Overexpression of apelin receptor (APJ/AGTRL1) on hepatic stellate cells and sinusoidal angiogenesis in human cirrhotic liver

Journal of Gastroenterology

Volumn 46, Issue 2, 2011, Pages 222-231

  Yokomori, Hiroaki ^a   Oda, Masaya ^b   Yoshimura, Kazunori ^c   MacHida, Sanae ^d   Kaneko, Fumihiko ^a   Hibi, Toshifumi ^e  

^a KITASATO UNIVERSITY   (Japan)

^b INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c NIHON INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

^e KEIO UNIVERSITY   (Japan)

Author keywords

Apelin receptor; Liver cirrhosis; Vascular remodeling

Indexed keywords

APELIN RECEPTOR;

AGED; ANGIOGENESIS; ARTICLE; CAPILLARY; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CIRRHOSIS; LIVER HOMOGENATE; LIVER RESECTION; LIVER SINUSOID; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STELLATE CELL; TISSUE SECTION; VASCULAR ENDOTHELIUM;

AGED; AGED, 80 AND OVER; ARTERIES; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; HEPATIC STELLATE CELLS; HEPATIC VEINS; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; NEOVASCULARIZATION, PATHOLOGIC; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, G-PROTEIN-COUPLED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79954444215     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0296-3     Document Type: Article

References (27)

1. S Chung T Funakoshi O Civelli 2008 Orphan PCR research Br J Pharmacol 153 Suppl 1 S339 S346 1:CAS:528:DC%2BD1cXislSjtLk%3D 18071299
2. BF O'Dowd M Heiber A Chan HH Heng LC Tsui JL Kennedy, et al. 1993 A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 Gene 136 355 360 10.1016/0378-1119(93)90495-O 8294032 (Pubitemid 24049270)
3. K Tatemoto M Hosoya Y Habata R Fujii T Kakegawa MX Zou, et al. 1998 Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor Biochem Biophys Res Commun 251 471 476 1:CAS:528: DyaK1cXmvF2msbY%3D 10.1006/bbrc.1998.9489 9792798 (Pubitemid 28505047)
4. MM Chen EA Ashley DX Deng A Tsalenko A Deng R Tabibiazar, et al. 2003 A novel role for the potent endogenous inotrope apelin in human cardiac dysfunction Circulation 108 1432 1439 1:CAS:528:DC%2BD3sXntlarur0%3D 10.1161/01.CIR.0000091235.94914.75 12963638 (Pubitemid 37176447)
5. MJ Kleinz AP Davenport 2004 Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells Regul Pept 118 119 125 1:CAS:528:DC%2BD2cXhvFajurw%3D 10.1016/j.regpep.2003.11.002 15003827 (Pubitemid 38296725)
6. MJ Kleinz JN Skepper AP Davenport 2005 Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells Regul Pept 126 233 240 1:CAS:528:DC%2BD2MXmsVCgtg%3D%3D 10.1016/j.regpep.2004.10.019 15664671 (Pubitemid 40128188)
7. AY Sheikh HJ Chun AJ Glassford RK Kundu I Kutschka D Ardigo, et al. 2008 In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure Am J Physiol Heart Circ Physiol 294 H88 H98 1:CAS:528: DC%2BD1cXhtVKisb4%3D 10.1152/ajpheart.00935.2007 17906101
8. J Ishida T Hashimoto Y Hashimoto S Nishiwaki T Iguchi S Harada, et al. 2004 Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo J Biol Chem 279 26274 26279 1:CAS:528:DC%2BD2cXkvVWgs7s%3D 10.1074/jbc.M404149200 15087458 (Pubitemid 38798776)
9. E Ashley HJ Chun T Quertermous 2006 Opposing cardiovascular roles for the angiotensin and apelin signaling pathways J Mol Cell Cardiol 41 778 781 1:CAS:528:DC%2BD28XhtFenurzL 10.1016/j.yjmcc.2006.08.013 17005196 (Pubitemid 44635576)
10. AG Japp DE Newby 2008 The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential Biochem Pharmacol 75 1882 1892 1:CAS:528:DC%2BD1cXlsFOmsr4%3D 10.1016/j.bcp.2007.12.015 18272138
11. A Principe P Melgar-Lesmes G Fernández-Varo LR Del Arbol J Ros M Morales-Ruiz, et al. 2008 The hepatic apelin system: a new therapeutic target for liver disease Hepatology 48 1193 1201 1:CAS:528:DC%2BD1cXht1Khu7%2FP 10.1002/hep.22467 18816630
12. R Mancini AM Jezequel A Benedetti F Paolucci L Trozzi F Orlandi 1992 Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine- induced cirrhosis. An immunohistochemical study J Hepatol 15 361 366 1:STN:280:DyaK3s%2Fnsl2gsQ%3D%3D 10.1016/0168-8278(92)90069-2 1447503
13. M Pinzani L Gesualdo GM Sabbah HE Abboud 1989 Effects of platelet derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells J Clin Invest 84 1786 1793 1:CAS:528:DyaK3cXkvFCgtg%3D%3D 10.1172/JCI114363 2592560 (Pubitemid 20016182)
14. Y Fukuda H Nagura M Imoto Y Koyama 1986 Immunohistochemical studies of structural changes of the hepatic lobules in chronic liver diseases Am J Gastroenterol 81 1149 1155 1:STN:280:DyaL2s%2Fntlelsg%3D%3D 3098090 (Pubitemid 17216843)
15. H Yokomori M Oda K Yoshimura T Nagai K Fujimaki S Watanabe, et al. 2009 Caveolin-1 and Rac regulate endothelial capillary-like tubular formation and fenestral contraction in sinusoidal endothelial cells Liver Int 29 266 276 1:CAS:528:DC%2BD1MXisV2ruro%3D 10.1111/j.1478-3231.2008.01891.x 19067793
16. CM Lam ST Fan CM Lo J Wong 1999 Major hepatectomy for hepatocellular carcinoma in patients with an unsatisfactory indocyanine green clearance test Br J Surg 86 1012 1017 1:STN:280:DyaK1MzptVahtA%3D%3D 10.1046/j.1365-2168.1999. 01204.x 10460635 (Pubitemid 29387065)
17. PW Hamilton DC Allen 1995 Morphometry in histopathology J Pathol 175 369 379 1:STN:280:DyaK2MzhtFSktQ%3D%3D 10.1002/path.1711750403 7790990
18. K Schutze H Posl G Lahr 1998 Laser micromanipulation systems as universal tools in cellular and molecular biology and in medicine Cell Mol Biol (Noisy-le-grand) 44 735 746 1:CAS:528:DyaK1cXmsVKhsrs%3D
19. MR Emmert-Buck RF Bonner PD Smith RF Chuaqui Z Zhuang SR Goldstein, et al. 1996 Laser capture microdissection Science 274 998 1001 1:CAS:528: DyaK28XmslKmt78%3D 10.1126/science.274.5289.998 8875945 (Pubitemid 26398425)
20. BM Humbel OC Sibon Y-D Stierhof H Schwarz 1995 Ultra-small gold particles and silver enhancement as a detection system in immunolabeling and in situ hybridization J Histochem Cytochem 43 735 737 1:STN:280:DyaK2Mzjt1Ojtg%3D%3D 7608530
21. R Bataller P Sancho-Bru P Ginès JM Lora A Al-Garawi M Solé, et al. 2003 Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II Gastroenterology 125 117 125 1:CAS:528:DC%2BD3sXmtVWqur4%3D 10.1016/S0016-5085(03)00695-4 12851877 (Pubitemid 36799113)
22. P Lindahl BR Johansson P Leveen C Betsholtz 1997 Pericyte loss and microaneurysm formation in PDGF-B-deficient mice Science 277 242 245 1:CAS:528:DyaK2sXksFCksb0%3D 10.1126/science.277.5323.242 9211853 (Pubitemid 27446080)
23. A Kasai N Shintani M Oda M Kakuda H Hashimoto T Matsuda, et al. 2004 Apelin is a novel angiogenic factor in retinal endothelial cells Biochem Biophys Res Commun 325 395 400 1:CAS:528:DC%2BD2cXpsVOlsr0%3D 10.1016/j.bbrc.2004.10. 042 15530405 (Pubitemid 39458008)
24. SC Sorli L Van den Berghe B Masri B Knibiehler Y Audigier 2006 Therapeutic potential of interfering with apelin signalling Drug Discov Today 11 1100 1106 1:CAS:528:DC%2BD28Xht1eqtb%2FE 10.1016/j.drudis.2006.10.011 17129829 (Pubitemid 44792480)
25. T Hashimoto M Kihara J Ishida N Imai S Yoshida Y Toya, et al. 2006 Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells Arterioscler Thromb Vasc Biol 26 1267 1272 1:CAS:528:DC%2BD28XksVGlsrk%3D 10.1161/01.ATV.0000218841.39828.91 16556853 (Pubitemid 44305369)
26. C Tiani E Garcia-Pras M Mejias A de Gottardi A Berzigotti J Bosch, et al. 2009 Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension J Hepatol 50 296 305 1:CAS:528:DC%2BD1MXntVGhtw%3D%3D 10.1016/j.jhep.2008.09.019 19070926
27. B Masri H Lahlou H Mazarguil B Knibiehler Y Audigier 2002 Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein Biochem Biophys Res Commun 290 539 545 1:CAS:528:DC%2BD38XhsFCksA%3D%3D 10.1006/bbrc.2001.6230 11779205 (Pubitemid 34694535)