DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease

Current Alzheimer Research

Volumn 9, Issue 5, 2012, Pages 550-554

  Coppedè, Fabio ^a   Zitarosa, Maria Teresa ^a   Migheli, Francesca ^a   Lo Gerfo, Annalisa ^a   Bagnoli, Silvia ^b   Dardano, Angela ^a   Nacmias, Benedetta ^b   Mancuso, Michelangelo ^a   Monzani, Fabio ^a   Siciliano, Gabriele ^a   Sorbi, Sandro ^b   Migliore, Lucia ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Alzheimer's disease; DNA methylation; DNA methyltransferases; DNMT3B; Epigenetics; Polymorphisms

Indexed keywords

DNA METHYLTRANSFERASE 3B;

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL;

EID: 84861160131     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720512800618062     Document Type: Article

References (32)

1. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging 32(7):1161-80 (2011).
2. Gius D, Cui H, Bradbury CM, Cook J, Smart DK, Zhao S, et al. Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell 6: 361-71 (2004).
3. Coppedè F. One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Curr Genomics. 11:246-60 (2010).
4. Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One 4: e6617 (2009).
5. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging 31: 2025-37 (2010).
6. Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One 3: e2698 (2008).
7. Bollati V, Galimberti D, Pergoli L, Dalla Valle E, Barretta F, Cortini F, et al. DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun 25(6):1078-83 (2011).
8. Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. Sadenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 28:195-204 (2005).
9. Fuso A, Nicolia V, Pasqualato A, Fiorenza MT, Cavallaro RA, Scarpa S. Changes in Presenilin 1 gene methylation pattern in dietinduced B vitamin deficiency. Neurobiol Aging 32(2):187-99. (2011).
10. Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, et al. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci 25: 823-9 (2005).
11. Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, et al. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci 28: 3-9 (2008).
12. Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology 9: 375-9 (2008).
13. Jones PA, Liang G. Rethinking how DNA methylation patterns are maintained. Nat Rev Genet 10: 805-11 (2009).
14. Métivier R, Gallais R, Tiffoche C, Le Péron C, Jurkowska RZ, Carmouche RP, et al. Cyclical DNA methylation of a transcriptionally active promoter. Nature 452: 45-50 (2008).
15. Fuso A, Nicolia V, Cavallaro RA, Scarpa S. DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models. J Nutr Biochem 22:242-51 (2011).
16. Singal R, Das PM, Manoharan M, Reis IM, Schlesselman JJ. Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk. Oncol Rep 14: 569-73 (2005).
17. Bao Q, He B, Pan Y, Tang Z, Zhang Y, Qu L, et al. Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer. Int J Colorectal Dis 26(9): 1107-12 (2011).
18. Hu J, Fan H, Liu D, Zhang S, Zhang F, Xu H. DNMT3B promoter polymorphism and risk of gastric cancer. Dig Dis Sci 55:1011-6 (2010).
19. Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 62: 4992-4995 (2002).
20. Lee SJ, Jeon HS, Jang JS, Park SH, Lee GY, Lee BH, et al. DNMT3B polymorphisms and risk of primary lung cancer. Carcinogenesis 26:403-409 (2005).
21. Haggarty P, Hoad G, Harris SE, Starr JM, Fox HC, Deary IJ, et al. Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. PLoS One 5: e11329 (2010).
22. Zhang C, Fang Y, Xie B, Cheng W, Du Y, Wang D, et al. DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Neurosci Lett 462: 308-11 (2009).
23. Nam EJ, Kim KH, Han SW, Cho CM, Lee J, Park JY, et al. The -283C/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis. Rheumatol Int 30: 1299-303 (2010).
24. American Psychiatric Association, Diagnostic and Statistic Manual of Mental Disorders, 4th ed., American Psychiatric Association, Washington, DC, (1994).
25. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944 (1984).
26. Xiao Y, Word B, Starlard-Davenport A, Haefele A, Lyn-Cook BD, Hammons G. Age and gender affect DNMT3a and DNMT3b expression in human liver. Cell Biol Toxicol 24: 265-72 (2008).
27. Migliore L, Coppedè F. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat Res 667: 82-97 (2009).
28. Feng J, Chang H, Li E, Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res 79: 734-46 (2005).
29. Watanabe D, Uchiyama K, Hanaoka K. Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development. Neuroscience 142: 727-37 (2006).
30. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 13: 423-30 (2010).
31. Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, et al. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 329: 444-8 (2010).
32. Coppedè F, Grossi E, Migheli F, Migliore L. Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks. BMC Med Genomics 3: 42 (2010).