메뉴 건너뛰기




Volumn 86, Issue 10, 2012, Pages 5885-5894

HIV-1 and HIV-2 reverse transcriptases: Different mechanisms of resistance to nucleoside reverse transcriptase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIDANOSINE; LAMIVUDINE; PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE MONOPHOSPHATE; ZIDOVUDINE TRIPHOSPHATE;

EID: 84861313397     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06597-11     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 0023656787 scopus 로고
    • Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity
    • Ahluwalia G, et al. 1987. Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity. Biochem. Pharmacol. 36:3797-3800.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 3797-3800
    • Ahluwalia, G.1
  • 2
    • 36849078038 scopus 로고    scopus 로고
    • Reverse transcription of the HIV-1 pandemic
    • Basavapathruni A, Anderson KS. 2007. Reverse transcription of the HIV-1 pandemic. FASEB J. 21:3795-3808.
    • (2007) FASEB J , vol.21 , pp. 3795-3808
    • Basavapathruni, A.1    Anderson, K.S.2
  • 3
    • 0029562206 scopus 로고
    • T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infection
    • Bofill M, Fairbanks LD, Ruckemann K, Lipman M, Simmonds HA. 1995. T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infection. J. Biol. Chem. 270:29690-29697.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29690-29697
    • Bofill, M.1    Fairbanks, L.D.2    Ruckemann, K.3    Lipman, M.4    Simmonds, H.A.5
  • 4
    • 0035031936 scopus 로고    scopus 로고
    • Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
    • Boyer PL, Sarafianos SG, Arnold E, Hughes SH. 2001. Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. J. Virol. 75:4832-4842.
    • (2001) J. Virol. , vol.75 , pp. 4832-4842
    • Boyer, P.L.1    Sarafianos, S.G.2    Arnold, E.3    Hughes, S.H.4
  • 6
    • 2642526847 scopus 로고    scopus 로고
    • Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase
    • Boyer PL, Stenbak CR, Clark PK, Linial ML, Hughes SH. 2004. Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase. J. Virol. 78:6112-6121.
    • (2004) J. Virol. , vol.78 , pp. 6112-6121
    • Boyer, P.L.1    Stenbak, C.R.2    Clark, P.K.3    Linial, M.L.4    Hughes, S.H.5
  • 7
    • 0021050706 scopus 로고
    • Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism
    • Cohen A, Barankiewicz J, Lederman HM, Gelfand EW. 1983. Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism. J. Biol. Chem. 258:12334-12340.
    • (1983) J. Biol. Chem. , vol.258 , pp. 12334-12340
    • Cohen, A.1    Barankiewicz, J.2    Lederman, H.M.3    Gelfand, E.W.4
  • 8
    • 27144549662 scopus 로고    scopus 로고
    • Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    • Deeks SG, et al. 2005. Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J. Infect. Dis. 192:1537-1544.
    • (2005) J. Infect. Dis. , vol.192 , pp. 1537-1544
    • Deeks, S.G.1
  • 9
    • 49449103962 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision
    • Delviks-Frankenberry KA, et al. 2008. HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. Proc. Natl. Acad. Sci. U. S. A. 105:10943-10948.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 10943-10948
    • Delviks-Frankenberry, K.A.1
  • 10
    • 0029585361 scopus 로고
    • Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors
    • Fairbanks LD, Bofill M, Ruckemann K, Simmonds HA. 1995. Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors. J. Biol. Chem. 270: 29682-29689.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29682-29689
    • Fairbanks, L.D.1    Bofill, M.2    Ruckemann, K.3    Simmonds, H.A.4
  • 11
    • 0034616958 scopus 로고    scopus 로고
    • The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
    • Gao HQ, Boyer PL, Sarafianos SG, Arnold E, Hughes SH. 2000. The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. J. Mol. Biol. 300:403-418.
    • (2000) J. Mol. Biol. , vol.300 , pp. 403-418
    • Gao, H.Q.1    Boyer, P.L.2    Sarafianos, S.G.3    Arnold, E.4    Hughes, S.H.5
  • 12
    • 77949567911 scopus 로고    scopus 로고
    • Reverse transcriptase in motion: conformational dynamics of enzymesubstrate interactions
    • Gotte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF. 2010. Reverse transcriptase in motion: conformational dynamics of enzymesubstrate interactions. Biochim. Biophys. Acta 1804:1202-1212.
    • (2010) Biochim. Biophys. Acta , vol.1804 , pp. 1202-1212
    • Gotte, M.1    Rausch, J.W.2    Marchand, B.3    Sarafianos, S.4    Le Grice, S.F.5
  • 13
    • 58749087228 scopus 로고    scopus 로고
    • Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resource-limited West Africa
    • Gottlieb GS, et al. 2009. Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resource-limited West Africa. Clin. Infect. Dis. 48: 476-483.
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 476-483
    • Gottlieb, G.S.1
  • 14
    • 77955702253 scopus 로고    scopus 로고
    • Retroviral reverse transcriptases
    • Herschhorn A, Hizi A. 2010. Retroviral reverse transcriptases. Cell. Mol. Life Sci. 67:2717-2747.
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 2717-2747
    • Herschhorn, A.1    Hizi, A.2
  • 15
    • 0025831249 scopus 로고
    • Catalytic properties of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2
    • Hizi A, Tal R, Shaharabany M, Loya S. 1991. Catalytic properties of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2. J. Biol. Chem. 266:6230-6239.
    • (1991) J. Biol. Chem. , vol.266 , pp. 6230-6239
    • Hizi, A.1    Tal, R.2    Shaharabany, M.3    Loya, S.4
  • 16
    • 0032573488 scopus 로고    scopus 로고
    • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance
    • Huang H, Chopra R, Verdine GL, Harrison SC. 1998. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282:1669-1675.
    • (1998) Science , vol.282 , pp. 1669-1675
    • Huang, H.1    Chopra, R.2    Verdine, G.L.3    Harrison, S.C.4
  • 17
    • 79953329829 scopus 로고    scopus 로고
    • Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations
    • Ibe S, Sugiura W. 2011. Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations. Future Microbiol. 6:295-315.
    • (2011) Future Microbiol , vol.6 , pp. 295-315
    • Ibe, S.1    Sugiura, W.2
  • 18
    • 79953293934 scopus 로고    scopus 로고
    • Differential persistence of transmitted HIV-1 drug resistance mutation classes
    • Jain V, et al. 2011. Differential persistence of transmitted HIV-1 drug resistance mutation classes. J. Infect. Dis. 203:1174-1181.
    • (2011) J. Infect. Dis. , vol.203 , pp. 1174-1181
    • Jain, V.1
  • 19
    • 67650034266 scopus 로고    scopus 로고
    • Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants
    • Jallow S, et al. 2009. Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants. J. Clin. Microbiol. 47: 2200-2208.
    • (2009) J. Clin. Microbiol. , vol.47 , pp. 2200-2208
    • Jallow, S.1
  • 20
    • 0031948662 scopus 로고    scopus 로고
    • Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance
    • Maeda Y, Venzon DJ, Mitsuya H. 1998. Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. J. Infect. Dis. 177:1207-1213.
    • (1998) J. Infect. Dis. , vol.177 , pp. 1207-1213
    • Maeda, Y.1    Venzon, D.J.2    Mitsuya, H.3
  • 21
    • 43049095987 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo
    • Martinez-Picado J, Martinez MA. 2008. HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo. Virus Res. 134:104-123.
    • (2008) Virus Res , vol.134 , pp. 104-123
    • Martinez-Picado, J.1    Martinez, M.A.2
  • 22
    • 70450228474 scopus 로고    scopus 로고
    • Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination
    • Matamoros T, Nevot M, Martinez MA, Menendez-Arias L. 2009. Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination. J. Biol. Chem. 284:32792-32802.
    • (2009) J. Biol. Chem. , vol.284 , pp. 32792-32802
    • Matamoros, T.1    Nevot, M.2    Martinez, M.A.3    Menendez-Arias, L.4
  • 23
    • 43049105858 scopus 로고    scopus 로고
    • Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase
    • Menendez-Arias L. 2008. Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase. Virus Res. 134:124-146.
    • (2008) Virus Res , vol.134 , pp. 124-146
    • Menendez-Arias, L.1
  • 24
    • 38149109662 scopus 로고    scopus 로고
    • Molecular characterization of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in Yaounde. Cameroon: evidence of major drug resistance mutations in newly diagnosed patients infected with subtypes other than subtype B
    • Ndembi N, et al. 2008. Molecular characterization of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in Yaounde, Cameroon: evidence of major drug resistance mutations in newly diagnosed patients infected with subtypes other than subtype B. J. Clin. Microbiol. 46:177-184.
    • (2008) J. Clin. Microbiol. , vol.46 , pp. 177-184
    • Ndembi, N.1
  • 26
    • 59749087787 scopus 로고    scopus 로고
    • Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2
    • Ntemgwa ML, et al. 2009. Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2. Antimicrob. Agents Chemother. 53:708-715.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 708-715
    • Ntemgwa, M.L.1
  • 27
    • 59649126954 scopus 로고    scopus 로고
    • In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine
    • Paredes R, et al. 2009. In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine. J. Virol. 83:2038-2043.
    • (2009) J. Virol. , vol.83 , pp. 2038-2043
    • Paredes, R.1
  • 28
    • 67650924884 scopus 로고    scopus 로고
    • Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility
    • Puertas MC, et al. 2009. Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility. J. Virol. 83:7434-7439.
    • (2009) J. Virol. , vol.83 , pp. 7434-7439
    • Puertas, M.C.1
  • 29
    • 42249099057 scopus 로고    scopus 로고
    • Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database
    • Ruelle J, et al. 2008. Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database. BMC Infect. Dis. 8:21.
    • (2008) BMC Infect. Dis. , vol.8 , pp. 21
    • Ruelle, J.1
  • 30
    • 34848925709 scopus 로고    scopus 로고
    • Genetic polymorphisms and resistance mutations of HIV type 2 in antiretroviral-naive patients in Burkina Faso
    • Ruelle J, et al. 2007. Genetic polymorphisms and resistance mutations of HIV type 2 in antiretroviral-naive patients in Burkina Faso. AIDS Res. Hum. Retroviruses 23:955-964.
    • (2007) AIDS Res. Hum. Retroviruses , vol.23 , pp. 955-964
    • Ruelle, J.1
  • 31
    • 9944232661 scopus 로고    scopus 로고
    • Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
    • Sarafianos SG, Das K, Hughes SH, Arnold E. 2004. Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases. Curr. Opin. Struct. Biol. 14:716-730.
    • (2004) Curr. Opin. Struct. Biol. , vol.14 , pp. 716-730
    • Sarafianos, S.G.1    Das, K.2    Hughes, S.H.3    Arnold, E.4
  • 32
    • 58149133507 scopus 로고    scopus 로고
    • Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
    • Sarafianos SG, et al. 2009. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J. Mol. Biol. 385:693-713.
    • (2009) J. Mol. Biol. , vol.385 , pp. 693-713
    • Sarafianos, S.G.1
  • 33
    • 78650891116 scopus 로고    scopus 로고
    • Effects of mutations F61A and A62V in the fingers subdomain of HIV-1 reverse transcriptase on the translocational equilibrium
    • Scarth B, McCormick S, Gotte M. 2011. Effects of mutations F61A and A62V in the fingers subdomain of HIV-1 reverse transcriptase on the translocational equilibrium. J. Mol. Biol. 405:349-360.
    • (2011) J. Mol. Biol. , vol.405 , pp. 349-360
    • Scarth, B.1    McCormick, S.2    Gotte, M.3
  • 34
    • 18244380815 scopus 로고    scopus 로고
    • Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations
    • Smith AJ, Meyer PR, Asthana D, Ashman MR, Scott WA. 2005. Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations. Antimicrob. Agents Chemother. 49:1761-1769.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 1761-1769
    • Smith, A.J.1    Meyer, P.R.2    Asthana, D.3    Ashman, M.R.4    Scott, W.A.5
  • 35
    • 33646519924 scopus 로고    scopus 로고
    • The influence of natural substrates and inhibitors on the nucleotide-dependent excision activity of HIV-1 reverse transcriptase in the infected cell
    • Smith AJ, Scott WA. 2006. The influence of natural substrates and inhibitors on the nucleotide-dependent excision activity of HIV-1 reverse transcriptase in the infected cell. Curr. Pharm. Des. 12:1827-1841.
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 1827-1841
    • Smith, A.J.1    Scott, W.A.2
  • 36
    • 65649146417 scopus 로고    scopus 로고
    • Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance
    • Smith RA, Anderson DJ, Pyrak CL, Preston BD, Gottlieb GS. 2009. Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance. J. Infect. Dis. 199: 1323-1326.
    • (2009) J. Infect. Dis. , vol.199 , pp. 1323-1326
    • Smith, R.A.1    Anderson, D.J.2    Pyrak, C.L.3    Preston, B.D.4    Gottlieb, G.S.5
  • 37
    • 79958823885 scopus 로고    scopus 로고
    • Drug resistance mutations in patients infected with HIV-2 living in Spain
    • Trevino A, et al. 2011. Drug resistance mutations in patients infected with HIV-2 living in Spain. J. Antimicrob. Chemother. 66:1484-1488.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1484-1488
    • Trevino, A.1
  • 38
    • 77957797787 scopus 로고    scopus 로고
    • Structural basis of HIV-1 resistance to AZT by excision
    • Tu X, et al. 2010. Structural basis of HIV-1 resistance to AZT by excision. Nat. Struct. Mol. Biol. 17:1202-1209.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 1202-1209
    • Tu, X.1
  • 39
    • 0028784434 scopus 로고
    • Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates
    • Ueno T, Shirasaka T, Mitsuya H. 1995. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates. J. Biol. Chem. 270: 23605-23611.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23605-23611
    • Ueno, T.1    Shirasaka, T.2    Mitsuya, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.