Enhanced expressions of apelin on proliferative hepatic arterial capillaries in human cirrhotic liver

Hepatology Research

Volumn 42, Issue 5, 2012, Pages 508-514

  Yokomori, Hiroaki ^a   Oda, Masaya ^c   Yoshimura, Kazunori ^b   Hibi, Toshifumi ^d  

^a KITASATO UNIVERSITY   (Japan)

^b NIHON INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

Apelin; Cirrhosis; Hepatic arterial capillary; Portal hypertension

Indexed keywords

APELIN;

ARTERIOLE; ARTICLE; CAPILLARY; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENDOTHELIUM CELL; GENE EXPRESSION; HEPATIC ARTERY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; LIVER; LIVER CIRRHOSIS; MICROSCOPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RATING SCALE; WESTERN BLOTTING;

EID: 84861313011     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00945.x     Document Type: Article

References (22)

1. Tatemoto K, Hosoya M, Habata Y et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998;251: 471-76.
2. Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine. Pharmacol Ther 2005; 107: 198-211.
3. McCuskey RS, Reilly FD. Hepatic microvasculature: dynamic structure and its regulation. Semin Liver Dis 1993;13: 1-12.
4. Saint-Geniez M, Masri B, Malecaze F, Knibiehler B, Audigier Y. Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mech Dev 2002; 110: 183-86.
5. Cox CM, D'Agostino SL, Miller MK, Heimark RL, Krieg PA. Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Dev Biol 2006; 296: 177-89.
6. Principe A, Melgar-Lesmes P, Fernández-Varo G et al. The hepatic apelin system: a new therapeutic target for liver disease. Hepatology 2008; 48: 1193-201.
7. Melgar-Lesmes P, Casals G, Pauta M et al. Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells. Endocrinology 2010; 151: 5306-14.
8. Yokomori H, Oda M, Yoshimura K, Machida S, Kaneko F, Hibi T. Overexpression of apelin receptor (APJ/AGTRL1) on hepatic stellate cells and sinusoidal angiogenesis in human cirrhotic liver. J Gastroenterol 2011; 46: 222-31.
9. Melgar-Lesmes P, Pauta M, Reichenbach V et al. Hypoxia and proinflammatory factors upregulate apelin receptor expression in human stellate cells and hepatocytes. Gut 2011; 60: 1404-11.
10. Lam CM, Fan ST, Low CM, Wong J. Major hepatectomy for hepatocellular carcinoma in patients with an unsatisfactory indocyanine green clearance test. Br J Surg 1999; 86:1012-17.
11. Schutze K, Posl H, Lahr G. Laser micromanipulation systems as universal tools in cellular and molecular biology and in medicine. Cell Mol Biol (Noisy-le-grand) 1998; 44: 735-46.
12. Emmert-Buck MR, Bonner RF, Smith PD et al. Laser capture microdissection. Science 1996; 274: 998-1001.
13. Humbel BM, Sibon OC, Stierhof Y-D, Schwarz H. Ultrasmall gold particles and silver enhancement as a detection system in immunolabeling and in situ hybridization. J Histochem Cytochem 1995; 43: 735-37.
14. Japp AG, Newby DE. The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential. Biochem Pharmacol 2008; 75: 1882-92.
15. Oda M, Azuma T, Nishizaki Y et al. Alterations of hepatic sinusoids in liver cirrhosis: their involvement in the pathogenesis of portal hypertension. J Gastroenterol Hepatol 1989;4 (Suppl 1): 111-3.
16. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008; 88:125-72.
17. Tugues S, Fernandez-Varo G, Munoz-Luque J et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 2007; 46: 1919-26.
18. Kidoya H, Ueno M, Yamada Y et al. Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J 2008; 27:522-34.
19. Schlingemann RO, Rietveld FJ, de Waal RM et al. Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma. Lab Invest 1990; 62: 690-96.
20. Di Carlo I, Fraggetta F, Lombardo R, Azzarello G, Vasquez E, Puleo S. CD 34 expression in chronic and neoplastic liver diseases. Panminerva Med 2002; 44: 365-7.
21. Masri B, Knibiehler B, Audigier Y. Apelin signalling: a promising pathway from cloning to pharmacology. Cell Signal 2005; 17: 415-26.
22. Medina J, Arroyo AG, Sanchez-Madrid F, Moreno-Otero R. Angiogenesis in chronic inflammatory liver disease. Hepatology 2004; 39: 1185-95.