Increased expression of HLA-DR and CD86 in nasal epithelial cells in allergic rhinitics: Antigen presentation to T cells and up-regulation by diesel exhaust particles

Clinical and Experimental Allergy

Volumn 37, Issue 3, 2007, Pages 420-433

  Takizawa, R ^a   Pawankar, R ^a   Yamagishi, S ^a   Takenaka, H ^b   Yagi, T ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Allergic rhinitis; APC; CD86; DEP; HLA DR; Nasal epithelial cells

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; HLA DR ANTIGEN; MITOMYCIN C;

ADULT; ALLERGIC RHINITIS; ANTIGEN PRESENTATION; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXHAUST GAS; FEMALE; FLOW CYTOMETRY; HAY FEVER; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NOSE MUCOSA; PERENNIAL ALLERGIC CONJUNCTIVITIS; PRIORITY JOURNAL; SEASONAL VARIATION; T LYMPHOCYTE; UPREGULATION;

ADULT; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD86; EPITHELIAL CELLS; HLA-DR ANTIGENS; HUMANS; JAPAN; MALE; NASAL MUCOSA; RHINITIS; UP-REGULATION; VEHICLE EMISSIONS;

EID: 33847775780     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2007.02672.x     Document Type: Article

References (57)

1. Jeffery PK. Morphologic features of airway surface epithelial cells and glands. Am Rev Respir Dis 1983; 128:S14-20.
2. Henke D, Danilowicz RM, Curtis JF, Boucher RC, Eling TE. Metabolism of arachidonic acid by human nasal and bronchial epithelial cells. Arch Biochem Byophys 1988; 267:426-36.
3. Daffern PJ, Jagels MA, Saad JJ, Fischer W, Hugli TE. Upper airway epithelial cells support eosinophil survival in vitro through production of GM-CSF and prostaglandin E2: regulation by glucocorticoids and TNF-α. Allergy Asthma Proc 1999; 20:243-53.
4. Nakano J, Takizawa H, Ohtoshi T et al. Endotoxin and proinflammatory cytokines stimulate endothelin-1 expression and release by airway epithelial cells. Clin Exp Allergy 1994; 24:330-6.
5. Ohnishi M, Ruhno J, Beinenstock J, Dolovich J, Denburg JA. Hematopetic growth factor production by cultured cells of human nasal polyp epithelial scraping: kinetics, cell source and relationship to clinical status. J Allergy Clin Immunol 1989; 83:1091-100.
6. Ohtoshi T, Tsuda T, Vancheri C et al. Human upper airway epithelial cell-derived granulocyte-macrophage colony-stimulating factor induces histamine-containing cell differentiation of human progenitor cells. Int Arch Allergy Appl Immunol 1991; 95:376-84.
7. Cromwell O, Hamid Q, Corrigan CJ et al. Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colonystimulating factor by bronchial epithelial cells and enhancement of IL-1β and tumor necrosis factor-α. Immunology 1992; 77:330-7.
8. Kenney JS, Baker C, Welch MR, Altman LC. Synthesis of interleukin-1 alpha, interleukin-6, and interleukin-8 by cultured human nasal epithelial cells. J Allergy Clin Immunol 1994; 93:1060-7.
9. Nonaka M, Nonaka R, Jordana M, Dolovich J. GM-CSF, IL-8, IL-1R, TNF-alpha R, and HLA-DR in nasal epithelial cells in allergic rhinitis. Am J Respir Crit Care Med 1996; 153:1675-81.
10. Tosi MF, Stark JM, Smith CW, Hamdani A, Gruenert DC, Infed MD. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: effects on neutrophil-epithelial cell adhesion. Am J Resir Cell Mol Biol 1992; 7:214-21.
11. Atsuta JS, Sterbinsky A, Plitt J, Schwiebert LM, Bochner BS, Schleimer RP. Phenotype and cytokine regulation of the BEAS-2B human bronchial epithelial cell: demonstration of inducible expression of the adhesion molecules VCAM-1 and ICAM-1. Am J Resir Cell Mol Biol 1997; 17:571-82.
12. Brandtzaeg P. Immunocompetent cells of the upper airway: functions in normal and diseased mucosa. Eur Arch Otorhinolaryngol 1995; 252:S8-21.
13. Brandtzaeg P, Halstensen TS, Huitfeldt HS et al. Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract. Ann NYAcad Sci 1992; 664:157-79.
14. Rossi GA, Sacco O, Balbi B et al. Human ciliated bronchial epithelial cells: expression of HLA-DR antigens and of the HLA-DR alpha gene, Modulation of the HLA-DR antigens by gamma-interferon and antigen-presenting function in the mixed lymphocyte reaction. Am J Resir Cell Mol Biol 1990; 3:431-9.
15. Mezzetti M, Soloperto M, Fasoli A, Mattoli S. Human bronchial epithelial cells modulate CD3 and mitogen-induced DNA synthesis in T cells but function poorly as antigen-presenting cells compared to pulmonary macrophages. J Allergy Clin Immunol 1991; 87:930-8.
16. Schwartz BD. HLA molecules: sentinel of the immune response. Am J Resir Cell Mol Biol 1991; 5:211-2.
17. Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2 enhancer activity by the T cell accessory molecule CD28. Science 1991; 251:313-6.
18. Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992; 356:607-9.
19. June CH, Ledbetter JA, Gillespie MM, Linsten T, Thompson CB. T cell proliferation involving the CD28 pathway is associated with cyclosporine- resistant interleukin 2 gene expression. Mol Cell Biol 1987; 7:4472-81.
20. Chambers CA, Allison JP. Co-stimulation in T cell responses. Curr Opin Immunol 1997; 9:396-404.
21. Gause WC, Mitro V, Via C, Linsley P, Urban JF, Greenwald RJ. Do effecter and memory T cells also need B7 ligand co-stimulatory signals? J Immunol 1997; 159:1055-8.
22. Salvi S, Blomberg A, Rudell B et al. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 1999; 159:702-9.
23. Ohtoshi T, Takizawa H, Okazaki H et al. Diesel exhaust particles (DEP) stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J Allergy Clin Immunol 1998; 101:778-85.
24. Pawankar R, Okuda M, Hasegawa S et al. Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am J Respir Crit Care Med 1995; 152:2059-67.
25. Takenaka H, Zhang K, Diaz-Sanchez D, Tsien A, Saxon A. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B-cell IgE production. J Allergy Clin Immunol 1995; 95: 103-15.
26. Muranaka M, Suzuki S, Koizumi K et al. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J Allergy Clin Immunol 1986; 77:616-23.
27. Schwaltz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71:1065-8.
28. Freeman GJ, Gribben JG, Boussiotis VA et al. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 1993; 262:909-11.
29. Azuma M, Ito D, Yagita H et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 1993; 366:76-9.
30. Fleming TE, Mirando WS, Trefzer U, Tubesing KA, Elmets CA. In situ expression of a B7-like adhesion molecule on keratinocytes from human epidermis. J Invest Dermatol 1993; 101:754-8.
31. Ye G, Barrera C, Fan X et al. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells. J Clin Invest 1997; 99:1628-36.
32. Nakazawa A, Watanabe M, Kanai T et al. Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa. Gastroenterology 1999; 117:536-45.
33. Fokkens WJ, Broekhuis-Fluitsma DM, Rijntjes E, Vroom TM, Hoefsmit EC. Langerhans cells in nasal mucosa of patients with grass pollen allergy. Immunobiology 1991; 182:135-42.
34. Godthelp T, Fokkens WJ, Kleinjan A et al. Antigen presenting cells in the nasal mucosa of patients with allergic rhinitis during allergen provocation. Clin Exp Allergy 1996; 26:677-88.
35. Robinson DS, Hamid Q, Ying S et al. Predominant TH-2 like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298-304.
36. Wills-karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999; 17:255-81.
37. Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol 2000; 105:399-408.
38. Lordan IL, Jaffer ZH. Role of CD28/B7 co-stimulation in airway T helper 2 (TH2) immune responses in asthma. Clin Exp Allergy 1998; 28:1317-20.
39. Pawankar R, Okuda M, Okubo K, Ra C. Lymphocyte subjects of the nasal mucosa in perennial allergic rhinitis. Am J Respir Crit Care Med 1995; 152:2049-58.
40. Pawankar R. Epithelial cells as immunoregulators in allergic airway diseases. Curr Opin Allergy Clin Immunol 2002; 2:1-5.
41. Yamagishi S, Pawankar R, Takizawa R, Nonaka M, Yagi T. Nasal epithelial cells express the FceRI: IL-4-induced upregulation of the FceRI and IL-6 production [abstract]. J Allergy Clin Immunol 2003; 111:s347.
42. Bachert C, Wagenmann M, Hauser U. Proinflammatory cytokines: measurement in nasal secretion and induction of adhesion receptor expression. Int Arch Allergy Immunol 1995; 107:106-8.
43. Lee CH, Rhee CS, Oh SH, Min YG, Lee MS. Increase in expression of IL-4 and IL-5 mRNA in the nasal mucosa of patients with perennial allergic rhinitis during natural allergen exposure. Ann Otol Rhinol Laryngol 1997; 106:215-9.
44. Durham SR, Ying S, Varney VA et al. Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol 1992; 148:2390-4.
45. Pawankar R, Ra C. Heterogeneity of mast cells and T cells in the nasal mucosa. J Allergy Clin Immunol 1996; 98:248-26.
46. Linden M, Greiff L, Andersson M et al. Nasal cytokines in common cold and allergic rhinitis. Clin Exp Allergy 1995; 25:166-72.
47. Takafuji S, Suzuki S, Koizumi K et al. Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice. J Allergy Clin Immunol 1987; 79:639-45.
48. Diaz-Sanchez D, Dotson AR, Takenaka H, Saxon A. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest 1994; 94:1417-25.
49. Diaz-Sanchez D, Tsien A, Casillas A, Dotson AR, Saxon A. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. J Allergy Clin Immunol 1996; 98:114-23.
50. Diaz-Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particle and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol 1997; 158:2406-13.
51. Asokananthan N, Graham PT, Stewart DJ et al. House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J Immnnol 2002; 169:4572-8.
52. Takizawa H, Abe S, Ohtoshi T et al. Diesel exhaust particles upregulate expression of intercellular adhesion molecule-1 (ICAM-1) in human bronchial epithelial cells. Clin Exp Immunol 2000; 120:356-62.
53. Takizawa H, Ohtoshi T, Kawasaki S et al. Diesel exhaust particles induce NF-kB activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J Immunol 1999; 162:4705-11.
54. Nel AE, Diaz-Sanchez D, Ng D, Hiura T, Saxon A. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 1998; 102:539-54.
55. Inoue K, Takano H, Yanagisawa R et al. The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles. Arch Toxicol 2006; 80:275-9.
56. Bleck B, Tse DB, Jaspers I, Curotto de Lafaille MA, Reibman J. Diesel exhaust particles-exposed human bronchial epithelial cells induce dendritic cell maturation. J Immunol 2006; 176:7431-7.
57. Mamessier E, Nieves A, Vervloet D, Magnan A. Diesel exhaust particles enhance T-cell activation in severe asthmatics. Allergy 2006; 61:581-8.