Human sinonasal explant system for testing cytotoxicity of intranasal agents

International Forum of Allergy and Rhinology

Volumn 2, Issue 1, 2012, Pages 63-68

  Lim, Jae H ^a   Davis, Greg E ^a   Rue, Tessa C ^b   Storm, Daniel R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cytotoxicity; Drug discovery; Human sinonasal explants; Intranasal agents; Organotypic tissue culture

Indexed keywords

AZELASTINE; BETA TUBULIN; CICLESONIDE; CROMOGLYCATE DISODIUM; FLUTICASONE PROPIONATE; IPRATROPIUM BROMIDE; KI 67 ANTIGEN; LACTATE DEHYDROGENASE; MOMETASONE FUROATE; NOSE SPRAY; OXYMETAZOLINE; PANTANASE; POLITEF; UNCLASSIFIED DRUG; ZICAM; ZINC SULFATE; BIOLOGICAL MARKER; RESPIRATORY TRACT AGENT;

ARTICLE; BIOCHEMISTRY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOSCOPIC SINUS SURGERY; EXPLANT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PARANASAL SINUS DISEASE; PRIORITY JOURNAL; TISSUE CULTURE; CELL CULTURE; DRUG DEVELOPMENT; DRUG TOXICITY; ENZYME ASSAY; ENZYMOLOGY; METABOLISM; METHODOLOGY; NOSE CAVITY; TOXICITY TESTING;

BIOLOGICAL MARKERS; CELLS, CULTURED; DRUG DISCOVERY; DRUG TOXICITY; ENZYME ASSAYS; HUMANS; L-LACTATE DEHYDROGENASE; NASAL CAVITY; PARANASAL SINUS DISEASES; RESPIRATORY SYSTEM AGENTS; TOXICITY TESTS;

EID: 84861163570     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.20110     Document Type: Article

References (13)

1. Lim JH, Davis GE, Wang Z, et al. Zicam-induced damage to mouse and human nasal tissue. PLoS One. 2009;4:e7647.
2. Davidson TM, Smith WM. The Bradford Hill criteria and zinc-induced anosmia: a causality analysis. Arch Otolaryngol Head Neck Surg. 2010;136:673-676.
3. Alexander TH, Davidson TM. Intranasal zinc and anosmia: the zinc-induced anosmia syndrome. Laryngoscope. 2006;116:217-220.
4. Gahwiler BH, Capogna M, Debanne D, McKinney RA, Thompson SM. Organotypic slice cultures: a technique has come of age. Trends Neurosci. 1997;20:471-477.
5. Bhadriraju K, Chen CS. Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov Today. 2002;7:612-620.
6. Schmeichel KL, Bissell MJ. Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci. 2003;116:2377-2388.
7. Alberty J, Stoll W, Rudack C. The effect of endogenous nitric oxide on mechanical ciliostimulation of human nasal mucosa. Clin Exp Allergy. 2006;36:1254-1259.
8. Wang D, Chen P, Quan W, Halpern M. Suprasternal gland secretion of male short-tailed opossum induces IP3 generation in the vomeronasal organ. Biochim Biophys Acta. 2007;1770:725-732.
9. Feron F, Perry C, McGrath JJ, Mackay-Sim A. New techniques for biopsy and culture of human olfactory epithelial neurons. Arch Otolaryngol Head Neck Surg. 1998;124:861-866.
10. Hahn CG, Han LY, Rawson NE, et al. In vivo and in vitro neurogenesis in human olfactory epithelium. J Comp Neurol. 2005;483:154-163.
11. 4 irrigation on behavior, biochemistry and morphology. Brain Res. 1978;140:271-285.
12. McBride K, Slotnick B, Margolis FL. Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study. Chem Senses. 2003;28:659-670.
13. Jafek BW, Linschoten MR, Murrow BW. Anosmia after intranasal zinc gluconate use. Am J Rhinol. 2004;18:137-141.