Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells

FEBS Journal

Volumn 273, Issue 6, 2006, Pages 1102-1114

  Clement, Paul M J ^a,d   Johansson, Hans E ^b,c,e   Wolff, Edith C ^a   Park, Myung H ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e Biosearch Technologies Inc   (United States)

Author keywords

Alternative polyadenylation; eIF5A; Hypusine; Post translational modification; Translation

Indexed keywords

CELL PROTEIN; EUKARYOTIC TRANSLATION INITIATION FACTOR 5A 1; EUKARYOTIC TRANSLATION INITIATION FACTOR 5A 2; GENE PRODUCT; HYPUSINE; INITIATION FACTOR 5A; ISOPROTEIN; MESSENGER RNA; PROTEIN PRECURSOR; SUCROSE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL FRACTIONATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOPLASM; EMBRYO; EXPRESSION VECTOR; GENE OVEREXPRESSION; GENETIC CODE; HETEROZYGOTE; HUMAN; HUMAN CELL; MAMMAL; OPEN READING FRAME; OVARY CANCER; POLYADENYLATION; POLYSOME; PRECURSOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RNA TRANSLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SUCROSE GRADIENT; VERTEBRATE;

BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; NEOPLASMS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PEPTIDE INITIATION FACTORS; POLYADENYLATION; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSFECTION;

EUKARYOTA; MAMMALIA; VERTEBRATA;

EID: 33644756933     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05135.x     Document Type: Article

References (50)

1. Caraglia M Budillon A Vitale G Lupoli G Tagliaferri P Abbruzzese A 2000 Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation Eur J Biochem 267 3919 3936
2. Benne R Hershey JWB 1978 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes J Biol Chem 253 3078 3087
3. Kang HA Hershey JW 1994 Effect of initiation factor 5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae J Biol Chem 269 3934 3940
4. Xu A Jao DL Chen KY 2004 Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display Biochem J 384 585 590
5. Hofmann W Reichart B Ewald A Müller E Schmitt I Stauber RH Lottspeich F Jockusch BM Scheer U Hauber J et al. 2001 Cofactor requirements for nuclear export of Rev response element (RRE) - and constitutive transport element (CTE) -containing retroviral RNAs: an unexpected role for actin J Cell Biol 152 895 910
6. Zuk D Jacobson A 1998 A single amino acid substitution in yeast eIF-5A results in mRNA stabilization EMBO J 17 2914 2925
7. Park MH 2006 The post-translational synthesis of a polyamine-derived amino-acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A) J Biochem (Tokyo) 139 161 169
8. Wolff EC Lee YB Chung SI Folk JE Park MH 1995 Deoxyhypusine synthase from rat testis: purification and characterization J Biol Chem 270 8660 8666
9. Abbruzzese A Park MH Folk JE 1986 Deoxyhypusine hydroxylase from rat testis: partial purification and characterization J Biol Chem 261 3085 3089
10. Chen KY Liu AY 1997 Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A Biol Signals 6 105 109
11. Byers TL Wiest L Wechter RS Pegg AE 1993 Effects of chronic 5′-([(Z)-4-amino-2-butenyl]methylamino)-5′-deoxy-adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells Biochem J 290 115 121
12. Tome ME Gerner EW 1997 Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis Biol Signals 6 150 156
13. Caraglia M Marra M Giuberti G D'Alessandro AM Budillon A Del Prete S Lentini A Beninati S Abbruzzese A 2001 The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis Amino Acids 20 91 104
14. Caraglia M Marra M Giuberti G D'Alessandro AM Baldi A Tassone P Venuta S Tagliaferri P Abbruzzese A 2003 The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by Interferon-alpha and EGF in human cancer cells J Biochem (Tokyo) 133 757 765
15. Schnier J Schwelberger HG Smit-McBride Z Kang HA Hershey JW 1991 Translation initiation factor 5A and its hypusine modification are essential for viability in the yeast Saccharomyces cerevisiae Mol Cell Biol 11 3105 3114
16. Wöhl T Klier H Ammer H 1993 The HYP2 gene of Saccharomyces cerevisiae is essential for aerobic growth: characterization of different isoforms of the hypusine-containing protein Hyp2p and analysis of gene disruption mutants Mol Gen Genet 241 305 311
17. Valentini SR Casolari JM Oliveira CC Silver PA McBride AE 2002 Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly (A)-binding protein and protein kinase C signaling Genetics 160 393 405
18. 1-guanyl-1,7-diaminoheptane J Bacteriol 182 1158 1161
19. Sasaki K Abid MR Miyazaki M 1996 Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae FEBS Lett 384 151 154
20. Park MH Joe YA Kang KR 1998 Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae J Biol Chem 273 1677 1683
21. Park MH Wolff EC Lee YB Folk JE 1994 Antiproliferative effects of inhibitors of deoxyhypusine synthase: inhibition of growth of Chinese hamster ovary cells by guanyl diamines J Biol Chem 269 27827 27832
22. Hanauske-Abel HM Park MH Hanauske AR Popowicz AM Lalande M Folk JE 1994 Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation Biochim Biophys Acta 1221 115 124
23. Chen ZP Yan YP Ding QJ Knapp S Potenza JA Schugar HJ Chen KY 1996 Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells Cancer Lett 105 233 239
24. Clement PM Hanauske-Abel HM Wolff EC Kleinman HK Park MH 2002 The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro Int J Cancer 100 491 498
25. Nishimura K Murozumi K Shirahata A Park MH Kashiwagi K Igarashi K 2005 Independent roles of eIF5A and polyamines in cell proliferation Biochem J 385 779 785
26. Jenkins ZA Hååg PG Johansson HE 2001 Human EIF5A2 on chromosome 3q25-q27, is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression Genomics 71 101 109
27. Dou Q-P Chen K-Y 1989 The hypusine-containing proteins identified by metabolic labelling in chick embryo fibroblasts J Chinese Chem Soc 36 443 450
28. Wolff EC Kinzy TG Merrick WC Park MH 1992 Two isoforms of eIF-5A in chick embryo: isolation, activity, and comparison of sequences of the hypusine-containing proteins J Biol Chem 267 6107 6113
29. Smit-McBride Z Dever TE Hershey JW Merrick WC 1989 Sequence determination and cDNA cloning of eukaryotic translation initiation factor 4D, the hypusine containing protein J Biol Chem 264 1578 1583
30. Koettnitz K Wöhl T Kappel B Lottspeich F Hauber J Bevec D 1995 Identification of a new member of the human eIF-5A gene family Gene 159 283 284
31. Clement PC Henderson CA Jenkins ZA Smit-McBride Z Wolff EC Hershey JWB Park MH Johansson HE 2003 Identification and characterization of eukaryotic initiation factor 5A-2 Eur J Biochem 147 4254 4263
32. Guan XY Sham JS Tang TC Fang Y Huo KK Yang JM 2001 Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer Cancer Res 61 3806 3809
33. Guan XY Fung JM Ma NF Lau SH Tai LS Xie D Zhang Y Hu L Wu QL Fang Y et al. 2004 Oncogenic role of eIF-5A2 in the development of ovarian cancer Cancer Res 64 4197 4200
34. Cracchiolo BM Heller DS Clement PM Wolff EC Park MH Hanauske-Abel HM 2004 Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva Gynecol Oncol 94 217 222
35. Ramaswamy S Ross KN Lander ES Golub TR 2003 A molecular signature of metastasis in primary solid tumors Nat Genet 33 49 54
36. Wei CL MacMillan SE Hershey JW 1995 Protein synthesis initiation factor eIF-1A is a moderately abundant RNA-binding protein J Biol Chem 270 5764 5771
37. Li AL Li HY Jin BF Ye QN Zhou T Yu XD Pan X Man JH He K Yu M et al. 2004 A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis J Biol Chem 279 49251 49258
38. Park JH Aravind L Wolff EC Kaevel J Kim YS Park MH 2006 Molecular cloning, expression and structural prediction of deoxyhypusine hydroxylase: a novel HEAT-repeat-containing metalloenzyme Proc Natl Acad Sci (USA) 103 51 56
39. Si K Das K Maitra U 1996 Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5) J Biol Chem 271 16934 16938
40. Jaramillo M Pelletier J Edery I Nielsen PJ Sonenberg N 1991 Multiple mRNAs encode the murine translation initiation factor eIF-4E J Biol Chem 266 10446 10451
41. Boelens W Jansen EJR van Venrooij WJ Stripecke R Mattaj IW Gunderson SI 1993 The human U1snRNP specific protein U1A inhibits polyadenylation of its own pre-mRNA Cell 72 881 892
42. Gunderson SI Beyer K Martin G Keller W Boelens WC Mattaj LW 1994 The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase Cell 76 531 541
43. Guan F Palacios D Hussein RI Gunderson SI 2003 Determinants within an 18-amino-acid U1A autoregulatory domain that uncouple cooperative RNA binding, inhibition of polyadenylation, and homodimerization Mol Cell Biol 23 3163 3172
44. Phillips C Virtanen A 1997 The murine IgM secretory poly(A) site contains dual upstream and downstream elements which affect polyadenylation Nucleic Acids Res 25 2344 2351
45. Phillips C Pachikara N Gunderson SI 2004 U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions Mol Cell Biol 24 6162 6171
46. Jakus J Wolff EC Park MH Folk JE 1993 Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies: effective inhibition by bis- and mono-guanylated diamines and polyamines J Biol Chem 268 13151 13159
47. Park MH Liu TY Leece SH Swiggard WJ 1986 Eukaryotic initiation factor 4D: purification from human red blood cells and the sequence of amino acids around its single hypusine residue J Biol Chem 261 14515 14519
48. Joe YA Park MH 1994 Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine J Biol Chem 269 25916 25921
49. Joe YA Wolff EC Park MH 1995 Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins J Biol Chem 270 22386 22392
50. Wolff EC Folk JE Park MH 1997 Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase J Biol Chem 272 15865 15871