A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008; 322:1539-1543.
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3
  • 7
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, et al.: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-1808.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3
  • 8
    • 34548395788 scopus 로고    scopus 로고
    • Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity
    • De Taeye BM, Novitskaya T, McGuinness OP, et al.: Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. Am J Physiol Endocrinol Metab 2007; 293:E713-E725.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • De Taeye, B.M.1    Novitskaya, T.2    McGuinness, O.P.3
  • 9
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, et al.: Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009; 15:921-929.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3
  • 10
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
    • Kraegen EW, Clark PW, Jenkins AB, et al.: Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 1991; 40:1397-1403.
    • (1991) Diabetes , vol.40 , pp. 1397-1403
    • Kraegen, E.W.1    Clark, P.W.2    Jenkins, A.B.3
  • 11
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • Marchesini G, Brizi M, Morselli-Labate AM, et al.: Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107:450-455.
    • (1999) Am J Med , vol.107 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 12
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: The emerging view
    • Baffy G: Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol 2009; 51:212-223.
    • (2009) J Hepatol , vol.51 , pp. 212-223
    • Baffy, G.1
  • 13
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, et al.: TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116:3015-3025.
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3
  • 14
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen MT, favelyukis S, Nguyen AK, et al.: A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007; 282:35279-35292
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3
  • 15
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al.: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 16
    • 77952717393 scopus 로고    scopus 로고
    • Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
    • Bieghs V, Wouters K, van Gorp PJ, et al.: Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology 2010; 138:2481-2486.
    • (2010) Gastroenterology , vol.138 , pp. 2481-2486
    • Bieghs, V.1    Wouters, K.2    Van Gorp, P.J.3
  • 18
    • 82655181355 scopus 로고    scopus 로고
    • Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet
    • Lanthier N, Molendi-Coste O, Cani PD, et al.: Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet. Faseb J 2011; 25:4301-4311.
    • (2011) Faseb J , vol.25 , pp. 4301-4311
    • Lanthier, N.1    Molendi-Coste, O.2    Cani, P.D.3
  • 19
    • 39849107173 scopus 로고    scopus 로고
    • Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
    • Cintra DE, Pauli JR, Araujo EP, et al.: Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol 2008; 48:628-637.
    • (2008) J Hepatol , vol.48 , pp. 628-637
    • Cintra, D.E.1    Pauli, J.R.2    Araujo, E.P.3
  • 20
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, et al.: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 21
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng CN, Del Proposto JB, Westcott DJ, et al.: Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008; 57:3239-3246.
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1    Del Proposto, J.B.2    Westcott, D.J.3
  • 22
    • 67649159879 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis
    • Deveaux V, Cadoudal T, Ichigotani Y, et al.: Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS One 2009; 4:e5844.
    • (2009) PLoS One , vol.4
    • Deveaux, V.1    Cadoudal, T.2    Ichigotani, Y.3
  • 23
    • 73349127065 scopus 로고    scopus 로고
    • Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    • Clementi AH, Gaudy AM, van Rooijen N, et al.: Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta 2009; 1792:1062-1072.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 1062-1072
    • Clementi, A.H.1    Gaudy, A.M.2    Van Rooijen, N.3
  • 24
    • 75449101395 scopus 로고    scopus 로고
    • Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity
    • Stienstra R, Saudale f, Duval C, et al.: Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology 2010; 51:511-522.
    • (2010) Hepatology , vol.51 , pp. 511-522
    • Stienstra, R.1    Saudale, F.2    Duval, C.3
  • 25
    • 67349130130 scopus 로고    scopus 로고
    • Critical role of Kupffer cells in the management of diet-induced diabetes and obesity
    • Neyrinck AM, Cani PD, Dewulf EM, et al.: Critical role of Kupffer cells in the management of diet-induced diabetes and obesity. Biochem Biophys Res Commun 2009; 385:351-356.
    • (2009) Biochem Biophys Res Commun , vol.385 , pp. 351-356
    • Neyrinck, A.M.1    Cani, P.D.2    Dewulf, E.M.3
  • 26
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W, Metlakunta A, Dedousis N, et al.: Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 2010; 59:347-357.
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3
  • 27
    • 0028944527 scopus 로고
    • Macrophage depletion in the rat after intraperitoneal administration of liposome-encapsulated clodronate: Depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of Freund's adjuvant
    • Biewenga J, van der Ende MB, Krist Lf, et al.: Macrophage depletion in the rat after intraperitoneal administration of liposome-encapsulated clodronate: depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of Freund's adjuvant. Cell Tissue Res 1995; 280:189-196.
    • (1995) Cell Tissue Res , vol.280 , pp. 189-196
    • Biewenga, J.1    Van Der Ende, M.B.2    Krist, L.F.3
  • 28
    • 75449085107 scopus 로고    scopus 로고
    • Clodronate liposomes: All sites of injection are not equal
    • Lanthier N, Horsmans Y, Leclercq IA.: Clodronate liposomes: all sites of injection are not equal. Hepatology 2010; 51:721-722.
    • (2010) Hepatology , vol.51 , pp. 721-722
    • Lanthier, N.1    Horsmans, Y.2    Leclercq, I.A.3
  • 29
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    • Stienstra R, Joosten LA, Koenen T, et al.: The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 2010; 12:593-605.
    • (2010) Cell Metab , vol.12 , pp. 593-605
    • Stienstra, R.1    Joosten, L.A.2    Koenen, T.3
  • 30
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, Chabanon H, Hainault I, et al.: GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009; 119:1201-1215.
    • (2009) J Clin Invest , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3


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