Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: A twin study

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 53, Issue 6, 2012, Pages 706-715

  Tye, Charlotte ^a   Rijsdijk, Frühling ^a   Greven, Corina U ^a   Kuntsi, Jonna ^a   Asherson, Philip ^a   McLoughlin, Gráinne ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

ADHD; EEG; endophenotype; genetics; heritability.; very low frequency activity

Indexed keywords

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; BIOLOGICAL MODEL; ELECTROENCEPHALOGRAPHY; ENDOPHENOTYPE; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MALE; REGRESSION ANALYSIS; TWINS; UNITED KINGDOM;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DISEASES IN TWINS; ELECTROENCEPHALOGRAPHY; ENDOPHENOTYPES; ENGLAND; GENE-ENVIRONMENT INTERACTION; HUMANS; MALE; MODELS, GENETIC; REGRESSION ANALYSIS; WALES;

EID: 84861334796     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/j.1469-7610.2011.02501.x     Document Type: Article

References (59)

1. Balduzzi, D., Riedner, B.A., &, Tononi, G., (2008). A BOLD window into brain waves. Proceedings of the National Academy of Sciences, 105, 15641-15642.
2. Biswal, B., Yetkin, F.Z., Haughton, V.M., &, Hyde, J.S., (2005). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine, 34, 537-541.
3. Broyd, S.J., Demanuele, C., Debener, S., Helps, S.K., James, C.J., &, Sonuga-Barke, E.J.S., (2009). Default-mode brain dysfunction in mental disorders: A systematic review. Neuroscience & Biobehavioral Reviews, 33, 279-296.
4. Broyd, S.J., Helps, S.K., &, Sonuga-Barke, E.J.S., (2011). Attention-induced deactivations in very low frequency EEG oscillations: Differential localisation according to ADHD symptom status. PLoS ONE, 6, e17325.
5. Buszaki, G., &, Draguhn, A., (2004). Neuronal oscillations in cortical networks. Science, 304, 1926-1929.
6. Castellanos, F.X., Sonuga-Barke, E.J.S., Scheres, A., Di Martino, A., Hyde, C., &, Walters, J.R., (2005). Varieties of attention-deficit/ hyperactivity disorder-related intra-individual variability. Biological Psychiatry, 57, 1416-1423.
7. Conners, C., Sitarenios, G., Parker, J., &, Epstein, J., (1998a). The Revised Conners' Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology, 26, 257-268.
8. Conners, C., Sitarenios, G., Parker, J., &, Epstein, J., (1998b). Revision and restandardization of the Conners' Teacher Rating Scale (CTRS-R): Factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology, 26, 279-291.
9. Doehnert, M., Brandeis, D., Straub, M., Steinhausen, H.-C., &, Drechsler, R., (2008). Slow cortical potential neurofeedback in attention deficit hyperactivity disorder: Is there neurophysiological evidence for specific effects? Journal of Neural Transmission, 115, 1445-1456.
10. Falconer, D.S., &, Mackay, T.F.C., (1996). Introduction to quantitative genetics. Harlow: Addison Wesley Longman Ltd.
11. Faraone, S.V., Biederman, J., &, Mick, E., (2006). The age-dependent decline of attention deficit hyperactivity disorder: A meta-analysis of follow-up studies. Psychological Medicine, 36, 159-165.
12. Faraone, S.V., Perlis, R.H., Doyle, A.E., Smoller, J.W., Goralnick, J.J., Holmgren, M.A., &, Sklar, P., (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 1313-1323.
13. Fox, M.D., Snyder, A.Z., Vincent, J.L., Corbetta, M., Van Essen, D.C., &, Raichle, M.E., (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America, 102, 9673-9678.
14. Fransson, P., (2005). Spontaneous low-frequency BOLD signal fluctuations: An fMRI investigation of the resting-state default mode of brain function hypothesis. Human Brain Mapping, 26, 15-29.
15. Fransson, P., (2006). How default is the default mode of brain function?: Further evidence from intrinsic BOLD signal fluctuations. Neuropsychologia, 44, 2836-2845.
16. de Geus, E.J.C., (2002). Introducing genetic psychophysiology. Biological Psychology, 61, 1-10.
17. Gottesman, I.I., &, Gould, T.D., (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636-645.
18. Haworth, C.M.A., Wright, M.J., Luciano, M., Martin, N.G., De Geus, E., Van Beijsterveldt, C., E,., ... &, Plomin, R., (2010). The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry, 15, 1112-1120.
19. He, B.J., &, Raichle, M.E., (2009). The fMRI signal, slow cortical potential and consciousness. Trends in Cognitive Sciences, 13, 302-309.
20. Helps, S.K., Broyd, S.J., James, C.J., Karl, A., Chen, W., &, Sonuga-Barke, E.J.S., (2010). Altered spontaneous low frequency brain activity in attention deficit/hyperactivity disorder. Brain Research, 1322, 134-143.
21. Helps, S.K., Broyd, S.J., James, C.J., Karl, A., &, Sonuga-Barke, E.J.S., (2009). The attenuation of very low frequency brain oscillations in transitions from a rest state to active attention. Journal of Psychophysiology, 23, 191-198.
22. Helps, S.K., James, C.J., Debener, S., Karl, A., &, Sonuga-Barke, E.J.S., (2008). Very low frequency EEG oscillations and the resting brain in young adults: A preliminary study of localisation, stability and association with symptoms of inattention. Journal of Neural Transmission, 115, 279-285.
23. Jensen, A.R., (1998). The g factor: The science of mental ability. Wesport: Praeger.
24. Jung, T.-P., Makeig, S., Humphries, C., Lee, T.-W., McKeown, M.J., Iragui, V., &, Sejnowski, T.J., (2000). Removing electroencephalographic artifacts by blind source separation. Psychophysiology, 37, 163-178.
25. Kendall, T., Taylor, E., Perez, A., &, Taylor, C., & Guideline Development Group. (2008). Diagnosis and management of attention-deficit/ hyperactivity disorder in children, young people, and adults: Summary of NICE guidance. British Medical Journal, 337, a1239.
26. Klein, C., Wendling, K., Huettner, P., Ruder, H., &, Peper, M., (2006). Intra-subject variability in attention-deficit hyperactivity disorder. Biological Psychiatry, 60, 1088-1097.
27. Kovas, Y., Haworth, C.M.A., Dale, P.S., &, Plomin, R., (2007). The genetic and environmental origins of learning abilities and disabilities in the early school years. Monographs of the Society for Research in Child Development, 72, 1-144.
28. Kovas, Y., &, Plomin, R., (2006). Generalist genes: Implications for the cognitive sciences. Trends in Cognitive Sciences, 10, 198-203.
29. Kuntsi, J., McLoughlin, G., &, Asherson, P., (2006a). Attention deficit hyperactivity disorder. Neuromolecular Medicine, 8, 461-484.
30. Kuntsi, J., Rogers, H., Swinard, G., Börger, N.A., Meere, J.v.d., Rijsdijk, F.V., &, Asherson, P., (2006b). Reaction time, inhibition, working memory and performance: Genetic influences and their interpretation. Psychological Medicine, 36, 1613-1624.
31. Kuntsi, J., Wood, A., Rijsdijk, F., Johnson, K., Andreou, P., Albrecht, B., ... &, Asherson, P., (2010). Separation of cognitive impairments in attention deficit hyperactivity disorder into two familial factors. Archives of General Psychiatry, 67, 1159-1166.
32. Kuntsi, J., Wood, A.C., Van der Meere, J., &, Asherson, P., (2009). Why cognitive performance in ADHD may not reveal true potential: Findings from a large population-based sample. Journal of the International Neuropsychological Society, 15, 570-579.
33. Loo, S.K., Hale, T., Hanada, G., Macion, J., Shrestha, A., McGough, J.J., ... &, Smalley, S.L., (2010). Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 368-377.
34. Loo, S.K., &, Smalley, S.L., (2008). Preliminary report of familial clustering of EEG measures in ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 107-109.
35. McLoughlin, G., Albrecht, B., Banaschewski, T., Rothenberger, A., Brandeis, D., Asherson, P., &, Kuntsi, J., (2010). Electrophysiological evidence for abnormal preparatory states and inhibitory processing in adult ADHD. Behavioral and Brain Functions, 6, 66.
36. McLoughlin, G., Asherson, P., Albrecht, B., Banaschewski, T., Rothenberger, A., Brandeis, D., &, Kuntsi, J., (2011). Cognitive- electrophysiological indices of attentional and inhibitory processing in adults with ADHD: Familial effects. Behavioral and Brain Functions, 7, 26.
37. McLoughlin, G., Kuntsi, J., Brandeis, D., &, Banaschewski, T., (2005). Electrophysiological parameters in psychiatric research: ADHD. Psychiatry, 4, 14-18.
38. Monto, S., Palva, S., Voipio, J., &, Palva, J.M., (2008). Very slow EEG fluctuations predict the dynamics of stimulus detection and oscillation amplitudes in humans. Journal of Neuroscience, 28, 8268-8272.
39. Neale, M.C., Boker, S.M., Xie, G., &, Maes, H., (1999). Mx: Statistical modeling, 5th edn. Richmond, VA 23298: Department of Psychiatry, Box 126 MCV.
40. Neale, M.C., &, Cardon, L.R., (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer.
41. Neale, M.C., Eaves, L.J., &, Kendler, K.S., (1994). The power of the classical twin study to resolve variation in threshold traits. Behavior Genetics, 24, 239-258.
42. Neale, M.C., &, Kendler, K.S., (1995). Models of comorbidity for multifactorial disorders. American Journal of Human Genetics, 57, 935-953.
43. Polanczyk, G., de Lima, M.S., Horta, B.L., Biederman, J., &, Rohde, L.A., (2007). The worldwide prevalence of ADHD: A systematic review and metaregression analysis. American Journal of Psychiatry, 164, 942-948.
44. Price, T.S., Freeman, B., Craig, I., Petrill, S.A., Ebersole, L., &, Plomin, R., (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research and Human Genetics, 3, 129-133.
45. Raven, J.C., Court, J.H., &, Raven, J., (1996). Manual for Raven's progressive matrices and vocabulary scales. Oxford: Oxford University Press.
46. Rijsdijk, F.V., &, Sham, P.C., (2002). Analytic approaches to twin data using structural equation models. Briefings in Bioinformatics, 3, 119-133.
47. Ronald, A., Simonoff, E., Kuntsi, J., Asherson, P., &, Plomin, R., (2008). Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. Journal of Child Psychology and Psychiatry, 49, 535-542.
48. Ruskin, D.N., Bergstrom, D.A., Shenker, A., Freeman, L.E., Baek, D., &, Walters, J.R., (2001). Drugs used in the treatment of attention-deficit/hyperactivity disorder affect postsynaptic firing rate and oscillation without preferential dopamine autoreceptor action. Biological Psychiatry, 49, 340-350.
49. Sergeant, J., (2000). The cognitive-energetic model: An empirical approach to attention-deficit hyperactivity disorder. Neuroscience & Biobehavioral Reviews, 24, 7-12.
50. Smit, D., Posthuma, D., Boomsma, D.I., &, Geus, E.J.C., (2005). Heritability of background EEG across the power spectrum. Psychophysiology, 42, 691-697.
51. Sonuga-Barke, E.J.S., &, Castellanos, F.X., (2007). Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis. Neuroscience and Biobehavioral Reviews, 31, 977-986.
52. Toulopoulou, T., Picchioni, M., Rijsdijk, F., Hua-Hall, M., Ettinger, U., Sham, P., &, Murray, R., (2007). Substantial genetic overlap between neurocognition and schizophrenia: Genetic modeling in twin samples. Archives of General Psychiatry, 64, 1348-1355.
53. Trouton, A., Spinath, F.M., &, Plomin, R., (2002). Twins early development study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research and Human Genetics, 5, 444-448.
54. Tye, C., McLoughlin, G., Kuntsi, J., &, Asherson, P., (2011). Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder. Expert Reviews in Molecular Medicine, 13, e9.
55. Valko, L., Doehnert, M., Müller, U.C., Schneider, G., Albrecht, B., Drechsler, R., ... &, Brandeis, D., (2010). Differences in neurophysiological markers of inhibitory and temporal processing deficits in children and adults with ADHD. Journal of Psychophysiology, 23, 235-246.
56. Vanhatalo, S., Palva, J.M., Holmes, M.D., Miller, J.W., Voipio, J., &, Kaila, K., (2004). Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. Proceedings of the National Academy of Sciences of the United States of America, 101, 5053-5057.
57. Walters, J.T.R., &, Owen, M.J., (2008). Endophenotypes in psychiatric genetics. Molecular Psychiatry, 12, 886-890.
58. Wechsler, D., (1992). Wechsler intelligence scale for children-Third edition UK (WISC-IIIUK) manual. London: The Psychological Corporation.
59. Willcutt, E.G., Doyle, A.E., Nigg, J.T., Faraone, S.V., &, Pennington, B.F., (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry, 57, 1336-1346.