Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time

European Journal of Human Genetics

Volumn 20, Issue 6, 2012, Pages 696-700

  Reiling, Erwin ^a   Lyssenko, Valeriya ^b   Boer, Jolanda M A ^a   Imholz, Sandra ^a   Verschuren, W Monique M ^a   Isomaa, Bo ^c,d   Tuomi, Tiinamaija ^c,e   Groop, Leif ^b,e   Dollé, Martijn E T ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^c The Folkhä lsan Institute of Genetics   (Finland)

^d Department of Social Services and Health Care ^*  (Finland)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

blood pressure; longitudinal study; metabolism; P53

Indexed keywords

GLUCOSE; PROTEIN P53;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CODON; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLISM; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE;

ADULT; AGED; BLOOD PRESSURE; CODON; COHORT STUDIES; FEMALE; GENOTYPE; HUMANS; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861190823     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2011.240     Document Type: Article

References (27)

1. Ko LJ: Prives C: p53: puzzle and paradigm. Genes Dev 1996; 10: 1054-1072. (Pubitemid 26152848)
2. Lozano G, Elledge SJ: p53 sends nucleotides to repair DNA. Nature 2000; 404: 24-25. (Pubitemid 30143112)
3. Orsted DD, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG: Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population. J Exp Med 2007; 204: 1295-1301. (Pubitemid 46919867)
4. van Heemst D, Mooijaart SP, Beekman M,et al.Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol 2005; 40: 11-15. (Pubitemid 40138741)
5. Whibley C, Pharoah PD, Hollstein M: p53 polymorphisms: cancer implications. Nat Rev Cancer 2009; 9: 95-107.
6. Ahima RS: Connecting obesity, ageing and diabetes. Nat Med 2009; 15: 996-997.
7. Minamino T, Orimo M, Shimizu I,et al.A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009; 15: 1082-1087.
8. Verschuren WM, Blokstra A, Picavet HS, Smit HA: Cohort profile: the Doetinchem Cohort Study. Int J Epidemiol 2008; 37: 1236-1241.
9. van den Berg SW, Dolle ME, Imholz S,et al.Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. Int J Obes (Lond) 2009; 33: 1143-1152.
10. Groop L, Forsblom C, Lehtovirta M,et al.Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 1996; 45: 1585-1593. (Pubitemid 26357553)
11. Lyssenko V, Almgren P, Anevski D,et al.Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 2005; 54: 166-174. (Pubitemid 40105109)
12. World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitus, Report of a WHO Consultation, Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva: WHO/NCD/NCS/99.2, 1999.
13. Faul F, Erdfelder E, Lang AG, Buchner A: G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175-191.
14. Franklin SS, Gustin Wt, Wong ND,et al.Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 1997; 96: 308-315. (Pubitemid 27298437)
15. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical ResearchSaxena R, Voight BF, Lyssenko V,et al.Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316: 1331-1336. (Pubitemid 46871653)
16. Kato N, Miyata T, Tabara Y,et al.High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet 2008; 17: 617-627. (Pubitemid 351201773)
17. Levy D, Ehret GB, Rice K,et al.Genome-wide association study of blood pressure and hypertension. Nat Genet 2009; 41: 677-687.
18. Levy D, Larson MG, Benjamin EJ,et al.Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet 2007; 8 (Suppl 1): S3.
19. Newton-Cheh C, Johnson T, Gateva V,et al.Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009; 41: 666-676.
20. Org E, Eyheramendy S, Juhanson P,et al.Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet 2009; 18: 2288-2296.
21. Sabatti C, Service SK, Hartikainen AL,et al.Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 2009; 41: 35-46.
22. Wang Y, O'Connell JR, McArdle PF,et al.From the Cover: whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci USA 2009; 106: 226-231.
23. Wellcome Trust Case Control C: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-678.
24. Bojesen SE, Nordestgaard BG: The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. Cell Cycle 2008; 7: 158-163. (Pubitemid 351366514)
25. Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G: Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol 1999; 19: 1092-1100. (Pubitemid 29046852)
26. Zhu F, Doll ME, Berton TR,et al.Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res 2010; 70: 5851-5859.
27. Bonafe M, Salvioli S, Barbi C,et al.The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ 2004; 11: 962-973. (Pubitemid 39232356)