Animal models and the developmental origins of polycystic ovary syndrome: Increasing evidence for the role of androgens in programming reproductive and metabolic dysfunction

Endocrinology

Volumn 153, Issue 6, 2012, Pages 2536-2538

  Franks, Stephen ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; LUTEINIZING HORMONE; TESTOSTERONE;

ANOVULATION; CARDIOVASCULAR RISK; DIET; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; FEMALE; FEMALE INFERTILITY; GENITAL SYSTEM DISEASE; HUMAN; HYPERINSULINEMIA; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LUTEINIZING HORMONE RELEASE; METABOLIC DISORDER; NONHUMAN; OBESITY; OVARY CYCLE; OVARY DEVELOPMENT; OVARY FOLLICLE DEVELOPMENT; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RHESUS MONKEY; SHORT SURVEY;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LIPID METABOLISM; POLYCYSTIC OVARY SYNDROME; REPRODUCTION;

EID: 84861316710     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1366     Document Type: Short Survey

References (33)

1. Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R 1998 Prevalence of the polycystic ovary syndrome in unselected black and whitewomenof the southeastern United States: a prospective study. J Clin Endocrinol Metab 83:3078-3082 (Pubitemid 28500937)
2. Franks S 1995 Polycystic ovary syndrome. N Engl J Med 333:853-861
3. Ehrmann DA 2005 Polycystic ovary syndrome. N Engl J Med 352: 1223-1236
4. Dunaif A 1997 Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18:774-800 (Pubitemid 28009567)
5. Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, Boivin J, Petraglia F, Wijeyeratne CN, Norman RJ, Dunaif A, Franks S, Wild RA, Dumesic D, Barnhart K 2012 Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 97:28-38, e25
6. Legro RS, Driscoll D, Strauss 3rd JF, Fox J, Dunaif A 1998 Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci USA 95:14956-14960 (Pubitemid 29003738)
7. Vink JM, Sadrzadeh S, Lambalk CB, Boomsma DI 2006 Heritability of polycystic ovary syndrome (PCOS) in a Dutch twin-family study. J Clin Endocrinol Metab 91:2100-2104 (Pubitemid 43854989)
8. Franks S, Webber LJ, Goh M, Valentine A, White DM, Conway GS, Wiltshire S, McCarthy MI 2008 Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. J Clin Endocrinol Metab 93:3396-3402
9. Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y 2011 Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet 43:55-59
10. Franks S 2008 Polycystic ovary syndrome in adolescents. Int J Obes (Lond) 32:1035-1041 (Pubitemid 351986206)
11. Parker Jr CR, Mahesh VB 1976 Interrelationship between excessive levels of circulating androgens in blood and ovulatory failure. J Reprod Med 17:75-90
12. Hemmings R, Farookhi R, Brawer JR 1983 Pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries. Biol Reprod 29:239-248
13. Mahesh VB, Mills TM, Bagnell CA, Conway BA 1987 Animal models for study of polycystic ovaries and ovarian atresia. Adv Exp Med Biol 219:237-257
14. Franks S 2009 Do animal models of polycystic ovary syndrome help to understand its pathogenesis and management? Yes, but their limitations should be recognized. Endocrinology 150:3983-3985
15. Walters KA, Allan CM, Handelsman DJ 15 February 2012 Rodent models for human polycystic ovary syndrome. Biol Reprod 10.1095/biolreprod.111.097808
16. Tyndall V, Broyde M, Sharpe R, Welsh M, Drake AJ, McNeilly AS 2012 Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats. Reproduction 143:21-33
17. Abbott DH, Dumesic DA, Franks S 2002 Developmental origin of polycystic ovary syndrome: a hypothesis. J Endocrinol 174:1-5 (Pubitemid 34830927)
18. Abbott DH, Dumesic DA, Eisner JR, Colman RJ, Kemnitz JW 1998 Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys. Trends Endocrinol Metab 9:62-67 (Pubitemid 28207615)
19. Abbott DH, Tarantal AF, Dumesic DA 2009 Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am J Primatol 71:776-784
20. Birch RA, Padmanabhan V, Foster DL, Unsworth WP, Robinson JE 2003 Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep. Endocrinology 144:1426-1434 (Pubitemid 36428485)
21. Steckler T, Wang J, Bartol FF, Roy SK, Padmanabhan V 2005 Fetal programming: prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment. Endocrinology 146:3185-3193 (Pubitemid 41007051)
22. Steckler T, Manikkam M, Inskeep EK, Padmanabhan V 2007 Developmental programming: follicular persistence in prenatal testosterone-treated sheep is not programmed by androgenic actions of testosterone. Endocrinology 148:3532-3540 (Pubitemid 46997017)
23. Padmanabhan V, Veiga-Lopez A 2011 Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming. Semin Reprod Med 29:173-186
24. Veiga-Lopez A, Steckler TL, Abbott DH, Welch KB, MohanKumar PS, Phillips DJ, Refsal K, Padmanabhan V 2011 Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep. Biol Reprod 84: 87-96
25. Forsdike RA, Hardy K, Bull L, Stark J, Webber LJ, Stubbs S, Robinson JE, Franks S 2007 Disordered follicle development in ovaries of prenatally androgenized ewes. J Endocrinol 192:421-428 (Pubitemid 46444443)
26. Webber LJ, Stubbs S, Stark J, Trew GH, Margara R, Hardy K, Franks S 2003 Formation and early development of follicles in the polycystic ovary. Lancet 362:1017-1021 (Pubitemid 37186878)
27. Maciel GA, Baracat EC, Benda JA, Markham SM, Hensinger K, Chang RJ, Erickson GF 2004 Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome. J Clin Endocrinol Metab 89:5321-5327 (Pubitemid 39518404)
28. Hogg K, Wood C, McNeilly AS, Duncan WC 2011 The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep. PLoS One 6:e24877
29. Xu N, Kwon S, Abbott DH, Geller DH, Dumesic DA, Azziz R, Guo X, Goodarzi MO 2011 Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys. PLoS One 6:e27286
30. Cole B, Hensinger K, Maciel GA, Chang RJ, Erickson GF 2006 Human fetal ovary development involves the spatiotemporal expression of p450c17 protein. J Clin Endocrinol Metab 91:3654-3661 (Pubitemid 44402151)
31. van Houten EL, Kramer P, McLuskey A, Karels B, Themmen AP, Visser JA 2012 Reproductive and metabolic phenotype of a mouse model of PCOS. Endocrinology 153:2861-2869
32. Barber TM, Hazell M, Christodoulides C, Golding SJ, Alvey C, Burling K, Vidal-Puig A, Groome NP, Wass JA, Franks S, McCarthy MI 2008 Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition. J Clin Endocrinol Metab 93:2859-2865 (Pubitemid 352008562)
33. Mannerås-Holm L, Leonhardt H, Kullberg J, Jennische E, Odén A, Holm G, Hellström M, Lönn L, Olivecrona G, Stener-Victorin E, Lönn M 2011 Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. J Clin Endocrinol Metab 96:E304-E311