Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 20, 2012, Pages 7770-7775

  Zhou, Jing ^a,b   Lee, Pei Ling ^a   Tsai, Chien Sung ^c   Lee, Chih I ^a   Yang, Tung Lin ^a   Chuang, Han Sheng ^d   Lin, Wei Wen ^e   Lin, Ting Er ^a   Lim, Seh Hong ^a   Wei, Shu Yi ^a   Chen, Yuh Lien ^f   Chien, Shu ^b   Chiu, Jeng Jiann ^a,g  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^g NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Atherosclerosis; Stenosis

Indexed keywords

APOLIPOPROTEIN E; CYCLIN A; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; LIGAND; MAMMALIAN TARGET OF RAPAMYCIN; NOGGIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMALL INTERFERING RNA;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; ARTICLE; ATHEROSCLEROSIS; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOWN REGULATION; ENDOTHELIUM CELL; FLOW KINETICS; FORCE; HEART FAILURE; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHEAR STRESS; THORACIC AORTA; UPREGULATION; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA, ABDOMINAL; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOMECHANICS; CELL CYCLE; CORONARY VESSELS; CYCLIN A; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; RATS; REGIONAL BLOOD FLOW; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SMAD1 PROTEIN; STRESS, MECHANICAL; TAIWAN; TOR SERINE-THREONINE KINASES;

MAMMALIA; MUS; RATTUS;

EID: 84861220379     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205476109     Document Type: Article

References (23)

1. Chiu JJ, Chien S (2011) Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives. Physiol Rev 91:327-387.
2. Resnick N, Gimbrone MA, Jr. (1995) Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J 9:874-882.
3. Traub O, Berk BC (1998) Laminar shear stress: Mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 18:677-685. (Pubitemid 28267645)
4. Hahn C, Schwartz MA (2009) Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol 10:53-62.
5. Kadohama T, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE (2007) Effects of different types of fluid shear stress on endothelial cell proliferation and survival. J Cell Physiol 212:244-251. (Pubitemid 46867607)
6. DePaola N, Gimbrone MA, Jr., Davies PF, Dewey CF, Jr. (1992) Vascular endothelium responds to fluid shear stress gradients. Arterioscler Thromb 12:1254-1257.
7. Chiu JJ, Wang DL, Chien S, Skalak R, Usami S (1998) Effects of disturbed flow on endothelial cells. J Biomech Eng 120:2-8. (Pubitemid 28110431)
8. Davies PF (2000) Spatial hemodynamics, the endothelium, and focal atherogenesis: A cell cycle link? Circ Res 86:114-116.
9. Chien S (2003) Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol 83:131-151.
10. Foteinos G, Hu Y, Xiao Q, Metzler B, Xu Q (2008) Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation 117:1856-1863. (Pubitemid 351507474)
11. Guo D, Chien S, Shyy JY (2007) Regulation of endothelial cell cycle by laminar versus oscillatory flow: Distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res 100:564-571. (Pubitemid 46673266)
12. Bobik A (2006) Transforming growth factor-betas and vascular disorders. Arterioscler Thromb Vasc Biol 26:1712-1720.
13. Sorescu GP, et al. (2003) Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem 278: 31128-31135. (Pubitemid 36994628)
14. Ankeny RF, et al. (2011) Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves - association with low BMP antagonists and SMAD6. PLoS ONE 6:e20969-e20977.
15. Chang SF, et al. (2009) BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol 23:1827-1838.
16. Suo J, et al. (2007) Hemodynamic shear stresses in mouse aortas: Implications for atherogenesis. Arterioscler Thromb Vasc Biol 27:346-351. (Pubitemid 46143050)
17. Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW (1998) Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res 82:532-539. (Pubitemid 28129023)
18. Zampetaki A, et al. (2010) Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation 121:132-142.
19. Gabriels JE, Paul DL (1998) Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ Res 83:636-643. (Pubitemid 28427747)
20. DePaola N, et al. (1999) Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro. Proc Natl Acad Sci USA 96:3154-3159. (Pubitemid 29148860)
21. Boström K, et al. (1993) Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 91:1800-1809. (Pubitemid 23127387)
22. Chang K, et al. (2007) Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: Role of bone morphogenic protein antagonists in inflammation and atherosclerosis. Circulation 116:1258-1266. (Pubitemid 47517537)
23. Stary HC, et al. (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol 15:1512-1531.