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Volumn 6, Issue 9, 2011, Pages

The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CERAMIDE GLUCOSYLTRANSFERASE; ESTROGEN RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SOMATOMEDIN C; TESTOSTERONE PROPIONATE; GLUCOSYLTRANSFERASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP);

EID: 80052830410     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024877     Document Type: Article
Times cited : (76)

References (55)
  • 2
    • 11844250659 scopus 로고    scopus 로고
    • The Developmental Origins of Adult Disease
    • Barker DJP, (2004) The Developmental Origins of Adult Disease. J Am Coll Nutr 23: 588S-595.
    • (2004) J Am Coll Nutr , vol.23 , pp. 588-595
    • Barker, D.J.P.1
  • 3
    • 34548854783 scopus 로고    scopus 로고
    • Mechanisms of Fetal Programming of Adult Hypertension: Role of Sex Hormones
    • Maric C, (2007) Mechanisms of Fetal Programming of Adult Hypertension: Role of Sex Hormones. Hypertension 50: 605-606.
    • (2007) Hypertension , vol.50 , pp. 605-606
    • Maric, C.1
  • 4
    • 78651326777 scopus 로고    scopus 로고
    • Epigenetic changes in early life and future risk of obesity
    • Lillycrop KA, Burdge GC, (2011) Epigenetic changes in early life and future risk of obesity. Int J Obes 35: 72-83.
    • (2011) Int J Obes , vol.35 , pp. 72-83
    • Lillycrop, K.A.1    Burdge, G.C.2
  • 5
    • 0036313064 scopus 로고    scopus 로고
    • Developmental origin of polycystic ovary syndrome - a hypothesis
    • Abbott DH, Dumesic DA, Franks S, (2002) Developmental origin of polycystic ovary syndrome- a hypothesis. J Endocrinol 174: 1-5.
    • (2002) J Endocrinol , vol.174 , pp. 1-5
    • Abbott, D.H.1    Dumesic, D.A.2    Franks, S.3
  • 6
    • 0029095150 scopus 로고
    • Polycystic Ovary Syndrome
    • Franks S, (1995) Polycystic Ovary Syndrome. N Engl J Med 333: 853-861.
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 7
    • 0031979511 scopus 로고    scopus 로고
    • Insights into the Development of Polycystic Ovary Syndrome (PCOS) from Studies of Prenatally Androgenized Female Rhesus Monkeys
    • Abbott DH, Dumesic DA, Eisner JR, Colman RJ, Kemnitz JW, (1998) Insights into the Development of Polycystic Ovary Syndrome (PCOS) from Studies of Prenatally Androgenized Female Rhesus Monkeys. Trends Endocrinol Metab 9: 62-67.
    • (1998) Trends Endocrinol Metab , vol.9 , pp. 62-67
    • Abbott, D.H.1    Dumesic, D.A.2    Eisner, J.R.3    Colman, R.J.4    Kemnitz, J.W.5
  • 8
    • 0037387354 scopus 로고    scopus 로고
    • Prenatal Programming of Reproductive Neuroendocrine Function: Fetal Androgen Exposure Produces Progressive Disruption of Reproductive Cycles in Sheep
    • Birch RA, Padmanabhan V, Foster DL, Unsworth WP, Robinson JE, (2003) Prenatal Programming of Reproductive Neuroendocrine Function: Fetal Androgen Exposure Produces Progressive Disruption of Reproductive Cycles in Sheep. Endocrinology 144: 1426-1434.
    • (2003) Endocrinology , vol.144 , pp. 1426-1434
    • Birch, R.A.1    Padmanabhan, V.2    Foster, D.L.3    Unsworth, W.P.4    Robinson, J.E.5
  • 9
    • 0036151008 scopus 로고    scopus 로고
    • Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess
    • Eisner JR, Barnett MA, Dumesic DA, Abbott DH, (2002) Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess. Fertil Steril 77: 167-172.
    • (2002) Fertil Steril , vol.77 , pp. 167-172
    • Eisner, J.R.1    Barnett, M.A.2    Dumesic, D.A.3    Abbott, D.H.4
  • 10
    • 34547138420 scopus 로고    scopus 로고
    • A New Rat Model Exhibiting Both Ovarian and Metabolic Characteristics of Polycystic Ovary Syndrome
    • Manneras L, Cajander S, Holmang A, Seleskovic Z, Lystig T, et al. (2007) A New Rat Model Exhibiting Both Ovarian and Metabolic Characteristics of Polycystic Ovary Syndrome. Endocrinology 148: 3781-3791.
    • (2007) Endocrinology , vol.148 , pp. 3781-3791
    • Manneras, L.1    Cajander, S.2    Holmang, A.3    Seleskovic, Z.4    Lystig, T.5
  • 12
    • 0036198971 scopus 로고    scopus 로고
    • Fetal Programming: Prenatal Androgen Disrupts Positive Feedback Actions of Estradiol but Does Not Affect Timing of Puberty in Female Sheep
    • Sharma TP, Herkimer C, West C, Ye W, Birch R, et al. (2002) Fetal Programming: Prenatal Androgen Disrupts Positive Feedback Actions of Estradiol but Does Not Affect Timing of Puberty in Female Sheep. Biol Reprod 66: 924-933.
    • (2002) Biol Reprod , vol.66 , pp. 924-933
    • Sharma, T.P.1    Herkimer, C.2    West, C.3    Ye, W.4    Birch, R.5
  • 13
    • 41549098869 scopus 로고    scopus 로고
    • Developmental Programming: Deficits in Reproductive Hormone Dynamics and Ovulatory Outcomes in Prenatal, Testosterone-Treated Sheep
    • Veiga-Lopez A, Ye W, Phillips DJ, Herkimer C, Knight PG, et al. (2008) Developmental Programming: Deficits in Reproductive Hormone Dynamics and Ovulatory Outcomes in Prenatal, Testosterone-Treated Sheep. Biol Reprod 78: 636-647.
    • (2008) Biol Reprod , vol.78 , pp. 636-647
    • Veiga-Lopez, A.1    Ye, W.2    Phillips, D.J.3    Herkimer, C.4    Knight, P.G.5
  • 14
    • 74949096775 scopus 로고    scopus 로고
    • Developmental Programming: Impact of Prenatal Testosterone Excess and Postnatal Weight Gain on Insulin Sensitivity Index and Transfer of Traits to Offspring of Overweight Females
    • Padmanabhan V, Veiga-Lopez A, Abbott DH, Recabarren SE, Herkimer C, (2010) Developmental Programming: Impact of Prenatal Testosterone Excess and Postnatal Weight Gain on Insulin Sensitivity Index and Transfer of Traits to Offspring of Overweight Females. Endocrinology 151: 595-605.
    • (2010) Endocrinology , vol.151 , pp. 595-605
    • Padmanabhan, V.1    Veiga-Lopez, A.2    Abbott, D.H.3    Recabarren, S.E.4    Herkimer, C.5
  • 15
    • 27144489633 scopus 로고    scopus 로고
    • Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone
    • Recabarren SE, Padmanabhan V, Codner E, Lobos A, Duran C, et al. (2005) Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone. Am J Physiol Endocrinol Metab 289: E801-806.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , pp. 801-806
    • Recabarren, S.E.1    Padmanabhan, V.2    Codner, E.3    Lobos, A.4    Duran, C.5
  • 16
    • 33646401803 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome
    • Setji TL, Holland ND, Sanders LL, Pereira KC, Diehl AM, et al. (2006) Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab 91: 1741-1747.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1741-1747
    • Setji, T.L.1    Holland, N.D.2    Sanders, L.L.3    Pereira, K.C.4    Diehl, A.M.5
  • 17
    • 13544268563 scopus 로고    scopus 로고
    • Abnormal aminotransferase activity in women with polycystic ovary syndrome
    • Schwimmer JB, Khorram O, Chiu V, Schwimmer WB, (2005) Abnormal aminotransferase activity in women with polycystic ovary syndrome. Fertil Steril 83: 494-497.
    • (2005) Fertil Steril , vol.83 , pp. 494-497
    • Schwimmer, J.B.1    Khorram, O.2    Chiu, V.3    Schwimmer, W.B.4
  • 18
    • 72849152902 scopus 로고    scopus 로고
    • Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome
    • Vassilatou E, Lafoyianni S, Vryonidou A, Ioannidis D, Kosma L, et al. (2010) Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome. Hum Reprod 25: 212-220.
    • (2010) Hum Reprod , vol.25 , pp. 212-220
    • Vassilatou, E.1    Lafoyianni, S.2    Vryonidou, A.3    Ioannidis, D.4    Kosma, L.5
  • 19
    • 58849159714 scopus 로고    scopus 로고
    • An association between non-alcoholic fatty liver disease and polycystic ovarian syndrome
    • Brzozowska M, M., Ostapowicz G, Weltman M, D, (2009) An association between non-alcoholic fatty liver disease and polycystic ovarian syndrome. J Gastroen Hepatol 24: 243-247.
    • (2009) J Gastroen Hepatol , vol.24 , pp. 243-247
    • Brzozowska, M.M.1    Ostapowicz, G.2    Weltman, M.D.3
  • 20
    • 34547394354 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in women with polycystic ovary syndrome
    • Cerda C, Pérez-Ayuso RM, Riquelme A, Soza A, Villaseca P, et al. (2007) Nonalcoholic fatty liver disease in women with polycystic ovary syndrome. J Hepatol 47: 412-417.
    • (2007) J Hepatol , vol.47 , pp. 412-417
    • Cerda, C.1    Pérez-Ayuso, R.M.2    Riquelme, A.3    Soza, A.4    Villaseca, P.5
  • 22
    • 7044250697 scopus 로고    scopus 로고
    • Direct effects of sex steroid hormones on adipose tissues and obesity
    • Mayes JS, Watson GH, (2004) Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev 5: 197-216.
    • (2004) Obes Rev , vol.5 , pp. 197-216
    • Mayes, J.S.1    Watson, G.H.2
  • 23
    • 0024587721 scopus 로고
    • Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus
    • Kissebah AH, Peiris AN, (1989) Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab Rev 5: 83-109.
    • (1989) Diabetes Metab Rev , vol.5 , pp. 83-109
    • Kissebah, A.H.1    Peiris, A.N.2
  • 24
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A, (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38: 1165-1174.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 25
    • 78649864843 scopus 로고    scopus 로고
    • Developmental Programming: Impact of Excess Prenatal Testosterone on Intrauterine Fetal Endocrine Milieu and Growth in Sheep
    • Veiga-Lopez A, Steckler TL, Abbott DH, Welch KB, MohanKumar PS, et al. (2011) Developmental Programming: Impact of Excess Prenatal Testosterone on Intrauterine Fetal Endocrine Milieu and Growth in Sheep. Biol Reprod 84: 87-96.
    • (2011) Biol Reprod , vol.84 , pp. 87-96
    • Veiga-Lopez, A.1    Steckler, T.L.2    Abbott, D.H.3    Welch, K.B.4    MohanKumar, P.S.5
  • 27
    • 70450150499 scopus 로고    scopus 로고
    • Abnormal serum alanine aminotransferase levels are associated with impaired insulin sensitivity in young women with polycystic ovary syndrome
    • Targher G, Solagna E, Tosi F, Castello R, Spiazzi G, et al. (2009) Abnormal serum alanine aminotransferase levels are associated with impaired insulin sensitivity in young women with polycystic ovary syndrome. J Endocrinol Invest 32: 695-700.
    • (2009) J Endocrinol Invest , vol.32 , pp. 695-700
    • Targher, G.1    Solagna, E.2    Tosi, F.3    Castello, R.4    Spiazzi, G.5
  • 28
    • 10944256867 scopus 로고    scopus 로고
    • Fetal Programming: Testosterone Exposure of the Female Sheep During Midgestation Disrupts the Dynamics of Its Adult Gonadotropin Secretion During the Periovulatory Period
    • Savabieasfahani M, Lee JS, Herkimer C, Sharma TP, Foster DL, et al. (2005) Fetal Programming: Testosterone Exposure of the Female Sheep During Midgestation Disrupts the Dynamics of Its Adult Gonadotropin Secretion During the Periovulatory Period. Biol Reprod 72: 221-229.
    • (2005) Biol Reprod , vol.72 , pp. 221-229
    • Savabieasfahani, M.1    Lee, J.S.2    Herkimer, C.3    Sharma, T.P.4    Foster, D.L.5
  • 29
    • 79952196830 scopus 로고    scopus 로고
    • Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease
    • Lockman KA, Nyirenda MJ, (2010) Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease. Curr Diabetes Rev 6: 341-347.
    • (2010) Curr Diabetes Rev , vol.6 , pp. 341-347
    • Lockman, K.A.1    Nyirenda, M.J.2
  • 31
    • 0029880488 scopus 로고    scopus 로고
    • Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
    • Dunaif A, Finegood DT, (1996) Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 81: 942-947.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 942-947
    • Dunaif, A.1    Finegood, D.T.2
  • 32
    • 79955376303 scopus 로고    scopus 로고
    • Prenatal Androgen Exposure Leads to Alterations in Gene and Protein Expression in the Ovine Fetal Ovary
    • Hogg K, McNeilly AS, Duncan WC, (2011) Prenatal Androgen Exposure Leads to Alterations in Gene and Protein Expression in the Ovine Fetal Ovary. Endocrinology 152: 2048-2059.
    • (2011) Endocrinology , vol.152 , pp. 2048-2059
    • Hogg, K.1    McNeilly, A.S.2    Duncan, W.C.3
  • 33
    • 34347223688 scopus 로고    scopus 로고
    • Developmental Programming: Follicular Persistence in Prenatal Testosterone-Treated Sheep Is Not Programmed by Androgenic Actions of Testosterone
    • Steckler T, Manikkam M, Inskeep EK, Padmanabhan V, (2007) Developmental Programming: Follicular Persistence in Prenatal Testosterone-Treated Sheep Is Not Programmed by Androgenic Actions of Testosterone. Endocrinology 148: 3532-3540.
    • (2007) Endocrinology , vol.148 , pp. 3532-3540
    • Steckler, T.1    Manikkam, M.2    Inskeep, E.K.3    Padmanabhan, V.4
  • 34
    • 0033304755 scopus 로고    scopus 로고
    • Prenatal Dihydrotestosterone Differentially Masculinizes Tonic and Surge Modes of Luteinizing Hormone Secretion in Sheep
    • Masek KS, Wood RI, Foster DL, (1999) Prenatal Dihydrotestosterone Differentially Masculinizes Tonic and Surge Modes of Luteinizing Hormone Secretion in Sheep. Endocrinology 140: 3459-3466.
    • (1999) Endocrinology , vol.140 , pp. 3459-3466
    • Masek, K.S.1    Wood, R.I.2    Foster, D.L.3
  • 35
    • 65249183137 scopus 로고    scopus 로고
    • Developmental Programming: Contribution of Prenatal Androgen and Estrogen to Estradiol Feedback Systems and Periovulatory Hormonal Dynamics in Sheep
    • Veiga-Lopez A, Astapova OI, Aizenberg EF, Lee JS, Padmanabhan V, (2009) Developmental Programming: Contribution of Prenatal Androgen and Estrogen to Estradiol Feedback Systems and Periovulatory Hormonal Dynamics in Sheep. Biol Reprod 80: 718-725.
    • (2009) Biol Reprod , vol.80 , pp. 718-725
    • Veiga-Lopez, A.1    Astapova, O.I.2    Aizenberg, E.F.3    Lee, J.S.4    Padmanabhan, V.5
  • 36
    • 0018800384 scopus 로고
    • Rate-limiting steps in metabolic pathways
    • Rognstad R, (1979) Rate-limiting steps in metabolic pathways. J Biol Chem 254: 1875-1878.
    • (1979) J Biol Chem , vol.254 , pp. 1875-1878
    • Rognstad, R.1
  • 37
    • 20644460348 scopus 로고    scopus 로고
    • Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C
    • Chakravarty K, Cassuto H, Reshef L, Hanson RW, (2005) Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C. Criti Rev Biochem Mol Biol 40: 129-154.
    • (2005) Criti Rev Biochem Mol Biol , vol.40 , pp. 129-154
    • Chakravarty, K.1    Cassuto, H.2    Reshef, L.3    Hanson, R.W.4
  • 38
    • 0028567884 scopus 로고
    • Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus
    • Valera A, Pujol A, Pelegrin M, Bosch F, (1994) Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 91: 9151-9154.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9151-9154
    • Valera, A.1    Pujol, A.2    Pelegrin, M.3    Bosch, F.4
  • 39
    • 0033847132 scopus 로고    scopus 로고
    • Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism
    • She P, Shiota M, Shelton KD, Chalkley R, Postic C, et al. (2000) Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism. Mol Cell Biol 20: 6508-6517.
    • (2000) Mol Cell Biol , vol.20 , pp. 6508-6517
    • She, P.1    Shiota, M.2    Shelton, K.D.3    Chalkley, R.4    Postic, C.5
  • 40
    • 0037163021 scopus 로고    scopus 로고
    • The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function
    • Owen OE, Kalhan SC, Hanson RW, (2002) The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function. J Biol Chem 277: 30409-30412.
    • (2002) J Biol Chem , vol.277 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 41
    • 30344468406 scopus 로고    scopus 로고
    • Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism
    • Hakimi P, Johnson M, Yang J, Lepage D, Conlon R, et al. (2005) Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. Nutr Metab 2: 33.
    • (2005) Nutr Metab , vol.2 , pp. 33
    • Hakimi, P.1    Johnson, M.2    Yang, J.3    Lepage, D.4    Conlon, R.5
  • 43
    • 0032499687 scopus 로고    scopus 로고
    • SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
    • Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, et al. (1998) SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A 95: 6881-6886.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6881-6886
    • Ganiatsas, S.1    Kwee, L.2    Fujiwara, Y.3    Perkins, A.4    Ikeda, T.5
  • 44
    • 0029895702 scopus 로고    scopus 로고
    • Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis
    • Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y, (1996) Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. Proc Natl Acad Sci U S A 93: 4638-4643.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 4638-4643
    • Ichikawa, S.1    Sakiyama, H.2    Suzuki, G.3    Hidari, K.I.4    Hirabayashi, Y.5
  • 45
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
    • Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, et al. (2005) Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 48: 634-642.
    • (2005) Diabetologia , vol.48 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vanni, E.3    Gambino, R.4    Cassader, M.5
  • 46
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, et al. (2001) Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120: 1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3    Rizzo, W.B.4    Contos, M.J.5
  • 47
    • 0033920612 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities
    • Baxter RC, (2000) Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol- Endocrinol Metab 278: E967-E976.
    • (2000) Am J Physiol - Endocrinol Metab , vol.278 , pp. 967-976
    • Baxter, R.C.1
  • 48
    • 1642446068 scopus 로고    scopus 로고
    • Association between Insulin-Like Growth Factor-I: Insulin-Like Growth Factor-Binding Protein-1 Ratio and Metabolic and Anthropometric Factors in Men and Women
    • Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ, (2004) Association between Insulin-Like Growth Factor-I: Insulin-Like Growth Factor-Binding Protein-1 Ratio and Metabolic and Anthropometric Factors in Men and Women. Cancer Epidemiol Biomarkers Prev 13: 166-170.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 166-170
    • Sandhu, M.S.1    Gibson, J.M.2    Heald, A.H.3    Dunger, D.B.4    Wareham, N.J.5
  • 49
    • 0029797870 scopus 로고    scopus 로고
    • Insulin like growth factor-binding protein-1 as a marker for hyperinsulinemia in obese menopausal women
    • Mogul HR, Marshall M, Frey M, Burke HB, Wynn PS, et al. (1996) Insulin like growth factor-binding protein-1 as a marker for hyperinsulinemia in obese menopausal women. J Clin Endocrinol Metab 81: 4492-4495.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4492-4495
    • Mogul, H.R.1    Marshall, M.2    Frey, M.3    Burke, H.B.4    Wynn, P.S.5
  • 50
    • 0028917349 scopus 로고
    • The relationship between circulating androgens, obesity, and hyperinsulinemia on serum insulin-like growth factor binding protein-1 in the polycystic ovarian syndrome
    • Buyalos RP, Pekonen F, Halme JK, Judd HL, Rutanen E-M, (1995) The relationship between circulating androgens, obesity, and hyperinsulinemia on serum insulin-like growth factor binding protein-1 in the polycystic ovarian syndrome. Am J Obstet Gynecol 172: 932-939.
    • (1995) Am J Obstet Gynecol , vol.172 , pp. 932-939
    • Buyalos, R.P.1    Pekonen, F.2    Halme, J.K.3    Judd, H.L.4    Rutanen, E.-M.5
  • 51
    • 0024559974 scopus 로고
    • Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease
    • Suikkari A-M, Ruutiainen K, Erkkola R, Sepälä M, (1989) Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease. Hum Reprod 4: 136-139.
    • (1989) Hum Reprod , vol.4 , pp. 136-139
    • Suikkari, A.-M.1    Ruutiainen, K.2    Erkkola, R.3    Sepälä, M.4
  • 52
    • 34250860909 scopus 로고    scopus 로고
    • Identification of Androgen Response Elements in the Insulin-Like Growth Factor I Upstream Promoter
    • Wu Y, Zhao W, Zhao J, Pan J, Wu Q, et al. (2007) Identification of Androgen Response Elements in the Insulin-Like Growth Factor I Upstream Promoter. Endocrinology 148: 2984-2993.
    • (2007) Endocrinology , vol.148 , pp. 2984-2993
    • Wu, Y.1    Zhao, W.2    Zhao, J.3    Pan, J.4    Wu, Q.5
  • 53
    • 0017107380 scopus 로고
    • Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle
    • McNatty KP, Baird DT, Bolton A, Chambers P, Corker CS, et al. (1976) Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle. J Endocrinol 71: 77-85.
    • (1976) J Endocrinol , vol.71 , pp. 77-85
    • McNatty, K.P.1    Baird, D.T.2    Bolton, A.3    Chambers, P.4    Corker, C.S.5
  • 54
    • 0017888731 scopus 로고
    • A radioimmunoassay for testosterone in various biological fluids without chromatography
    • Corker CS, Davidson DW, (1978) A radioimmunoassay for testosterone in various biological fluids without chromatography. J Steroid Biochem 9: 373-374.
    • (1978) J Steroid Biochem , vol.9 , pp. 373-374
    • Corker, C.S.1    Davidson, D.W.2
  • 55
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • In: S K, S M, editors, Totowa, NJ, Humana Press
    • Rozen S, Skaletsky HJ, (2000) Primer3 on the WWW for general users and for biologist programmers. In: S K, S M, editors. Bioinformatics Methods and Protocols: Methods in Molecular Biology. 365-386 Totowa, NJ Humana Press.
    • (2000) Bioinformatics Methods and Protocols: Methods in Molecular Biology , pp. 365-386
    • Rozen, S.1    Skaletsky, H.J.2


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