Restored PB1-F2 in the 2009 pandemic H1N1 influenza virus has minimal effects in swine

Journal of Virology

Volumn 86, Issue 10, 2012, Pages 5523-5532

  Pena, Lindomar ^a   Vincent, Amy L ^b   Loving, Crystal L ^b   Henningson, Jamie N ^b   Lager, Kelly M ^b   Lorusso, Alessio ^b   Pereza, Daniel R ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AMINO ACID; INTERLEUKIN 1BETA; PROTEIN PB1 F2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

2009 H1N1 INFLUENZA; ANIMAL TISSUE; ARTICLE; BRONCHITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DISEASE SEVERITY; LUNG PARENCHYMA; NONHUMAN; OPEN READING FRAME; PANDEMIC INFLUENZA; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SWINE; UPREGULATION; VIRUS REPLICATION; VIRUS SHEDDING; VIRUS VIRULENCE;

ANIMALS; CELL LINE; CYTOKINES; HOST SPECIFICITY; INFLUENZA A VIRUS, H1N1 SUBTYPE; LUNG; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; RECOMBINATION, GENETIC; SWINE; SWINE DISEASES; VIRAL PROTEINS;

AVES; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE; SUIDAE; SUS; SUS SCROFA DOMESTICA;

EID: 84861302762     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00134-12     Document Type: Article

References (78)

1. Al Hajjar S, McIntosh K. 2010. The first influenza pandemic of the 21st century. Ann. Saudi Med. 30:1-10.
2. Barnard DL. 2009. Animal models for the study of influenza pathogenesis and therapy. Antiviral Res. 82:A110 -A122.
3. Basler CF, Aguilar PV. 2008. Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses. Antiviral Res. 79:166 -178.
4. Britton AP, Sojonky KR, Scouras AP, Bidulka JJ. 2010. Pandemic (H1N1) 2009 in skunks, Canada. Emerg. Infect. Dis. 16:1043-1045.
5. Brockmeier SL, et al. 2009. Adenovirus-mediated expression of interferonalpha delays viral replication and reduces disease signs in swine challenged with porcine reproductive and respiratory syndrome virus. Viral Immunol. 22:173-180.
6. Brookes SM, et al. 2009. Influenza A (H1N1) infection in pigs. Vet. Rec. 164:760 -761.
7. Chan MC, et al. 2010. Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract. Am. J. Pathol. 176:1828 -1840.
8. Chen CJ, et al. 2010. Differential localization and function of PB1-F2 derived from different strains of influenza A virus. J. Virol. 84:10051- 10062.
9. Chen H, et al. 2007. Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice. Virus Res. 128:159- 163.
10. Chen W, et al. 2001. A novel influenza A virus mitochondrial protein that induces cell death. Nat. Med. 7:1306 -1312.
11. Conenello GM, Palese P. 2007. Influenza A virus PB1-F2: a small protein with a big punch. Cell Host Microbe 2:207-209.
12. Conenello GM, Zamarin D, Perrone LA, Tumpey T, Palese P. 2007. A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog. 3:1414 -1421.
13. Dawood FS, et al. 2009. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med. 360:2605-2615.
14. Dundon WG, De Benedictis P, Viale E, Capua I. 2010. Serologic evidence of pandemic (H1N1) 2009 infection in dogs, Italy. Emerg. Infect. Dis. 16:2019 -2021.
15. Garten RJ, et al. 2009. Antigenic and genetic characteristics of swineorigin 2009 A(H1N1) influenza viruses circulating in humans. Science 325:197-201.
16. Gauger PC, et al. 2011. Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Vaccine 29:2712- 2719.
17. Gibbs AJ, Armstrong JS, Downie JC. 2009. From where did the 2009 'swine-origin' influenza A virus (H1N1) emerge? Virol. J. 6:207.
18. Graef KM, et al. 2010. The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon. J. Virol. 84:8433- 8445.
19. Hai R, et al. 2010. PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models. J. Virol. 84:4442- 4450.
20. Halbur PG, et al. 1995. Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol. 32:648-660.
21. Hale BG, Randall RE, Ortin J, Jackson D. 2008. The multifunctional NS1 protein of influenza A viruses. J. Gen. Virol. 89:2359 -2376.
22. Hatta M, Gao P, Halfmann P, Kawaoka Y. 2001. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293:1840- 1842.
23. Hayden FG, et al. 1998. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J. Clin. Invest. 101:643- 649.
24. Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. 2000. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. U. S. A. 97:6108-6113.
25. Hofshagen M, et al. 2009. Pandemic influenza A(H1N1)v: human to pig transmission in Norway? Euro Surveill. 14(45). pii:19406.
26. Howard WA, et al. 2011. Reassortant pandemic (H1N1) 2009 virus in pigs, United Kingdom. Emerg. Infect. Dis. 17:1049 -1052.
27. Howden KJ, et al. 2009. An investigation into human pandemic influenza virus (H1N1) 2009 on an Alberta swine farm. Can. Vet. J. 50:1153-1161.
28. Ito T, et al. 1998. Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J. Virol. 72:7367-7373.
29. Itoh Y, et al. 2009. In vitro and in vivo characterization of new swineorigin H1N1 influenza viruses. Nature 460:1021-1025.
30. Kida H, et al. 1994. Potential for transmission of avian influenza viruses to pigs. J. Gen. Virol. 75:2183-2188.
31. Kimble B, Nieto GR, Perez DR. 2010. Characterization of influenza virus sialic acid receptors in minor poultry species. Virol. J. 7:365.
32. Lange E, et al. 2009. Pathogenesis and transmission of the novel swineorigin influenza virus A/H1N1 after experimental infection of pigs. J. Gen. Virol. 90:2119 -2123.
33. Le Goffic R, et al. 2010. Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells. J. Immunol. 185:4812- 4823.
34. Loving CL, et al. 2010. Influenza virus coinfection with Bordetella bronchiseptica enhances bacterial colonization and host responses exacerbating pulmonary lesions. Microb. Pathog. 49:237-245.
35. Ma W, et al. 2011. 2009 Pandemic H1N1 influenza virus causes disease and upregulation of genes related to inflammatory and immune responses, cell death, and lipid metabolism in pigs. J. Virol. 85:11626- 11637.
36. Maes L, Haesebrouck F, Pensaert M. 1984. Experimental reproduction of clinical disease by intratracheal inoculation of fattening pigs with swine influenza virus isolates. Proc. Int. Congr. Pig Vet. Soc. 8:60.
37. Mathieu C, et al. 2010. Pandemic (H1N1) 2009 in breeding turkeys, Valparaiso, Chile. Emerg. Infect. Dis. 16:709 -711.
38. Mazur I, et al. 2008. The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell. Microbiol. 10:1140 -1152.
39. McAuley JL, et al. 2010. PB1-F2 proteins from H5N1 and 20th century pandemic influenza viruses cause immunopathology. PLoS Pathog. 6:e1001014.
40. McAuley JL, et al. 2007. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2:240 -249.
41. McAuley JL, Zhang K, McCullers JA. 2010. The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis. J. Virol. 84:558 -564.
42. Moreno A, et al. 2011. Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus. Vet. Microbiol. 149: 472-477.
43. Myers KP, Olsen CW, Gray GC. 2007. Cases of swine influenza in humans: a review of the literature. Clin. Infect. Dis. 44:1084 -1088.
44. Nelli RK, et al. 2010. Comparative distribution of human and avian type sialic acid influenza receptors in the pig. BMC Vet. Res. 6:4.
45. Newman AP, et al. 2008. Human case of swine influenza A (H1N1) triple reassortant virus infection, Wisconsin. Emerg. Infect. Dis. 14:1470 -1472.
46. Nofs S, et al. 2009. Influenza virus A (H1N1) in giant anteaters (Myrmecophaga tridactyla). Emerg. Infect. Dis. 15:1081-1083.
47. Ozawa M, et al. 2011. Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses. J. Virol. 85:4596-4601.
48. Pappas C, et al. 2008. Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus. Proc. Natl. Acad. Sci. U. S. A. 105:3064 -3069.
49. Pena L, et al. 2011. Modifications in the polymerase genes of a swine-like triple reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses. J. Virol. 85:456-469.
50. Pereda A, et al. 2010. Pandemic (H1N1) 2009 outbreak on pig farm, Argentina. Emerg. Infect. Dis. 16:304 -307.
51. Pereda A, et al. 2011. Evidence of reassortment of pandemic H1N1 influenza virus in swine in Argentina: are we facing the expansion of potential epicenters of influenza emergence? Influenza Other Respi. Viruses 5:409-412.
52. Reed LJ, Muench H. 1938. A simple method for estimating 50 percent endpoints. Am. J. Hyg. 37:493.
53. Robb NC, Smith M, Vreede FT, Fodor E. 2009. NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J. Gen. Virol. 90:1398 -1407.
54. Robinson JL, et al. 2007. Swine influenza (H3N2) infection in a child and possible community transmission, Canada. Emerg. Infect. Dis. 13:1865- 1870.
55. Shinya K, et al. 2006. Avian flu: influenza virus receptors in the human airway. Nature 440:435- 436.
56. Smith AM, et al. 2011. Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics. PLoS Comput. Biol. 7:e1001081.
57. Smith GJ, et al. 2009. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122-1125.
58. Song MS, et al. 2010. Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea. J. Clin. Microbiol. 48:3204 -3211.
59. Sponseller BA, et al. 2010. Influenza A pandemic (H1N1) 2009 virus infection in domestic cat. Emerg. Infect. Dis. 16:534 -537.
60. Starick E, et al. 2011. Reassorted pandemic (H1N1) 2009 influenza A virus discovered from pigs in Germany. J. Gen. Virol. 92:1184 -1188.
61. Swenson SL, et al. 2010. Natural cases of 2009 pandemic H1N1 influenza A virus in pet ferrets. J. Vet. Diagn. Invest. 22:784 -788.
62. Taubenberger JK, Kash JC. 2010. Influenza virus evolution, host adaptation, and pandemic formation. Cell Host Microbe 7:440-451.
63. Trifonov V, Rabadan R. 2009. The contribution of the PB1-F2 protein to the fitness of influenza A viruses and its recent evolution in the 2009 influenza A (H1N1) pandemic virus. PLoS Curr. 1:RRN1006.
64. Tscherne DM, Garcia-Sastre A. 2011. Virulence determinants of pandemic influenza viruses. J. Clin. Invest. 121:6 -13.
65. Van Poucke SG, Nicholls JM, Nauwynck HJ, Van Reeth K. 2010. Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution. Virol. J. 7:38.
66. Van Reeth K. 2000. Cytokines in the pathogenesis of influenza. Vet. Microbiol. 74:109 -116.
67. Van Reeth K, Labarque G, Nauwynck H, Pensaert M. 1999. Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res. Vet. Sci. 67:47-52.
68. Van Reeth K, Van Gucht S, Pensaert M. 2002. Correlations between lung proinflammatory cytokine levels, virus replication, and disease after swine influenza virus challenge of vaccination-immune pigs. Viral Immunol. 15:583-594.
69. Vijaykrishna D, et al. 2010. Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 328:1529.
70. Vincent AL, et al. 2010. Experimental inoculation of pigs with pandemic H1N1 2009 virus and HI cross-reactivity with contemporary swine influenza virus antisera. Influenza Other Respi. Viruses 4:53- 60.
71. Vincent AL, et al. 2009. Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States. Vet. Microbiol. 137:51-59.
72. Vincent LL, Janke BH, Paul PS, Halbur PG. 1997. A monoclonalantibody-based immunohistochemical method for the detection of swine influenza virus in formalin-fixed, paraffin-embedded tissues. J. Vet. Diagn. Invest. 9:191-195.
73. Wan H, Perez DR. 2006. Quail carry sialic acid receptors compatible with binding of avian and human influenza viruses. Virology 346:278 -286.
74. Watanabe T, et al. 2009. Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc. Natl. Acad. Sci. U. S. A. 106:588 -592.
75. Weingartl HM, et al. 2009. Experimental infection of pigs with the human 1918 pandemic influenza virus. J. Virol. 83:4287- 4296.
76. Ye J, et al. 2010. Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype? PLoS Pathog. 6:e1001145.
77. Zamarin D, Ortigoza MB, Palese P. 2006. Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J. Virol. 80:7976 -7983.
78. Zell R, et al. 2007. Prevalence of PB1-F2 of influenza A viruses. J. Gen. Virol. 88:536 -546.