Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3754-3757

  Smith, Garry R ^a   Caglič, Dejan ^b   Čapek, Petr ^b   Zhang, Yan ^a   Godbole, Sujata ^b   Reitz, Allen B ^a   Dickerson, Tobin J ^b  

^a Fox Chase Chemical Diversity Center   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Bioterrorism; Botulinum neurotoxin; Hydroxamic acids; Rational inhibitor design

Indexed keywords

2,4 DICHLOROCINNAMYL HYDROXAMATE; BOTULINUM TOXIN A; HYDROXAMIC ACID DERIVATIVE; METALLOPROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; IC 50; LIGHT CHAIN; NONHUMAN; PLASTICITY; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; BOTULINUM TOXINS, TYPE A; COMPUTER SIMULATION; HYDROXAMIC ACIDS; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861187380     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.019     Document Type: Article

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