메뉴 건너뛰기




Volumn 31, Issue 3, 2012, Pages 337-344

Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: A randomized, double-blind, placebo-controlled nutrition intervention

Author keywords

T cell; Aged garlic extract; Colds; Flu; Garlic; Human immunity; NK cell

Indexed keywords

AGED GARLIC EXTRACT; GAMMA INTERFERON; GARLIC EXTRACT; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84861339537     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2011.11.019     Document Type: Article
Times cited : (86)

References (44)
  • 1
    • 67650656651 scopus 로고    scopus 로고
    • Identification of the protein components displaying immunomodulatory activity in aged garlic extract
    • Chandrashekar P.M., Venkatesh Y.P. Identification of the protein components displaying immunomodulatory activity in aged garlic extract. J Ethnopharmacol 2009, 124:384-390.
    • (2009) J Ethnopharmacol , vol.124 , pp. 384-390
    • Chandrashekar, P.M.1    Venkatesh, Y.P.2
  • 2
    • 78951476685 scopus 로고    scopus 로고
    • Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract
    • Chandrashekar P.M., Prashanth K.V.H., Venkatesh Y.P. Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract. Phytochemistry 2011, 72:255-264.
    • (2011) Phytochemistry , vol.72 , pp. 255-264
    • Chandrashekar, P.M.1    Prashanth, K.V.H.2    Venkatesh, Y.P.3
  • 3
    • 0035127029 scopus 로고    scopus 로고
    • N alpha-(1-deoxy-D-fructos-1-yl)-L-arginine, an antioxidant compound identified in aged garlic extract
    • Ryu K., Ide N., Matsuura H., Itakura Y. N alpha-(1-deoxy-D-fructos-1-yl)-L-arginine, an antioxidant compound identified in aged garlic extract. J Nutr 2001, 131:972S-976S.
    • (2001) J Nutr , vol.131
    • Ryu, K.1    Ide, N.2    Matsuura, H.3    Itakura, Y.4
  • 4
    • 0141922866 scopus 로고    scopus 로고
    • Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract
    • Ichikawa M., Ryu K., Yoshida J., Ide N., Yoshida S., Sasaoka T., et al. Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract. Biofactors 2002, 16:57-72.
    • (2002) Biofactors , vol.16 , pp. 57-72
    • Ichikawa, M.1    Ryu, K.2    Yoshida, J.3    Ide, N.4    Yoshida, S.5    Sasaoka, T.6
  • 5
    • 18644378769 scopus 로고    scopus 로고
    • Gamma delta T cells respond directly to pathogen-associated molecular patterns
    • Hedges J.F., Lubick K.J., Jutila M.A. Gamma delta T cells respond directly to pathogen-associated molecular patterns. J Immunol 2005, 174:6045-6053.
    • (2005) J Immunol , vol.174 , pp. 6045-6053
    • Hedges, J.F.1    Lubick, K.J.2    Jutila, M.A.3
  • 6
    • 50549104485 scopus 로고    scopus 로고
    • Antigen-independent priming: a transitional response of bovine gammadelta T-cells to infection
    • Jutila M.A., Holderness J., Graff J.C., Hedges J.F. Antigen-independent priming: a transitional response of bovine gammadelta T-cells to infection. Anim Health Res Rev 2008, 9:47-57.
    • (2008) Anim Health Res Rev , vol.9 , pp. 47-57
    • Jutila, M.A.1    Holderness, J.2    Graff, J.C.3    Hedges, J.F.4
  • 8
    • 0033730550 scopus 로고    scopus 로고
    • Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system
    • Morita C.T., Mariuzza R.A., Brenner M.B. Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system. Springer Semin Immunopathol 2000, 22:191-217.
    • (2000) Springer Semin Immunopathol , vol.22 , pp. 191-217
    • Morita, C.T.1    Mariuzza, R.A.2    Brenner, M.B.3
  • 9
    • 0029073751 scopus 로고
    • Natural and synthetic non-peptide antigens recognized by human gamma delta T cells
    • Tanaka Y., Morita C.T., Tanaka Y., Nieves E., Brenner M.B., Bloom B.R. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. Nature 1995, 375:155-158.
    • (1995) Nature , vol.375 , pp. 155-158
    • Tanaka, Y.1    Morita, C.T.2    Tanaka, Y.3    Nieves, E.4    Brenner, M.B.5    Bloom, B.R.6
  • 10
    • 0034933714 scopus 로고    scopus 로고
    • Non-MHC-restricted cytotoxic cells: their roles in the control and treatment of leukaemias
    • Lowdell M.W., Lamb L., Hoyle C., Velardi A., Prentice H.G. Non-MHC-restricted cytotoxic cells: their roles in the control and treatment of leukaemias. Br J Haematol 2001, 114:11-24.
    • (2001) Br J Haematol , vol.114 , pp. 11-24
    • Lowdell, M.W.1    Lamb, L.2    Hoyle, C.3    Velardi, A.4    Prentice, H.G.5
  • 11
    • 34848922112 scopus 로고    scopus 로고
    • Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances γδ T cell function: a randomized, double-blind, placebo-controlled study
    • Rowe C.A., Nantz M.P., Bukowski J.F., Percival S.S. Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances γδ T cell function: a randomized, double-blind, placebo-controlled study. J Am Coll Nutr 2007, 26:445-452.
    • (2007) J Am Coll Nutr , vol.26 , pp. 445-452
    • Rowe, C.A.1    Nantz, M.P.2    Bukowski, J.F.3    Percival, S.S.4
  • 12
    • 0010159927 scopus 로고    scopus 로고
    • Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity
    • Bukowski J.F., Morita C.T., Brenner M.B. Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 1999, 11:57-65.
    • (1999) Immunity , vol.11 , pp. 57-65
    • Bukowski, J.F.1    Morita, C.T.2    Brenner, M.B.3
  • 13
    • 0038623877 scopus 로고    scopus 로고
    • Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses
    • Kamath A.B., Wang L., Das H., Li L., Reinhold V.N., Bukowski J.F. Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc Natl Acad Sci U S A 2003, 100:6009-6014.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6009-6014
    • Kamath, A.B.1    Wang, L.2    Das, H.3    Li, L.4    Reinhold, V.N.5    Bukowski, J.F.6
  • 14
    • 38449104165 scopus 로고    scopus 로고
    • Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells
    • Holderness J., Jackiw L., Kimmel E., Kerns H., Radke M., Hedges J.F., et al. Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells. J Immunol 2007, 179:6468-6478.
    • (2007) J Immunol , vol.179 , pp. 6468-6478
    • Holderness, J.1    Jackiw, L.2    Kimmel, E.3    Kerns, H.4    Radke, M.5    Hedges, J.F.6
  • 15
    • 34548416749 scopus 로고    scopus 로고
    • Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols
    • Graff J.C., Jutila M.A. Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols. J Leukoc Biol. 2007, 82:603-607.
    • (2007) J Leukoc Biol. , vol.82 , pp. 603-607
    • Graff, J.C.1    Jutila, M.A.2
  • 16
    • 70249104143 scopus 로고    scopus 로고
    • Polysaccharides derived from Yamoa (Funtumia elastica) prime gammadelta T cells in vitro and enhance innate immune responses in vivo
    • Graff J.C., Kimmel E.M., Freedman B., Schepetkin I.A., Holderness J., Quinn M.T., et al. Polysaccharides derived from Yamoa (Funtumia elastica) prime gammadelta T cells in vitro and enhance innate immune responses in vivo. Int Immunopharmacol 2009, 9:1313-1322.
    • (2009) Int Immunopharmacol , vol.9 , pp. 1313-1322
    • Graff, J.C.1    Kimmel, E.M.2    Freedman, B.3    Schepetkin, I.A.4    Holderness, J.5    Quinn, M.T.6
  • 18
    • 34247591059 scopus 로고    scopus 로고
    • A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
    • Hanson M.G., Ozenci V., Carlsten M.C., Glimelius B.L., Frodin J.E., Masucci G., et al. A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients. Cancer Immunol Immunother 2007, 56:973-984.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 973-984
    • Hanson, M.G.1    Ozenci, V.2    Carlsten, M.C.3    Glimelius, B.L.4    Frodin, J.E.5    Masucci, G.6
  • 19
    • 0026652721 scopus 로고
    • Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice
    • Meadows G., Wallendal M., Kosugi A., Wunderlich J., Singer D.S. Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcohol Clin Exp Res 1992, 16:474-479.
    • (1992) Alcohol Clin Exp Res , vol.16 , pp. 474-479
    • Meadows, G.1    Wallendal, M.2    Kosugi, A.3    Wunderlich, J.4    Singer, D.S.5
  • 20
    • 33847657527 scopus 로고    scopus 로고
    • Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients. A randomized phase III trial
    • Schink M., Troger W., Dabidian A., Goyert A., Scheuerecker H., Meyer J., et al. Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients. A randomized phase III trial. Forsch Komplementarmed 2007, 14:9-17.
    • (2007) Forsch Komplementarmed , vol.14 , pp. 9-17
    • Schink, M.1    Troger, W.2    Dabidian, A.3    Goyert, A.4    Scheuerecker, H.5    Meyer, J.6
  • 21
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    • Oppenheim D.E., Roberts S.J., Clarke S.L., Filler R., Lewis J.M., Tigelaar R.E., et al. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol 2005, 6:928-937.
    • (2005) Nat Immunol , vol.6 , pp. 928-937
    • Oppenheim, D.E.1    Roberts, S.J.2    Clarke, S.L.3    Filler, R.4    Lewis, J.M.5    Tigelaar, R.E.6
  • 22
    • 44849110066 scopus 로고    scopus 로고
    • Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptideTLRs mediate IFN-gamma production by human uterine NK cells in endometrium
    • Athie-Morales V., O'Connor Geraldine M., Gardiner C.M. Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptideTLRs mediate IFN-gamma production by human uterine NK cells in endometrium. J Immunol 2008, 180:4082-4089.
    • (2008) J Immunol , vol.180 , pp. 4082-4089
    • Athie-Morales, V.1    O'Connor, G.M.2    Gardiner, C.M.3
  • 23
    • 33646484491 scopus 로고    scopus 로고
    • TLRs mediate IFN-gamma production by human uterine NK cells in endometrium
    • Eriksson Mikael, Meadows Sarah K., Basu Satarupa, Mselle Teddy F., Wira Charles R., Sentman Charles L. TLRs mediate IFN-gamma production by human uterine NK cells in endometrium. J Immunol 2006, 176:6219-6224.
    • (2006) J Immunol , vol.176 , pp. 6219-6224
    • Eriksson, M.1    Meadows, S.K.2    Basu, S.3    Mselle, T.F.4    Wira, C.R.5    Sentman, C.L.6
  • 24
    • 33644843621 scopus 로고    scopus 로고
    • Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer
    • Ishikawa H., Saeki T., Otani T., Suzuki T., Shimozuma K., Nishino H., et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr 2006, 136:816S-820S.
    • (2006) J Nutr , vol.136
    • Ishikawa, H.1    Saeki, T.2    Otani, T.3    Suzuki, T.4    Shimozuma, K.5    Nishino, H.6
  • 25
    • 0000954486 scopus 로고
    • Garlic and the immune-system in humans - its effect on natural-killer-cells
    • Kandil O.M., Abdullah T.H., Elkadi A. Garlic and the immune-system in humans - its effect on natural-killer-cells. Fed Proc 1987, 46. pp. 441-441.
    • (1987) Fed Proc , vol.46 , pp. 441-441
    • Kandil, O.M.1    Abdullah, T.H.2    Elkadi, A.3
  • 26
    • 79956321246 scopus 로고    scopus 로고
    • Galactooligosaccharide supplementation reduces stress-induced gastrointestinal dysfunction and days of cold or flu: a randomized, double-blind, controlled trial in healthy university students
    • Hughes C., Davoodi-Semiromi Y., Colee J.C., Culpepper T., Dahl W.J., Mai V., et al. Galactooligosaccharide supplementation reduces stress-induced gastrointestinal dysfunction and days of cold or flu: a randomized, double-blind, controlled trial in healthy university students. Am J Clin Nutr 2011, 93:1305-1311.
    • (2011) Am J Clin Nutr , vol.93 , pp. 1305-1311
    • Hughes, C.1    Davoodi-Semiromi, Y.2    Colee, J.C.3    Culpepper, T.4    Dahl, W.J.5    Mai, V.6
  • 27
    • 0037196148 scopus 로고    scopus 로고
    • Physical, chemical, and biological properties of S-allylcysteine, an amino acid derived from garlic
    • Kodera Y., Suzuki A., Imada O., Kasuga S., Sumioka I., Kanezawa A., et al. Physical, chemical, and biological properties of S-allylcysteine, an amino acid derived from garlic. J Agric Food Chem 2002, 50:622-632.
    • (2002) J Agric Food Chem , vol.50 , pp. 622-632
    • Kodera, Y.1    Suzuki, A.2    Imada, O.3    Kasuga, S.4    Sumioka, I.5    Kanezawa, A.6
  • 28
    • 0003460085 scopus 로고
    • Topics in Intermediate Statistical Methods
    • 1st;
    • Bancroft TA. Topics in Intermediate Statistical Methods. 1st; 1968, pp. 7-9.
    • (1968) , pp. 7-9
    • Bancroft, T.A.1
  • 29
    • 42949115977 scopus 로고    scopus 로고
    • L-theanine intervention enhances human gammadeltaT lymphocyte function
    • Bukowski J.F., Percival S.S. L-theanine intervention enhances human gammadeltaT lymphocyte function. Nutr Rev 2008, 66:96-102.
    • (2008) Nutr Rev , vol.66 , pp. 96-102
    • Bukowski, J.F.1    Percival, S.S.2
  • 30
    • 38149127981 scopus 로고    scopus 로고
    • Bioactive food components that enhance gamma/delta T cell function may play a role in cancer prevention
    • Percival S.S., Bukowski J.F., Milner J. Bioactive food components that enhance gamma/delta T cell function may play a role in cancer prevention. J Nutr 2008, 138:1-4.
    • (2008) J Nutr , vol.138 , pp. 1-4
    • Percival, S.S.1    Bukowski, J.F.2    Milner, J.3
  • 31
    • 0030951318 scopus 로고    scopus 로고
    • Epidemiology, pathogenesis, and treatment of the common cold
    • Turner R.B. Epidemiology, pathogenesis, and treatment of the common cold. Ann Allergy Asthma Immunol 1997, 78:531-539.
    • (1997) Ann Allergy Asthma Immunol , vol.78 , pp. 531-539
    • Turner, R.B.1
  • 32
    • 53849113686 scopus 로고    scopus 로고
    • The impact of influenza on working days lost: a review of the literature
    • Keech M., Beardsworth P. The impact of influenza on working days lost: a review of the literature. Pharmacoeconomics 2008, 26:911-924.
    • (2008) Pharmacoeconomics , vol.26 , pp. 911-924
    • Keech, M.1    Beardsworth, P.2
  • 34
    • 0034781441 scopus 로고    scopus 로고
    • Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey
    • Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther 2001, 18:189-193.
    • (2001) Adv Ther , vol.18 , pp. 189-193
    • Josling, P.1
  • 35
    • 79955464184 scopus 로고    scopus 로고
    • S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type
    • Epub@2011 Mar 1.: 133-142
    • Javed H., Khan M.M., Khan A., Vaibhav K., Ahmad A., Khuwaja G., et al. S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Res 2011, 1389:133-142. Epub@2011 Mar 1.: 133-142.
    • (2011) Brain Res , vol.1389 , pp. 133-142
    • Javed, H.1    Khan, M.M.2    Khan, A.3    Vaibhav, K.4    Ahmad, A.5    Khuwaja, G.6
  • 36
    • 84861346336 scopus 로고    scopus 로고
    • Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes
    • Saravanan G., Ponmurugan P. Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Exp Toxicol Pathol 2011.
    • (2011) Exp Toxicol Pathol
    • Saravanan, G.1    Ponmurugan, P.2
  • 37
    • 79251626570 scopus 로고    scopus 로고
    • Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats
    • 1-15
    • Saravanan G., Ponmurugan P. Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chem Biol Interact 1-15-2011, 189:100-106.
    • (2001) Chem Biol Interact , vol.189 , pp. 100-106
    • Saravanan, G.1    Ponmurugan, P.2
  • 38
    • 78049319057 scopus 로고    scopus 로고
    • Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model
    • Tang F.Y., Chiang E.P., Pai M.H. Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model. J Agric Food Chem 9-24-2010.
    • (2010) J Agric Food Chem , pp. 24
    • Tang, F.Y.1    Chiang, E.P.2    Pai, M.H.3
  • 39
    • 62249096975 scopus 로고    scopus 로고
    • Glutathione dysregulation and the etiology and progression of human diseases
    • Ballatori N., Krance S.M., Notenboom S., Shi S., Tieu K., Hammond C.L. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 2009, 390:191-214.
    • (2009) Biol Chem , vol.390 , pp. 191-214
    • Ballatori, N.1    Krance, S.M.2    Notenboom, S.3    Shi, S.4    Tieu, K.5    Hammond, C.L.6
  • 40
    • 0037081744 scopus 로고    scopus 로고
    • The involvement of L-gamma-glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPK(p38)-dependent regulation of pro-inflammatory cytokine production
    • Haddad J.J. The involvement of L-gamma-glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPK(p38)-dependent regulation of pro-inflammatory cytokine production. Biochem Pharmacol 2002, 63:305-320.
    • (2002) Biochem Pharmacol , vol.63 , pp. 305-320
    • Haddad, J.J.1
  • 41
    • 27544440248 scopus 로고    scopus 로고
    • Regulation of glutathione in inflammation and chronic lung diseases
    • Rahman I. Regulation of glutathione in inflammation and chronic lung diseases. Mutat Res 2005, 579:58-80.
    • (2005) Mutat Res , vol.579 , pp. 58-80
    • Rahman, I.1
  • 42
    • 0037090226 scopus 로고    scopus 로고
    • Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense
    • Villa P., Saccani A., Sica A., Ghezzi P. Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense. J Infect Dis 2002, 185:1115-1120.
    • (2002) J Infect Dis , vol.185 , pp. 1115-1120
    • Villa, P.1    Saccani, A.2    Sica, A.3    Ghezzi, P.4
  • 43
    • 57649136749 scopus 로고    scopus 로고
    • Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells
    • Papi A., Contoli M., Gasparini P., Bristot L., Edwards M.R., Chicca M., et al. Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells. J Biol Chem 2008, 283:28595-28606.
    • (2008) J Biol Chem , vol.283 , pp. 28595-28606
    • Papi, A.1    Contoli, M.2    Gasparini, P.3    Bristot, L.4    Edwards, M.R.5    Chicca, M.6
  • 44
    • 0028363328 scopus 로고
    • In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects
    • Wu D., Meydani S.N., Sastre J., Hayek M., Meydani M. In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects. J Nutr 1994, 124:655-663.
    • (1994) J Nutr , vol.124 , pp. 655-663
    • Wu, D.1    Meydani, S.N.2    Sastre, J.3    Hayek, M.4    Meydani, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.