5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity

British Journal of Pharmacology

Volumn 161, Issue 4, 2010, Pages 936-949

  Fischer, A S ^a   Metzner, J ^a   Steinbrink, S D ^a   Ulrich, S ^a   Angioni, C ^a   Geisslinger, G ^a   Steinhilber, D ^a   Maier, T J ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

apoptosis; cytotoxicity; leukotriene; off target effect; pancreatic cancer; zileuton

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; CJ 13610; CYCLOOXYGENASE 2 INHIBITOR; DOCEBENONE; LACTATE DEHYDROGENASE; LIPOXYGENASE INHIBITOR; N [3 (3 PHENOXYPHENYL)ALLYL]ACETOHYDROXAMIC ACID; RNA; UNCLASSIFIED DRUG; ZILEUTON;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; DRUG CYTOTOXICITY; ENZYME ASSAY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; ARACHIDONATE 5-LIPOXYGENASE; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPOXYGENASE INHIBITORS; NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 77957240474     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00915.x     Document Type: Article

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