HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children

PLoS Pathogens

Volumn 8, Issue 3, 2012, Pages

  Walther, Michael ^a,b   de Caul, Adam ^a   Aka, Peter ^a   Njie, Madi ^a   Amambua Ngwa, Alfred ^a   Walther, Brigitte ^a   Predazzi, Irene M ^c   Cunnington, Aubrey ^a,d   Deininger, Susanne ^a,e   Takem, Ebako N ^a   Ebonyi, Augustine ^a   Weis, Sebastian ^f   Walton, Robert ^a,g   Rowland Jones, Sarah ^a,h   Sirugo, Giorgio ⁱ   Williams, Scott M ^c   Conway, David J ^a,d  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY HOSPITAL BONN   (Germany)

^f UNIVERSITY OF LEIPZIG   (Germany)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h JOHN RADCLIFFE HOSPITAL   (United Kingdom)

ⁱ FATEBENEFRATELLI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; HMOX1 PROTEIN; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; HMOX1 PROTEIN, HUMAN;

ALLELE; ARTICLE; BLOOD; CELL LEVEL; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NEUTROPHIL; PROMOTER REGION; PROTEIN EXPRESSION; CHILD; GAMBIA; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MORTALITY; PRESCHOOL CHILD; RESPIRATORY BURST; SURVIVAL RATE;

MURINAE; PLASMODIUM FALCIPARUM;

CHILD; CHILD, PRESCHOOL; FEMALE; GAMBIA; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEME OXYGENASE-1; HUMANS; LEUKOCYTES; MALARIA, FALCIPARUM; MALE; NEUTROPHILS; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RESPIRATORY BURST; RNA, MESSENGER; SURVIVAL RATE;

EID: 84861218407     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002579     Document Type: Article

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