Epithelial tight junction alterations in nasal polyposis

International Forum of Allergy and Rhinology

Volumn 1, Issue 1, 2011, Pages 50-54

  Rogers, G Aaron ^a   Beste, Kyle Den ^a   Parkos, Charles A ^a   Nusrat, Asma ^a   Delgaudio, John M ^a   Wise, Sarah K ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Interferon gamma; Nasal polyps; Rhinitis; Tight junctions; Tumor necrosis factor alpha

Indexed keywords

CLAUDIN 1; CYTOKINE; GAMMA INTERFERON; OCCLUDIN; TUMOR NECROSIS FACTOR ALPHA; MEMBRANE PROTEIN;

ARTICLE; BRONCHUS MUCOSA; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EPITHELIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; NOSE POLYP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; TIGHT JUNCTION; WESTERN BLOTTING; CASE CONTROL STUDY; CELL CULTURE; CONFOCAL MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NOSE MUCOSA; RHINITIS;

BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTERFERON-GAMMA; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; NASAL MUCOSA; NASAL POLYPS; RHINITIS; TIGHT JUNCTIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861181095     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.20014     Document Type: Article

References (17)

1. Litvack JR, Griest S, James KE, Smith TL. Endoscopic and quality-of-life outcomes after revision endoscopic sinus surgery. Laryngoscope. 2007;117:2233-2238.
2. Soler ZM, Sauer D, Mace J, Smith TL. Impact of mucosal eosinophilia and nasal polyposis on quality-of-life outcomes after sinus surgery. Otolaryngol Head Neck Surg. 2010;142:64-71.
3. Pinto da Silva P, Kachar B. On tight-junction structure. Cell. 1982;38:441-450.
4. Gumbiner B. Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol. 1987;253(6 Pt 1):C749-C758.
5. Laukoetter MG, Nava P, Nusrat A. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2008;14:401-407.
6. Zuckerman JD, Lee WY, DelGaudio JM, et al. Pathophysiology of nasal polyposis: the role of desmosomal junctions. Am J Rhinol. 2008;22:589-597.
7. Coyne CB, Vanhook MK, Gambling TM, et al. Regulation of airway tight junctions by proinflammatory cytokines. Mol Biol Cell. 2002;13:3218-3234.
8. Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest. 2004;84:282-291.
9. Bruewer M, Samarin S, Nusrat A. Inflammatory bowel disease and the apical junctional complex. Review. Ann N Y Acad Sci. 2006;1072:242-252.
10. Kucharzik T, Walsh SV, Chen J, Parkos CA, Nusrat A. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am J Pathol. 2001;159:2001-2009.
11. Alexander JS, Elrod JW, Park JH. Roles of leukocyte and immune cell junctional proteins. Microcirculation. 2001;8:169-179.
12. Zen K, Parkos CA. Leukocyte-epithelial interactions. Curr Opin Cell Biol. 2003;15:557-564.
13. Takano K, Kojima T, Go M, et al. HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis. J Histochem Cytochem. 2005;53:611-619.
14. Takizawa R, Pawankar R, Yamagishi S, Takenaka H, Yagi T. Increased expression of HLA-DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up-regulation by diesel exhaust particles. Clin Exp Allergy. 2007;37:420-433.
15. Boivin MA, Ye D, Kennedy JC, et al. Mechanism of glucocorticoid regulation of the intestinal tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2007;292:G590-G598.
16. Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005;129:550-564.
17. Ahdieh M, Vandenbos T, Youakim A. Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ. Am J Physiol Cell Physiol. 2001;281:C2029-C2038.