Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy [2]

Annals of Neurology

Volumn 58, Issue 1, 2005, Pages 169-170

  Ahboucha, Samir ^a   Layrargues, Gilles Pomier ^a   Mamer, Orval ^a   Butterworth, Roger F ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYPREGNANE; BRAIN EXTRACT; DEUTERIUM; NEUROSTEROID; UNCLASSIFIED DRUG;

ASTROCYTOSIS; AUTOPSY; BRAIN LEVEL; CONTROLLED STUDY; FRONTAL CORTEX; GAS CHROMATOGRAPHY; HEPATIC COMA; HEPATIC ENCEPHALOPATHY; HUMAN; HUMAN TISSUE; LETTER; LIVER CIRRHOSIS; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; RADIOMETRY; STEROIDOGENESIS;

BRAIN CHEMISTRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEPATIC ENCEPHALOPATHY; HUMANS; PREGNANOLONE;

EID: 21844477555     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20534     Document Type: Letter

References (5)

1. Ahboucha S, Desjardins P, Chatauret N, et al. Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy. Neurochem Int 2003;43:551-556.
2. Lan NC, Gee KW, Bolger MB, Chen JS. Differential responses of expressed recombinant human γ-aminobutyric acid-A receptors to neurosteroids. J Neurochem 1991;57:1818-1821.
3. Lavoie J, Pomier Layrargues G, Butterworth RF. Increased densities of "peripheral-type" benzodiazepine receptors in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Hepatology 1990;11:874-878.
4. Zhu D, Wang MD, Backstrom T, Wahlström G. Evaluation and comparison of the pharmacokinetic and pharmacodynamic properties of allopregnanolone and pregnanolone at induction of anaesthesia in the male rat. Br J Anaesth 2001;86:403-412.
5. Jones EA. Potential mechanisms of enhanced GABA-mediated inhibitory neurotransmission in liver failure. Neurochem Int 2003;43:509-516.