Biomarkers of leukocyte traffic and activation in the vaginal mucosa

Biomarkers

Volumn 12, Issue 6, 2007, Pages 608-622

  Trifonova, Radiana T ^a   Bajpai, Malini ^b   Pasicznyk, Jenna Malia ^a   Chandra, Neelima ^b   Doncel, Gustavo F ^b   Fichorova, Raina N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Anti HIV 1 microbicides; CD14; E selectin; Myeloperoxidase; Vaginitis; VCAM 1

Indexed keywords

BIOLOGICAL MARKER; CD14 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MICROBICIDE; MYELOPEROXIDASE; SPERMICIDAL AGENT; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; MUCOSA CELL; MUCOSA INFLAMMATION; NONHUMAN; PROTEIN ANALYSIS; RABBIT; VAGINA MUCOSA; VAGINA SECRETION; VAGINAL LAVAGE; VAGINITIS;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ANTIGENS, CD14; BENZALKONIUM COMPOUNDS; BIOLOGICAL MARKERS; CHEMOTAXIS, LEUKOCYTE; E-SELECTIN; FEMALE; HUMANS; LEUKOCYTES; MUCOUS MEMBRANE; NONOXYNOL; PEROXIDASE; RABBITS; REPRODUCIBILITY OF RESULTS; SODIUM DODECYL SULFATE; SPERMATOCIDAL AGENTS; TIME FACTORS; TOXICITY TESTS; VAGINA; VAGINITIS; VASCULAR CELL ADHESION MOLECULE-1;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS;

EID: 35748977128     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500701600670     Document Type: Article

References (51)

1. Ahmad, M., Theofanidis, P. and Medford, RM (1998) Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha. Journal of Biological Chemistry, 273, pp. 4616-4621. 1998
2. Alfano, M. and Poli, G. (2005) Role of cytokines and chemokines in the regulation of innate immunity and HIV infection. Molecular Immunology, 42, pp. 161-182.
3. Blann, AD, Herrick, A. and Jayson, MI (1995) Altered levels of soluble adhesion molecules in rheumatoid arthritis, vasculitis and systemic sclerosis. British Journal of Rheumatology, 34, pp. 814-819.
4. Carlos, TM and Harlan, JM (1994) Leukocyte-endothelial adhesion molecules. Blood, 84, pp. 2068-2101.
5. Catalone, BJ, Miller, SR, Ferguson, ML, Malamud, D., Kish-Catalone, T., Thakkar, NJ, Krebs, FC, Howett, MK and Wigdahl, B. (2005) Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G. Biomedical Pharmacotherapy, 59, pp. 430-437.
6. Coleman, N. and Stanley, MA (1994) Characterization and functional analysis of the expression of vascular adhesion molecules in human papillomavirus-related disease of the cervix. Cancer, 74, pp. 884-892.
7. Collins, T., Read, M., Neish, A., Whitley, M., Thanos, D. and Maniatis, T. (1995) Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB Journal, 9, pp. 899-909.
8. Cone, RA, Hoen, T., Wong, X., Abusuwwa, R., Anderson, DJ and Moench, TR (2006) Vaginal microbicides: Detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infectious Diseases, 6, p. 90.
9. Cummins Jr, JE, Guarner, J., Flowers, L., Guenthner, PC, Bartlett, J., Morken, T., Grohskopf, LA, Paxton, L. and Dezzutti, CS (2007) Preclinical testing of candidate topical microbicides for anti-HIV-1 activity and tissue toxicity in a human cervical explant culture. Antimicrobial Agents and Chemotherapy, 51, pp. 1770-1779.
10. Dhawan, D. and Mayer, KH (2006) Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection. Journal of Infectious Diseases, 193, pp. 36-44. 2006
11. Doncel, GF, Chandra, N. and Fichorova, RN (2004) Preclinical assessment of the proinflammatory potential of microbicide candidates. Journal of Acquired Immune Deficiency Syndrome, 37, pp. S174-S180.
12. Eckstein, P., Jackson, MCN, Millman, N. and Sobrero, AJ (1969) Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys. Journal of Reproductive Fertility, 20, pp. 85-93.
13. Fichorova, RN, Desai, PJ, Gibson, F. and Genco, CA (2001) Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infection and Immunity, 69, pp. 5840-5848.
14. Fichorova, RN, Tucker, L. and Anderson, DJ (2001) The molecular basis of nonoxynol-9 induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. Journal of Infectious Diseases, 184, pp. 418-428.
15. Fichorova, RN, Cronin, A., Lien, E., Anderson, DJ and Ingalls, RR (2002) Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of TLR-4-mediated signaling. Journal of Immunology, 168, pp. 2424-2432.
16. Fichorova, RN (2004) Guiding the vaginal microbicide trials with biomarkers of inflammation. Journal of Acquired Immune Deficiency Syndrome, 35, pp. S1-S8.
17. Fichorova, RN, Bajpai, M., Chandra, N., Hsiu, JG, Spangler, M., Ratnam, V. and Doncel, GF (2004) Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biological Reproduction, 71, pp. 761-769.
18. Fichorova, RN, Zhou, F., Ratnam, V., Atanassova, V., Jiang, S., Strick, N. and Neurath, AR (2005) Anti-human immunodeficiency virus type 1 microbicide cellulose acetate 1,2-benzenedicarboxylate in a human in vitro model of vaginal inflammation. Antimicrobial Agents and Chemotherapy, 49, pp. 323-335.
19. Fletcher, PS, Wallace, GS, Mesquita, PM and Shattock, RJ (2006) Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. Retrovirology, 3, p. 46.
20. Foster, JR (2001) The functions of cytokines and their uses in toxicology. International Journal of Experimental Pathology, 82, pp. 171-192.
21. Fujihara, M., Muroi, M., Tanamoto, K., Suzuki, T., Azuma, H. and Ikeda, H. (2003) Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex. Pharmacology & Therapeutics, 100, pp. 171-194.
22. Galen, BT, Martin, AP, Hazrati, E., Garin, A., Guzman, E., Wilson, SS, Porter, DD, Lira, SA, Keller, MJ and Herold, BC (2007) A comprehensive murine model to evaluate topical vaginal microbicides: Mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety. Journal of Infectious Disease, 195, pp. 1332-1339.
23. Garton, KJ, Gough, PJ, Philalay, J., Wille, PT, Blobel, CP, Whitehead, RH, Dempsey, PJ and Raines, EW (2003) Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). Journal of Biological Chemistry, 278, pp. 37459-37464.
24. Hillier, SL, Moench, T., Shattock, R., Black, R., Reichelderfer, P. and Veronese, F. (2005) In vitro and in vivo: The story of nonoxynol 9. Journal of Acquired Immune Deficiency Syndrome, 39, pp. 1-8.
25. Howett, MK and Kuhl, JP (2005) Microbicides for prevention of transmission of sexually transmitted diseases. Current Pharmaceutical Design, 11, pp. 3731-3746.
26. Johansson, EL, Rudin, A., Wassen, L. and Holmgren, J. (1999) Distribution of lymphocytes and adhesion molecules in human cervix and vagina. Immunology, 96, pp. 272-277.
27. Kitani, A., Nakashima, N., Izumihara, T., Inagaki, M., Baoui, X., Matsuda, T. and Matsuyama, T. (1998) Soluble VCAM-1 induces chemotaxis of Jurkat and synovial fluid T cells bearing high affinity very late antigen-4. Journal of Immunology, 161, pp. 4931-4938.
28. Klebanoff, SJ (2005) Myeloperoxidase: Friend and foe. Journal of Leukocyte Biology, 77, pp. 598-625.
29. Krebs, FC, Miller, SR, Catalone, BJ, Fichorova, R., Anderson, D., Malamud, D., Howett, MK and Wigdahl, B. (2002) Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate. Antimicrobial Agents and Chemotherapy, 46, pp. 2292-2298.
30. Lard-Whiteford, SL, Matecka, D., O'Rear, JJ, Yuen, IS, Litterst, C. and Reichelderfer, P. (2004) Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission: An update. Journal of Acquired Immune Deficiency Syndrome, 36, pp. 541-552.
31. Lawn, SD, Subbarao, S., Wright Jr, TC, Evans-Strickfaden, T., Ellerbrock, TV, Lennox, JL, Butera, ST and Hart, CE (2000) Correlation between human immunodeficiency virus type 1 RNA levels in the female genital tract and immune activation associated with ulceration of the cervix. Journal of Infectious Disease, 181, pp. 1950-1956.
32. Lee, DK, Kang, JE, Park, HJ, Kim, MH, Yim, TH, Kim, JM, Heo, MK, Kim, KY, Kwon, HJ and Hur, MW (2005) FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB. Journal of Biological Chemistry, 280, pp. 27783-27791.
33. Lichtenwalner, AB, Patton, DL, Klebanoff, SJ, Headley, CM and Hillier, SL (2000) Vaginal myeloperoxidase and flora in the pig-tailed macaque. Journal of Medical Primatology, 29, pp. 36-41.
34. Littler, A., Buckley, C., Wordsworth, P., Collins, I., Martinson, J. and Simmons, D. (1997) A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis. Rheumatology, 36, pp. 164-169.
35. Mansoor, MA, Seljeflot, I., Arnesen, H., Knudsen, A., Bates, CJ, Mishra, G. and Larsen, TW (2004) Endothelial cell adhesion molecules in healthy adults during acute hyperhomocysteinemia and mild hypertriglyceridemia. Clinical Biochemistry, 37, pp. 408-414.
36. Matsuda, M., Tsukada, N., Miyagi, K. and Yanagisawa, N. (1995) Increased levels of soluble vascular cell adhesion molecule-1 (VCAM-1) in the cerebrospinal fluid and sera of patients with multiple sclerosis and human T lymphotropic virus type-1-associated myelopathy. Journal of Neuroimmunology, 59, pp. 35-40.
37. McGowan, I. (2006) Microbicides: A new frontier in HIV prevention. Biologicals, 34, pp. 241-255.
38. Molad, Y., Miroshnik, E., Sulkes, J., Pitlik, S., Weinberger, A. and Monselise, Y. (2002) Urinary soluble VCAM-1 in systemic lupus erythematosus: A clinical marker for monitoring disease activity and damage. Clinical and Experimental Rheumatology, 20, pp. 403-406.
39. O'Neil, LA and Greene, C. (1998) Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects and plants. Journal of Leukocyte Biology, 63, pp. 650-657.
40. Phillips, DM and Maguire, RA (2002) The development of microbicides for clinical use to prevent sexually transmitted diseases. Current Infectious Disease Reports, 4, pp. 135-140.
41. Quinn, TC (1996) Association of sexually transmitted diseases and infection with the human immunodeficiency virus: Biological cofactors and markers of behavioral interventions. International Journal of STD & AIDS, 7, pp. 17-24.
42. Salmi, M. and Jalkanen, S. (2005) Cell-surface enzymes in control of leukocyte trafficking. Nature Reviews. Immunology, 5, pp. 760-771.
43. Segura, RM, Alegre, J., Varela, E., Marti, R., Surinach, JM, Jufresa, J., Armadans, L., Pascual, C. and de Sevilla, T Fernandez (1998) Interleukin-8 and markers of neutrophil degranulation in pleural effusions. American Journal of Respiratory & Critical Care Medicine, 157, pp. 1565-1572.
44. Shattock, RJ and Moore, JP (2003) Inhibiting sexual transmission of HIV-1 infection. Nature Reviews. Microbiology, 1, pp. 25-34.
45. Simon, V., Ho, DD and Karim, Q Abdool (2006) HIV/AIDS epidemiology, pathogenesis, prevention, and treatment. Lancet, 368, pp. 489-504.
46. Stone, A. (2002) Microbicides: A new approach to preventing HIV and other sexually transmitted infections. Nature Reviews. Drug Discovery, 1, pp. 977-985.
47. Sugawara, T., Gallucci, RM, Simeonova, PP and Luster, MI (2001) Regulation and role of interleukin 6 in wounded human epithelial keratinocytes. Cytokine, 15, pp. 328-336.
48. Triantafilou, M. and Triantafilou, K. (2005) The dynamics of LPS recognition: Complex orchestration of multiple receptors. Journal of Endotoxin Research, 11, pp. 5-11.
49. Trifonova, RT, Pasicznyk, JM and Fichorova, RN (2006) Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo. Antimicrobial Agents and Chemotherapy, 50, pp. 4005-4010.
50. Brink, GR Van den, Kate, FJ ten, Ponsioen, CY, Rive, MM, Tytgat, GN, van Deventer, SJH and Peppelenbosch, MP (2000) Expression and activation of NF-κB in the antrum of the human stomach. Journal of Immunology, 164, pp. 3353-3359.
51. Xyni, K., Rizos, D., Giannaki, G., Sarandakou, A., Phocas, I. and Creatsas, G. (2000) Soluble form of ICAM-1, VCAM-1, E- and L-selectin in human milk. Mediators of Inflammation, 9, pp. 133-140.