Enhancing the pharmacokinetic properties of botulinum neurotoxin serotype A protease inhibitors through rational design

ACS Chemical Neuroscience

Volumn 2, Issue 6, 2011, Pages 288-293

  Čapek, Petr ^a   Zhang, Yan ^b   Barlow, Deborah J ^c   Houseknecht, Karen L ^c   Smith, Garry R ^b   Dickerson, Tobin J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Fox Chase Chemical Diversity Center Inc   (United States)

^c UNIVERSITY OF NEW ENGLAND   (United States)

Author keywords

ADME; benzothiophene; Botulinum neurotoxin; competitive inhibitor; zinc metalloprotease

Indexed keywords

BOTULINUM TOXIN A; HYDROXAMIC ACID; METALLOPROTEINASE;

ARTICLE; DRUG EFFICACY; DRUG TARGETING; FOLLOW UP; IN VIVO STUDY; PRIORITY JOURNAL;

EID: 79959281217     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200021q     Document Type: Article

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