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Volumn 121, Issue 7, 2011, Pages 2534-2542

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; AIN 457; ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CONJUGATED ESTROGEN; DENOSUMAB; ESTRADIOL; ETANERCEPT; IBANDRONIC ACID; INFLIXIMAB; INTERLEUKIN 17; LY 2439821; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; PROTEIN INHIBITOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RISEDRONIC ACID; TOCILIZUMAB; UNCLASSIFIED DRUG; USTEKINUMAB; ZOLEDRONIC ACID;

EID: 79959941928     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46262     Document Type: Review
Times cited : (67)

References (127)
  • 1
    • 0038688357 scopus 로고    scopus 로고
    • The genetic basis for skeletal diseases
    • DOI 10.1038/nature01659
    • Zelzer E, Olsen BR. The genetic basis for skeletal diseases. Nature. 2003;423(6937):343-348. (Pubitemid 40852709)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 343-348
    • Zelzer, E.1    Olsen, B.R.2
  • 2
    • 34447132814 scopus 로고    scopus 로고
    • Skeletal remodeling in health and disease
    • DOI 10.1038/nm1593, PII NM1593
    • Zaidi M. Skeletal remodeling in health and disease. Nat Med. 2007;13(7):791-801. (Pubitemid 47038187)
    • (2007) Nature Medicine , vol.13 , Issue.7 , pp. 791-801
    • Zaidi, M.1
  • 3
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • DOI 10.1016/S1534-5807(02)00157-0
    • Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. 2002;2(4):389-406. (Pubitemid 34436569)
    • (2002) Developmental Cell , vol.2 , Issue.4 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 4
    • 75049085147 scopus 로고    scopus 로고
    • Osteoimmunology and the effects of the immune system on bone
    • Takayanagi H. Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol. 2009;5(12):667-676.
    • (2009) Nat Rev Rheumatol , vol.5 , Issue.12 , pp. 667-676
    • Takayanagi, H.1
  • 5
    • 79959974072 scopus 로고    scopus 로고
    • TRANCE, a new tumor necrosis factor (TNF) family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    • Wong BR, et al. TRANCE, a new tumor necrosis factor (TNF) family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med. 1997;186(1):1-6.
    • (1997) J Exp Med , vol.186 , Issue.1 , pp. 1-6
    • Wong, B.R.1
  • 7
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397(6717):315-323.
    • (1999) Nature , vol.397 , Issue.6717 , pp. 315-323
    • Kong, Y.Y.1
  • 8
    • 0034718609 scopus 로고    scopus 로고
    • Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene
    • Kim N, Odgren PR, Kim DK, Marks SC Jr, Choi Y. Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A. 2000;97(20):10905-10910.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.20 , pp. 10905-10910
    • Kim, N.1    Odgren, P.R.2    Kim, D.K.3    Marks Jr., S.C.4    Choi, Y.5
  • 9
  • 11
    • 55849088412 scopus 로고    scopus 로고
    • NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism
    • Aliprantis AO, et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008;118(11):3775-3789.
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3775-3789
    • Aliprantis, A.O.1
  • 13
    • 70349100754 scopus 로고    scopus 로고
    • Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation
    • Negishi-Koga T, Takayanagi H. Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation. Immunol Rev. 2009;231(1):241-256.
    • (2009) Immunol Rev , vol.231 , Issue.1 , pp. 241-256
    • Negishi-Koga, T.1    Takayanagi, H.2
  • 14
    • 77953151846 scopus 로고    scopus 로고
    • Novel functions of RANK(L) signaling in the immune system
    • Leibbrandt A, Penninger JM. Novel functions of RANK(L) signaling in the immune system. Adv Exp Med Biol. 2010;658:77-94.
    • (2010) Adv Exp Med Biol , vol.658 , pp. 77-94
    • Leibbrandt, A.1    Penninger, J.M.2
  • 16
    • 47249086030 scopus 로고    scopus 로고
    • The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis
    • DOI 10.1111/j.1600-065X.2008.00648.x
    • Noss EH, Brenner MB. The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunol Rev. 2008;223:252-270. (Pubitemid 351986192)
    • (2008) Immunological Reviews , vol.223 , Issue.1 , pp. 252-270
    • Noss, E.H.1    Brenner, M.B.2
  • 17
    • 33846781303 scopus 로고    scopus 로고
    • Outcomes in rheumatoid arthritis: Incorporating the patient perspective
    • DOI 10.1097/BOR.0b013e32802bf79d, PII 0000228120070300000004
    • Heller JE, Shadick NA. Outcomes in rheumatoid arthritis: incorporating the patient perspective. Curr Opin Rheumatol. 2007;19(2):101-105. (Pubitemid 46208765)
    • (2007) Current Opinion in Rheumatology , vol.19 , Issue.2 , pp. 101-105
    • Heller, J.E.1    Shadick, N.A.2
  • 18
    • 70349140060 scopus 로고    scopus 로고
    • Biologics for rheumatoid arthritis: An overview of Cochrane reviews
    • CD007848
    • Singh JA, et al. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev. 2009;(4):CD007848.
    • (2009) Cochrane Database Syst Rev , Issue.4
    • Singh, J.A.1
  • 20
    • 77953261340 scopus 로고    scopus 로고
    • Bone damage in rheumatoid arthritis: Mechanistic insights and approaches to prevention
    • Karmakar S, Kay J, Gravallese EM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010;36(2):385-404.
    • (2010) Rheum Dis Clin North Am , vol.36 , Issue.2 , pp. 385-404
    • Karmakar, S.1    Kay, J.2    Gravallese, E.M.3
  • 23
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong YY, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999;402(6759):304-309.
    • (1999) Nature , vol.402 , Issue.6759 , pp. 304-309
    • Kong, Y.Y.1
  • 26
    • 33646484359 scopus 로고    scopus 로고
    • Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis
    • Jarrett SJ, et al. Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis. Arthritis Rheum. 2006;54(5):1410-1414.
    • (2006) Arthritis Rheum , vol.54 , Issue.5 , pp. 1410-1414
    • Jarrett, S.J.1
  • 27
    • 43949139580 scopus 로고    scopus 로고
    • Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
    • DOI 10.1002/art.23417
    • Cohen SB, et al. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum. 2008;58(5):1299-1309. (Pubitemid 351705919)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.5 , pp. 1299-1309
    • Cohen, S.B.1    Dore, R.K.2    Lane, N.E.3    Ory, P.A.4    Peterfy, C.G.5    Sharp, J.T.6    Van Der, H.D.7    Zhou, L.8    Tsuji, W.9    Newmark, R.10
  • 28
    • 60549110257 scopus 로고    scopus 로고
    • Immune regulation of bone loss by Th17 cells
    • Adamopoulos IE, Bowman EP. Immune regulation of bone loss by Th17 cells. Arthritis Res Ther. 2008;10(5):225.
    • (2008) Arthritis Res Ther , vol.10 , Issue.5 , pp. 225
    • Adamopoulos, I.E.1    Bowman, E.P.2
  • 31
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
    • Takayanagi H, et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature. 2000;408(6812):600-605.
    • (2000) Nature , vol.408 , Issue.6812 , pp. 600-605
    • Takayanagi, H.1
  • 36
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W, et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med. 2010;2(52):52ra72.
    • (2010) Sci Transl Med , vol.2 , Issue.52
    • Hueber, W.1
  • 37
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese MC, et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 2010;62(4):929-939.
    • (2010) Arthritis Rheum , vol.62 , Issue.4 , pp. 929-939
    • Genovese, M.C.1
  • 38
    • 60649092609 scopus 로고    scopus 로고
    • New biologics for psoriasis and psoriatic arthritis
    • Rozenblit M, Lebwohl M. New biologics for psoriasis and psoriatic arthritis. Dermatol Ther. 2009;22(1):56-60.
    • (2009) Dermatol Ther , vol.22 , Issue.1 , pp. 56-60
    • Rozenblit, M.1    Lebwohl, M.2
  • 42
    • 33749604848 scopus 로고    scopus 로고
    • RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis
    • DOI 10.1093/rheumatology/kel045
    • Pettit AR, Walsh NC, Manning C, Goldring SR, Gravallese EM. RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2006;45(9):1068-1076. (Pubitemid 44542091)
    • (2006) Rheumatology , vol.45 , Issue.9 , pp. 1068-1076
    • Pettit, A.R.1    Walsh, N.C.2    Manning, C.3    Goldring, S.R.4    Gravallese, E.M.5
  • 44
    • 77953639101 scopus 로고    scopus 로고
    • Regulatory T cells protect from local and systemic bone destruction in arthritis
    • Zaiss MM, et al. Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol. 2010;184(12):7238-7246.
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 7238-7246
    • Zaiss, M.M.1
  • 45
    • 66149146340 scopus 로고    scopus 로고
    • Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis
    • Kelchtermans H, Geboes L, Mitera T, Huskens D, Leclercq G, Matthys P. Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann Rheum Dis. 2009;68(5):744-750.
    • (2009) Ann Rheum Dis , vol.68 , Issue.5 , pp. 744-750
    • Kelchtermans, H.1    Geboes, L.2    Mitera, T.3    Huskens, D.4    Leclercq, G.5    Matthys, P.6
  • 46
    • 47249103596 scopus 로고    scopus 로고
    • CTLA-4 directly inhibits osteoclast formation
    • Axmann R, et al. CTLA-4 directly inhibits osteoclast formation. Ann Rheum Dis. 2008;67(11):1603-1609.
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1603-1609
    • Axmann, R.1
  • 48
    • 34247882571 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells
    • DOI 10.1016/j.bbrc.2007.04.042, PII S0006291X07007681
    • Kim YG, Lee CK, Nah SS, Mun SH, Yoo B, Moon HB. Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2007;357(4):1046-1052. (Pubitemid 46693677)
    • (2007) Biochemical and Biophysical Research Communications , vol.357 , Issue.4 , pp. 1046-1052
    • Kim, Y.G.1    Lee, C.-K.2    Nah, S.-S.3    Mun, S.H.4    Yoo, B.5    Moon, H.-B.6
  • 49
    • 49449100184 scopus 로고    scopus 로고
    • Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: Fibroblast-mediated pathologic bone resorption
    • Tunyogi-Csapo M, et al. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 2008; 58(8):2397-2408.
    • (2008) Arthritis Rheum , vol.58 , Issue.8 , pp. 2397-2408
    • Tunyogi-Csapo, M.1
  • 50
    • 54449101331 scopus 로고    scopus 로고
    • IL-6 transsignaling directly induces RANKL on fibroblastlike synovial cells and is involved in RANKL induction by TNFα and IL-17
    • Hashizume M, Hayakawa N, Mihara M. IL-6 transsignaling directly induces RANKL on fibroblastlike synovial cells and is involved in RANKL induction by TNFα and IL-17. Rheumatology (Oxford). 2008;47(11):1635-1640.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.11 , pp. 1635-1640
    • Hashizume, M.1    Hayakawa, N.2    Mihara, M.3
  • 52
    • 0034523328 scopus 로고    scopus 로고
    • TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNFα induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 2000;106(12):1481- 1488. (Pubitemid 32038586)
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.12 , pp. 1481-1488
    • Lam, J.1    Takeshita, S.2    Barker, J.E.3    Kanagawa, O.4    Ross, F.P.5    Teitelbaum, S.L.6
  • 53
    • 77949454280 scopus 로고    scopus 로고
    • Interleukin-17A upregulates receptor activator of NFκB on osteoclast precursors
    • Adamopoulos IE, et al. Interleukin-17A upregulates receptor activator of NFκB on osteoclast precursors. Arthritis Res Ther. 2010;12(1):R29.
    • (2010) Arthritis Res Ther , vol.12 , Issue.1
    • Adamopoulos, I.E.1
  • 54
    • 0036733711 scopus 로고    scopus 로고
    • Bone and joint destruction in rheumatoid arthritis: What is really happening?
    • Goldring SR. Bone and joint destruction in rheumatoid arthritis: what is really happening? J Rheumatol Suppl. 2002;65:44-48.
    • (2002) J Rheumatol Suppl , vol.65 , pp. 44-48
    • Goldring, S.R.1
  • 55
    • 72749102524 scopus 로고    scopus 로고
    • Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis
    • Walsh NC, et al. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res. 2009;24(9):1572-1585.
    • (2009) J Bone Miner Res , vol.24 , Issue.9 , pp. 1572-1585
    • Walsh, N.C.1
  • 56
    • 33846949349 scopus 로고    scopus 로고
    • Dickkopf-1 is a master regulator of joint remodeling
    • Diarra D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007;13(2):156-163.
    • (2007) Nat Med , vol.13 , Issue.2 , pp. 156-163
    • Diarra, D.1
  • 57
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • DOI 10.1016/S0960-9822(01)00290-1
    • Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol. 2001;11(12):951-961. (Pubitemid 32589186)
    • (2001) Current Biology , vol.11 , Issue.12 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3    Kuhl, M.4    Sokol, S.5    He, X.6
  • 58
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass DA 2nd, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005;8(5):751-764.
    • (2005) Dev Cell , vol.8 , Issue.5 , pp. 751-764
    • Glass II, D.A.1
  • 59
    • 78649723963 scopus 로고    scopus 로고
    • Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
    • Heiland GR, et al. Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Ann Rheum Dis. 2010;69(12):2152-2159.
    • (2010) Ann Rheum Dis , vol.69 , Issue.12 , pp. 2152-2159
    • Heiland, G.R.1
  • 62
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • DOI 10.1210/er.23.3.279
    • Riggs BL, Khosla S, Melton LJ 3rd. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002;23(3):279-302. (Pubitemid 34651948)
    • (2002) Endocrine Reviews , vol.23 , Issue.3 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 63
    • 13444256417 scopus 로고    scopus 로고
    • Mechanisms of sex steroid effects on bone
    • DOI 10.1016/j.bbrc.2004.11.097, Vertebrate Skeletal Biology
    • Syed F, Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun. 2005;328(3):688-696. (Pubitemid 40214350)
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , Issue.3 , pp. 688-696
    • Syed, F.1    Khosla, S.2
  • 64
    • 33645059209 scopus 로고    scopus 로고
    • Preventing osteoporosis-related fractures: An overview
    • Gass M, Dawson-Hughes B. Preventing osteoporosis-related fractures: an overview. Am J Med. 2006;119(4 suppl 1):S3-S11.
    • (2006) Am J Med , vol.119 , Issue.4 SUPPL. 1
    • Gass, M.1    Dawson-Hughes, B.2
  • 65
    • 0031955217 scopus 로고    scopus 로고
    • A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men
    • DOI 10.1359/jbmr.1998.13.5.763
    • Riggs BL, Khosla S, Melton LJ 3rd. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in post-menopausal women and contributes to bone loss in aging men. J Bone Miner Res. 1998;13(5):763-773. (Pubitemid 28224192)
    • (1998) Journal of Bone and Mineral Research , vol.13 , Issue.5 , pp. 763-773
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 66
    • 34548321649 scopus 로고    scopus 로고
    • Estrogen and CD4+ T cells
    • DOI 10.1097/BOR.0b013e328277ef2a, PII 0000228120070900000004
    • Pernis AB. Estrogen and CD4+ T cells. Curr Opin Rheumatol. 2007;19(5):414-420. (Pubitemid 47344231)
    • (2007) Current Opinion in Rheumatology , vol.19 , Issue.5 , pp. 414-420
    • Pernis, A.B.1
  • 67
    • 0033708837 scopus 로고    scopus 로고
    • Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
    • Cenci S, et al. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest. 2000;106(10):1229-1237.
    • (2000) J Clin Invest , vol.106 , Issue.10 , pp. 1229-1237
    • Cenci, S.1
  • 68
    • 44949083462 scopus 로고    scopus 로고
    • Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis
    • D'Amelio P, et al. Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. Bone. 2008;43(1):92-100.
    • (2008) Bone , vol.43 , Issue.1 , pp. 92-100
    • D'Amelio, P.1
  • 69
    • 2042545404 scopus 로고    scopus 로고
    • Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappaB ligand-mediated osteoclastogenesis
    • DOI 10.1210/en.2003-1536
    • Yoneda T, et al. Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis. Endocrinology. 2004;145(5):2384-2391. (Pubitemid 38535068)
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2384-2391
    • Yoneda, T.1    Ishimaru, N.2    Arakaki, R.3    Kobayashi, M.4    Izawa, T.5    Moriyama, K.6    Hayashi, Y.7
  • 71
    • 49949119153 scopus 로고    scopus 로고
    • Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents
    • Yamaza T, et al. Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. PLoS One. 2008;3(7):e2615.
    • (2008) PLoS One , vol.3 , Issue.7
    • Yamaza, T.1
  • 72
    • 77955842458 scopus 로고    scopus 로고
    • T cells: Critical bone regulators in health and disease
    • Pacifici R. T cells: critical bone regulators in health and disease. Bone. 2010;47(3):461-471.
    • (2010) Bone , vol.47 , Issue.3 , pp. 461-471
    • Pacifici, R.1
  • 73
    • 33846017422 scopus 로고    scopus 로고
    • T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy
    • Lee SK, et al. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res. 2006;21(11):1704-1712.
    • (2006) J Bone Miner Res , vol.21 , Issue.11 , pp. 1704-1712
    • Lee, S.K.1
  • 74
    • 64649084316 scopus 로고    scopus 로고
    • Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure
    • Anginot A, Dacquin R, Mazzorana M, Jurdic P. Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure. PLoS One. 2007;2(7):e585.
    • (2007) PLoS One , vol.2 , Issue.7
    • Anginot, A.1    Dacquin, R.2    Mazzorana, M.3    Jurdic, P.4
  • 75
    • 0025746581 scopus 로고
    • Pathophysiology of primary hyperparathyroidism
    • Spiegel AM. Pathophysiology of primary hyperparathyroidism. J Bone Miner Res. 1991;6(suppl 2):S15-S17.
    • (1991) J Bone Miner Res , vol.6 , Issue.SUPPL. 2
    • Spiegel, A.M.1
  • 76
    • 48149095459 scopus 로고    scopus 로고
    • T cells potentiate PTH-induced cortical bone loss through CD40L signaling
    • Gao Y, et al. T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell Metab. 2008;8(2):132-145.
    • (2008) Cell Metab , vol.8 , Issue.2 , pp. 132-145
    • Gao, Y.1
  • 77
    • 77957891185 scopus 로고    scopus 로고
    • Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss
    • Tawfeek H, et al. Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One. 2010;5(8):e12290.
    • (2010) PLoS One , vol.5 , Issue.8
    • Tawfeek, H.1
  • 78
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • DOI 10.1016/j.bone.2007.03.017, PII S8756328207001731
    • Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007;40(6):1434-1446. (Pubitemid 46756429)
    • (2007) Bone , vol.40 , Issue.6 , pp. 1434-1446
    • Jilka, R.L.1
  • 79
    • 70349573790 scopus 로고    scopus 로고
    • Clinical update on teriparatide
    • File E, Deal C. Clinical update on teriparatide. Curr Rheumatol Rep. 2009;11(3):169-176.
    • (2009) Curr Rheumatol Rep , vol.11 , Issue.3 , pp. 169-176
    • File, E.1    Deal, C.2
  • 80
    • 34250823973 scopus 로고    scopus 로고
    • Minireview: Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    • DOI 10.1210/en.2007-0270
    • Baron R, Rawadi G. Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007;148(6):2635-2643. (Pubitemid 46984775)
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 83
    • 67449092765 scopus 로고    scopus 로고
    • Cancer stem cells and their niche
    • Iwasaki H, Suda T. Cancer stem cells and their niche. Cancer Sci. 2009;100(7):1166-1172.
    • (2009) Cancer Sci , vol.100 , Issue.7 , pp. 1166-1172
    • Iwasaki, H.1    Suda, T.2
  • 84
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-κB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, et al. A study of the biological receptor activator of nuclear factor-κB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res. 2006;12(4):1221-1228.
    • (2006) Clin Cancer Res , vol.12 , Issue.4 , pp. 1221-1228
    • Body, J.J.1
  • 85
    • 70349488703 scopus 로고    scopus 로고
    • An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma
    • Vij R, et al. An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma. Am J Hematol. 2009;84(10):650-656.
    • (2009) Am J Hematol , vol.84 , Issue.10 , pp. 650-656
    • Vij, R.1
  • 86
    • 73949150107 scopus 로고    scopus 로고
    • Effect of bisphosphonates on pain and quality of life in patients with bone metastases
    • Costa L, Major PP. Effect of bisphosphonates on pain and quality of life in patients with bone metastases. Nat Clin Pract Oncol. 2009;6(3):163-174.
    • (2009) Nat Clin Pract Oncol , vol.6 , Issue.3 , pp. 163-174
    • Costa, L.1    Major, P.P.2
  • 89
    • 0342322717 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
    • Choi SJ, et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood. 2000;96(2):671-675. (Pubitemid 30463390)
    • (2000) Blood , vol.96 , Issue.2 , pp. 671-675
    • Choi, S.J.1    Cruz, J.C.2    Craig, F.3    Chung, H.4    Devlin, R.D.5    Roodman, G.D.6    Alsina, M.7
  • 90
    • 4644343663 scopus 로고    scopus 로고
    • The RANK/RANK ligand system is involved in interleukin-6 and interleukin-11 up-regulation by human myeloma cells in the bone marrow microenvironment
    • Giuliani N, Colla S, Morandi F, Rizzoli V. The RANK/RANK ligand system is involved in interleukin-6 and interleukin-11 up-regulation by human myeloma cells in the bone marrow microenvironment. Haematologica. 2004;89(9):1118-1123. (Pubitemid 39295483)
    • (2004) Haematologica , vol.89 , Issue.9 , pp. 1118-1123
    • Giuliani, N.1    Colla, S.2    Morandi, F.3    Rizzoli, V.4
  • 91
  • 92
    • 0037108435 scopus 로고    scopus 로고
    • Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
    • Standal T, et al. Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood. 2002;100(8):3002-3007.
    • (2002) Blood , vol.100 , Issue.8 , pp. 3002-3007
    • Standal, T.1
  • 94
    • 0036758243 scopus 로고    scopus 로고
    • Clinical evaluation of onset of analgesia using intravenous pamidronate in metastatic bone pain
    • Petcu EB, Schug SA, Smith H. Clinical evaluation of onset of analgesia using intravenous pamidronate in metastatic bone pain. J Pain Symptom Manage. 2002;24(3):281-284.
    • (2002) J Pain Symptom Manage , vol.24 , Issue.3 , pp. 281-284
    • Petcu, E.B.1    Schug, S.A.2    Smith, H.3
  • 97
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood. 2009;114(2):371-379.
    • (2009) Blood , vol.114 , Issue.2 , pp. 371-379
    • Fulciniti, M.1
  • 98
    • 0034730327 scopus 로고    scopus 로고
    • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    • Fata JE, et al. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000;103(1):41-50.
    • (2000) Cell , vol.103 , Issue.1 , pp. 41-50
    • Fata, J.E.1
  • 99
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • Schramek D, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 2010;468(7320):98-102.
    • (2010) Nature , vol.468 , Issue.7320 , pp. 98-102
    • Schramek, D.1
  • 100
    • 78149284767 scopus 로고    scopus 로고
    • RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    • Gonzalez-Suarez E, et al. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature. 2010;468(7320):103-107.
    • (2010) Nature , vol.468 , Issue.7320 , pp. 103-107
    • Gonzalez-Suarez, E.1
  • 101
    • 33645453481 scopus 로고    scopus 로고
    • Regulation of cancer cell migration and bone metastasis by RANKL
    • Jones DH, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 2006; 440(7084):692-696.
    • (2006) Nature , vol.440 , Issue.7084 , pp. 692-696
    • Jones, D.H.1
  • 102
    • 9144236929 scopus 로고    scopus 로고
    • Osteoblast responses to bacterial pathogens: A previously unappreciated role for bone-forming cells in host defense and disease progression
    • DOI 10.1385/IR:30:3:291
    • Marriott I. Osteoblast responses to bacterial pathogens: a previously unappreciated role for boneforming cells in host defense and disease progression. Immunol Res. 2004;30(3):291-308. (Pubitemid 39546231)
    • (2004) Immunologic Research , vol.30 , Issue.3 , pp. 291-308
    • Marriott, I.1
  • 104
    • 79951610661 scopus 로고    scopus 로고
    • Inflammation and uncoupling as mechanisms of periodontal bone loss
    • Graves DT, Li J, Cochran DL. Inflammation and uncoupling as mechanisms of periodontal bone loss. J Dent Res. 2011;90(2):143-153.
    • (2011) J Dent Res , vol.90 , Issue.2 , pp. 143-153
    • Graves, D.T.1    Li, J.2    Cochran, D.L.3
  • 105
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373-384.
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 106
    • 41449102471 scopus 로고    scopus 로고
    • Taking a Toll on the bones: Regulation of bone metabolism by innate immune regulators
    • DOI 10.1080/08916930701694469, PII 789050133, Osteoimmunology in Skeletal Cell Biology and Disease
    • Bar-Shavit Z. Taking a toll on the bones: regulation of bone metabolism by innate immune regulators. Autoimmunity. 2008;41(3):195-203. (Pubitemid 351454989)
    • (2008) Autoimmunity , vol.41 , Issue.3 , pp. 195-203
    • Bar-Shavit, Z.1
  • 107
    • 0026069940 scopus 로고
    • Evidence for interleukin-1β production by cultured normal human osteoblast-like cells
    • Keeting PE, et al. Evidence for interleukin-1β production by cultured normal human osteoblast-like cells. J Bone Miner Res. 1991;6(8):827-833.
    • (1991) J Bone Miner Res , vol.6 , Issue.8 , pp. 827-833
    • Keeting, P.E.1
  • 108
    • 0025259989 scopus 로고
    • IL-6 is produced by osteoblasts and induces bone resorption
    • Ishimi Y, et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol. 1990; 145(10):3297-3303.
    • (1990) J Immunol , vol.145 , Issue.10 , pp. 3297-3303
    • Ishimi, Y.1
  • 110
    • 35348948929 scopus 로고    scopus 로고
    • Proinflammatory cytokine expression in cyclooxygenase-2-deficient primary osteoblasts
    • He J, Tomlinson R, Coon D, Gulati A, Cowan C. Proinflammatory cytokine expression in cyclooxygenase-2-deficient primary osteoblasts. J Endod. 2007;33(11):1309-1312.
    • (2007) J Endod , vol.33 , Issue.11 , pp. 1309-1312
    • He, J.1    Tomlinson, R.2    Coon, D.3    Gulati, A.4    Cowan, C.5
  • 111
    • 0036073481 scopus 로고    scopus 로고
    • Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4
    • DOI 10.1128/IAI.70.8.4075-4082.2002
    • Gasper NA, Petty CC, Schrum LW, Marriott I, Bost KL. Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4. Infect Immun. 2002;70(8):4075-4082. (Pubitemid 34790915)
    • (2002) Infection and Immunity , vol.70 , Issue.8 , pp. 4075-4082
    • Gasper, N.A.1    Petty, C.C.2    Schrum, L.W.3    Marriott, I.4    Bost, K.L.5
  • 112
    • 78649443034 scopus 로고    scopus 로고
    • Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation
    • Bandow K, et al. Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation. Biochem Biophys Res Commun. 2010;402(4):755-761.
    • (2010) Biochem Biophys Res Commun , vol.402 , Issue.4 , pp. 755-761
    • Bandow, K.1
  • 113
    • 0344628647 scopus 로고    scopus 로고
    • Hard labour: Bacterial infection of the skeleton
    • DOI 10.1016/j.tim.2003.10.005
    • Henderson B, Nair SP. Hard labour: bacterial infection of the skeleton. Trends Microbiol. 2003;11(12):570-577. (Pubitemid 37500908)
    • (2003) Trends in Microbiology , vol.11 , Issue.12 , pp. 570-577
    • Henderson, B.1    Nair, S.P.2
  • 114
    • 79952695473 scopus 로고    scopus 로고
    • Causative agents of osteomyelitis induce death domain - Containing TNF - Related apoptosis - Inducing ligand receptor expression on osteoblasts
    • Young AB, Cooley ID, Chauhan VS, Marriott I. Causative agents of osteomyelitis induce death domain - containing TNF - related apoptosis - inducing ligand receptor expression on osteoblasts. Bone. 2011;48(4):857-863.
    • (2011) Bone , vol.48 , Issue.4 , pp. 857-863
    • Young, A.B.1    Cooley, I.D.2    Chauhan, V.S.3    Marriott, I.4
  • 115
    • 3042589918 scopus 로고    scopus 로고
    • Staphylococcus aureus - Induced tumor necrosis factor - Related apoptosis - Inducing ligand expression mediates apoptosis and caspase- 8 activation in infected osteoblasts
    • Alexander EH, Rivera FA, Marriott I, Anguita J, Bost KL, Hudson MC. Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase- 8 activation in infected osteoblasts. BMC Microbiol. 2003;3:5.
    • (2003) BMC Microbiol , vol.3 , pp. 5
    • Alexander, E.H.1    Rivera, F.A.2    Marriott, I.3    Anguita, J.4    Bost, K.L.5    Hudson, M.C.6
  • 116
    • 58149354657 scopus 로고    scopus 로고
    • Osteoblasts participate in the innate immunity of the bone by producing human β-defensin-3
    • Varoga D, et al. Osteoblasts participate in the innate immunity of the bone by producing human β-defensin-3. Histochem Cell Biol. 2009;131(2):207-218.
    • (2009) Histochem Cell Biol , vol.131 , Issue.2 , pp. 207-218
    • Varoga, D.1
  • 117
    • 57249084060 scopus 로고    scopus 로고
    • The role of human β-defensin-2 in bone
    • Varoga D, et al. The role of human β-defensin-2 in bone. J Anat. 2008;213(6):749-757.
    • (2008) J Anat , vol.213 , Issue.6 , pp. 749-757
    • Varoga, D.1
  • 118
    • 0036681842 scopus 로고    scopus 로고
    • Stimulation by toll-like receptors inhibits osteoclast differentiation
    • Takami M, Kim N, Rho J, Choi Y. Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol. 2002;169(3):1516-1523. (Pubitemid 34809198)
    • (2002) Journal of Immunology , vol.169 , Issue.3 , pp. 1516-1523
    • Takami, M.1    Kim, N.2    Rho, J.3    Choi, Y.4
  • 119
    • 73349101077 scopus 로고    scopus 로고
    • Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-γ in human osteoclast precursors
    • Ji JD, et al. Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-γ in human osteoclast precursors. J Immunol. 2009;183(11):7223-7233.
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7223-7233
    • Ji, J.D.1
  • 120
    • 0031790387 scopus 로고    scopus 로고
    • Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin- 8
    • Rothe L, et al. Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8. Endocrinology. 1998;139(10):4353-4363. (Pubitemid 28513725)
    • (1998) Endocrinology , vol.139 , Issue.10 , pp. 4353-4363
    • Rothe, L.1    Collin-Osdoby, P.2    Chen, Y.3    Sunyer, T.4    Chaudhary, L.5    Tsay, A.6    Goldring, S.7    Avioli, L.8    Osdoby, P.9
  • 121
    • 67649407259 scopus 로고    scopus 로고
    • Mouse macrophages primed with alendronate down-regulate monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) production in response to Toll-like receptor (TLR) 2 and TLR4 agonist via Smad3 activation
    • Masuda T, Deng X, Tamai R. Mouse macrophages primed with alendronate down-regulate monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) production in response to Toll-like receptor (TLR) 2 and TLR4 agonist via Smad3 activation. Int Immunopharmacol. 2009;9(9):1115-1121.
    • (2009) Int Immunopharmacol , vol.9 , Issue.9 , pp. 1115-1121
    • Masuda, T.1    Deng, X.2    Tamai, R.3
  • 122
    • 77955475327 scopus 로고    scopus 로고
    • Cross talk between the bone and immune systems: Osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells
    • Li H, Hong S, Qian J, Zheng Y, Yang J, Yi Q. Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood. 2010;116(2):210-217.
    • (2010) Blood , vol.116 , Issue.2 , pp. 210-217
    • Li, H.1    Hong, S.2    Qian, J.3    Zheng, Y.4    Yang, J.5    Yi, Q.6
  • 123
    • 33646836925 scopus 로고    scopus 로고
    • Systematic review: Bisphosphonates and osteonecrosis of the jaws
    • Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 2006;144(10):753-761. (Pubitemid 46780635)
    • (2006) Annals of Internal Medicine , vol.144 , Issue.10 , pp. 753-761
    • Woo, S.-B.1    Hellstein, J.W.2    Kalmar, J.R.3
  • 124
    • 77950658125 scopus 로고    scopus 로고
    • Effects of antiresorptive agents on osteomyelitis: Novel insights into the pathogenesis of osteonecrosis of the jaw
    • Li D, et al. Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Ann N Y Acad Sci. 2010;1192:84-94.
    • (2010) Ann N Y Acad Sci , vol.1192 , pp. 84-94
    • Li, D.1
  • 125
    • 77954620010 scopus 로고    scopus 로고
    • Bisphosphonates cause osteonecrosis of the jaw-like disease in mice
    • Bi Y, et al. Bisphosphonates cause osteonecrosis of the jaw-like disease in mice. Am J Pathol. 2010;177(1):280-290.
    • (2010) Am J Pathol , vol.177 , Issue.1 , pp. 280-290
    • Bi, Y.1
  • 126
    • 77953454405 scopus 로고    scopus 로고
    • Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
    • Kendler DL, et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res. 2010;25(1):72-81.
    • (2010) J Bone Miner Res , vol.25 , Issue.1 , pp. 72-81
    • Kendler, D.L.1
  • 127
    • 65449137137 scopus 로고    scopus 로고
    • Denosumab: Anti-RANKL antibody
    • Miller PD. Denosumab: anti-RANKL antibody. Curr Osteoporos Rep. 2009;7(1):18-22.
    • (2009) Curr Osteoporos Rep , vol.7 , Issue.1 , pp. 18-22
    • Miller, P.D.1


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