Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: A pilot randomized, double-blind, placebo-controlled trial

Pediatric Critical Care Medicine

Volumn 13, Issue 3, 2012, Pages 328-337

  Bhutta, Adnan T ^a   Schmitz, Michael L ^a   Swearingen, Christopher ^a   James, Laura P ^a   Wardbegnoche, Wendy L ^a   Lindquist, Diana M ^a   Glasier, Charles M ^a   Tuzcu, Volkan ^a   Prodhan, Parthak ^a   Dyamenahalli, Umesh ^a   Imamura, Michiaki ^a   Jaquiss, Robert D B ^a   Anand, Kanwaljeet J S ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

cardiopulmonary bypass; excitotoxicity; infants; inflammation; ketamine

Indexed keywords

BICARBONATE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHEMOKINE; CHOLINE; CISATRACURIUM; CREATINE; CYTOKINE; FENTANYL; GLUTAMIC ACID; GLUTAMINE; ISOFLURANE; KETAMINE; MIDAZOLAM; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURON SPECIFIC ENOLASE; NITROUS OXIDE; OXYGEN; PANCURONIUM; PLACEBO; PROTEIN S 100; SEVOFLURANE; SODIUM CHLORIDE; STEROID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BAYLEY SCALE OF INFANT DEVELOPMENT II; BICARBONATE BLOOD LEVEL; BLOOD SAMPLING; BODY TEMPERATURE; BREATHING RATE; CARDIOPULMONARY BYPASS; CENTRAL NERVOUS SYSTEM DISEASE; CENTRAL NERVOUS SYSTEM INJURY; CHILD; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; COOLING; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FRONTAL CORTEX; HEART VENTRICLE SEPTUM DEFECT; HEMODYNAMICS; HOSPITAL DISCHARGE; HUMAN; HYPOTHERMIA; INFANT; INSPIRATORY CAPACITY; INTRAOPERATIVE PERIOD; MALE; NEAR INFRARED SPECTROSCOPY; NEUROLOGICAL COMPLICATION; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; PATIENT MONITORING; PILOT STUDY; POSTOPERATIVE INFLAMMATION; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RISK REDUCTION; SURGICAL TECHNIQUE; THROMBOCYTE COUNT; WHITE MATTER;

ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; BRAIN; BRAIN INJURIES; C-REACTIVE PROTEIN; CARDIOPULMONARY BYPASS; CENTRAL NERVOUS SYSTEM; CHILD DEVELOPMENT; CYTOKINES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART SEPTAL DEFECTS, VENTRICULAR; HUMANS; INFANT; INFLAMMATION; INJECTIONS, INTRAVENOUS; INTENTION TO TREAT ANALYSIS; KETAMINE; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPROTECTIVE AGENTS; PILOT PROJECTS; SPECTROSCOPY, NEAR-INFRARED; TREATMENT OUTCOME;

EID: 84861188343     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31822f18f9     Document Type: Article

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