Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae: A review of epidemiological and clinical aspects

Expert Opinion on Biological Therapy

Volumn 12, Issue 6, 2012, Pages 663-671

  Da Silva, Rosemeri Maurici ^a   Traebert, Jefferson ^a   Galato, Dayani ^a  

^a UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

Author keywords

Antibiotics; Antimicrobial resistance; Carbapenemase; Klebsiella pneumoniae

Indexed keywords

AMIKACIN; CEPHALOSPORIN; CIPROFLOXACIN; CLAVULANIC ACID; COLISTIN; GENTAMICIN; LEVOFLOXACIN; MEROPENEM; MINOCYCLINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TIGECYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM CULTURE; COMORBIDITY; GEOGRAPHY; HAND WASHING; HEALTH CARE PERSONNEL; HUMAN; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE CARBAPENEMASE KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LENGTH OF STAY; MINIMUM INHIBITORY CONCENTRATION; MORBIDITY; MORTALITY; NONHUMAN; PANDEMIC; PATIENT TRANSPORT; PROGNOSIS; REVIEW; UNITED STATES;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; FEMALE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT FAILURE;

KLEBSIELLA PNEUMONIAE;

EID: 84861316686     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.681369     Document Type: Review

References (47)

1. Yigit H, Queenan AM, Anderson GJ, et al. Novel cabapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001;45:1151-1161
2. Gupta N, Limbago BM, Patel JB, et al. Carbapenem-resistance Enterobacteriaceae: Epidemiology and prevention. Clin Infect Dis 2011;53:60-7
3. Queenan AM, Bush K. Carbapenemases: The versatile beta-lactamases. Clin Microbiol Rev 2007;20:440-458
4. Nordmann P, Poirel L. Emerging cabapenemases in Gram-negative aerobes. Clin Microbiol Infect 2002;8:321-331
5. Giani T, D'Andrea MM, Pecile P, et al. Emergency in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 Carbapenemase. J Clin Microbiol 2009;47:3793-3794
6. Bogaerts P, Montesinos I, Rodrigues-Villalobos H, et al. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing KPC-2 carbapenemase in Belgium. J Antimicrob Chemother 2010;65:361-376
7. Navon-Venezia S, Chmelnitsky I, Leavitt A, et al. Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel. Antimicrob Agents Chemother 2006;50:3098-3101
8. Kochar S, Sheard T, Sharma R, et al. Success of an infection control program to reduce the spread of carbapenem-resistant Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2009;30:447-452
9. Mammina C, Palma DM, Bonura C, et al. Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae carbapenemase 3 in intensive care unit in Italy. J Clin Microbiol 2010;48:1506-1507
10. Endimiani A, DePasquale JM, Forero S, et al. Emergence of blakpc-containing Klebsiella pneumoniae in a long-term acute care hospital: A new challenge to our healthcare system. J Antimicrob Chemother 2009;64:1102-1110
11. Poulou A, Spanakis N, Pournaras S, et al. Recurrent healthcare-associated community-onset infections due to Klebsiella pneumoniae producing VIM-1 metallo-beta-lactamase. J Antimicrob Chemother 2010;65:2538-2542
12. Wei ZQ, Du XX, Yu YS, et al. Plasmid-mediad KPC-2 in Klebsiella pneumoniae isolad from China. Antimicrob Agents Chemother 2007;51:763-765
13. Leavitt A, Navon-Venezia S, Chmelnitsky I, et al. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella penumoniae strains in an Israeli Hospital. Antimicrob Agents Chemother 2007;51:3026-3029
14. Nass T, Nordmann P, Vedel G, et al. Plasmid-mediated carbapenem- hydrolyzing beta-lactamase KPC in a Klebsiella pneumoniae isolate from France. Antimicrob Agents Chemother 2005;49:4423-4424
15. Woodford N, Zhang J, Warner M, et al. Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom. J Antimicrob Chemother 2008;62:1261-1264
16. Hammerum AM, Hansen F, Lester C, et al. Detection of the first two Klebsiella pneumoniae isolates with sequence type 258 producing KPC-2 carbapenemase in Denmark. Int J Antimicrob Agents 2010;35:610-612
17. Carbonne A, Thiolet JM, Fournier S, et al. Control of a multi-hospital outbreak of KCP-producing Klebsiella pneumoniae type 2 in France, September to October 2009. Euro Surveill 2010;15(48): Pii=19734-Available from: http://www. eurosurveillance.org/viewArticle.aspx? articleld=19734 [[Accessed 1 March 2011]
18. Peirano G, Seki LM, Passos VLV, et al. Carbapenem-hidrolysind beta-lactamase KPC-2 in Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil. J Antimicrob Chemother 2009;63:265-268
19. Villegas MV, Lolans K, Correa A, et al. First detection of plamid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrob Agents Chemother 2006;50:2880-2882
20. Pillai DR, Melano R, Rawte P, et al. Klebsiella pneumoniae carbapenemase, Canada. Emerg Infect Dis 2009;5:827-829
21. Adler A, Navon-Venezia S, Moran-Gilard J, et al. Laboratory and clinical evaluation of screening agar plates for the detection of carbapenem-resistant enterobacteriaceae from surveillance rectal swabs. J Clin Microbiol 2011;49(6):2239-2232
22. CDC. Centers for Disease Control and Prevention. Laboratory Protocol for Detection of Carbapenem-Resistant or Carbapenemase-Producing, Klebsiella spp. And E. coli from Rectal Swabs 2009 [Internet site]. Available from: http://www.ndhealth.gov/microlab/Uploads/Lab-Protocol-KPC.pdf [Accessed March 28 2011]
23. Landman D, Salvani JK, Bratu S, et al. Evaluation of techniques for detection of carbapenem-resistent Klebsiella penumoniae in stool surveillance cultures. J Clin Microbiol 2005;43(11):5639-5641
24. CDC. Centers for Disease Control and Prevention. Modified hodge test for carbapenemase detection in Enterobacteriaceae 2009 [Internet site]. Available from: http://www.ndhealth.gov/microlab/Uploads/HodgeTest.pdf. Accessed March 28 2011
25. Tsakris A, Krista I, Poulou A, et al. Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory. J Clin Microbiol 2009;47:362-367
26. Kitchel B, Rasheed JK, Patel JB, et al. Molecular epidemiology of (KPC)-producing Klebsiella pneumoniae isolates in the United States: Clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 2009;53:3365-3370
27. Gootz TD, Lescoe MK, Dib-Haij F, et al. Genetic organization of transponase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolate in a New York City Hospital. Antimicrob Agents Chemother 2009;53:1998-2004
28. Wolter DJ, Kurpiel PM, Woodford N, et al. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. Antimicrob Agents Chemoter 2009;53:557-562
29. Curiaou T, Morosini MI, Ruiz-Garbajosa P, et al. Emergence of blakpc3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain. J Antimicrob Chemother 2010;65:1608-1614
30. Naas T, Cuzon G, Villegas MV, et al. Genetic structures at the origen of acquisition of the beta-lactamase blakpc gene. Antimicrob Agents Chemoter 2008;52:1257-1263
31. Le J, Castanheira M, Burgess DS, et al. Clonal dissemination of Klebsiella pneumoniae carbapenemase KPC-3 in Long Beach, California. J Clin Microbiol 2010;48:623-625
32. Goldfarb D, Harvey SB, Jessamine K, et al. Detection of plasmid-mediated (KPC)-producing Klebsiella pneumoniae in Otawa, Canada: Evidence of intrahospital transmission. J Clin Microbiol 2009;47:1920-1922
33. Roche C, Cotter M. O'Connell N, et al. First identification of class A carbapenemase-producing Klebsiella pneumoniae in the Republic of Ireland. Euro Surveill 2009;14(13):pii=19163-Available from: http://www.eurosurveillance.org/ ViewArticle.aspx?ArticleId=19163
34. Gasink LB, Edelstein PH, Lautenbach E, et al. Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Infect Control Hosp Epidemiol 2009;30:1180-1185
35. Pournaras S, Krista I, Vrioni G, et al. Characteristics of meropenem heteroresistance in Klebsiella pneumoniae KPC-producing clinical isolates of K. pneumoniae. J Clin Microbiol 2010;48:2601-2604
36. Landman D, Bratu S, Quale J. Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae. J Med Microbiol 2009;58:1303-1308
37. Pournaras S, Protonotariou E, Voulgari E, et al. Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains in Greece. J Antimicrob Chemoter 2009;64:348-352
38. Souli M, Galani I, Antoniadou A, et al. An outbreak of infection due to beta-lactamase Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: Molecular characterization, epidemiology and outcomes. Clin Infect Dis 2010;50:364-373
39. Fontana C, Favaro M, Sarmati L, et al. Emergence of (KPC)-producing Klebsiella pneumoniae in Italy. BMC Res Notes 2010;3:40
40. Hirsch EB, Tam VH. Detection and treatment options for Klebsiella peneumoniae carbapenemases (KPCs): An emerging cause of multidrug-resistant infection. J Antimicrob Chemother 2010;65:1119-1125
41. Livermore DM, Warner M, Mushtaq S, et al. What remains against carbapenem-reistent Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, termocillin and tigecycline. Int J Antimicrob Chem 2011;37:415-419
42. Patel G, Huprikar S, Factor SH, et al. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008;29:1099-1106
43. Clinical and Laboratory Standards institute. CLSI M100-S20 (2010) Cephalosporins and Aztreonam breakpoint revisions Fact Sheet. Available from: http://www.clsi.org/Content/NavigationMenu/Committees/Microbiology/AST/ CephalosporinandAztreonam BreakpointRevisionFactSheet/CephalosporinAztreonam BreakpointFactSheet.pdf [Accessed 15 March 2012]
44. Schwaber MJ, Lev B, Israeli A, et al. Containment of a country-wide outbreak of carbapenem-resistant Kleibsiella peneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis 2011;52:848-855
45. Bilavsky E, Schwaber MJ, Carmeli Y. How to stem the tide of carbapenemase-producing Enterobacteriaceae? Proactive versus reactive strategies. Current Opin Infect Dis 2010;23:327-331
46. Mendes RE, Bell JM, Turnidge JD, et al. Carbapenem-resistant isolates of Klebsiella pneumoniae in China and detection of conjugative plasmid (blakpc-2 plus qnrB4) and blaIMP-4 gene. Antimicrob Agents Chemother 2008;52:789-799
47. Wendt C, Schutt S, Dalpke AH, et al. First outbreak of Klebsiella pneumoniae KPC-producing K. pneumoniae in Germany. Eur J Clin Microbiol Infect Dis 2010;29:563-570