Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 7, 2012, Pages 1139-1152

  Zhu, Lingxin ^a   Wei, Hongxia ^a   Wu, Yan ^a   Yang, Shasha ^a   Xiao, Lan ^a   Zhang, Jie ^a   Peng, Bin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Isoliquiritigenin; Lipopolysaccharide; NFATc1; Osteoclastogenesis; RANKL

Indexed keywords

F ACTIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOLIQUIRITIGENIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DESTRUCTION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GLYCYRRHIZA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY BONE LOSS; MACROPHAGE; MALE; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; ANTIBODIES; BONE RESORPTION; CELL SURVIVAL; CHALCONES; GLYCYRRHIZA; MALE; MICE; MICE, INBRED C57BL; OSTEOCLASTS; RANK LIGAND; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSFECTION;

GLYCYRRHIZA; MUS;

EID: 84861232042     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.04.003     Document Type: Article

References (39)

1. Y. Abu-Amer, I. Darwech, and J. Otero Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss Autoimmunity 41 2008 204 211
2. F. Arai, T. Miyamoto, O. Ohneda, T. Inada, T. Sudo, and K. Brasel Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors Journal of Experimental Medicine 190 1999 1741 1754
3. M. Asagiri, and H. Takayanagi The molecular understanding of osteoclast differentiation Bone 40 2007 251 264
4. M.N. Asl, and H. Hosseinzadeh Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds Phytotherapy Research 22 2008 709 724
5. C. Bodet, V.D. La, S. Gafner, C. Bergeron, and D. Grenier A licorice extract reduces lipopolysaccharide-induced proinflammatory cytokine secretion by macrophages and whole blood Journal of Periodontology 79 2008 1752 1761
6. G. Franzoso, L. Carlson, L. Xing, L. Poljak, E.W. Shores, and K.D. Brown Requirement for NF-kappaB in osteoclast and B-cell development Genes and Development 11 1997 3482 3496
7. H. Haraguchi, H. Ishikawa, K. Mizutani, Y. Tamura, and T. Kinoshita Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata Bioorganic and Medicinal Chemistry 6 1998 339 347
8. A.C. Hardcastle, L. Aucott, D.M. Reid, and H.M. Macdonald Associations between dietary flavonoid intakes and bone health in a Scottish population Journal of Bone and Mineral Research 26 2011 941 947
9. Horcajada MN, Offord E. Naturally plant-derived compounds: role in bone anabolism. Current Molecular Pharmacology, 2011 June 25 [Epub ahead of print].
10. H. Huang, E.J. Chang, J. Ryu, Z.H. Lee, Y. Lee, and H.H. Kim Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway Biochemical and Biophysical Research Communications 351 2006 99 105
11. Q.Q. Huang, and R.M. Pope The role of toll-like receptors in rheumatoid arthritis Current Rheumatology Reports 11 2009 357 364
12. F. Ikeda, T. Matsubara, T. Tsurukai, K. Hata, R. Nishimura, and T. Yoneda JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts Journal of Bone and Mineral Research 23 2008 907 914
13. D. Jones, L.H. Glimcher, and A.O. Aliprantis Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection Journal of Clinical Investigation 121 2011 2534 2542
14. S.W. Kang, J.S. Choi, Y.J. Choi, J.Y. Bae, J. Li, and D.S. Kim Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases The Journal of Nutritional Biochemistry 21 2010 55 65
15. J.Y. Kim, S.J. Park, K.J. Yun, Y.W. Cho, H.J. Park, and K.T. Lee Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264. 7 macrophages European Journal of Pharmacology 584 2008 175 184
16. K.R. Kim, C.K. Jeong, K.K. Park, J.H. Choi, J.H. Park, and S.S. Lim Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice J Biomedicine and Biotechnology 2010 2010 709378
17. F.E. Koehn, and G.T. Carter The evolving role of natural products in drug discovery Nature Reviews Drug Discovery 4 2005 206 220
18. S.F. Krens, H.P. Spaink, and B.E. Snaar-Jagalska Functions of the MAPK family in vertebrate-development FEBS Letters 580 2006 4984 4990
19. S. Kumar, A. Sharma, B. Madan, V. Singhal, and B. Ghosh Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells Biochemical Pharmacology 73 2007 1602 1612
20. J.H. Lee, H. Jin, H.E. Shim, H.N. Kim, H. Ha, and Z.H. Lee Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the nuclear factor-kappaB signal Molecular Pharmacology 77 2010 17 25
21. M.S. Lee, H.S. Kim, J.T. Yeon, S.W. Choi, C.H. Chun, and H.B. Kwak GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway Journal of Immunology 183 2009 3390 3399
22. M. Maggiolini, G. Statti, A. Vivacqua, S. Gabriele, V. Rago, and M. Loizzo Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells Journal of Steroid Biochemistry and Molecular Biology 82 2002 315 322
23. K. Matsuo, D.L. Galson, C. Zhao, L. Peng, C. Laplace, and K.Z. Wang Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos Journal of Biological Chemistry 279 2004 26475 26480
24. D.V. Novack, and S.L. Teitelbaum The osteoclast: friend or foe? Annual Review of Pathology 3 2008 457 484
25. S.J. Park, and H.S. Youn Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin Phytochemistry 71 2010 1736 1740
26. S.E. Putnam, A.M. Scutt, K. Bicknell, C.M. Priestley, and E.M. Williamson Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health Phytotherapy Research 21 2007 99 112
27. M.G. Ruocco, S. Maeda, J.M. Park, T. Lawrence, L.C. Hsu, and Y. Cao I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss Journal of Experimental Medicine 201 2005 1677 1687
28. Y. Sekine-Osajima, N. Sakamoto, M. Nakagawa, Y. Itsui, M. Tasaka, and Y. Nishimura-Sakurai Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication Hepatology Research 39 2009 60 69
29. D.A. Stevenson, E.L. Schwarz, J.C. Carey, D.H. Viskochil, H. Hanson, and S. Bauer Bone resorption in syndromes of the Ras/MAPK pathway Clinical Genetics 80 2011 566 573
30. H. Takatsuna, M. Asagiri, T. Kubota, K. Oka, T. Osada, and C. Sugiyama Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1 Journal of Bone and Mineral Research 20 2005 653 662
31. H. Takayanagi Osteoimmunology and the effects of the immune system on bone Nature Reviews Rheumatology 5 2009 667 676
32. H. Takayanagi Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems Nature Reviews Immunology 7 2007 292 304
33. Y. Tanaka, S. Nakayamada, and Y. Okada Osteoblasts and osteoclasts in bone remodeling and inflammation Current Drug Targets - Inflammation & Allergy 4 2005 325 328
34. M. Tawata, K. Aida, T. Noguchi, Y. Ozaki, S. Kume, and H. Sasaki Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice European Journal of Pharmacology 212 1992 87 92
35. S. Vaira, M. Alhawagri, I. Anwisye, H. Kitaura, R. Faccio, and D.V. Novack RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice Journal of Clinical Investigation 118 2008 2088 2097
36. C. Wang, J.H. Steer, D.A. Joyce, K.H. Yip, M.H. Zheng, and J. Xu 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation Journal of Bone and Mineral Research 18 2003 2159 2168
37. Z.Q. Wang, C. Ovitt, A.E. Grigoriadis, U. Mohle-Steinlein, U. Ruther, and E.F. Wagner Bone and haematopoietic defects in mice lacking c-fos Nature 360 1992 741 745
38. S.M. Yu, and S.C. Kuo Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta British Journal of Pharmacology 114 1995 1587 1594
39. L. Zhu, Y. Wu, H. Wei, X. Xing, N. Zhan, and H. Xiong IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: differential involvement of NF-kappaB versus JNK/AP-1 pathways Molecular Immunology 48 2011 647 656