MDA-7/IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Tian, Hui ^a   Wang, Jing ^a   Zhang, BaoFu ^a   Di, JieHui ^a   Chen, FeiFei ^a   Li, HuiZhong ^a   Li, LianTao ^a   Pei, DongSheng ^a   Zheng, JunNian ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; 26S PROTEASOME; AURANOFIN; CASPASE; CONDITIONALLY REPLICATING ADENOVIRUS; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 24; NITRIC OXIDE; PROTEASOME; PROTEIN BCL 2; SMALL INTERFERING RNA; THIOREDOXIN REDUCTASE 1; UBIQUITIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DENITROSYLATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME REGULATION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MELANOMA CELL; NITROSYLATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; HELA CELLS; HUMANS; INTERLEUKINS; NEOPLASMS; NITRIC OXIDE DONORS; NITROPRUSSIDE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UBIQUITIN;

ADENOVIRIDAE;

EID: 84861313000     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037200     Document Type: Article

References (39)

1. Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB, (1995) Subtraction hybridization identifies a novel melanoma differentiation associated gene, MDA-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11: 2477-2486.
2. Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CSH, et al. (1996) The melanoma differentiation associated gene MDA-7 suppresses cancer cell growth. Proc Natl Acad Sci USA 93: 9160-9165.
3. Fickenscher H, Hor S, Kupers H, Knappe A, Wittmann S, et al. (2002) The interleukin-10 family of cytokines. Trends Immunol 23: 89-96.
4. Gupta P, Su ZZ, Lebedeva IV, Sarkar D, Sauane M, et al. (2006) MDA-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine. Pharmacol Ther 111: 596-628.
5. Su ZZ, Lebedeva IV, Sarkar D, Gopalkrishnan RV, Sauane M, et al. (2003) Melanoma differentiation associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner. Oncogene 22: 1164-1180.
6. Yacoub A, Mitchell C, Lebedeva IV, Sarkar D, Su ZZ, et al. (2003) MDA-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling. Cancer Biol Ther 2: 347-353.
7. Lebedeva IV, Su ZZ, Sarkar D, Kitada S, Dent P, et al. (2003) Melanoma differentiation associated gene-7, MDA-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. Cancer Res. 63: 8138-8144.
8. Lebedeva IV, Sarkar D, Su ZZ, Kitada S, Dent P, et al. (2003) Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, MDA-7/IL-24. Oncogene 22: 8758-8773.
9. Fisher PB, (2005) Is MDA-7/IL-24 a "magic bullet" for cancer? Cancer Res 65: 10128-10138.
10. Lebedeva IV, Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, et al. (2005) MDA-7/IL-24: exploiting cancer's Achilles' heel. Mol Ther 11: 4-18.
11. Lebedeva IV, Sarkar D, Su ZZ, Gopalkrishnan RV, Athar M, et al. (2006) Molecular target-based therapy of pancreatic cancer. Cancer Res 66: 2403-2413.
12. Su Z, Lebedeva IV, Gopalkrishnan RV, Goldstein NI, Stein CA, et al. (2001) A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. Proc Natl Acad Sci U S A 98: 10332-10337.
13. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD, (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136.
14. Osford SM, Dallman CL, Johnson PW, Ganesan A, Packham G, (2004) Current strategies to target the anti-apoptotic Bcl-2 protein in cancer cells. Curr Med Chem 11: 1031-1039.
15. Liu XY, Gu JF, (2006) Targeting gene-virotherapy of cancer. Cell Res 16: 25-30.
16. Azad N, Vallyathan V, Wang L, Tantishaiyakul V, Stehlik C, et al. (2006) S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis. J Biol Chem 281: 34124-34134.
17. Cory S, Adams JM, (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656.
18. Breitschopf K, Haendeler J, Malchow P, Zeiher AM, Dimmeler S, (2000) Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol Cell Biol 20: 1886-1896.
19. Schinzel A, Kaufmann T, Borner C, (2004) Bcl-2 family members: integrators of survival and death signals in physiology and pathology. Biochim Biophys Acta 1644 (2-3): 95-105.
20. Kutuk O, Letai A, (2008) Regulation of Bcl-2 family proteins by posttranslational modifications. Curr Mol Med 8 (2): 102-18.
21. Stamler JS, Lamas S, Fang FC, (2001) Nitrosylation. the prototypic redox-based signaling mechanism. Cell 106: 675-683.
22. Knowles RG, Moncada S, (1994) Nitric oxide synthases in mammals. Biochem J 298: 249-258.
23. Azad N, Iyer AK, Wang L, Lu Y, Medan D, et al. (2010) Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells. Am J Respir Cell Mol Biol 42: 578-585.
24. Ekmekcioglu S, Ellerhorst J, Smid CM, Prieto VG, Munsell M, et al. (2000) Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. Clin Cancer Res 6: 4768-4775.
25. Ekmekcioglu S, Ellerhorst JA, Mumm JB, Zheng M, Broemeling L, et al. (2003) Negative association of melanoma differentiation-associated gene (MDA-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. Mol Cancer Ther 2: 9-17.
26. Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS, (2005) Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 6: 150-166.
27. Chanvorachote P, Nimmannit U, Stehlik C, Wang L, Jiang BH, et al. (2006) Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination. Cancer Res 66: 6353-6360.
28. Grandgirard D, Studer E, Monney L, Belser T, Fellay I, et al. (1998) Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J 17: 1268-1278.
29. Lebedeva IV, Sarkar D, Su ZZ, Kitada S, Dent P, et al. (2003) Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, MDA-7/IL-24. Oncogene 22: 8758-8773.
30. Ekmekcioglu S, Mumm JB, Udtha M, Chada S, Grimm EA, (2008) Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24. Cytokine 43 (1): 34-44.
31. Mannick JB, Schonhoff CM, (2002) Nitrosylation: the next phosphorylation? Arch Biochem Biophys 408 (1): 1-6.
32. Benhar M, Forrester MT, Stamler JS, (2009) Protein denitrosylation: enzymatic mechanisms and cellular functions. Nat Rev Mol Cell Biol 10: 721-732.
33. Benhar M, Forrester MT, Hess DT, Stamler JS, (2008) Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. Science 320: 1050-1054.
34. Forrester MT, Foster MW, Stamler JS, (2007) Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. J Biol Chem 282: 13977-13983.
35. Mannick JB, Hausladen A, Liu L, Hess DT, Zeng M, et al. (1999) Fas-induced caspase denitrosylation. Science 284: 651-654.
36. Marshall HE, Stamler JS, (2001) Inhibition of NF-kappa B by S-nitrosylation. Biochemistry 40: 1688-1693.
37. Hoffmann J, Haendeler J, Zeiher AM, Dimmeler S, (2001) TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells. J Biol Chem 276: 41383-41387.
38. Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, et al. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304: 1328-1331.
39. Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, et al. (2005) S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem 280: 7511-7518.