Early cardiac dysfunction is rescued by upregulation of SERCA2a pump activity in a rat model of metabolic syndrome

Acta Physiologica

Volumn 205, Issue 3, 2012, Pages 381-393

  Miklos Z ^a   Kemecsei, P ^a   Biro T ^b   Marincsak R ^b   Toth B I ^b   Op den Buijs, J ^c   Benis, E ^a   Drozgyik, A ^a   Ivanics, T ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Cai 2+ handling; Echocardiography; Isolated hearts; Metabolic syndrome; SERCA2a

Indexed keywords

CALCIUM; CYCLOPIAZONIC ACID; FRUCTOSE; INDO 1; PHOSPHOLAMBAN; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DYSLIPIDEMIA; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME KINETICS; FLUOROMETRY; HEART DISEASE; HEART HEMODYNAMICS; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; INSULIN RESISTANCE; ISOLATED HEART; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; HEART; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MODELS, THEORETICAL; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; UP-REGULATION;

EID: 84861235480     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2012.02420.x     Document Type: Article

References (49)

1. Adeghate, E. 2004. Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review. Mol Cell Biochem 261, 187-191.
2. Aiba, T. & Tomaselli, G.F. 2010. Electrical remodeling in the failing heart. Curr Opin Cardiol 25, 29-36.
3. Arai, M., Matsui, H. & Periasamy, M. 1994. Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure. Circ Res 74, 555-564.
4. Arnlöv, J., Ingelsson, E., Sundström, J. & Lind, L. 2010. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 121, 230-236.
5. Asghar, O., Al-Sunni, A., Khavandi, K., Khavandi, A., Withers, S., Greenstein, A., Heagerty, A.M. & Malik, R.A. 2009. Diabetic cardiomyopathy. Clin Sci (Lond) 116, 741-760.
6. Babujanarthanam, R., Kavitha, P., Mahadeva Rao, U.S. & Pandian, M.R. 2011. Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. Mol Cell Biochem 358, 121-129.
7. Balke, C.W., Egan, T.M. & Wier, W.G. 1994. Processes that remove calcium from the cytoplasm during excitation-contraction coupling in intact rat heart cells. J Physiol 474, 447-462.
8. i in intact rabbit cardiac myocytes. Biophys J 68, 1453-1460.
9. Baumann, M., Janssen, B.J., Hermans, J.J., Peutz-Kootstra, C., Witzke, O., Smits, J.F. & Struijker Boudier, H.A. 2007. Transient AT1 receptor-inhibition in prehypertensive spontaneously hypertensive rats results in maintained cardiac protection until advanced age. J Hypertens 25, 207-215.
10. Bers, D.M. 2000. Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res 87, 275-281.
11. 2+ signaling contributes to cardiomyopathy in Type 1 diabetic rats. Am J Physiol Heart Circ Physiol 283, H1398-H1408.
12. Coort, S.L., Bonen, A., van der Vusse, G.J., Glatz, J.F. & Luiken, J.J. 2007. Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters. Mol Cell Biochem 299, 5-18.
13. Daniels, A., van Bilsen, M., Janssen, B.J., Brouns, A.E., Cleutjens, J.P., Roemen, T.H., Schaart, G., van der Velden, J., van der Vusse, G.J. & van Nieuwenhoven, F.A. 2010. Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling. Acta Physiol (Oxf) 200, 11-22.
14. Day, C. 2007. Metabolic syndrome, or what you will: definitions and epidemiology. Diab Vasc Dis Res 4, 32-38.
15. Dhalla, N.S., Liu, X., Panagia, V. & Takeda, N. 1998. Subcellular remodeling and heart dysfunction in chronic diabetes. Cardiovasc Res 40, 239-247.
16. Dillmann, W.H. 1984. Fructose feeding increases Ca++-activated myosin ATPase activity and changes myosin isoenzyme distribution in the diabetic rat heart. Endocrinology 114, 1678-1685.
17. Eckel, R.H., Grundy, S.M. & Zimmet, P.Z. 2005. The metabolic syndrome. Lancet 365, 1415-1428.
18. Falcão-Pires, I. & Leite-Moreira, A.F. 2011. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail Rev doi: 10.1007/s10741-011-9257-z. [Epub ahead of print].
19. Fang, Z.Y., Prins, J.B. & Marwick, T.H. 2004. Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev 25, 543-567.
20. Fülöp, L., Bányász, T., Szabó, G., Tóth, I.B., Bíró, T., Lorincz, I., Balogh, Á., Peto, K., Mikó, I. & Nánási, P.P. 2006. Effect of sex hormones on ECG parameters and expression of cardiac ion channels in dogs. Acta Physiol (Oxf) 188, 163-171.
21. Gaddam, K.K., Ventura, H.O. & Lavie, C.J. 2011. Metabolic syndrome and heart failure-the risk, paradox, and treatment. Curr Hypertens Rep 13, 142-148.
22. Glennon, P.E., Sugden, P.H. & Poole-Wilson, P.A. 1995. Cellular mechanisms of cardiac hypertrophy. Br Heart J 73, 496-499.
23. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260, 3440-3450.
24. 2+ overload. J Physiol 527, 85-94.
25. Howarth, F.C., Jacobson, M., Qureshi, M.A., Shafiullah, M., Hameed, R.S., Zilahi, E., Al Haj, A., Nowotny, N. & Adeghate, E. 2009. Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart. Mol Cell Biochem 328, 57-65.
26. 2+ signalling in young type 2 Zucker diabetic fatty rat heart. Exp Physiol 96, 325-337.
27. Ivanics, T., Miklós, Z., Dézsi, L., Ikrényi, K., Tóth, A., Roemen, T.H., Van der Vusse, G.J. & Ligeti, L. 2001. Concomitant accumulation of intracellular free calcium and arachidonic acid in the ischemic-reperfused rat heart. Mol Cell Biochem 226, 119-128.
28. Kemecsei, P., Miklós, Z., Bíró, T., Marincsák, R., Tóth, B.I., Komlódi-Pásztor, E., Barnucz, E., Mirk, E., Van der Vusse, G.J., Ligeti, L. & Ivanics, T. 2010. Hearts of surviving MLP-KO mice show transient changes of intracellular calcium handling. Mol Cell Biochem 342, 251-260.
29. 2+-ATPase and phospholamban protein expression. Life Sci 70, 367-379.
30. Koss, K.L. & Kranias, E.G. 1996. Phospholamban: a prominent regulator of myocardial contractility. Circ Res 79, 1059-1063.
31. Li, L., Desantiago, J., Chu, G., Kranias, E.G. & Bers, D.M. 2000. Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation. Am J Physiol Heart Circ Physiol 278, H769-H779.
32. 2+ regulatory proteins. Cell Biochem Biophys 42, 1-12.
33. Ligeti, L., Szenczi, O., Prestia, C.M., Szabó, C., Horváth, K., Marcsek, Z.L., van Stiphout, R.G., van Riel, N.A., Op den Buijs, J., Van der Vusse, G.J. & Ivanics, T. 2007. Altered calcium handling is an early sign of streptozotocin-induced diabetic cardiomyopathy. Int J Mol Med 17, 1035-1043.
34. MacLennan, D.H. & Kranias, E.G. 2003. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4, 566-577.
35. Malik, S., Wong, N.D., Franklin, S.S., Kamath, T.V., L'Italien, G.J., Pio, J.R. & Williams, G.R. 2004. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 110, 1245-1250.
36. 2+ binding. FEBS Lett 576, 73-76.
37. 2+-cycling proteins may underlie sarcoplasmic reticulum dysfunction in the diabetic heart. Diabetes 50, 2133-2138.
38. Op den Buijs, J., Juloski, A.L., Ivanics, T., Ligeti, L., van der Vusse, G.J. & van Riel, N.A. 2004. Identification of a switching model of calcium cycling in isolated rat hearts. Conf Proc IEEE Eng Med Biol Soc 2, 841-844.
39. Op den Buijs, J., Miklós, Z., van Riel, N.A., Prestia, C.M., Szenczi, O., Tóth, A., Van der Vusse, G.J., Szabó, C., Ligeti, L. & Ivanics, T. 2005. β-Adrenergic activation reveals impaired cardiac calcium handling at early stage of diabetes. Life Sci 76, 1083-1098.
40. 2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology. Cardiovasc Res 77, 265-273.
41. 2+ content in isolated failing and nonfailing human myocardium. Circ Res 85, 38-46.
42. Pillai, J.B., Chen, M., Rajamohan, S.B., Samant, S., Pillai, V.B., Gupta, M. & Gupta, M.P. 2008. Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression. Am J Physiol Heart Circ Physiol 294, H1388-H1397.
43. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 85, 1009-1019.
44. Shimoni, Y., Ewart, H.S. & Severson, D. 1998. Type I and II models of diabetes produce different modifications of K+ currents in rat heart: role of insulin. J Physiol 507 (Pt 2), 485-496.
45. Takizawa, T., Arai, M., Yoguchi, A., Tomaru, K., Kurabayashi, M. & Nagai, R. 1999. Transcription of the SERCA2 gene is decreased in pressure-overloaded hearts: a study using in vivo direct gene transfer into living myocardium. J Mol Cell Cardiol 31, 2167-2174.
46. Ter Horst, P., Smits, J.F. & Blankesteijn, W.M. 2012. The Wnt/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand? Acta Physiol (Oxf) 204, 110-117.
47. Tran, L.T., Yuen, V.G. & McNeill, J.H. 2009. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem 332, 145-159.
48. 2+ oscillations. Biophys J 67, 447-456.
49. Yao, L., Chen, G.P., Lu, X., Zheng, L.R., Mou, Y. & Hu, S.J. 2009. Effects of atorvastatin on calcium-regulating proteins: a possible mechanism to repair cardiac dysfunction in spontaneously hypertensive rats. Basic Res Cardiol 104, 258-683.